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The introduction of substituents on bare heterocyclic scaffolds can selectively be achieved by directed C-H functionalization. However, such methods have only occasionally been used, in an iterative manner, to decorate various positions of a medicinal scaffold to build chemical libraries. We herein report the multiple, site selective, metal-catalyzed C-H functionalization of a “programmed” 4-hydroxyquinoline.
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Brazil is home to 30% of the world’s Eucalyptus trees. The seedlings are fertilized at plantation to support biomass production until canopy closure. Thereafter, fertilization is guided by state standards that may not apply at the local scale where myriads of growth factors interact. Our objective was to customize the nutrient diagnosis of young Eucalyptus trees down to factor-specific levels. We collected 1861 observations
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Current methods for determining “LDL-C” in clinical practice measure the cholesterol content of both LDL and lipoprotein(a) [Lp(a)-C]. We developed a high-throughput, sensitive, and rapid method to quantitate Lp(a)-C and improve the accuracy of LDL-C by subtracting for Lp(a)-C (LDL-Ccorr). Lp(a)-C is determined following isolation of the Lp(a) on magnetic beads linked to monoclonal antibody LPA4 recognizing apolipoprote
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BACKGROUND Despite advances in microsurgical techniques of flap transfer, complex upper extremity trauma reconstruction remains a challenge for surgeons. This study aimed to present the outcomes in using flaps in the subacute reconstruction of complex upper extremity injuries. METHODS From July 2013 to December 2016, 35 patients ranging in age from 23 to 69 years with complicated upper extremity traumatic injuries were t
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The scope of health information and health care services available online is rapidly expanding. At the same time, COVID-19 is causing vulnerable elders to reconsider in-person provider visits. In that context, recently published research by Y. Mizrachi et al. examining obstacles to the use of online health services (OHS) among adults age 50 and up takes on new importance. An iconic Israeli song begins, “Will you hear my
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Objective To evaluate the prevalence of chronic respiratory morbidity (CRM) in preterm infants (born ≤28 weeks gestational age (GA)) and compare healthcare resource utilization and costs among infants with/without CRM, and with/without bronchopulmonary dysplasia (BPD). Methods Commercial claims data from the Truven MarketScan database were retrospectively analyzed. Included infants were born ≤28 weeks GA and adm
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단체의 디지털 전환이 진전됨에 맞물려 인터넷 등록 및 인증 절차의 필요성이 더한 커지고 있습니다. 특별하게, 신속하고 보안적인 010 인증은 회사가 고객과의 신뢰를 형성하고 경쟁 우위를 높이는 데 중점적인 역할을 합니다. 그렇지만 이 같은 인증 과정을 스스로 처리하기에는 인력이 부족한 많은 경우가 있습니다. 이때 010 인증대행 서비스 회사의 보조를 받는 것이 신속하고 방안이 될 것입니다.
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People with diabetes could have an increased risk of falls as they show more complications, morbidity and use of medication compared to the general population. This study aimed to estimate the risk of falls and to identify risk factors associated with falls in people with diabetes. The second aim was to estimate fall-related injuries, such as lesions and fractures, including their anatomic localization in people with
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디지털 시대에 진입하면서 모든 비즈니스가 온라인으로 이동하고 있습니다. 이와 함께 기업의 정보와 자산을 보호하는 것이 더욱 필요해졌습니다. 010 인증 기능은 사용자 인증의 일환으로 적극적으로 활용되며, 비즈니스 포털에 안전하게, 간편하게 접근할 수 있는 방법으로 자리잡고 있습니다. 특히 010 인증 제공업체들은 이 과정을 더 간편하고 효율적으로 만들어주는 솔루션을 제공합니다.
다수의 기업이 비즈니스 포털을 통해 고객과 의사소통하고 정보를 공유하고 있지만, 인증 과정에서 불편함을 느끼는 경우가 많습니다. 010 인증을 도입하면 이러한 문제를 해결할 수 있으며, 보안성을 향상시키는 데도 큰 도움이 됩니다. 이번 글에서는 010 인증을 잘 활용하여 비즈니스 포털 접근성을 향상시키는 방법에 대해 살펴보겠습니다.
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요즘 인터넷 서비스의 급증로 인해 개인 정보 보안와 안전성이 지금보다 중요해졌습니다. 특별히, 웹 포털에 가입할 때 필요한 인증 절차는 고객에게 안전한 경험을 제공하는 중요한 요소입니다. 010 번호 인증은 편리하면서도 효과적인 인증 수단으로 자주 활용되고 있으며, 이는 사용자의 전화번호를 기반으로 하는 확인 과정입니다.
이 가이드에서는 010 번호 인증의 절차를 쉽고 설명하고, 안전한 웹 포털 가입을 위한 필수 정보를 제공합니다. 010번호인증 업체를 통해 인증을 진행하면, 개인 데이터의 안전하게 안전하게 신속하게 간편하게 서비스를 이용할 수 있습니다. 이제 인증 과정에 대한 이해를 높이고, 더 나은 온라인 체험을 위해 필요한 사항을 배워봅시다.
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This study aimed to test the hypothesis that the elevation in internal body temperature during exercise in a hot environment is influenced by the combination of exercise intensity and BSA burned.
Ten healthy participants (8 males, 2 females; 32 ± 9 yr; 75.3 ± 11.7 kg) completed eight exercise trials on a cycle ergometer, each with different combinations of metabolic heat pr
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Background and aims Tri-typing of acute-on-chronic liver failure (ACLF), as proposed by the World Gastroenterology Organization (WGO), has not been validated in patients infected with hepatitis B virus (HBV). We aim to compare the three types of ACLF patients in clinic characteristics. Methods Hospitalized ACLF patients with chronic hepatitis B from 5 hepatology centers were retrospectivel
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The protocol provided here describes methodologies for making a highly cost-effective, chemically defined medium for culturing hiPSCs we call B8 medium. The typical cost of B8 medium is US$10 per liter, which with modifications included here is more affordable than standard media. We provide simple protocols for making B8 supplement aliquots, making the basal media DMEM/F12, Matrigel-coated plates, thawing, passagi
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Fine root production accounts for a large proportion of net primary production (NPP) in forest ecosystems that is highly responsive to environmental and biotic changes. The underlying mechanisms of the relationship between tree species richness and fine root production have not been fully examined. Here we hypothesized that (i) the relationship between aboveground species richness and fine root production coul
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9 ± 13.4 years, 43.2% female). Polyp recurrence occurred in 4.3% (6.4% of patients, n = 7 unilateral) of sinus cavities. Frontal and ethmoid sinus cavities were most affected in those with polyp recurrence, compared to the maxilla and sphenoid (100% vs 100% vs 53% vs 53%, p 4/week; 66.7% vs 48.9%, p = 0.13). Prior surgery was more common in patients with polyp recurrence (86.7% vs 53.5%, p = 0.01). CONCLUSION The frontal and e
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Larvae of the rhinoceros beetle (Allomyrina dichotoma) (ADL) are used ethnopharmacologically to treat gut-related disorders in Korea and China since 1596 and are also approved as a safe novel food with high nutritional value.
We investigated the protective effects of ADL extract against leaky gut disease using a Drosophila mode
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5 (95% CI 1.190-5.431; p = .02). Furthermore, when we used absent, present in less than 7.39% of glomeruli, and present in greater than or equal to 7.39% of glomeruli as cutoffs in all the patients, a gradation appeared, with adjusted HRs of 2.9 (95% CI 1.326-6.313; p = .008) for crescents in greater than or equal to 7.39% of glomeruli, in reference to no crescents.Conclusion We proposed that the crescent
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Oxidative stress can play an important role in the autoxidation of glucose, glycation of proteins and activation of polyol metabolism, and the development of various complications in diabetes. This study investigated the protective effect of Paliurus spina-christi (PSC) fruit against diabetes-induced pathologies such as inflammation caused by oxidative stress and its phytochemical content. The
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mm Hg, because these recommendations differ from some other guidelines.Background Vancomycin is associated with nephrotoxicity and the mechanism may in part be related to oxidative stress. In vitro and preclinical studies suggest melatonin supplementation decreases oxidative stress. The objective of this study was to evaluate concomitant use of melatonin and vancomycin and the incidence of acute kidney injury (AKI). Me
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최근 온라인 비즈니스의 중요성이 한층 부각되고 있는 시점에서, Naver 계정 구입가 회사의 성과 향상 향상에 주는 영향에 대한 관계이 증가하고 있습니다 . 블로그나 또는 카페와 같은 플랫폼을 통해 고객와 효과적으로 소통하며 , 상표 가치을 늘리기하는 데 있어 Naver 계정의 기능은 더욱 부각되고 있습니다 . 특히 , 네이버 아이디 구매가 증가함에 따라 기업들은 여러 가지 두루으로 네이버 계정 구매 이용하여 마케팅 계획을 보강하고 있다 .
Naver 아이디은 그냥 로그인 수단을 넘어서 , 회사이 Naver 플랫폼 내에서 효과적으로 운영할 수 있도록 도와주는 필수적인 자산으로 정착하고 있습니다 . 계정을 사게 되면 회사은 신규 소비자 그룹에 접근할 수 있을 뿐만 아니라 , 콘텐츠의 신뢰성를 높이고 활성화
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블로그와 카페를 운영하는 것은 디지털 마케팅 시대가 도래함에 따라 많은 기업 및 개인에게 중요한 요소가 되었습니다. 네이버는 한국에서 인기 있는 포털 사이트로 블로그와 카페를 통해 고객과 고객과 직접적으로 소통하고 콘텐츠를 제공할 수 있는 탁월한 플랫폼입니다. 그러므로 경쟁이 치열한 만큼 시의적절한 계정 운영이 필요합니다.
이러한 배경 속에서 검증된 네이버 계정 구매는 다수의 기업들이 선호하는 선택입니다. 특히 문제는 신규 계정을 처음부터 키우는 건 시간과 노력이 많이 필요하기 때문입니다 이미 신뢰를 구축한 계정을 사용하는 것이 도움이 될 수 있습니다. 이 가이드는 네이버 계정 구매 시 참고할 수 있는 중요한 내용과 유의할 점을 다루어 블로그와 카페를 효과적으로 운영하는 방법을 제공합니다.
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Background The term “uterine smooth muscle tumor of uncertain malignant potential” (STUMP) indicates a rare tumor that cannot be classified as a benign leiomyoma or malignant leiomyosarcoma. In this study, we assessed the clinical characteristics, fertility, and oncologic outcomes of patients diagnosed as STUMP in 14 years. In addition, we analyzed the risk factors for recurrence in
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We conclude that such multi-level frameworks are key for the development of new biological and psychosocial treatments and may advance progress towards an individualized treatment of negative symptoms.Nitrites are present in the food chain as naturally occurring species or contaminants. Additionally, sodium and potassium nitrites are authorised food additives. Nitrites exert acute toxicity through methaemo
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strongly associated with Asian ethnicity.
Reproducibility amongst instruments was moderate; therefore, interchangeability between instruments, particularly for research purposes, cannot be assumed. In this cohort, GDM risk was modestly associated with increasing BFP and strongly associated with Asian ethnicity.The pathogenesis of ascending thoracic aortic aneurysm (aTAA) is thought to differ betwe
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Clubroot, caused by Plasmodiophora brassicae Woronin, is an important soilborne disease of Brassica napus L. and other crucifers. To improve understanding of the mechanisms of resistance and pathogenesis in the clubroot pathosystem, the rutabaga (B. napus subsp. rapifera Metzg) cultivars ‘Wilhelmsburger’ (resistant) and ‘Laurentian’ (susceptible) were inoculated with P. brassicae pathotype 3A and their transc
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Grocery shopping frequency was associated with multiple dimensions of diet quality at the home and individual levels. These results offer a potential strategy to intervene on home food availability and individual dietary intake.Clinical prediction scores support the assessment of patients in the emergency setting to determine the need for further diagnostic and
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0008); (3) BFM was positively correlated to DBP (R2 = 0.1232, P = 0.02) and partially correlated to urine protein (R2 = 0.047, P = 0.12) and FBG (R2 = 0.07, P = 0.06); (4) overweight young adults had higher urinary mRNA levels of renin, angiotensinogen, IL-18 and CTGF. These suggest that BMI directly affects BP, kidney injury markers, and the activation of the intra-tubular RAS even in normotensive young adults.
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Cardiac hypertrophy is a significant risk factor for cardiovascular disease, including heart failure, arrhythmia, and sudden death. Cardiac hypertrophy involves both embryonic gene expression and transcriptional reprogramming, which are tightly regulated by epigenetic mechanisms. An increasing number of studies have demonstrated that epigenetics plays an influential role in the occurrence and development of
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Twice Crystallization as well as Period Separation in Polyethylene-Syndiotactic Polypropylene Di-Block Copolymers.
Recent studies have demonstrated that various long non-coding RNAs (lncRNAs) participate in the gastric cancer (GC) development and metastasis. Some lncRNAs exert their regulatory function by interacting with microRNAs. BAF312 supplier Here we identified a novel lncRNA RP11-8
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However, a longer breakthrough time was observed for the retinotopic as compared to the control location, suggesting that a form of retinotopic adaptation to the grating suppressed the priority to access visual awareness after a saccade.Motor hand deficits impact autonomy in everyday life, and neuroplasticity processes of motor recovery can be explored using functional MRI (fMRI). However, few studies have used
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A recent study reported a tuberculosis (TB) outbreak in which, among newly infected individuals, exposure to additional active infections was associated with a higher probability of developing active disease. Referred to as
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In pregnancies complicated by fetal congenital cardiac anomaly, mothers of infants with planned future surgery or neonatal death are at significant risk for postpartum depression.
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These data suggest that typical atrial flutter constitutes a manifestation of previously asymptomatic CAD. Due to the inclusion criteria, CAD has to be considered silent and chronic in most of the patients. Therefore, the presence of typical atrial flutter in formerly healthy patients should raise suspicion of otherwise silent CAD and initiate further investigations and risk stratification wit
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Early diagnosis, surgical intervention, and application of intravenous antibiotics can improve the prognosis and quality of life of patients. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.BACKGROUND Gallbladder adenomyomatosis (GAM) is a benign lesion, characterized by thickening of the gallbladder wall and a focal mass, which overlap with the features of gallbladder mal
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Brain development and deterioration across the lifespan are integral to the etiology of late-life neurodegenerative disease. Factors that influence the health of the adult brain remain to be elucidated and include risk factors, protective factors, and factors related to cognitive and brain reserve. To address this knowledge gap we designed a life-course study on brain health, which received funding through the EU ERC Pro
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Hinge-type molecular models for electron donors in reaction centers of Photosystems I and II and purple bacteria were investigated using a two-state computational approach based on frozen-density embedding (FDE). This methodology, dubbed FDE-diab, is known to avoid consequences of the self-interaction error as far as intermolecular phenomena are concerned, which allows a prediction of qualitatively co
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Thus, natriuresis due to hypertension and hydrodiuresis due to heart failure may cause nocturia, which can effectively be treated by the administration of thiazide diuretics and loop diuretics in the morning, respectively. Because cardiovascular diseases, such as hypertension and heart failure, can cause nocturia and because the treatment methods differ dep
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Conversely, estimating population MEP amplitude and hypothesis testing are markedly more dependent on the number of subjects than on the number of trials. These tools and results help to clarify the impact of the number of trials in the design and reproducibility of past and future experiments.Dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesi
네이버 비실명 ID 판매
네이버는 대한민국에서 가장 인기 있는 포털 사이트 중 하나로, 블로깅 서비스, 카페 참여 참여, 그리고 지식인 기여 기여를 통해 기업을 확장할 수 있는 훌륭한 플랫폼입니다. 하지만 이러한 행동을 시작하고 성장하기 위해서는 적절한 네이버 계정 확보하는 것이 아주 중요합니다. 특히, 이미 존재하는 계정을 활용하거나 새로운 계정을 신뢰성 있게 구매하는 절차을 아는 것이 여전히 필요합니다.
이 글에서는 기업 확장을 위해 네이버 계정을 구매할 때 주의사항과 안전하게 구매할 수 있는 방법에 대해 자세히 안내하고자 합니다. 안전한 거래를 통해 사업의 성장에 실질적인 도움을 줄 수 있는 네이버 아이디 판매 정보와 함께, 계정 구매 시 유의해야 할 점까지 폭넓게 다루어 보겠습니다.
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e settings.The self-assembly of a nickel-porphyrin derivative (Ni-DPPyP) containing two pyridyl coordinating sites and two pentyl chains at trans meso positions was studied with scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED) on Au(111). Deposition of Ni-DPPyP onto Au(111) gave rise to a close-packed network for coverages smaller or equal to one mon
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NR2E3-associated recessive disease in humans is historically defined by congenital night blinding retinopathy, characterized by an initial increase in short-wavelength (S)-cone sensitivity and progressive loss of rod and cone function. The retinal degeneration 7 (rd7) murine model, harboring a recessive mutation in the mouse ortholog of NR2E3, has been a well-studied disease model and recently evaluated as a the
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The Minnesota remdesivir allocation framework specifies an ethical approach to distributing the drug to facilities across the state and then among COVID-19 patients within each facility. This article describes the process of developing the framework and adjustments in the framework over time with emergence of new data, analyzes key issues addressed, and suggests next steps. Sharing this framework and the development process
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However, robust clinical trials are necessary to assess the real efficacy of these treatments.The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay detects DNA breakage by labeling the free 3′-hydroxyl termini. Given that genomic DNA breaks arise during early and late stages of apoptosis, TUNEL staining continues to be widely used as a measure of apoptotic cell death. The advantages of
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After a median 229 (2-2280) days follow-up after diagnosis, the 2-year overall survival was (24.0±14.5) %. Conclusion The major pathogen of NAMI after allo-HSCT was Rhizopus, and the mortality of NAMI after allo-HSCT was very high due to lack of early effective therapy.
The COVID pandemic has impacted almost every aspect of human interaction, causing gl
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Manipulating fungal genomes is an important tool to understand the function of target genes, pathobiology of fungal infections, virulence potential, and pathogenicity of medically important fungi, and to develop novel diagnostics and therapeutic targets. Here, we provide an overview of recent advances in genetic manipulation techniques used in the field of medical mycology. Fungi use several strategies to cope with
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Chimeric antigen receptor T (CAR T) cell immunotherapy has shown remarkable efficacy in non-Hodgkin’s lymphoma (NHL) patients. Minimal residual disease (MRD) monitoring in NHL is essential after CAR T cell therapy, which can be achieved by monitoring circulating tumor DNA (ctDNA). The mutation of TP53 in NHL has been suggested to be associated with a poor prognosis. However, whether TP53-mutated ctDNA can be used as a bio
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The severe acute respiratory syndrome coronavirus 2 is currently spreading across the world at an alarming rate, resulting in the coronavirus disease 2019 pandemic. Amidst this crisis, tourism scholars are directing their attention to communities at tourist destinations, looking at their safety and well-being and the costs that they will bear due to the cessation of tourism activity. This article desc
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Overall, in our children and adolescents with T1D glycemic control im
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Adolescent connectedness to adults, schools, and peers is a protective factor for development. This study aimed to describe parental perceptions of opportunities for youth connectedness and the potential role of the primary care provider in supporting these opportunities.
Eleven parents or caregivers of youth aged 11-18 years participated
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Expected final online publication date for the Annual Review of Neuroscience, Volume 43 is July 8, 2020. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Context We previously developed the reintegration model to describe the adjustment process for individuals at the end of life. However, caregivers and loved ones also require significant support and must work to reimagine their relationship
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Accurate and fast human motion pattern recognition is the key to ensuring lower limb assistive devices’ appropriate assistance. The research on human motion pattern recognition of lower limb assistive devices mainly focuses on sagittal gait. The motion pattern such as circular walking (CW) is asymmetric about the sagittal plane of the body. CW is common in daily living. However, the recognition algorithm of CW is rare
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Reducing Cd bioavailability in the systemic circulation is an alternative strategy to reduce Cd exposure. The influence of 39 dietary components on Cd bioaccessibility in water or rice was determined using an in vitro gastrointestinal model, following which an in vivo bioassay was used to determine the most effective components on Cd bioavailability in rice. The results showed that several component
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블로거와 카페 관리자에게 있어, 인터넷에서의 믿음는 성장의 중추적인 요소입니다. Naver는 대한민국의 주요한 포털 사이트로, 다수의 사용자가 자료를 찾고 교류하는 공간입니다. 이 때문에 Naver에서 인증 계정을 보유하는 것은 기업의 신뢰성를 증진시키는 데 중요한 도움이 됩니다. 많은 이들이 네이버 인증 계정을 사려는 이유는 확실합니다. 공식적인 계정은 우수한 가시성와 향상된 신뢰도를 제공하며, 이는 블로깅나 커뮤니티 운영에 있어 경쟁력을 높이는 수 있습니다.
하지만 네이버 계정 구매에는 여러 가지 유의사항이 존재합니다. 정확한 정보를 근거로 안전하게 계정을 사들이는 것이 중요하며, 또한 신뢰할 수 있는 판매자와의 거래 관계가 필수적입니다. 이 가이드는 블로거와 카페 운영자가 인증 계정을 안전하고 구입
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네이버는 한국에서 가장 주요 포털 사이트 중 하나로, 다수의 기업들이 NAVER 블로그와 카페를 통해 소비자와 커뮤니케이션하고 있습니다. 이러한 플랫폼에서의 참여는 상표 인지도를 증대시키며, 소비자와의 관계를 강하게 하는 데 상당한 역할을 하죠. 최근에는 비즈니스의 성과를 최대화하기 위한 방식으로 NAVER 계정 매입가 주목을 받고 있습니다. 이를 통해 회사들은 많이 상당한 유입을 유도하고, 효율적인 마케팅 전략을 실행할 수 있죠.
네이버 계정 판매는 특히 새로운 시장에 진출하거나 상표의 가시성을 높이려는 하려는 소형 기업들과 신생기업들에게 많은 이점을 제공합니다. 여러 계정을 사용함으로써 여러 가지 소비자층에 접근할 수 있고, 이를 통해 비즈니스 성장의 기회를 만들 수 있습니다. 본 글에서는 네이버 계정 구매
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BACKGROUND Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination of zidovudine and interferon-alpha. However, most patients experience relapse less than 6 months after diagnosis. Allogeneic stem cell transplantation is the only curative treatment, but is only feasible in a minority of cases.
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The quality sequence check revealed a low library depth for two fecal samples. Therefore, the gut microbiota analyses were conducted on 21 patients. The α-diversity was significantly lower in PFS group, showing a reduction of richness and diversity of gut microbiota structure. Moreover, when visualizing β-diversity, a clustering effect was found in the gut microbiota of a subset of PFS subjects, whic
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Increasing evidence has demonstrated the correlation between hepatocellular carcinoma (HCC) prognosis and RNA binding proteins (RBPs) dysregulation. Thus, we aimed to develop and validate a reliable prognostic signature that can estimate the prognosis for HCC.
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These correlations were particularly strong for visuospatial materials, were distributed over multiple fronto-parietal locations, and remained significant even after a correction for multiple comparisons (False Discovery Rate) and after robust correlation methods were applied. These results suggest that computational models could be individually tailored for pred
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The results indicated that interactions among the PER1 rs2518023, ARNTL2 rs2306074 and NR1D1 rs939347 were associated with the risk of ADHD in children. Individuals carrying the combination genotypes of the PER1 rs2518023 GG or GT, ARNTL2 rs2306074 TC or TT and NR1D1 rs939347 GA or AA displayed a significantly higher risk for ADHD than who carry the PER1 rs2518023 TT and CRY2 rs2292910 CA/CC genotypes (adjuste
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Enhancing immune cell functions in tumors remains a major challenge in cancer immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by upregulating the transcription factor HIF-1α. Here, we defined the transcriptional landscape of mouse tumor-infiltrating natural killer (NK) cells by using single-cell RNA sequencing. Conditional deletion of Hif1a in NK cells resulted in reduced tumor growt
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Finally, NEI commissioned the creation of AREDS2 participant-derived induced pluripotent stem cell (iPSC) lines linked to their associated genomic and phenotypic datasets. These datasets will also be linked to the data obtained using their associated iPSC-derived cells (RPE, retina, choroid) and made publicly available.
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Parent attachment avoidance was related to increased parent cortisol levels in the clinic and increased child cortisol levels at home. Parent and child cortisol levels had a strong, positive relationship in the clinic but not at home. We did not observe a difference between cortisol levels in children or parents in the clinic or at home.
We concluded that this protocol is feasi
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Experimental development of a compact optical emission detector based on the assembly of a polymer-metal and a standard silica fiber is presented in this paper. This device is exploited in a proof-of-principle experiment for gas detection application by means of plasma spectroscopy in the visible-Near Infrared spectral region. A multimode fiber (MMF) is associated with a functional hollow dual-electrodes e
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While causation cannot be assessed from these population-level data, our observations indicate that there is no evidence that introduction of mandatory folic acid fortification of bread flour has influenced colorectal cancer incidence in Australia.
While causation cannot be assessed from these population-level data, our observations indicate that there is no evidence that introduction
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The amount of intact spermatozoa in the groups containing 5% ethylene glycol and 1.5% ethylene glycol +100 mM trehalose was found to be higher than other groups (p less then 0.05). As a result, it was suggested that the groups of 5% ethylene glycol and 1.5% ethylene glycol +100 mM trehalose provided the highest protection for the ultrastructural morphology of frozen-thawed Konya Merino ram spermatozo
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es and Delivery Research programme. BACKGROUND Severe mental illness diagnoses have overlapping symptomatology and shared genetic risk, motivating cross-diagnostic investigations of disease-relevant quantitative measures. We analysed relationships between neurocognitive performance, symptom domains, and diagnoses in a large sample of people with severe mental illness not ascertained for a specific diagnosis (cases)
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An 86-year-old woman presented with symptomatic hypotony on the left eye since a few weeks, blurry vision and a very sensitive eye. She had a history of bilateral intracapsular cataract extraction (ICCE) in 1982 and secondary intraocular lens implantation in 1988. The patient mentioned a fall on the left side of the head 6 months earlier. The diagnosis of a superior scleral fistula was made, confirmed by gonioscopy an
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Increasing availability of ocean biogeochemical data, as well as an improved understanding of the underlying processes, allows advances in the marine biogeochemical components of the current generation of ESMs. The present study scrutinizes the extent to which marine biogeochemistry components of ESMs have progressed between the 5th and the 6th phases of the Coupled Model Intercomparison Project (CMIP).The wo
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These results indicate that BCO2 gene could be used as a candidate gene in molecular marker-assistant breeding of prawns. In order to investigate the anti-fibrotic effect of different molecular weight (Mw) fucoidans on TGF-β1-induced mouse renal tubular epithelial cell (MTEC) mode. Oxidative degradation method was used to obtain fucoidans with different molecular weights and the reaction time, reaction temperature
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Urate transporters, which are located in the kidneys, significantly affect the level of uric acid in the body. We looked at genetic variants of genes encoding the major reabsorption proteins GLUT9 (SLC2A9) and URAT1 (SLC22A12) and their association with hyperuricemia and gout. In a cohort of 250 individuals with primary hyperuricemia and gout, we used direct sequencing to examine the SLC22A12 and SLC2A9 genes. Identifi
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The study’s objective was to identify the association between sustained viral suppression (all viral load tests less then 200 copies/ml per year) and patterns of co-occurring risk factors including, mental health, substance use, sexual risk behavior, and adverse social conditions for people with HIV (PWH). Latent class analysis followed by multivariable logistic regression was conducted for 6554 PWH in the
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The most common adverse effects included discomfort (18 percent), swelling (15 percent), and bruising (13 percent). There was no statistically significant difference in questionnaire responses between men and women, except that men were more likely to consider repeated injection (92 percent versus 58 percent; p = 0.005).
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104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (β = -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect β = -.002, 95% CI [-.0044 -.0002]), and Degreesubcortical mediated the relationship between CD and emotion recognition memory performance (indirect β = -.002, 95% CI [-.0046 -.0005]). CD appe
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Many glasses exhibit fractional power law (FPL) between the mean atomic volume va and the first diffraction peak position q1, i.e. [Formula see text] with d ≃ 2.5 deviating from the space dimension D = 3, under compression or composition change. What structural change causes such FPL and whether the FPL and d are universal remain controversial. Here our simulations show that the FPL holds in both two- and th
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The immune system of human and mouse neonates is relatively immature. However, innate lymphoid cells (ILCs), commonly divided into the subsets ILC1, ILC2, and ILC3, are already present in the placenta and other fetal compartments and exhibit higher activity than what is seen in adulthood. Recent reports have suggested the potential role of ILCs, especially ILC2s, in spontaneous preterm labor, which is associated wi
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These themes reveal complex relations to help, and help-seeking in men lost to suicide, as well as bereaved men’s reliance on normative masculinities as an explanatory framing of these practices. Discussed within a critical masculinities framework, the current study highlights the need to destigmatize men’s mental illness and help-seeking as well as address significant health inequities to aid the eff
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Sinonasal inverted papillomas occasionally undergo malignant transformation into squamous cell carcinoma, which can be associated with EGFR mutations. Since biopsy can potentially under-sample the tumor, CT and MRI can provide clues as to the presence of malignant transformation. In particular, this entity tends to appear different from benign inverted papilloma on imaging, including prominent bon
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Cases of H7N9 human infection caused by an avian-origin H7N9 virus emerged in eastern China in 2013, leading to the urgent requirement of developing an effective vaccine to reduce its pandemic potential. In this report, the full-length recombinant H7 protein (rH7) of A/Hangzhou/1/2013 (H7N9) virus was expressed by a glycoengineered Pichia pastoris system. The rH7 protein underwent complex glycosylation modificatio
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Common peroneal nerve palsy (CPNP) after total knee arthroplasty (TKA) may impact extremity pain and function. Incidence and rates of
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and CDO for the bioproduction of dehydrogenated cyclodipeptides. It constitutes the first step toward the bioproduction of more complex and diverse 2,5-diketopiperazines.
Benzimidazole resistance is associated with isotype-1 β-tubulin gene F200Y, E198A and F167Y SNPs. In this study, the recently described polymorphism E198L was reported and analysed in Teladorsagia circumcincta.
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Background Thymidylate synthase is one of the target enzymes of 5-fluorouracil. However, the clinical and prognostic significance of TS expression in gastric cancer has remained controversial. In this study, the expression of thymidylate synthase was evaluated in gastric cancer patients treated with combinational chemotherapy; moreover, the association between TS expression and clinicopathologic characteristi
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Besides the well-known use in supporting the non-invasive diagnosis of non-tumoral dermatoses (general dermatology), dermoscopy has been shown to be a promising tool also in predicting and monitoring therapeutic outcomes of such conditions, with the consequent improvement/optimization of their treatment. In the present paper, we sought to provide an up-to-date overview on the use of dermo
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NAVER는 한국에서 가장 널리 사용되는 온라인 플랫폼 중 일부로, 다양한 사용자들이 블로그 공간, 카페, 지식인 등 각종 기능을 활용하고 있습니다. 이런 플랫폼에서 활동 중인 기업나 사용자은 가끔 해당 계정을 매각하는 상황에 직면하기도 합니다. 하지만 네이버 계정은 프라이버시 보호와 사용자 신뢰 유지를 위해 매우 엄격한 규정을 따릅니다. 그렇기 때문에 아이디를 안전히 매각하는 방법을 이해하는 것이 중요합니다.
계정 매각 과정에서 계정이 비활성화되거나 제한될 위험을 피하기 위해서는 일부 주의할 점을 염두에 두어야 합니다. 많은 사용자들이 네이버 아이디 구매에 관심을 갖고 있지만, 안전하고 방법으로 거래하는 것이 가장 필요합니다. 글에서는 이런 위험을 감소시키고, 네이버 아이디를 안전하게 매각하는 법에
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There are controversies in the literature on the blood supply to the forearm after surgical removal of the radial artery in coronary artery bypass grafting (CABG). The objective was to investigate the arterial remodeling of the ulnar artery after the removal of the radial artery in myocardial revascularization by means of ultrasound examination with color Doppl
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Tigecycline, a new agent against multidrug-resistant (MDR) bacteria, is especially licensed for use in complicated skin and soft tissue and intra-abdominal infections. We aimed to study the recent
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X-chromosome inactivation (XCI) is a developmental process that aims to equalize the dosage of X-linked gene products between XY males and XX females in eutherian mammals. In female mouse embryos, paternal XCI is initiated at the 4-cell stage; however, the X chromosome is reactivated in the inner cell mass cells of blastocysts, and random XCI is subsequently initiated in epiblast cells. However, recent findings s
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Mechanisms of the upper esophageal sphincter (UES) when exposed to acid are still incompletely understood. The presented work investigated the reaction of the UES to acid exposure during swallowing. Ten healthy individuals swallowed ten 2 ml neutral water boli of pH 7, followed by 10 swallows each of different levels of acidity (pH 1.8, pH 3 and pH 5). Effects were analyzed by high-resolution manometry (HRM) for the pr
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3 (SD 8.3) years, whereas the “Non-loading group” included 126 males and 153 females with average age 63.7 (SD 14.1) years. Age was significantly higher in the loading group (p 0.05). Conclusion Long-term shoulder loading in youth is a risk factor for pathological thoracic kyphosis especially in the lower thoracic spinal segments when farmers getting older.Background Human-animal interactions with mutual benefits i
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We extended our analysis to several analogous platinum complexes containing N-heterocyclic carbene, as well as DMSO or other ligands, and found varying inhibitory activities toward the Cag system which were not congruent with their DNA-binding properties, suggesting that protein interactions may cause the inhibitory effect. Inhibition experiments under varying conditions rev
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The findings expand our knowledge of peach-infecting viruses and alphanucleorhabdoviruses. The leaf blight caused by the genus Alternaria is one of the most epidemic diseases on watermelon, and A. tenuissima is the dominant pathogenic species in China. Mycoviruses are found ubiquitously in filamentous fungi, and an increasing number of novel mycoviruses infecting the genus Alternaria have been reported. In this stu
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Root pressure, also manifested as profusive sap flowing from cut stems, is a phenomenon in some species that has perplexed biologists for much of the last century. It is associated with increased crop production under drought, but its function and regulation remain largely unknown. In this study, we investigated the initiation, mechanisms, and possible adaptive function of root pressure in six genotypes of Sorghum bicolo
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Little research has examined the effects of high concentration, medium-duration smoke exposure on cardiovascular health. We investigated whether six weeks of exposure to smoke from the 2014 Hazelwood coal mine fire in Victoria (Australia), was associated with long-term clinical or subclinical cardiovascular disease approximately four years later, in adult residents of the towns of Morwell (exposed
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BACKGROUND Triple progressive thermopreconditioning (3PTP) may induce high Hsp-70 expression to maintain cardiac function. We suggest that 3PTP may reduce myocardial ischemia/reperfusion (I/R) injury during organ transplantation through Bag3/Hsp-70 mediated defense mechanisms. METHODS Male Wistar rats were divided into sham control group and 72 hours after 3PTP in a 42°C water bath (3PTP) group. Rats underwent 60 minute
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That population will be expected to pass on that recommendation to their acquaintances, resulting in widening dissemination of HPV vaccine among the majority.Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 access
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Short-term change in odor identification performance needs further investigation as a potential predictor of cognitive improvement with cholinesterase inhibitor treatment.
Change in odor identification with atropine challenge is not a useful predictor of treatment response to cholinesterase inhibitors. Short-term change in odor identification performance needs further investigation as a potential pred
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This was a drop of 40 points or a 40% decrease in his in-game performance. Player 3 had a pre-injury score of 67/100 and a post-injury score of 43/100 for a drop of 24 points or a 36% decrease in his in-game performance.Conclusions We reported three college football players who suffered concussions but did not immediately disclose their symptoms. Each had a marked decrease in performance grades a
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We propose that our new preoperational in vitro Drug-LGIR test, which specifies the most efficacious medication for each recipient, is useful for controlling immune attacks with personalized treatment for each patient after retinal transplantation.Pancreatic cancer (PC) is one of the most severe cancers, and its incidence and mortality rates have steadily increased in the past decade. In this study, we demonstrate the
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Patient derived expanded CTCs successfully generated patient derived xenograft (PDX) models with a 100% take rate. Our results demonstrate that CTC cultures are possible and provide a valuable resource for translational pancreatic cancer research, while also providing meaningful insight into the development of distant metastasis, as well as treatment resistance.The efficient locomotion of insects is not only inspi
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Alzheimer’s disease is the most common cause of dementia and the only illness among the top 10 causes of death for which there is no disease-modifying therapy. The failure rate of clinical trials is very high, in part due to the premature translation of successful results in transgenic mouse models to patients. Extensive evidence suggests that dysregulation of innate immunity and microglia/macrophage
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225). In a multivariable analysis using propensity score to adjust clinical patient characteristics, segmentectomy was not found to be an independent prognostic factor of RFS (hazard ratio, 0.732, P = 0.326) among patients with STAS. Among the patients with STAS, only one patient (1.0%) with insufficient resection margin (0.5 mm) experienced local recurrence and one patient (1.0%) with invasive mucinous adenoc
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Season significantly modified the effect of CO on pneumonia, the effect of SO2 on cardiovascular disease, the effect of PM10 on stroke, and the effect of O3 on stroke, asthma and pneumonia. The effect modifications of air pollution by season were similar among males and females, while the effect estimates seem to be higher among chi
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Heterosis refers to the superior performance of hybrid lines over inbred parental lines. Besides genetic variation, epigenetic differences between parental lines are suggested to contribute to heterosis. However, the precise nature and extent of differences between the parental epigenomes and the reprograming in hybrids that govern heterotic gene expression remain unclear. In this work, we analyzed DNA methylomes and tra
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To our knowledge, we report the first case of percutaneous pulmonary thrombectomy and catheter directed thrombolysis for massive pulmonary embolism (PE) in a patient with presumed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Standard treatments of anticoagulation and systemic thrombolysis were unsuccessful and the patient continued to deteriorate. Percutaneous pulmonary thrombectomy and l
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Patency in all surviving animals was 94% (17/18). Bypass flow after six months was 156.5 ± 24.7 mL/min. Full endothelialization of the SEcl pins was observed after 3 weeks.
The SEcl technique is not inferior to the ELANA technique regarding patency, flap retrieval rate, flow, and endothelialization. On the basis of a significantly shorter application time and superior h
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The Connectomes Related to Human Diseases (CRHD) initiative was developed with the Human Connectome Project (HCP) to provide high-resolution, open-access, multi-modal MRI data to better understand the neural correlates of human disease. Here, we present an introduction to a CRHD project, the Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA) study, which is coll
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The 48 included patients comprised 37 categorized into the good-outcome group and 11 into the poor-outcome group. The presence of acute metabolic disturbances was significantly correlated with poor outcome (
=0.036), while the other analyzed variables were not significantly correlated with outcomes.
Acute metabolic disturbances in NCSE are associated with poor ou
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Animals exposed to this cocaine dose showed similar open field activity and brain metabolic activity as compared with controls. However, histological analysis showed alterations in the prefrontal cortex and hippocampus of mice exposed to cocaine. For the first time, it has been demonstrated that a single low dose of cocaine, which can cause no locomotor behavioral and brain metabolic changes, can induce structural
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The whole mitochondrial genome associated with Juema this halloween Sus scrofa (Suina: Suidae) coming from southeast Gansu.
These results are consistent with the idea that SCZ use a different strategy while they perform the DRM paradigm. © 2020 The Authors.Objective To assess cognitive functioning in adolescents (12-17 years old) with schizophrenia during open-label treatment with paliperidone exten
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We monitored NP aggregation induced by interaction with several analytes like acids and spermine (SPN). Assessment of NPs was achieved in less than 10 min and it permitted to develop suitable plasmonic tests. Here, it was also demonstrated that these assays can be followed by IT-SPME-miniaturized LC-DAD and more sensitivity and selectivity than those provided by UV-Vis spectrometry were achieved. Analy
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Analysis of monitoring water quality data show that on average 50 water supplies, or about 5% of the Icelandic registered water supplies have contained faecal matter every year. The most frequent cause of waterborne outbreak were poor design and inadequate maintainance of water intakes. Conclusions It is likely that waterborne outbreaks are more numerous than are registered in official reports, especi
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Mink enteritis virus (MEV) is a major pathogen inducing acute hemorrhagic enteritis in mink. This study aims to determine the pathogenicity of the isolated MEV strain (SMPV-11) compared with the attenuated MEV strain (MEV-F61) in the mink. The two MEV strains were inoculated in the two mink groups, respectively. Then the clinical symptom, hematological, serological, and histopathological change were evaluated. Our findings showed
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This was treated with protocolized nebulizer treatments, prone-positioning, early tracheostomy, and frequent bronchoscopy. Over his hospital course he required lower extremity amputation and numerous excision and grafting procedures. Ultimately, he exhibited renal and respiratory recovery. He was discharged on PBD 75 to a rehabilitation hospital.
This case highlights that el
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Given that few studies investigated the efficacy of catheter ablation (CA) in patients with paroxysmal atrial fibrillation (AF) and atrial septal defect (ASD), this study evaluated its effectiveness in patients with paroxysmal AF and ASD.
Of the 216 patients who underwent ASD device closure at two hospitals, 36 patients had paroxysmal AF. After April 2012, CA for AF was
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0001); Erythroplakia (p less then 0.019); Red patch (p less then 0.010); White patch (p less then 0.020); Tobacco consultation (p less then 0.0001); Intraoral examination (p less then 0.0001) and Up-to-date knowledge (p less then 0.002). Overall, the incidence of OSCC screening is low. Most HCPs feel the need to increase KAP. Data confirmed gaps in KAP, highlighting the need for a more efficient pre- and post-grad
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Among the approximately 8000 Mendelian disorders, >1000 have cutaneous manifestations. In many of these conditions, the underlying mutated genes have been identified by DNA-based techniques which, however, can overlook certain types of mutations, such as exonic-synonymous and deep-intronic sequence variants. Whole-transcriptome sequencing by RNA sequencing (RNA-seq) can identify such mutati
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Incorporation of ribonucleotides into DNA can severely diminish genome integrity. However, how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote replication stress and genomic instability and have been implicated in several diseases. We report here the impact of the ribonucleotide rATP and of its naturally occurring damaged analog 1,N 6-ethenoadenosine (1,N 6-εrA) on translesion sy
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Searching for high-activity, stable and low-cost catalysts toward oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are of significant importance to the development of renewable energy technologies. By using the computational screening method based on the density functional theory (DFT), we have systematically studied a wide range of transition metal (TM) atoms doped a defective BC3 monolayer (B ato
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Noradrenaline (NA) promotes breakdown of the glucose-polymer, glycogen, and hence enhances glycolytic production of lactate in astrocytes. Here, in cultured rat cerebrocortical astrocytes, we examined the contributions of different adrenoceptor subtypes to NA-modulated glucose metabolism, and the relationship of NA-induced glycogenolysis to lactate production. Stimulation of astrocytic glucose metabolism by
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The aim of this study was to identify the risk factors for adverse events following the surgical correction of cervical spinal deformities in adults.
We identified adult patients who underwent corrective cervical spinal surgery between 1 January 2007 and 31 December 2015 from the MarketScan database. The baseline comorbidities and characteristics of the operation were recorded.
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When excited at sufficiently high acoustic pressures, a wall-attached bubble may exhibit asymmetric nonspherical modes. These vibration modes can be decomposed over the set of spherical harmonics Y_nm(θ,ϕ) for a degree n and order m. We experimentally capture the time-resolved dynamics of asymmetric bubble oscillations in a top-view configuration. A spatiotemporal modal analysis is performed and allowed recovering the set of zonal (m=0
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Febrile neutropenia(FN)is an adverse event associated with chemotherapy. Because well-maintained dose intensity improves survival rate, suppression of FN is important. While the incidence of FN has been recognized to be higher with docetaxel/cyclophosphamide(TC)therapy, it is generally considered lower with doxorubicin/cyclophosphamide(AC)therapy, and primary prophylaxis with granulocyte-colony stimulating f
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58, P less then 0.001). Disabled or unemployed status was independently associated with both lower PROMIS PF and HOOS, JR scores (regression coefficient [β] -3.4; 95% confidence interval [CI] -5.8 to -1.0; P = 0.006 and β -11; 95% CI -17 to -5.0; P less then 0.001, respectively). Private rather than public insurance was associated with both higher PROMIS PF and HOOS, JR scores (β 4.5; 95% CI 2.2 to 6.8; P less then 0.001
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eir total iron deficits relieved in a single infusion. These data support expanded use of LMWID in the management of pediatric iron deficiency.Hydrogels are widely used in various biomedical applications, as they cannot only serve as materials for biofabrication but also as depots for the administration of drugs. However, the possibilities of formulation of water-insoluble drugs in hydrogels are rather
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Based on the results of the present study, it can be concluded that the porous scaffold derived from fish cartilage ECM possesses an excellent potential for cartilage tissue engineering.
To investigate the proportion of insulin-dependent diabetes mellitus (IDDM) patients among diabetic patients undergoing total joint arthroplasty (TJA) and whether insulin dependence is
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d prioritize candidate genes for further analyses.
We identified genomic regions that may provide background knowledge to understand the mechanisms that are involved in economic traits and adaptation to cold climate in cattle. Incorporating p-values of different statistics in a single DCMS framework may help select and prioritize candidate genes for further analyses.
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Generation and maintenance of antigen-specific effector and memory T cells are central events in immune responses against infections. We show that TNF receptor-associated factor 2 (TRAF2) maintains a survival signaling axis in effector and memory CD8 T cells required for immune responses against infections. This signaling axis involves activation of Tpl2 and its downstream kinase ERK by NF-κB-inducing kinase
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This study aimed to evaluate the effects of feeding frequency on behavioral patterns and on diurnal fermentation and bacteriome profiles of the rumen and feces in Holstein and Jersey cows. Ten Holstein and 10 Jersey cows were offered a TMR (5347 forage-to-concentrate ratio dry matter basis) for ad libitum consumption and were randomly allocated within breed to one of the following feeding freq
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Beating Healing Difficulties regarding Pancreatic Ductal Adenocarcinoma using xCT Inhibitors.
SKBHT induced the expression of tumor necrosis factor α-induced protein 3 (TNFAIP3), an ubiquitin-modulating protein that suppresses various cellular signals to NF-κB. Concordantly, SKBHT suppressed NF-κB activity and the expression of inflammatory cytokine genes regulated by NF-κB. Given that Nrf2 and TNFA
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are the main limitations of this study. Moreover, the follow-up period of the most recently operated patients was too short to draw conclusions on long-term outcomes, including sexual function.
In all patients in this case series, vNOTES hysterectomy after prior vNOTES adnexal surgery was successfully performed. Large-scale prospective trials with long-term follow-up are needed t
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The resection speeds for lesions of the ESTD were faster than those of cESD (19.3 mm
/min versus 17.7 mm
/min, P = 0.009). There was no need to use additional countertraction by clip-with-line technique or snare for the submucosal dissection in the ESTD procedure. The incidence of perforation was significantly higher in the cESD group (6.0%) than in the ESTD group (0.9%)
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In addition, their roles and mechanisms in patients with HF with preserved ejection fraction or acute HF have also attracted attention. In this review article, we discuss the possible mechanisms and applications of SGLT2 inhibitors in HF.Background Screening echocardiograms can detect early-stage rheumatic heart disease (RHD), offering a chance to limit progression. Implementation of screening programs is challeng
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We previously developed the Tobacco Craving Index (TCI) to assess craving of smokers. In the present study, we validated the relationship between the TCI grade over the 5 sessions of Japanese smoking cessation therapy (SCT) and success of quitting smoking among 889 Japanese patients.
The Japanese SCT consists of 5 sessions of SCT (first session and sessions 2, 4, 8 and 12 weeks l
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The acute phase response (APR) to CNS insults contributes to the overall magnitude and nature of the systemic inflammatory response. Aspects of this response are thought to drive secondary inflammatory pathology at the lesion site, and suppression of the APR can therefore afford some neuroprotection. In this study, we examined the APR in a mouse model of traumatic spinal cord injury (SCI), along with its relationship toneutr
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Outdoor ultrafine particles (UFPs) ( less then 0.1 µm) may have an important impact on public health but exposure assessment remains a challenge in epidemiological studies. We developed a novel method of estimating spatiotemporal variations in outdoor UFP number concentrations and particle diameters using street-level images and audio data in Montreal, Canada. As a secondary aim, we also developed models for noise. Convolu
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The molecular target and mechanism by which d-limonene induces LC3 lipidation and autophagosome formation remain elusive. Here, we report that this monoterpene rapidly enhances Ca2+ levels in SH-SY5Y cells; yet this effect does not lead to calpain- or caspase-mediated proteolysis of α-spectrin, nor calpain activity is required for the established enhancement of LC3-II levels by d-limonene. However, d-limonene rapidl
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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.In 1913, eccentric French composer Erik Satie wrote a fragmentary, diary-like essay where he depicted a strikingly rigid diet consisting solely of white foods eggs, sugar, coconuts, rice, cream cheese, fuchsia juice and so on. Satie’s brief essay has later been used as one of many puzzle pieces in attempts to re
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네이버는 대한민국에서 가장 인기 있는 인터넷 플랫폼 중 하나로, 블로그 및 카페는 많은 사용자들에게 정보와 공간을 제공합니다. 최근에 회사들이 네이버의 여러 기능을 활용하여 브랜드 인식 높이고, 고객과의 연결을 강화하는 방법에 대해 많은 관심을 보이고 있습니다. 이 글에서는 네이버 계정을 구매하여 기업들이 블로그와 카페를 효과적으로 활용할 수 있는 가능성에 대해서 살펴보겠습니다.
블로그는 개인의 정보를 전달하는 데 알맞은 공간이며, 카페는 특정 주제에 대해 사람들과 소통할 수 있는 사람들과의 형성할 수 있는 장소입니다. 기업들이 이러한 플랫폼을 통해 더 많은 소비자와 소비자들과 연결되고, 그들의 피드백을 실시간으로 받을 수 있는 기회를 가질 수 있다는 점에서. 네이버 아이디 판매를 통해 특화된 블로그나 카페를 운용
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Purpose Cardiac diffusion tensor imaging using EPI readout is prone to image distortions in the presence of field inhomogeneities. In this work, a framework to analyze and correct image distortions in cardiac diffusion tensor imaging is presented. Methods A multi-coil reconstruction framework was implemented to enable field map-based off-resonance correction. Numerical simulations were used to examine reconstru
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Chronic Disease Self-Management Program (CDSMP) has been demonstrated effective in addressing the self-management of chronic conditions among older adults. With a higher attrition rate, this study investigated whether attending with family members influenced completion of and benefits accrued from the CDSMP.
The baseline data were collected from CDSMP participants in N
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The ECL biosensor achieved a low detection limit of 4.92 fM within a wide linear range from 10 fM to 100 nM. This approach offers a new insight for ECL efficiency increase and location-controllable strategies with improved reaction efficiency, demonstrating potential in diagnostic analysis.Intermittent subcutaneous (S.C.) injection of teriparatide [PTH (1-34)] is one of the effective therapies to cure osteoporos
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네이버는 대한민국에서 가장 유명한 포털 사이트 중의 하나로, 블로그와 카페들을 통해 다양한 종류의 정보가 공유되고 있습니다. 수많은 기업들이 NAVER 블로그과 카페을 활용하여 마케팅 전략을 수립하고 이용자와의 소통을 더욱 강화하기 데 노력하고 있습니다. 하지만 NAVER 계정을 생성하고 활용하는 생성하고 때로 과정은 어려울 수 있고 시간이 많이 수 있습니다. 이러한 상황에서 네이버 아이디 구매의 개념이 등장하게 됩니다 .
네이버 계정을 구매하면 기업은 신속하게 블로그와 카페 세계에 진입할 수 있으며, 기존의 사용자가 신뢰성과 권위를 권위를 있습니다. 그렇게 함으로써 시간을 절약하고, 절약하고 보다 효율적으로 포스팅과 진행할 수 진행할 합니다. 알맞은 네이버 계정 활용은 브랜드 인지도 향상과 향상과 고객과의 유대감
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MORC4 has recently been characterized as a breast cancer-associated anti-apoptotic oncoprotein. In the current study, we explored its downstream regulation in luminal A/B breast tumors.
Bioinformatic prediction was performed using data from The Cancer Genome Atlas (TCGA)-breast cancer (BRCA). Cellular and molecular studies were conducted using luminal A/B
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Furthermore, DYRK1a promotes a mouse model of B-ALL through activation of the noncanonical NF-kB pathway. These results establish DYRK1a as a critical BAFFR signaling mediator and provide novel insight into B-ALL pathogenesis.Cytoarchitectonical parcellation of the visual cortex into the striate and extrastriate cortex requires complex histogenetic events within a precise spatio-temporal f
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These findings should increase wildlife managers’ confidence that dehorning does not negatively impact white rhinoceros physiology as measured hormonally.The cardiovascular system is a major limiting system in thermal adaptation, but the exact physiological mechanisms underlying responses to thermal stress are still not completely understood. Recent studies have uncovered the possible role of reactive oxy
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Polychlorinated dibenzothiophenes (PCDTs) are a class of compounds structurally similar to dioxins that possess various toxicological impacts on living organisms. Unfortunately, information on the levels of PCDTs in freshwater lakes in China is still scarce. In this work, the occurrence of 14 congeners of PCDTs in different matrices (i.e., sediment, suspended particulate matter (SPM), and
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Faster shortening of the telomere lengths in men was the major reason of the estimation of the shorter life span for men.
A higher rate of metabolism causes higher entropy generation and hints correlations that can be helpful in future ageing research. Faster shortening of the telomere lengths in men was the major reason of the estimation of the shorter life span for men.The autonomic nervous sy
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5% of the accessions, with higher frequencies in Europe than in other continents. The old European wheat variety “Mediterranean” was identified as a putative source of this translocation, suggesting that Yr34 has been used for over 200 years. Finally, we designed diagnostic CAPS and sequenced-based markers that will be useful to accelerate the deployment of Yr34 in wheat breeding programs to improve resistance
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When deciding on an online purchase, consumers often face a plethora of information. Yet, individuals consumers differ greatly in the amount of information they are willing and able to acquire and process before making purchasing decisions. Extensively processing all available information does not necessarily promote good decisions. Instead, the empirical evidence suggests that reviewing too much infor
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The outbreak of COVID-19 has become a global public health event. Many researchers have proposed many epidemiological models to predict the outbreak trend of COVID-19, but all use confirmed cases to predict “onset cases.” In this article, a total of 5434 cases were collected from National Health Commission and other provincial Health Commission in China, spanning from 1 December 2019 to 23 February 2020. We studied the dela
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The main objectives in Crohn’s disease are to avoid disease complications and preserve the patient’s quality of life. Early disease control and close monitoring with specific targets to reach might be the only way to change the disease course. In two decades, we have moved from clinical response to full remission (clinical and endoscopic remission) requiring a tight monitoring of both symptoms and objective signs of i
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The performance of a routine third trimester ultrasound in women with BMI≥35kg/m
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Self-reported racial discrimination was associated with cynical hostility but did not influence the MetS level among nondiabetics. Despite higher NCEP scores and MetS prevalence rates for Blacks compared with Whites, race did not have direct effect on MetS levels when adjusted for the other characteristics in our model. Conclusions Neither race nor self-reported racial discrimination had direct effects on MetS level in our
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For older people gardens may be paradoxical sites. Whilst gardening is associated in multiple ways with wellbeing and health, gardens may also become a source of frustration and worry as ageing bodies limit gardening activities. Yet determination remains. However, little of the well-established body of work on gardens and old age includes people in advanced age. In this paper, we draw on interviews with Māori a
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Problem Conferences are the most common form of continuing medical education (CME), but their effect on clinician practice is inconsistent. Reflection is a critical step in the process of practice change among clinicians and may lead to improved outcomes following conference-based CME. However, reflection requires time to process newly-learned material. Adequate time for reflection may be noticeably absent dur
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No significant difference was observed in axial estimation due to presence of phase information and high sampling frequency. Our results suggest that this simple approach makes Bayesian regularization robust to over-regularization artifacts.Ultrasound elastography is used to estimate the mechanical properties of the tissue by monitoring its response to an internal or external force. Different levels of deformatio
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6 days. Six patients were completely tetraplegic. Fourteen patients had fractures and 20 patients had subluxation. The carotid tubercle was palpable in all the 34 cases. Twenty-two (68.8%) patients had partial or complete neurologic recovery. Complete anatomic reduction was achieved in 30 cases. One case of slight malalignment of the plate was observed. No case of significant deviation nor penetratio
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After controlling for having NCDs, workers with adequate peer support had increased odds of uptake of NCD screening by more than two times (OR 2.37, 95% CI 1.29-4.37).
Peer support is important in persuading workers to utilize NCD screening. Therefore, it is necessary to develop health promotion programs in the workplace and to empower peer educators to encourage their colle
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54; 95% confidence interval [CI], -2.02 – -1.06; I2 = 52%), representing a number needed to treat of two. The analgesic efficacy of salmon calcitonin at 4 weeks was unclear due to substantial heterogeneity. There was low certainty evidence that calcitonin did not increase the overall risk of adverse events, including nausea and vomiting (risk ratio, 2.10; 95% CI, 0.87-5.08; I2 = 47%). CONCLUSIONS Calcitonin is bene
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CPT codes used today for E/M services were established in 1995 and define the components of history, examination, and medical decision making necessary to determine the level of each cognitive care service as delivered by a physician or other qualified health care professionals (eg, advanced practice providers). E/M rules were modified in 1997 and allowed some specialty services, such as neurology, to su
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Young men who have sex with men (YMSM) represent one of the most at-risk groups for HIV infection and experience sexual minority stress especially in high-stigma settings, which affects their psychological health and increases likelihood of HIV-risk behaviors. The HIV epidemic in China is increasing rapidly among YMSM. However, no evidence-based intervention has specifically targeted Chinese YMSM’s minority stress to impr
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eep disorders, was also related to more severe outcomes in multiple-vehicle crashes, given that a crash occurred. This was not identified in single-vehicle crashes.
This study has made first steps toward understanding the relationship between some of the most common diseases that are known to contribute to EDS and crashes. Having Parkinson’s/epilepsy, in particular, elevated the probability of a
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Decellularized natural bladder matrices (neobladders) represent an exciting means to regenerate the bladder following bladder cancer-associated cystectomy. In this study, we compare the evolution of decellularized matrices with recellularized matrices by seeding it with human adipose-derived mesenchymal stem cells (ADSC) after implantation following partial cystectomy in rats. We discovered significant anatomical differen
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To determine the correlation of the endoscopic findings with portal Doppler and ultrasound (USG) in children with suspected portal hypertension (PHT).
Eighty children with extrahepatic portal vein obstruction (EHPVO) and chronic liver disease (CLD) were included in this retrospective study conducted over a period of 1 year. All patients underwent upper gastro
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Salvage surgery after failed organ preservation treatment offers challenges for both the patient and the surgeon. The outcome is often uncertain and even today, 5-year overall survival does not exceed 50 per cent. The chemoradiotherapy induced toxicity asks for meticulous discussion and planning in a multidisciplinary manner in a changing environment of increasing incidence of human papillomavirus induce
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Light emitting diodes (LEDs) are an energy efficient alternative to high-pressure sodium (HPS) lighting in tomato cultivation. In the past years, we have learned a lot about the effect of red and blue LEDs on plant growth and yield of tomatoes. From previous studies, we know that plants absorb and utilize most of the visible spectrum for photosynthesis. This part of the spectrum is
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β-carotene loaded zein-based NPs resulted in a mean size of 83 ± 8 nm and encapsulation efficiency of 93 ± 4%. Results obtained from the in vitro digestion showed that β-carotene bioaccessibility when encapsulated in zein NPs is 37 ± 1%, which is higher than the value of 8.3 ± 0.1% obtained for the ethylcellulose NPs.The industrial particle sensor market lacks simple, easy to use, low cost yet robust, safe and fast resp
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057% to 0.021%. Therefore, it was concluded that the clinical decision support system provides evidenced-based support to nurses and is effective in identifying patient-specific prevention nursing plans of care.Objectives Recent studies have reported a high prevalence of thrombotic events in coronavirus disease 2019. However, the significance of thromboembolic complications has not been widely app
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Final results subsequent in advance the radiation compared to keeping track of in atypical meningiomas: 16-year expertise in a tertiary hospital.
Evidence about altered bimanual coordination has been reported in Parkinson’s Disease. However, no previous study has explored such an alteration quantifying the interference effect that the trajectory of each hand might impo
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Liver lesions have a broad spectrum of pathologies ranging from benign liver lesions such as hemangiomas to malignant lesions such as primary hepatocellular carcinoma and metastasis. Imaging is a crucial step in diagnosing these conditions as liver enzymes can elevate in 8% of people in the U.S. A combination of medical history, serologic, and radiologic investigations can provide the diagnosis
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Health-promoting effects, recent human clinical studies, safety and adverse effects of Ficus plants also are covered. The medical potential and long-term pharmacotherapeutic use of the genus Ficus along with no serious reported adverse events, suggests that it can be considered as being safe.Understanding how inbreeding affects endangered species in conservation breeding programs is essential for their recovery. The Hawaiia
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After treatment with five cycles of bortezomib, the patient’s free kappa to lambda ratio improved to 2.35 from 5.52. Acute kidney injury (AKI) and the cutaneous vasculopathy gradually improved with treatment. This is an extremely rare occurrence of crystalglobulin in a living kidney transplant recipient.
The high prevalence of emotional disorders leads to a high demand for mental care which results i
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Background Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in type 2 diabetes patients. Materials & methods Patients receiving the maximum sulfonylurea and metformin doses for >1 year were enrolled. Secondary sulfonylurea failure was defined as HbA1c >7.0% (>53 mmol/mol) aft
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A median of 6.5 (range 4-9) valves were present in the great cardiac vein. Several parameters, among which the dimensions of the oval fossa and the length of the great cardiac vein, were significantly positively correlated with bodyweight and aortic diameter.
Measurements do not consider the dynamic changes during the cardiac cycle as measurements were performed ex vivo. All spec
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Parasitoids spent the same amount of time probing eggs of the two species, but they spent significantly more time drilling into A. tristis eggs than A. armigera eggs. Measurements taken using transmission electron microscopy determined that the average combined width of the epicuticle and exocuticle of the egg chorion was significantly greater for A. tristis eggs than for A. armigera eggs. T
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-etiology BAP or HLAP patients in the early stage of AP (within 7 days). It should be recognized as a new etiological type named biliary-hyperlipidemic acute pancreatitis (BHAP).
Patients with both biliary and hyperlipidemic etiologies suffer from more severe clinical course of the disease and have worse prognosis than single-etiology BAP or HLAP patients in the early stage of AP
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Сегодня, когда обучение уходит в цифровой формат всё чаще можно услышать о таком явлении, как доступ к обучающим материалам без оплаты. Это не просто тренд, который волнует и новичков, и опытных специалистов.
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The aim of the present study was to provide a systematic review and meta-analysis of the main biases in practical applications of the different types of elastography in assessment of the stiffness of healthy patellar tendons. A literature search on four databases (Scopus, Web of Science, Pubmed and SportDiscus) was conducted on March 25, 2020. After analysis of 1,052 resultant articles, studies were included if they met two inclusion
Veliparib nmr
downfield peaks confirm the presence of CN group near the benzylic protons. Methine protons show a signal at 5.2 ppm, which ensures the basic skeleton of glycoluril. Ureidyl protons also confirm the synthesis of the heterocyclic 2,4-Bis(4-cyanobenzyl)glycoluril compound. The negative and positive electrostatic potential sites, molecular descriptors, and charge density distribution of frontier molecular orbitals are r
YM201636 inhibitor
Secondary central nervous system (CNS) lymphoma is a rare and often fatal complication of non-Hodgkin lymphoma (NHL). Treatment options include radiation therapy, high-dose systemic chemotherapy, intrathecal chemotherapy, and high-dose chemotherapy with autologous stem cell rescue, but outcomes remain poor. Allogeneic blood or marrow transplantation (alloBMT) is widely used in patients with relapsed/refractory s
Filanesib datasheet
The authors conducted a multicenter retrospective study on the outcome of programmed death-ligand 1 tumor proportion score≥50% advanced non-small cell lung cancer patients treated with first-line pembrolizumab according to the presence/absence of brain metastases. A total of 282 patients were included, of whom 56 had brain metastases that were treated with upfront local radiation therapy in 80.3% of cases. The
Pancuroniumdibromide
The NiTi ultrasonic instrument could effectively remove biofilms in the curved canal and lateral canals. This instrument should be introduced close to the working length. An up-and-down motion of the activation instrument is recommended.Membrane distillation (MD) is a promising desalination technology for the treatment of high salinity water. Here, we investigated the fouling characteristic
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We observe that although increased Ct screening, rescreening, and treating most of the partners of infected people will reduce the prevalence, these mitigations alone are not sufficient to control the epidemic. The current practice is to treat the partners of an infected individual without first testing them for infection. The model predicts that if a sufficient number of the partners of all infected people are tested
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In this work, an efficient and stable fluorescent probe for Al3+was established. The fluorescent probe based on the fluorescence ‘turn-on’ mode of zinc sulfide crystal composite zinc oxide quantum dots (ZnS/ZnO QDs). The ZnS/ZnO QDs were synthesized via two-step method using L-Cysteine (L-Cys) as a sulfur source and stabilizer. In the synthesis of ZnS/ZnO QDs, the fluorescence of zinc oxide quantum dots (ZnO QDs) d
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An evaluation of the quality of these articles was mixed. CONCLUSIONS The results of this study provide an understanding of the use and patterns of citations to predatory articles in legitimate nursing journals. Authors who choose predatory journals as the channel to disseminate their publications devalue the work that publishers, editors, and peer reviewers play in scholarly dissemination. Likewise, those who cite thes
Coleonol
Obesity and associated metabolic disorders are worldwide public health issues. The gut microbiota plays a key role in the pathophysiology of diet-induced obesity. Glycerol monolaurate (GML) is a widely consumed food emulsifier with antibacterial properties. Here, we explore the anti-obesity effect of GML (1,600 mg/kg of body weight) in high-fat diet (HFD)-fed mice. HFD-fed mice were treated with 1,600 mg/kg GML. Integrat
Selleckchem Peptide 17
Atorvastatin attenuated the overexpression of bax, cytochrome C, p53, and caspase8 mRNAs and induced expression of bcl-2 mRNA (P<0.001). Atorvastatin treatment increased anti-oxidant enzyme levels (P<0.01). Treatment with atorvastatin reduced the number of TUNEL-positive cells. It could decrease the cytochrome c release (P<0.01), inhibit the decrease of MMP (P<0.001) and i
Bcl-2 activation
Luciferase reporter assay showed that the BECN1 was the target gene of miR-142-5p. Additionally, the loss/gain of BECN1 rescued/blocked the effects of miR-142-5p on the viability of 6-OHDA-induced SH-SY5Y cells. Conclusions These results highlight that miR-142-5p functions as a neuroprotective regulator in 6-OHDA-induced neuronal SH-SY5Y cells simulating PD model in vitro via regulating autophagy-related protein BECN1 and aut
LOXO101
Skull base chordomas account for less than 0.2% and chondrosarcomas for less than 0.15% of all intracranial tumors. Although their clinical and imaging presentation is similar, they derive from different origins. Chordomas arise from embryonic remnants of the primitive notochord and chondrosarcomas from primitive mesenchymal cells or from the embryonic rest of the cranial cartilaginous matrix. Both entities are characteriz
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Chemotherapeutic resistance represents a major obstacle for the treatment of patients with non-small cell lung cancer (NSCLC); however, the associated molecular mechanisms underpinning the development of resistance remain poorly characterized. In the current study, 5-fluorouracil (5-FU)-resistant A549 cells (A549/5-FU) were generated from A549 cells. Reverse transcription-quantitative PCR and western blotting were used to detect microRNA(miR)-
S63845
This article details the design, modeling, construction, and evaluation of an open system calorimeter that operates in a normal room environment to measure endothermic or exothermic events in a system subjected to a steady heat flux. The calorimeter is unique because it allows the measurement of energy and power from an “open” system, where a heat flux enters and leaves the calorimetric boundary in a well-controlled manner. I
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Australian national mental health policy outlines the need for a nationally coordinated strategy to address stigma and discrimination, particularly towards people with complex mental illness that is poorly understood in the community. To inform implementation of this policy, this review aimed to identify and examine the effectiveness of existing Australian programs or initiatives that aim to reduce stigma
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Polycystic ovary syndrome (PCOS) is a life-long reproductive, endocrine, and metabolic disorder that affects up to 17% of women of reproductive age. However, the effect of granulosa cells (GCs) transcriptome changes on oocyte capacity and follicular development in patients with PCOS has not been elucidated. This study aims to analyze transcriptome changes in GCs of PCOS from different perspectives and explore potentia
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the currently available prescription medications, which are important factors to consider for future development of migraine therapies.
There is an unmet need for improved HRQoL and work productivity in Japanese migraine patients despite the currently available prescription medications, which are important factors to consider for future development of migraine therapies.
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Resiquimod in vitro
Antimicrobial susceptibility testing (AST) for H. pylori is essential to accurately assess the prevalence of antibiotic resistance in each population. Antibiotic resistance rates form the basis of local guidelines for H. pylori treatment and AST may also be used as a personalized medicine approach to tailor therapy. This chapter provides an update on global antibiotic resistance rates and describes molecular
Trimethoprim
These results suggest that it is more effective to simultaneously evaluate the effect of SBP and DBP to predict mortality; clinicians should manage DBP less then 70 mm Hg when treating hypertensive patients.Radiotherapy is a common therapy method for nasopharyngeal carcinoma (NPC) treatment; however, radioresistance greatly limits the clinical efficiency and prognosis of NPC patients. Therefore, it is extremely ur
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n arm participants enjoyed the program and found that the messages were motivating. Both the mROAD and sham message groups showed promising changes in alcohol use and motivation to change. mROAD is a feasible intervention that may reduce rates of risky alcohol use in ED patients. Trial registration ClinicalTrials.gov NCT02158949; https//clinicaltrials.gov/ct2/show/NCT02158949.Background Health care te
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In rats receiving [2,3-13 C2 ]glucose, brain extracts showed well-resolved signals from both [2,3-13 C2 ]lactate and [4,5-13 C2 ]glutamate in 13 C NMR spectra. Assessment of the PPP in the brain based on glutamate had a strong linear correlation with lactate-based assessment. In summary, 13 C NMR analysis of glutamate enabled detection of the low PPP activity in isolated hearts. This analyte is an alternative to lactate for
Adezmapimod in vitro
To evaluate the performance and test-retest reliability obtained when administering a computerized baseline neurocognitive exam to NCAA Division I student-athletes in a controlled laboratory setting versus an uncontrolled remote location.
A sample of 129 (female = 100) Division I student-athletes completed Immediate Post-Concussion Assessment and Cognitive Testing (ImPA
BMS-794833
38 (1.16- 1.63), alcohol consumption 1.25 (1.02- 1.52), previous treatment 1.23 (1.10- 1.38) and lack of treatment monitoring data 4.92 (3.69- 6.56). Being deprived of liberty 0.65 (0.47- 0.89) and TB/diabetes comorbidity 0.80 (0.67- 0.95) were considered protective factors.
Paraguay has a high percentage of unsuccessful treatment in almost the entire country, without reaching t
Nedometinib
Extracellular polysaccharides (ECPs) produced by biofilm-producing marine bacterium have great applications in biotechnology, pharmaceutical, food engineering, bioremediation, and bio-hydrometallurgy industries. The ECP-producing strain was identified as Acinetobacter indicus M6 species by 16S rDNA analysis. The polymer produced by the isolate was quantified and purified and chemically analyzed, and antioxidant acti
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Due to increasing care needs and decreasing care potentials, research around informal caregiving gains attention. Relatively new – but of utmost importance – is the role of socioeconomic inequalities in care and wellbeing. Although caregiving can be rewarding, a growing body of research shows that informal caregiving often has negative consequences for individuals’ wellbeing. Theoretically, we expect these
BMS-986235 mouse
Airway management, mechanical ventilation, and treatment of systemic poisoning in burn patients with inhalation injury remains challenging. This review summarizes new concepts as well as open questions.
Several life-threatening complications, such as airway patency impairment and respiratory insufficiency, can arise in burn patients and require adequate and timely airway m
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Statins, a class of commonly prescribed cholesterol‑lowering medications, have been revealed to influence the risk of multiple types of cancer. However, the antitumor effects of statins on pancreatic cancer and their differential efficacy among a variety of statins are not currently well‑defined. The aim of the present study was therefore to identify and compare the genes and related biological pathways that were affected b
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Turbulence in care transition can result from sources other than transitioning between settings. The data-driven case report approach using electronic health records uncovered relational processes important for care coordination and may inform patient-centered approaches to improve care for patients with HF.
In the present study, we reviewed and analyzed the currently available data on the Flebogri
Telacebec mw
ve as a reference for clinical choice of plate.
Human milk is recommended for very preterm infants, but its variable macronutrient content may contribute to undernutrition during a critical period in development. We hypothesize that individually targeted human milk fortification is more effective in meeting macronutrient requirements than the current standard of care.
Varespladib
The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging ma
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Molecular gels are formed by the supramolecular assembly of low molecular weight gelators (LMWGs) in organic solvents or water. Despite significant advances in the field, our understanding of how gelator molecules lead to complex self-assembled fibrillar network (SAFIN) is rather poor. Here, we present molecular dynamics simulations to gain insights into the early-stage aggregation of self-assembled fibrillar network (SAF
selleck screening library
Hydrogel microneedle patch enables the extraction of skin interstitial fluid (ISF) through in situ swelling in a minimally invasive manner without assistance of mechano-chemical peripherals. However, existing hydrogel microneedles require tens of minutes with multistep process to collect sufficient volume (1 mL) for effective analysis. This study introduces an osmolyte-powered hydrogel microneedle patch that can extract ISF th
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Glacier retreat caused by global warming alters the hydrological regime and poses far-reaching challenges to water resources and nature conservation of the headwater of Yangtze River, and its vast downstream regions with dense population. However, there is still lack of a robust modeling framework of the “climate-glacier-streamflow” in this water tower region, to project the future changes of glacier mass bala
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R2TP is a well-conserved molecular chaperone complex, composed of Pontin, Reptin, RPAP3, and PIH1D, in eukaryotes. Recent studies have suggested an involvement of R2TP in cancer development. However, it remains unclear if it is related to the development of oral squamous cell carcinoma (OSCC), which is the most common type of oral cancer. Here, we identify and investigate the function of R2TP in OSCC
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6%) were women. Single session of Savary-Gilliard bougie dilation was successful in 90.7% of patients in relieving dysphagia and 9.3% developed recurrence, requiring repeated dilations. Four patients had concomitant squamous cell carcinoma of esophagus along with PVS and two developed upper gastrointestinal malignancy during follow-up. Conclusion Plummer-Vinson syndrome is predominantly seen in middle ag
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Although rare, GD needs to be included on a differential diagnosis when evaluating gastrointestinal symptoms in the ED. Patients may present with an array of complaints but can potentially develop serious complications. Providers should be familiar with the diagnostic options and treatment regimens available to better care for patients presenting with GD.
Spontaneous rupture of an inferior epigastric a
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Results The difference to the target angle was 1.8 ± 1.3° in group A, whereas the difference was 2.5 ± 1.4° in group B (p = 0.04). The patients with difference within 3° to the target angle were 78.7% in group A and 61.8% in group B (p = 0.024). Conclusion The sagittal reference line using the preoperative lateral radiograph was helpful as a reference guide for the tibial slope in TKA.The present study sought to
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Recent investigations have proposed that sesame and canola oils might affect body fat distribution. The present study aimed to examine the effects of sesame, canola and sesame-canola (a blend of sesame and canola oils) oils on body weight and composition in adults with type 2 diabetes mellitus in the context of a randomized, triple-blind, three-way, cross-over clinical trial.
Eligi
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High molecular weight poly (p-phenylene-terephthalamide) (h-PPTA) was blended with the commercial PPTA in concentrated sulfuric acid to improve the spinnability of the polymer solutions and the mechanical properties of the as-spun fibers. h-PPTA in the solution has an influence on the temperature of the formation of liquid crystalline phenomenon. The temperature range with the existence of the liquid crystalline
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Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure. Overexpression of ATP binding cassette (ABC) transporters is a major contributing factor resulting in MD
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Arsenic exposure induced dose-dependent structural and ultrastructural remodeling of cardiac tissue, with parenchyma loss, increase of stroma components, collagen deposition, and pathological damages such as inflammation, sarcomere disorganization, mitochondria degeneration and myofilament dissociation. Moreover, this metalloid was bioaccumulated in the tissue affecting its micromineral conten
Selleckchem PF 429242
Scenario document of serious Cushing’s syndrome inside medullary hypothyroid cancer complicated through well-designed diabetes insipidus, aortic dissection, jejunal intussusception, and also paraneoplastic dysautonomia: remission using sorafenib with out lowering of cortisol awareness.
Invasion depth, differentiation, and tumor size differed significantly in high-risk patients. Overall 3-y
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The on-demand CXR protocol decreased the number of CXRs per patient, which thereby decreased radiation exposure for patients, decreasing their risk of potential toxicity and malignancy.
Routine daily CXR protocols are no longer recommended due to lack of clinical value, similar outcomes, increased cost, and since it places patients at risk for undue radiation exposure.
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Nanoarchitected materials are considered as a promising research field, deriving distinctive mechanical properties by combining nanomechanical size effects with conventional structural engineering. Despite the successful demonstration of the superiority and feasibility of nanoarchitected materials, scalable and facile fabrication techniques capable of macroscopically producing such materials at a low cost are r
Ku-0059436
Overall, using lung and breast cancer models, we identified the PROS1/MERTK axis within BMDMs as a potent regulator of adaptive immune responses with a potential to suppress metastatic seeding and revealed IL-10 regulation by PROS1 to deviate from that of TNF-α and IL-6.Bariatric surgery is the most effective method for weight loss in morbid obesity. There is significant individual variability in the weight los
Pentylenetetrazol antagonist
Aconitum L., the main source of Aconitum medicinal materials, is rich in diterpenoid alkaloids. Several drugs derived from diterpenoid alkaloids are widely used to the current clinical treatment of pain, inflammation, and other symptoms. This paper aims to clarify the main metabolites and distribution of diterpenoid alkaloids in different parts of Aconitum plants. To that end, 7 species of Aco
Novobiocin in vivo
The association between muscle strength and body fat mass was modified by the genotypes studied.
SLC22A4 c.150C > T and SLC22A5 -207C > G polymorphisms are associated with tooth loss and markers of body shape in women but not in men.
Tooth loss may be related to obesity beyond inflammatory mechanisms, concei
010번호인증
요즘 온라인 비즈니스가 급증하면서 기업들이 안전하게 고객 정보를 처리하는 방법에 대한 요구가 커지고 있어요. 특히 010 인증서 신청은 중요한 단계로 자리를 잡고 있으며, 소비자의 개인정보를 보호 신뢰성을 형성하는 데 중요한 임무을 수행합니다. 그러나 많은 회사들이 이 과정를 간단히 이해하지 못하거나 못하거나 복잡한 생각하는 사람들이 많습니다.
따라서 이번 글쓰기에서는 10분 안에 끝낼 수 있는 간단하고 안전한 010 인증 서비스 신청 방법에 대해 알아보겠습니다. 중요히 010 대행 서비스를 이용하면 더 빠르고 효율적으로 이 절차를 진행할 수 있습니다. 기업이 소비자의 신뢰을 확보하고, 법적 의무을 충족하기 위해서 중요한 이 인증 과정에 지금 바로 주의를 기울여보세요.
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Removal of both pathways in the met-2;nrde-3 double mutant leads to the loss of somatic H3K9me2 and me3 and the synergistic derepression of transposons in embryos, strongly elevating embryonic lethality.Here, we showed that the acetylation-defective p53-4KR mice, lacking the ability of cell cycle arrest, senescence, apoptosis, and ferroptosis, were tumor prone but failed to develop early-onset tumors. By identifying a n
JAK Inhibitor I nmr
Assess the discordance between scalp pH and lactates performed from the same sample during labor.
This single-center retrospective study included all women with a singleton fetus who had at least one fetal blood sample taken during labor. Some of them had up to seven samples. Scalp pH was the reference parameter for obstetric decision-making. The correlation betwe
T-705
Glial cells are critically important for maintenance of neuronal activity in the central nervous system (CNS), including the optic nerve (ON). However, the ON has several unique characteristics, such as an extremely high myelination level of retinal ganglion cell (RGC) axons throughout the length of the nerve (with virtually all fibers myelinated by 7 months of age in humans), lack of synapses and very narrow geomet
Selleck Kaempferide
The present investigation demonstrates a green and scalable chemical approach to prepare aminoborate-functionalized reduced graphene oxide (rGO-AmB) for aqueous lubricants. The chemical, structural, crystalline, and morphological features of rGO-AmB are probed by XPS, FTIR, Raman, XRD, and HRTEM measurements. The spectroscopic analyses revealed the multiple interaction pathways between rGO and AmB. rGO-AmB
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The mean follow-up was 43.5 months. The mean age of the 70 patients at operation was 32.0 years, with a mean defect size of 2.7 cm
. The mean length of hospitalization was shorter in the MFx cohort (
= 0.01). No difference was found between the two cohorts in terms of length of prior surgery symptoms and follow-up, mean age and BMI, sex and side, and defect size. At
당근010번호인증
온라인 서비스의 사용이 많아짐에 따라 보안의 중요성 또한 나날이 커지고 있습니다. 특히 개인정보 보호에 관한 문제는 이제는 선택이 아닌 필수가 되었습니다. 그 시점에, 010번호 인증은 간단하면서도 효과적인 방법으로 인식되고 있습니다. 고객에게는 번거로운 절차 없이도 안전하게 서비스에 이용할 수 있는 통로를 마련하고, 사업자에게는 신뢰성을 향상시키는 수단이 될 수 있습니다.
이번 게시물에서는 010번호 인증을 통해 더 쉽게 보안을 강화하는 방법을 살펴보겠습니다. 이를 통해 사용자는 간편하고 신속하게 포털에 등록하고, 제공자는 사용자 정보를 보다 안
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05, 95% CI 0.77-1.43, P = 0.74), 1-year LTP rate (OR 1.28, 95% CI 0.52-3.18,P = 0.59), technical efficacy rate (OR 1. 35, 95% CI 0. 85-2.15, P = 0.20), and major complication rate (OR 1.04, 95% CI 0.56-1.93, P = 0.90). When comparing MWA with hepatic resection, the 3-year OS rate was not significantly different (OR 0.89, 95% CI 0.59-1.35, P = 0.59). Compared with RFA and hepatic resection, MWA showed similar saf
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We also revealed a biochemical effect on DNA damage and caspase-dependent apoptosis pathways through the phosphorylation of H2AX, the degradation of full-length PARP, and the increase of caspases 3 and 8 activity. This agent also demonstrated synergistic activity in a platinum-resistant cell line, inducing an increase in cell death in response to cisplatin only when combined with rabusertib, while no toxic effec
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[This corrects the article DOI 10.1039/C9SC05710B.].In this work we develop photoreactive cocrystals/salts of a commercially-important diacetylene, 10,12-pentacosadiynoic acid (PCDA, 1) and report the first X-ray crystal structures of PCDA based systems. The topochemical reactivity of the system is modified depending on the coformer used and correlates with the structural parameters. Crystallisation
Selleckchem Lipopolysaccharides
Background The major risk of kidney biopsy is severe bleeding. Numerous risk factors for bleeding after biopsy have been reported, but findings have been inconsistent. Methods We retrospectively reviewed medical records of adult patients enrolled in a native kidney biopsy cohort study to identify major bleeding events (red blood cell [RBC] transfusions, invasive procedures, kidney loss, o
Isuzinaxib in vivo
A novel orange to pink coloured bacterial strain designated as CT19T was isolated from the gastrointestinal tract of mirror carp, Cyprinus carpio var. specularis (Lacepède, 1803) collected from the Gobind Sagar reservoir at village Lathiani, Una, Himachal Pradesh, India. Cells of the strain were found to be aerobic, Gram-stain-positive, non-motile and non-spore-forming coccoids. Based on the 16S rRNA ge
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Applying this system to three validation datasets of fundus images, we demonstrate performance comparable to that of human experts in diagnosing glaucoma. Moreover, it markedly improves the diagnostic accuracy of ophthalmologists. This system may expedite the screening and diagnosis of glaucoma, resulting in improved clinical outcomes.There is limited information regarding the effect of
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Purpose This study examines the effect of age and task complexity on the macrostructure of story production in preschool- and school-age Kuwaiti Arabic-speaking children. It also compares the children’s production of core and complementary macrostructure story elements. Method A descriptive, cross-sectional research design was used to explore the participants’ narrative skills. A total of 122 monolingual speakers of K
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The design and construction of highly efficient and durable non-noble metal bifunctional catalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in alkaline media is essential for developing the hydrogen economy. To achieve this goal, we have developed a bifunctional nanowire-structured FeP-CoP array catalyst on carbon cloth with uniform distribution through in-situ hydrothermal growth and ph
CX-4945 solubility dmso
These are the first descriptions in Chile of CST-HR in ESBL-producing K. pneumoniae isolates. The emergence of these isolates could have a major impact on the effectiveness of colistin as a “last resort” against these isolates, thus jeopardizing current antibiotic alternatives; therefore, it is important to consider the epidemiology of the CST-HR phenotype.Prolonged treatment with cisplatin (CD
010문자인증
기업의 디지털 전환이 진전됨에 따라 웹 등록 과 인증 과정들의 중요성이 더욱 커지고 있습니다. 특히, 빠르고 안전한 010 CERTIFICATION은 회사가 고객과의 신뢰를 형성하는 경쟁 우위를 향상시키는 데 중점적인 역할을 하고 있습니다. 그렇지만 이러한 인증 과정을 자신이 수행하기에는 시간과 부족한 많은 경우가 있습니다. 그럴 경우 010 인증 서비스 업체의 도움을 받는 것이 빠르고 방안이 될 것입니다.
010 AUTHORIZATION 사용자의 개인 정보를 보호하며, 같이 인증 시스템을 단순화하는 특성을 가지고 있습니다. 이제는 비즈니스들은 인증 절차를 더욱 효율적으로 다룰 수며, 또한 비즈니스 성장에 집중할 수 있는 길을 얻게 됩니다. 신뢰성 있는 인증 프로세스를 통해 안전하게 이용할 수 있습니다, 비즈니스는 이러한
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5 months was 34% (95% CI 27%-42%), and all-cause mortality rate was 12% (95% CI 6%-24%). Conclusions The use of fenestrated/branched stent grafts for the treatment of PD-TAAA appears generally feasible based on the limited literature, but endoleaks and reinterventions are frequent.Background Hospitalized children have the right to “partake in practices related to their treatment and care.” Midwives and nur
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Parvovirus B19 is the most common causative agent of papular-purpuric gloves and socks syndrome (PPGSS), an often-underreported condition in the pediatric population. Classically, PPGSS presents with a papular-purpuric and at times petechial eruption of the hands and feet. (Dermatology. 1994;18885; Int J Dermatol. 1996;35626) We report a unique variant of juvenile PPGSS with prominent involvement of the flexural and extensor elbows, w
VT107
To externally validate the previously published pre-treatment prediction models for lymph nodes failure after definitive radiotherapy in head and neck squamous cell carcinoma (HNSCC) patients.
This external validation cohort consisted of 143 node positive HNSCC patients treated between July 2007 and June 2016 by curative radiotherapy with or without either cisplatin or cetuximab. Imaging
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5, PM10, SO2, CO, and NO2 were positively correlated with hospital visits for depression. The strongest effects all occurred on lag0 (the same) day, and the corresponding excess risks (ERs) were 2.59 (95%CI 0.72, 4.49) for PM2.5, 3.08 (95%CI 1.05, 5.16) for PM10, 3.22 (95%CI 1.16, 5.32) for SO2, 4.38 (95%CI 1.83, 6.99) for CO, and 4.94 (95%CI 2.03, 7.92) for NO2 per IQR increase, respectively. The associations wer
Veliparib
The probability of “nearly every day” showed a reverse U-shaped pattern, in that it was low from 12-29 years, increased during 30-50 years, and then decreased at ≥60 years. The age-related change in the probability of a response of “nearly every day” coincided with the trajectory of the PHQ-9 total scores.
This study demonstrated that item responses for the PHQ-9 followed a similar
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Stem cell-derived cardiac myocytes are potential sources for testing cardiocytoprotective molecules against ischemia/reperfusion injury in vitro.
Here we performed a systematic analysis of two different induced pluripotent stem cell lines (iPSC 3.4 and 4.1) and an embryonic stem cell (ESC) line-derived cardiac myocytes at two different developmental stages. Cell viability in sim
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It remains uncertain whether the hypertension (HT) medications angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) mitigate or exacerbate SARS-CoV-2 infection. We evaluated the association of ACEi and ARB with severe coronavirus disease 19 (COVID-19) as defined by hospitalization or mortality among individuals diagnosed with COVID-19. We investigated whether these associations were mod
شراء متابعين فيس بوك
In today’s digital age, having a solid social media presence will be crucial for the two individuals and companies. Instagram, with its above 1 billion effective users, is among the virtually all powerful platforms for building a personal or brand personality. But how can easily you increase your current followers on Instagram? Listed here are several verified strategies to help a person grow your Instagram following organically.
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CFTR modulator
53% were functionally annotated. Benchmarking Universal Single-Copy Orthologs (BUSCO) analysis showed the completeness of assembled genome is 98.3%. We found significantly expanded gene families involved in metabolic processes, transmembrane transport, cell signal communication and oxidoreductase activity, in particular ATP-binding cassette (ABC) transporter, Cytochrome P450 and venom proteins. The olfactory receptors
국내010인증
온라인 서비스의 이용이 증가함에 따라 보안의 중요성이 점점 커지고 있습니다. 개인정보 보호와 연결된 이슈는 이제는 선택이 아닌 필수가 되었습니다. 그 시점에, 010번호 인증은 간단하면서도 효과적인 방법으로 주목받고 있습니다. 사용자에게는 귀찮은 절차 없이도 안정적으로 서비스에 접속할 수 있는 길을 열어주고, 서비스 제공 업체에게는 신뢰성을 더하는 열쇠가 될 수 있습니다.
이번 포스팅에서는 010번호 인증을 통해 더 쉽게 보안을 강화하는 방법을 검토하겠습니다. 이로 인해 사용자는 편리하게 포털에 등록하고, 제공자는 이용자 정보를 효과적으로 보호할 수 있습니다. 여러 010번호 인증 업체의 장단점을 분석하고, 서비스 도입 시 고려해야 할 사항들에 대해서도 알아보겠습니다.
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PF07799933
We measured the faradaic current of an anti-cocaine aptamer using cyclic voltammetry and square wave voltammetry and demonstrated that KickStat’s response was within 0.6% of a high-end benchtop potentiostat. To further support others in electrochemical biosensors development, we have made KickStat’s design and firmware available in an online GitHub repository.Bacillus thuringiensis (Bt) Vip3A proteins are important i
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Our purpose was to contrast mortality associated with clinically undiagnosed prevalent vertebral fracture recognized on densitometric vertebral fracture assessment (VFA) and prior clinically diagnosed vertebral fracture.
Between 2010 and 2016, 9679 men and women (mean age [SD] 76 [6.9] years, 93% women) with central site bone density T-score≤-1.5 had
RU58841
Pgr5 proteins play a major direct role in cyclic electron flow paths in plants and eukaryotic phytoplankton. The genomes of many cyanobacterial species code for Pgr5-like proteins but their function is still uncertain. Here, we present evidence that supports a link between the Synechocystis sp. PCC6803 Pgr5-like protein and the regulation of intracellular redox balance. The knockout strain, pgr5KO, did not display substanti
شراء متابعين انستقرام
In today’s modern world, having a sturdy social media presence is usually crucial for equally individuals and businesses. Instagram, having its more than 1 billion lively users, is probably the nearly all powerful platforms for building a personal or brand personality. But how may you increase your own followers on Instagram? Allow me to share several verified ways to help an individual grow your Instag
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As expected, the visually impaired scored significantly higher than the general population on the Growth and development subscale.In the past two decades, a growing number of early childhood interventions that aim to improve school readiness have also targeted children’s executive function (EF), building on the theory that promoting EF skills in preschool may play a key role in reducing the substantial gaps
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For last decades, the mortality rate of hajj pilgrims from Indonesia was between 2.1 and 3.2 per 1000 hajj pilgrims. At the same time, morbidity affected 87% of the elderly (>65 years old), of which 83% faced high risk of health problems. This is a complex problem affecting hajj health care in Indonesia. The study was aimed to understand what extent of the hajj implementation on health care in Indonesia.
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Findings showed that elderly with comorbidities such as cerebrovascular diseases had an increased risk of death. Some complications such as pneumonia, septic shock, ARDS, AHF, and AKF played crucial roles as well death (Tab. 2, Ref. 25).
Findings showed that elderly with comorbidities such as cerebrovascular diseases had an increased risk of death. Some complications such as pneumonia, sept
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This paper has been focused on the a detail study on non-ionizing and ionizing electromagnetic (EM) shielding features and build-up factors of reinforced with ferrochrome (FeCr) composites. The non-inozing electromagnetic shielding performance quantities of composites have been determined in the frequency range between 12.4 and 18.0 GHz. Also, the experimental mass attenuation coefficients (MAC) have been estimated using gamma
How to Increase Instagram Supporters (زيادة متابعين انستقرام) 473916
In today’s digital age, having a strong social websites presence is usually crucial for both individuals and businesses. Instagram, having its more than 1 billion energetic users, is probably the most powerful
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IgPro20 is the first approved subcutaneous immunoglobulin (SCIg) preparation for the treatment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Two different doses of the SCIg preparation were investigated in the pivotal PATH study. Real-world data, and particularly the efficacy of an equivalent dose switch from intravenous immunoglobulin (IVIg) to SCIg, are still not available.
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Reconstructions of the global mean annual temperature evolution during the Holocene yield conflicting results. One temperature reconstruction shows global cooling during the late Holocene. The other reconstruction reveals global warming. Here we show that both a global warming mode and a cooling mode emerge when performing a spatio-temporal analysis of annual temperature variability during the Holocene using data from
Tips on how to Increase Instagram Followers (زيادة متابعين انستقرام) 864207
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Background Acute limb ischemia (ALI) carries significant overall morbidity and mortality. Pregnant and postpartum women are physiologically hypercoagulable, but little is known about the impact of ALI in this cohort of patients. The goal of this systematic review was to gather available data on diagnosis and treatment of ALI during pregnancy and the postpartum period. Methods A systematic review of studies on p
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Cellular mechanisms causing insulin resistance (IR) in chronic kidney disease (CKD) are poorly understood. One potential mechanism is that CKD-induced inflammation activates the signal transducer and activator of transcription 3 (Stat3) in muscle. We uncovered increased p-Stat3 in muscles of mice with CKD or mice fed high fat diet (HFD). Activated Stat3 stimulates the expression of Fbxo40,
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The simulations show that the preference of Ca2+ to the LAS molecules is due to a strong specific attraction with the sulfonate head-group, besides the electrostatic one. This specific attraction involves significant reduction of the hydration shells of the interacting calcium cation and sulfonate group, which couple directly and form surface clusters of LAS molecules, coordinated around the adsorbed Ca2+ ions. In cont
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When you’re secured from home, car, or even office, or in the event that you need to change your security method, your first thought might be in order to call a big-name locksmith company. On the other hand, there’s a compelling case to always be made for picking an independent locksmith instead. Independent locksmith durham north carolina give you a variety regarding advantages that greater companies often can’t match, making
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Present clinical updates, current research findings, and consensus statements relevant to the care of the acute kidney injury (AKI) patient.
Acute kidney injury is one of the most frequent and debilitating complications of surgery and critical illness. Consensus criteria use serum creatinine and urine output measurements to diagnose AKI and allow for objective diagnosis and more accurate comparis
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If you already have at least one child than you know just how difficult it can be. If you are expecting you first child perhaps you are a bit worried about what to do. This article is great for all types of parents as it will provide you with some great tips on how to be the best parent possible.
Get your kids in the kitchen. Asking them to help, even in
010번호인증
디지털 시대에 접어들면서 비즈니스 포털의 보호는 극히 중요해졌습니다. 특별히 중요한 자료와 정보를 다루는 업체의 경우, 신뢰할 수 있는 인증 방법은 필수적입니다. 이런 010 인증 방식이 인기있고 있습니다, 이렇게 사용자에게 편리하면서도 높은 수준의 보안을 제공하죠.
010 인증은 다수의 비즈니스 포털에서 폭넓게 사용되는 인증 방법으로, 사용자는 자신의 전화 번호를 이용하여 간편하게 인증을 받을 수 있게 됩니다. 이 체계는 해킹 및 데이터 유출의 위험을 감소시키고, 사용자 경험을 증진하는 데 큰 기여를 할 수 있습니다. 이 글에서는 010 인증을 이용하여 비즈니스 포털을 신뢰성 있게 이용하는 방법과 관련된 회사를
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A total of 387 amplicons from 29 ARGs were detected, which confer resistance to β-lactams, quinolones, aminoglycosides, tetracyclines, sulphonamides, phenicols, macrolides, glycopeptides, and polymyxins, including extended-spectrum β-lactamases-encoding genes, and mcr-7.1. The sul1 gene had higher total concentrations than blaTEM, tetB and qnrB in the environmental samples, and the diversity and abundance of ARGs in
Aristolochic acid A clinical trial
Alloying is an effective method to refine coarse grains of an Al13Fe4 phase and strengthen Al-Fe alloys. However, the grain refinement mechanism remains unclear in terms of the thermodynamics. Herein, the influence of M-element, i.e., Cr, Mn, Co and Ni, addition on the activity of Al and Fe atoms, Gibbs free energy of the Al13Fe4 nucleus in Al-Fe melt and the formation enthalpy of an A
Asunaprevir
The experimental results demonstrated that the proposed method achieved a state-of-the-art performance for multifocus images.
The molecular mechanism of nonobstructive azoospermia (NOA) remains unclear. The aim of this study was to identify gene expression changes in NOA patients and to explore potential biomarkers and therapeutic targets.
The gene expressi
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Finally, we discuss the potential use of recombinant GDF11 as a therapeutic option for a wide range of medical conditions and the possible adverse effects of GDF11 inhibition mediated by MSTN inhibitors.Mammalian pheromones often linger in the environment and thus are particularly susceptible to interceptive eavesdropping, commonly understood as a one-way dyadic interaction, where prey sense and re
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Surprisingly, the mechanism does not take place at the transcriptional level but at the translational level.Aspergillus flavus (A. flavus)-mediated aflatoxin contamination in maize is a major global economic and health concern. As A. flavus is an opportunistic seed pathogen, the identification of factors contributing to kernel resistance will be of great importance in the development of novel mitigation strategies. Usin
010인증
비즈니스 상황이 점점 디지털화 되어감에 따라 필수적이 되어갑니다. 특히, 다양한 서비스들에 접속하기 위해 필요한 인증 절차 과정은 고객에게 고민을 줄 수 있습니다. 이런 문제를 해결하기 위해 많은 기업들이 010 전화번호 인증 수단을 도입하고 있습니다.
010 인증은 이용자에게 편리한 확인 방법을 보장하고, 인간 정보의 안전성을 보장해 줍니다. 이 글 비즈니스 포털에서 010 검증을 적용하여 막힘 없이 이용할 수 있는 방식를 고찰하겠습니다. 인증을 통해 고객의 신뢰도를 확보하고, 또한 상업의 효율 극대화하는 전략에 대하여 알아보겠습니다.
0일0 확인의 필요성
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In the present work, the lowest energy structures and electronic properties of Agn clusters up to n = 16 are investigated using a successive growth algorithm coupled with density functional theory calculations (DFT). In the literature, a number of putative global minimum structures for silver clusters have been reported by using different approaches, but a comparative study for n = 15-16 has not been undertaken so far. Here,
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To assess intervention impact by group, we used an intention-to-treat analysis, comparing men in each masculinity class, by intervention and control arm, using generalized estimating equations reporting unadjusted and adjusted odds ratios (aORs). In total 674 were recruited at baseline, and the LCA identified three classes of men high violence (29% of men), medium violence (50% of men) and low v
Entinostat in vivo
RESULTS In our cohort, all tested tTg IgA-automated assays showed sensitivities above 98% and specificities above 99%. ROC analysis demonstrated AUC (area under the curve) >0.99 for all 4 analyzers. The positive-predictive values (PPV) were all >0.99 and negative-predictive values (NPV) were >0.97. The Elisa kit had sensitivity of 95%, specificity of 96%, AUC of 0.96, PPV of 0.98 and NPV of 0.93. CONCLUSI
Foxy-5 clinical trial
s to how those declines might affect bird ecology and evolution. First, differences in declines among behavioral components may allow identification of behaviors that are most susceptible to decline in the wild. Second, variation in performance declines and heat dissipation behaviors among individuals suggests variability in heat tolerance, which could lead to differential fitness in the wild. Last, these result
Indisulam
001) lower TLI in the VIM region than in the Zi region. CONCLUSION Zi DBS performed asleep appears to be safe and effective. LDF monitoring provides direct in vivomeasurement of the microvascular blood flow in front of the probe, which can help reduce the risk of hemorrhage. LDF can differentiate between the grey substance in the thalamus and the transmission border entering the posterior subthalamic area where the tiss
https://aqueduct-translations.it/
Viceversa, la legalizzazione di atti e documenti prodotti all’estero e da far valere in Italia deve essere richiesta presso la rappresentanza diplomatica o consolare italiana nel paese che ha redatto il documento. Dopo aver ricevuto il preventivo e aver concordato i termini, il traduttore procederà con la conversione del testo. Tieni presente che la qualità del lavoro dipende non solo dalle competenze linguistiche
PARP/HDAC-IN-1
© 2020 Yaniv et al.Importance Esophageal perforations are difficult to diagnose and have a high mortality rate. Cervical esophageal perforations (CEPs) are the second most common anatomic type of esophageal perforations and are most often due to iatrogenic injury. They are often managed more conservatively than thoracic perforations. The current literature on CEPs is mostly observational, with a paucity o
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Device insertion is relatively quick and the “learning curve” is short, centering mainly around managing large bore access. Our limited experience suggests that not only is high-risk PCI with Impella support feasible in a non-surgical center, but that it may be crucial to enable success.
The relationship between exercise and cerebral oxygenation has gained increasing attention. However, few
OTSSP167
Sutorius is a poroid genus in Boletaceae that typically has chocolate brown to reddish brown or purplish brown basidiomata with a finely scaly stipe and produces a reddish brown spore deposit. During the survey on diversity of boletes in Northern and Northeastern Thailand, several Sutorius collections were obtained. Combined evidence from morphology and phylogenetic analyses of a combined three-gene data set (atp6, tef1 a
ML141
Findings obtained from this study suggest that isolates can easily spread through the hospital via isolate cross-contamination caused by health personnel. These contaminating isolates may be able to maintain their presence within the hospital for a long time.
Findings obtained from this study suggest that isolates can easily spread through the hospital via isolate cross-contamination caused by health personne
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Environmental water quality monitoring plays an important role in human health risk assessments for pharmaceuticals in water and pollutant source control. A new chemical detection method was developed to enhance molecular selectivity and portability by combining the molecularly imprinted technique and an electroosmotic pump (EOP), which requires only a small pump, batteries and stopwatch in principle. Selective chem
Bemnifosbuvir datasheet
Of 2519 patients analysed, 1669 (66.3%) received ApOx via NC while 850 (33.7%) did not. Desaturation in the cohort receiving ApOx was 10.4% compared with standard care (no ApOx) 13.7%. ApOx had a protective effect for desaturation (OR 0.71 95% CI 0.53 to 0.95). Single intubation attempt was associated with reduced risk of desaturation of (OR 0.10, 95% CI 0.06 to 0.17); this was incre
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After 18 months of intervention, we observed significant effects for the MetSZ score (p<0.001), with significant improvements in the HIT-RT and significant worsening in the CG. In detail, all parameters constituting the MetS contributed to this result, however, only waist-circumference, HDL-cholesterol and mean arterial blood pressure revealed significant effects. No adverse events were reported and high adherence was
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There continues to be an interest in minimally invasive approaches to pancreatic surgery. At our institution, there has been a progressive change from an open to minimally invasive surgery (MIS) (laparoscopic, robotic, or laparoscopic-robotic) approach for central pancreatectomies (CP). The aim of this study was to evaluate surgical outcomes with open CP (O-CP) versus minimally invasive CP (MI
CVT-313
The drastic temperature variation has almost no influence on the diffusion and transfer rate of electrolyte ions, further evidencing the advanced feature of the hierarchical pore structure. Additionally, HPC//Li4Ti5O12 LIC assembled with the Li-based electrolyte also presents a superior Ragone performance. The coexistence of micro- and mesopores for the HPC makes it an attractive electrode material for various capacitive-e
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In this review we summarized the diagnosis and endoscopic treatment of stricturing CD. This article is protected by copyright. All rights reserved.The assurance method is growing in popularity in clinical trial planning. The method involves eliciting a prior distribution for the treatment effect, and then calculating the probability that a proposed trial will produce a “successful” outcome. For normally distri
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In this study, we explored whether variability in children’s physiological reactivity-respiratory sinus arrhythmia and electrodermal activity-predict concurrent and subsequent levels of children’s observed help-seeking (HS) from their mothers during a failure task. In addition, we tested whether children’s perceptions of maternal positivity pre-task (CPMP) and children’s fearful temperament moderate these effects. In
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Detecting vasculature at the placenta-myometrium interface and classifying vascular diseases according to hemodynamics in the remnant would facilitate the development of specific treatments.The concept of the Mediterranean Diet has substantially evolved in the last decade and a half. From a model focused uniquely on nutrition and public health, in recent years, and after its registration as Intan
Apilimod
cular MIP subfamily in vegetative growth and the environmental stress response in fungi. Ultimately, these findings have implications for the ecophysiology of Trichoderma spp. in natural, agronomic, and industrial systems.The reasons for selecting a gene for further study might vary from historical momentum to funding availability, thus leading to unequal attention distribution among all genes. However, certain biological
네이버 아이디 판매
NAVER는 대한민국에서 가장 유명한 포털사이트 중에서 많은 기업들이 블로그 및 커뮤니티를 이용해 고객과 의사소통하고 있습니다. 그렇기 때문에 사업 성장에 있어 NAVER 아이디를 구매하는 것은 중요한 전략이 될 수 있습니다 하지만 단순히 계정을 구매하는 것만으로는 충분하지 않습니다. 성공적인 인터넷 비즈니스를 구축하려면 사전에 살펴봐야 할 요소들이 필요합니다.
이번 기회에 기사에서는 네이버 계정을 구입하기 전 알아야 할 필수적인 체크리스트을 제시하겠습니다. 이는 비즈니스의 목표 달성을 돕고, 효과적으로 고객과의 연결을 강화하는 데 도움이 줄 것입니다. 계정 구매를 생각하고 있다면, 꼭 이 체크리스트를 이용해 신중한 해야 합니다.
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UNC 3230
153 (±0.24) QALY’s in comparison to continued conventional SCS. Besides the potential of HD-SCS to salvage patients with failed responses to conventional SCS, this treatment seems to be a more efficient treatment than conventional SCS.A 2-year-old female Mongrel dog weighing 3.12 kg presented with a 2-month history of progressive exophthalmos of the left eye and periorbital swelling. Fine-needle aspiration cytology of the
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However, diversified systems with a high proportion of cover crops in winter are economically infeasible because their net return is negative.Spiny lobsters (Family Palinuridae) are a popular seafood in Brazil. We characterize the fishing activity and analyze the population of lobster species captured in the coast of the state of Rio Grande do Norte, Northeast Brazil. We monitored the landings of lobster fishermen a
Heysham
It’s a effectively known undeniable fact that individuals who live and even work in large cities are indulged for choice when it comes to booking independent tradespeople such as plumbers, electricians, locksmiths and many others but what regarding those who live inside more rural locations, such as elements of the Lake Area or the Highlands of Scotland with regard to example where your current nearest town may be many kilom
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04). Overall, the effect of the coaching intervention did not differ across GE and SE teachers; both had significantly improved instructional and behavior management practices and student outcomes when compared with teachers in the control condition. Limitations and future directions for research and practice are discussed.Between demand and reality – Perspectives of case-leading nurses on rationing in home care A
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The study of cell migration has been greatly enhanced by the development of new model systems and analysis protocols to study this process in vivo. Zebrafish embryos have been a principal protagonist because they are easily accessible, genetically tractable, and optically transparent. Neural crest cells, on the other hand, are the ideal system to study cell migration. These cells migrate extensively, using differ
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SUMMARY The phenotype observed in Japan shows distinct clinical features compared with the classical phenotype, that is, increased levels of eosinophils, suggestive of ‘eosinophilic shift’ alongside symptomatic differences, making it difficult to categorize.BACKGROUND Previous studies have provided conflicting evidence about the increased overall survival (OS) in lung cancer patients with diabetes mellitus (DM) compared with thos
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03; 95% confidence interval [CI], 1.39-2.96; p less then 0.001) and recurrence-free survival (RFS) (HR, 2.31; 95% CI, 1.68-3.17; p less then 0.001). After PSM, the prognostic impact of LVI was greater in the sublobar resection group (HR = 4.93 and 4.25 for OS and RFS, respectively) than in the lobectomy group (HR = 1.77 and 2.51 for OS and RFS, respectively). Conclusions The presence of
GNE-317 mw
Two-dimensional (2D) transition-metal dichalcogenides (TMDs) hold great potential for many important device applications, such as field effect transistors and sensors, which require a robust control of defect type, density, and distribution. However, how to control the defect type, density, and distribution in these materials is still a challenge. In this study, we explore the kinetics and dynamics of four types of grain
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Patients with predominant inflammatory pain, with high levels of psychosocial factors, increased central sensitization and not improving after a trial of MWM, were recognized as non-responders. Improvement of different aspects of movement (e.g. ROM, less fear) are the most common outcomes observed.
This study provides factors believed to be important in the decision m
NST628
ced mean attenuation, with percentage change ranging from -5.4% to -1.0% (p less then .001) and from -8.7% to -1.8% (p less then .001), respectively. CONCLUSION. Acquisition parameters significantly affect CSA and mean attenuation of adipose tissue. Details of acquisition parameters used for CT-based body composition analysis need to be scrutinized and reported to facilitate interpretation of research studies.OBJECTIVE. The
Wnt agonist 1 beta-catenin activator
In ALC levels of interleukins and CCL2 increased as compared with AA. PNPLA3 rs738409 CC carriers had lower cirrhosis stage as compared with CG+GG carriers, however there were no differences of IL6, IL10, IL8 or CCL2 levels between G allele carriers and non-carriers in heavy drinkers.
Thus, in the Russian population heavy drinkers carrying PNPLA3 rs7
NSC 707544
The detection of objects concealed under people’s clothing is a very challenging task, which has crucial applications for security. When testing the human body for metal contraband, the concealed targets are usually small in size and are required to be detected within a few seconds. Focusing on weapon detection, this paper proposes using a real-time detection method for detecting concealed metal
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The false aneurysm of the aortic isthmus is, given its severity and case fatality rate, a subject of interest in vascular surgery. The interest of this article is the analysis of the different characteristics of this pathology based on the study of a case report and on a review of the literature.
This is a 21-year-old patient admitted for the management of a severe polytrauma
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I traduttori devono essere ben versati in questi quadri legali per garantire che il testo tradotto si allinei ai principi legali e ai precedenti della lingua di destinazione. aqueduct-translations.it/chi-siamo/ Comprendere l’importanza della sensibilità culturale nella traduzione legale richiede un profondo apprezzamento per le sottili sfumature culturali. Nel campo della comunicazione intercul
네이버 아이디 판매
네이버는 대한민국에서 가장 많은 사용자를 보유한 포털 사이트로, 블로거와 카페 등 다양한 플랫폼을 통해 비즈니스을 홍보하는데 강력한 도구가 될 수 있습니다. 많은 회사들이 NAVER 계정 구매를 고려하면서, 이를 통해 보다 손쉽게 소비자와 커뮤니케이션하고, 다양한 마케팅 전략을 펼칠 수 있다고 생각합니다. 그러나 이러한 아이디 구매에는 몇 가지 주의점이 있습니다.
아이디 구매가 간편하고 신속한 방법처럼 보일 수 있지만, 실제로는 법적인 리스크와 계정 안전성 문제 등 유의해야 할 사안가 많습니다. 따라서 비즈니스를 위해 NAVER 아이디를 구매하려는 회사라면, 많은 정보 수집과 면밀한 판단이 필요합니다. 이 글에서는 NAVER 계정 구매의 장점과 단점과 주의해야 할 사항을 안내하여, 귀하의 사업에 도움이 될 되도록
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Multivariate analysis revealed that low postoperative albumin (p = 0.044), tumor close to the anus (p = 0.004), diabetes (p = 0.003), perioperative blood transfusion (p less then 0.001), diarrhea (p = 0.005), later tumor stage, and high score of PG-SGA (p less then 0.001) were the independent risk factors for postoperative AL. Conclusions AL in rectal cancer operation is a common postoperative compli
FTI 277 concentration
To identify the frequency of falls among older people with and without cataracts and to verify the association of sociodemographic, clinical and behavioral variables with the number of falls among community-dwelling older adults according to self-reported cataracts.
Although the literature on the topic is vast, no studies were found that described the explanatory fac
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69, 95% CI 0.53-0.84).
This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET.
This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary
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BACKGROUND The National Early Warning Score 2 (NEWS2) scores can help identify clinical deterioration. OBJECTIVE To assess the predictive capacity of the NEWS2 at prehospital level for the detection of early mortality in the hospital. METHODS Prospective multicenter cohort study, in which we compiled a database of observed vital signs between March 1, 2018 and May 30, 2019. We collected demographic data, vital signs (respi
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≥70% attendance in the high-intensity intervention resulted in a persistent BMI SDS reduction of -0.22 after 24 months (95%CI -0.38, -0.06).
This trial was negative in terms of primary outcome at 24 months. However, high engagement led to sustained treatment effect, and there were multiple improvements in health measures.
This trial was negative in terms o
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The competitive performance of the solution-processed absorber is accompanied by a significant cost reduction compared with vacuum-deposited absorbers. All these merits render it a cost-effective, universal solution to offering high efficiency (89-93%) for both low- and high-temperature solar-thermal applications.Randomized trials are considered the gold standard for estimating ca
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ment and prolonged antifungal therapy for a number of months, if not lifelong, treatment. Initiating empirical antifungal therapy may be justified in some patients. However, this should be judged on a case-by-case basis and guided by discussion with the local microbiology and infectious diseases departments. However, there is no national guideline or consensus regarding treatment of these patients, especially
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An open question in quantum optics is how to manipulate and control complex quantum states in an experimentally feasible way. Here we present concepts for transformations of high-dimensional multiphotonic quantum systems. The proposals rely on two new ideas (i) a novel high-dimensional quantum nondemolition measurement, (ii) the encoding and decoding of the entire quantum transformation in an ancillary state for shari
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The fact that positive body image is not protective against fitspiration suggests that fitspiration is just as harmful, if not more, than is thinspiration and highlights the need for media literacy programs targeting fitspiration and so-called “healthy living” websites.This study investigated the effects of taking photos (of the self or objects) on women. Objectification theory states that women are subjected to
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The importance of inhibiting the kinases of the DDR pathway for radiosensitizing cancer cells is well established. Cancer cells exploit these kinases for their survival, which leads to the development of resistance towards DNA damaging therapeutics.
In this article, the focus is on targeting the key mediator of the DDR pathway, the ATM kinase. A new set of quinoline-3-carboxamide
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These nanotube arrays maintain a high reversible capacity of 875 mAh g-1 after 200 cycles at a current density of 200 mA g-1. This simple, cost-effective, and scalable electrode fabrication strategy can be implemented in the fabrication of high-performance wearable energy storage devices. Copyright © 2020 Xu, Zhang, Zhang, Shen, Zhao, Zhou and Weng.The 1D Cu(II) coordination polymers [Cu3(L1)(NO3)4(H2O)2]n (1) and [Cu
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Damage to DNA elicits both checkpoint and repair responses. These are complex events that involve many genes whose products assemble at lesions and form signaling cascades to recruit additional factors and regulate the cell cycle. The fission yeast Schizosaccharomyces pombe has proven to be an excellent model to study these events, and has led gene and pathway discovery efforts. Recent progress has involved a more detail
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The aim of the present study was to examine the clinical outcome of ovarian clear cell borderline tumor (CCBT) through pathological review for cases with clear cell carcinoma (CCC) and CCBT between 1984 and 2015 who received surgery at the National Defense Medical College Hospital using 2020 World Health Organization (WHO) criteria. In addition to the definition of CCBT in 2020 WHO criteria, clear cell wit
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9188 based on receiver operating characteristic (ROC) analysis. N-NOSE index at 100-fold dilutions was also significantly different between the two groups (p less then 0.0001), with an AUC of 0.9032 based on ROC analysis. In this clinical study, we further improve N-NOSE with a combined method of two dilutions (10-fold and 100-fold) of urine samples, which results in a markedly improvement in cancer de
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It would be necessary to deepen those factors that depend on the professional or health organizations to finish finding an optimal model of resource allocation in the PC.
The budget allocation in PC can be based on a model that incorporates the main determinants of patient’ frequentation and adapts to their real needs. It would be necessary to deepen those factors that depend on the professional o
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BACKGROUND Family planning counseling is critical for women to make informed reproductive and sexual health decisions. Despite Ethiopia’s success in expanding access to family planning services, information on the quality of family planning counseling is limited. The objectives of this study were to assess whether the quality of counseling from the female client´s perspective has changed over time (2014 to 2018) and to in
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Numerous kindreds with familial frontotemporal lobar degeneration have been linked to mutations in microtubule-associated protein tau (MAPT) or progranulin (GRN) genes. While there are many similarities in the clinical manifestations and associated neuroimaging findings, there are also distinct differences. In this review, we compare and contrast the demographic/inheritance characteristics, histopathol
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At 6
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weeks of gestation, stillbirth, SGA and birthweight <2500g, were significantly associated with haemoglobin of 70-89g/l compared with haemoglobin of 110-129g/l The relationships of adverse pregnancy outcomes with various haemoglobin levels were more marked at 26-30weeks of gestation.
Both lower and some higher haemo
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Evaluation of an activity where Personal Awareness Sustains Studying in a Formal Middle School School room Context.
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at
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Examine of HLA-A, -B, -C, -DRB1 along with -DQB1 polymorphisms in COVID-19 people.
Mutations of the STAT3 gene and an increase in the number of LGLs above 2 × 109/L were detected in RA-associated T-LGLL, but not in FS (39% vs 0% and 21% vs 0%, respectively). Mutations in the STAT5b gene were not observed in either group. Expression of CD57, CD16, and CD5-/dim on CD3+CD8+ T-lymphocytes was obse
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For risedronate, a delayed-release (DR) tablet was designed to solve the malabsorption problem in the presence of food, hence DR risedronate can be ingested following breakfast. For other oral bisphosphonates, the proper interval between drug and food, beverages, and dietary supplements intake should be maintained to minimize the risk of interactions. The effect of food on pha
MER-29
The combined experimental and theoretical investigation of the magnetic properties of the cobalt(ii) NHC complexes (NHC = N-heterocyclic carbene); [Co(CH2SiMe3)2(IPr)] (1), [CoCl2(IMes)2] (2) and [Co(CH3)2(IMes)2] (3) revealed a large easy plane anisotropy for 1 (D = +73.7 cm-1) and a moderate easy axis anisotropy for 2 (D = -7.7 cm-1) due to significant out-of-state spin-orbit coupling. Dynamic magnetic measuremen
SAdenosylLhomocysteine
Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its
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Hepatocellular carcinoma (HCC) is a common fatal malignant tumor worldwide. STAT4 is HCC susceptibility gene identified by genome-wide association study. The purpose of this study was to determine the association between four candidate single nucleotide polymorphisms (SNPs) in STAT4 genes and HCC risk in Chinese Han population.
A case-control study was conducted to
Selleckchem CHIR-124
These soil high-flow OTUs were also found in streams and biofilms at other times of the year. These results demonstrate the relevance of floods in generating short and reoccurring inoculation events for flowing waters. Moreover, they show that soil microbial inoculation during high flow enhances microbial diversity and shapes fluvial BCC even during low flow. Hence, soil microbial inoculation during floods cou
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Circulating cell-free DNA (cfDNA) level has been demonstrated to be associated with efficacy in first generation EGFR TKIs in non-small cell lung cancer (NSCLC). However, the role of dynamic cfDNA analysis using next-generation sequencing (NGS) in patients with subsequent third-generation EGFR TKIs remains unclear.
From 2016 to 2019, 81 NSCLC patients with
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ETC-159 in vivo
This beverage is suitable for vegans, celiac patients, and lactose intolerants.
Long non-coding RNAs (lncRNAs) may serve as biomarkers for complex disease states, such as intracranial aneurysms. In this study, we investigated lncRNA expression differences in the whole blood of patients with unruptured aneurysms.
Whole blood RNA from 67 subjects (34 with ane
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Objective To estimate the cost-effectiveness of first line tyrosine kinase inhibitors (TKI), afatinib and osimertinib, for the treatment of epidermal growth factor receptor (EGFR) mutation-positive (Exon 19 deletion or L858R) non-small cell lung cancer (NSCLC), stages IIIB – IV in Colombia. Methods A partitioned survival model was designed, using information from global and progression-free survival curves. For
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Lotus seed starch (LS) was enzymatically hydrolyzed by pullulanase, β-amylase and α-amylase to obtain three types of starch nanoparticles (SNPs) P-SNPs, β-SNPs and α-SNPs, respectively. The structure and physicochemical properties of lotus seed starch nanoparticles (LS-SNPs) were systematically studied by Laser particle size analysis, Scanning electron micros
For online lotto fanatics, selecting a situs toto terpercaya, or a “trusted toto site,” is important to take pleasure in safe and reasonable gameplay. With the rise in popularity of online lottery video games, particularly in regions like Southeast Asia, there has actually been a rise in the number of systems providing these services. Not all sites offer the reliability and safety and security players look for. In this guide, we’ll discuss what makes a lotto site trustworthy, how to find a trust
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Prosthetic joint infection (PJI) is the most common cause of failure following total knee arthroplasty (TKA). This study aimed to determine the success of debridement, antibiotics, and implant retention (DAIR) in a large cohort of TKA PJIs and assess the utility of current classification systems in predicting DAIR outcomes in early postoperative, late hematogenous, and chronic PJIs.
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yer increased two-fold during lockdown compared to the BLD phase. Such restrictions could be applied in the future to control air pollution but should be approached with caution.
The authors declare no competing financial interests.
The authors declare no competing financial interests.
There are frequent reports of unsafe pesticide use in m
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In this qualitative study, women with episodic migraine after receiving comprehensive chiropractic care described chiropractic as a multimodal intervention where they learned about musculoskeletal contributions to migraine, discovered new ways to affect their symptoms, and developed a collaborative patient-practitioner relationship. The results of this study provide insights into perceptions of chiropractic care among
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Constitutive over-expression of Deg-GST-2 was detected in RS strain, and GSTs genes were all inducible with the treatment of beta-cypermethrin in SS and RS strains. More importantly, knocking down Deg-GST-2 gene expression by RNAi increased the susceptibility of RS strain to beta-cypermethrin. HPLC analysis indicated that rGST-1 protein could metabolize phoxim directly, but rGSTs could not directly metabolize beta-cyp
PIK-75 nmr
Hydatid cyst in the cervical region is an extremely rare condition that can create challenges for anesthesiologists. Timely recognition of difficult airway and preparing the management plan is crucial to avoid life-threatening complications such as hypoxic brain damage. We describe a case of difficult airway management in a patient with massive cervical hydatid cyst. We used a low-dose ketamine-propofol seda
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In the study areas, five gastric nematodes from different harbour porpoise hosts were selected to be investigated with restriction enzymes HinfI, RsaI and HaeIII, which were able to differentiate several anisakid nematode species by characteristic banding patterns. Anisakis simplex s. s. was the dominant species found in the North Sea and Baltic porpoises, identified by all three restriction enzymes. Addi
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In conclusion, triclosan presents a deep impact on the microalga P. subcapitata morphology and physiology translated by multiple target sites instead of a specific point (cellular membrane) observed in the target organism (bacteria). Additionally, this study contributes to clarify the toxicity mechanisms of triclosan, in green algae, showing the existence of distinct modes of action of the biocide dependin
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marcgravii growth. Outbreaks of P. marcgravii poisoning coincided with periods of creation of large deforested pastures in the Southeast and Midwest regions of Brazil, and the poisoning should be considered an additional risk after deforestation. The most effective prophylaxis is fencing off the forest areas that contain these plants.
This study aimed to investigate the association between the p
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Six RCTs and eight non-RCTs were included. In total, 821 patients with SqCLC were included.
The response rate (RR) was 2.12 (95% CI 1.57-2.85, p < 0.00001). The disease control rate (DCR) was 2.38 (95% CI 1.70-3.32, p < 0.00001). The difference between the two groups was statistically significant. Regarding safety, the incidence rates of the adverse reactions cardi
10074-G5 in vitro
Antiretroviral therapy (ART) dispensing is strongly associated with treatment adherence. Among illicit drug-using populations, whom experience greater structural barriers to adherence, directly administered antiretroviral therapy (DAAT) is often regarded as a stronger predictor of optimal adherence over self-administered medications. In Vancouver, Canada, people living with HIV (PLHIV) who use drugs and live in l
JNJ42226314
High priority scores were assigned for progression during preoperative therapy. Low scores were assigned for re-excisions, atypical lesions and other benign indications. There was good agreement of the tool’s ranking of sample patients with rankings by experienced clinicians. The tool generates risk-stratified patient lists by surgeon or institution to facilitate assignment of surgery dates.
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Speech restructuring was included in all but one study (tDCS study) and had the most evidence i.e. supported by the greatest number of RCTs. On average, stuttering frequency was reduced by 50-57 % using speech restructuring approaches. No study reduced stuttering to the same level as community controls who don’t stutter. The study on tDCS reduced stuttering frequency by 22-27 %. Speech restructuring delivered via telehe
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RNA-seq analysis revealed that, although deletion of FgSRP2 alone had minimal effects, deletion of both FgSRP1 and FgSRP2 caused significant changes in gene transcription and RNA splicing. Overall, our results indicated that FgSrp2 regulates vegetative growth, sexual reproduction and pre-mRNA processing by interacting with FgSrp1.PURPOSE Nonsteroidal anti-inflammatory drugs (NSAIDs) have been sho
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Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have been identified, including cancer stem-like cell (CSC) activity. Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its effects on breast CSC activity in ER+ preclinical models. SFX-01 reduced mammosphere formation efficiency (MFE) of ER+ pr
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X-linked adrenoleukodystrophy (ALD) is a peroxisomal disorder caused by mutations in the ABCD1 gene and characterized by impaired very long-chain fatty acid beta-oxidation. Clinically, male patients develop adrenal failure and a progressive myelopathy in adulthood, although age of onset and rate of progression are highly variable. Additionally, 40% of male patients develop a leukodystrophy (cerebral ALD) before the age o
NPD4928
They also influenced different factors at other socio-ecological levels to act as barriers. Awareness in community along with accessibility and availability of comprehensive mental health services were recommended by the participants for increasing service utilization from Primary Health Care facilities.
Individual, family and community awareness could help reduce and/or eliminate men
MGCD0103
lar risk in the long term.
CICTD-specific biomarker profiles revealed an anti-angiogenic, interferon-driven environment during active disease, with incomplete normalization under treatment. This warrants further investigation into monitoring of vascular biomarkers during clinical follow-up, or targeted interventions to minimize cardiovascular risk in the long term.In United Lincolnshire NH
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der and younger age are significant predictors associated with TP. © 2020 Chang et al.Background Abnormal RGS4 gene expression may cause neurotransmitter disorders, resulting in schizophrenia. The association between RGS4 and the risk of schizophrenia is controversial, and there has been little research on the SNPs in the promoter region of RGS4. Purpose The present study was performed to detect the association betw
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Background Prostate cancer (PCa)is a malignancy of the urinary system with a high incidence, which is the second most common male cancer in the world. There are still huge challenges in the treatment of prostate cancer. It is urgent to screen out potential key biomarkers for the pathogenesis and prognosis of PCa. Methods Multiple gene differential expression profile datasets of PCa tissues and normal prostate tissues wer
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Quando si ha bisogno di assistenza, è fondamentale conoscere i diversi canali attraverso cui è possibile richiederla. La varietà dei mezzi di comunicazione offre flessibilità e consente di scegliere l’opzione più comoda e adatta alle proprie esigenze. Ogni canale ha caratteristiche specifiche che possono influenzare la rapidità e l’efficacia della risposta. Per ottenere un aiuto tempestivo, è essenziale conoscere le opzioni disponibili pe
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For online lottery game fanatics, picking a situs toto terpercaya, or a “trusted toto site,” is necessary to enjoy safe and reasonable gameplay. With the increase in popularity of online lottery video games, particularly in areas like Southeast Asia, there has been a boost in the variety of systems using these services. Not all webs
Antineoplastic and Immunosuppressive Antibiotics inhibitor
Robotic surgical technology has grown in popularity and applicability, since its conception with emerging uses in general surgery. The robot’s contribution of increased stability and dexterity may be beneficial in technically challenging surgeries, namely, inguinal hernia repair. The aim of this project is to contribute to the growing body of literature
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© Georg Thieme Verlag KG Stuttgart · New York.OBJECTIVE The aim of this study is to define data model requirements supporting the development of a digital cognitive aid (CA) for intraoperative crisis management in anesthesia, including medical emergency text modules (text elements) and branches or loops within emergency instructions (control structures) as well as their properties, data types, and value range
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be quicker to perform than full-thickness skin grafting. Nijhuis THJ, Özer M, van der Sluis WB, et al. The Bilateral Pedicled Epilated Scrotal Flap A Powerful Adjunctive for Creation of More Neovaginal Depth in Penile Inversion Vaginoplasty. J Sex Med 2020;XXXXX-XXX. BACKGROUND Previous research has found differences in sexual motives and, separately, sexual satisfaction in con
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nitive declines. These findings provide the clinical evidence that CSF and blood exosomes Ng can be used as a cognitive biomarker for AD and MCI-AD, and further studies are needed to define the specific range of Ng values for diagnosis at the different stages of AD.According to the World Health Organization cardiovascular disease risk charts, the mortality rate of cardiovascular diseases in people is still high. The
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Una cattiva traduzione, o che nella lingua di arrivo possa essere riconosciuta facilmente come traduzione, è un vero danno per una pubblicazione tecnica nel settore psicologico. Una traduzione accurata ed efficace di documenti scientifici contribuisce in senso più ampio a creare una comunità globale di scienziati e professionisti di settore che possono così condividere conoscenze ed esperienze indipendentemente dal Paese di proven
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The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that
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Magnification devices improve direct and indirect vision and precision being significantly higher in microscope use compared to the loupes. Dental loupes are the most commonly used devices for magnification, due to the more affordable prices and the ease of use without major changes in the working protocol and ergonomics. Loupes primary benefits reported refers to ergonomics and posture, restorati
Selleckchem POMHEX
Clear cell renal cell carcinoma (ccRCC), with an increasing incidence rate, is one of the ubiquitous cancers. Its pathogenic factors are complicated and the molecular mechanism is not clear. It is essential to analyze the potential key genes related to ccRCC carcinogenesis. In this study, the differentially expressed mRNAs, miRNAs and lncRNAs (DEmRNAs, DEmiRNAs and DElncRNAs) of ccRCC were screened from TCGA datab
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Inhibition of programmed death-ligand 1 (PD-L1) in cancer cells provides a reasonable avenue to prevent cancer progression. Although oleate is known to exert anti-cancer effects, its PD-L1 inhibitory effects have not been proven. This study investigated the effects of oleic acid and an oleic acid metabolite, oleoylethanolamide (OEA), on PD-L1 expression and biomarkers of tumorigenesis in several cancer cell lines, namely A
N-Nitroso-N-methylurea
Indium has been regarded as one of the most rarely used metal ions; however, the consumption of indium has increased intensively due to its increasing use in electrodes of liquid crystal displays (LCDs). In recent years, warnings have been issued about the toxicity of indium to aquatic ecosystems and humans. Thus, the development of efficient and selective detection methods for In3+ in aquatic
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Endocasts (i.e., replicas of the inner surface of the bony braincase) constitute a critical proxy for qualifying and quantifying variations in brain shape and organization in extinct taxa. In the absence of brain tissues preserved in the fossil record, endocasts provide the only direct evidence of brain evolution. However, debates on whether or not information inferred from the study of endocasts
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BACKGROUND Malignant disease is a common etiology of superior vena cava syndrome (SVCS). Being a medical emergency, it often requires rapid diagnostic evaluation and therapy. Transcaval biopsy and endovascular stenting in a single-setting has been described, but only in a handful of cases. These cases utilized intra-operative venograms. In this study, we also used intra-operative cone beam computed tomo
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Various studies have identified that between 2012 and 2017, Brazil’s semiarid region suffered severe drought. However, few studies have analyzed whether this drought also affected the eastern coastal region of Northeast Brazil (ENEB). Therefore, the objective of this work is to identify rainfall anomalies in these regions and verify the hydrometeorological impact on reservoirs in the 2012-2017 interval. For this purp
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Several strategies, such as chemical cleaning protocols, turbulence promoters and backwashing with air or liquids are currently used in the industry, mainly focusing around early prevention and treatment, so that the separation efficiency of MF membranes will not decrease over time. Other strategies include combining coagulation with either inorganic or organic coagulants, with membrane treatment which can poten
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Hepcidins, a group of antimicrobial peptides (AMPs), play a key role in the innate immune system of fishes and act against different pathogens. In this study, antimicrobial and immune-inflammatory activity of a synthetic EC-hepcidin1, previously identified from orange-spotted grouper, were evaluated. EC-hepcidin1 showed weak activity against the zoonotic fish pathogen Streptococcus iniae (MIC 100 μg mL-1 and
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Low-input analytical technologies now enable us to analyze the genome of gametes and embryos in a high-throughput, genome-wide manner. These technologies are being applied rapidly to the SCNT field, providing evidence for incomplete reprogramming of the donor genome in cloned embryos or offspring. Insights from the study of epigenetic phenomena in SCNT are highly relevant for our understanding of the mechanisms of ge
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In addition, we summarize in vivo experiments with emphasis on the effect of the activation of certain key signalings on AHN in AD rodent models. We propose that these signaling targets and corresponding interventions should be considered when developing novel therapies for AD.
To estimate rates and settings of low-value imaging among pediatric Medicaid beneficiaries, and estimate asso
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mock exam tasks did not relate to condition.This research examines whether the items of some of the most well-established five-factor inventories refer to competence. Results reveal that both experts and laymen can distinguish between items that refer to how competently a behavior is performed and items that do not (Study 1). Responses to items that refer to competence create a higher-order factor in the pe
DBr-1 chemical
How genetic changes are linked to morphological novelties and developmental constraints remains elusive. Here, we investigate genetic apparatuses that distinguish fish fins from tetrapod limbs by analyzing transcriptomes and open-chromatin regions (OCRs). Specifically, we compared mouse forelimb buds with the pectoral fin buds of an elasmobranch, the brown-banded bamboo shark (Chiloscyllium punctatum). A transcriptomic
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AlexisTogel: A Comprehensive Look right into Online Togel Betting.xxx.AlexisTogel has actually emerged as a well-known system in the on-line togel (lottery) wagering world, offering gamers a convenient method to participate in lottery-style video games from the convenience of their own homes. AlexisTogel provides a safe and secure and straightforward platform for players who desire to involv
Linsitinib
Lymphatic filariasis causes disfiguring and disabling lymphoedema, which is commonly and frequently exacerbated by acute dermatolymphangioadenitis (ADLA). Affected people require long-term care and monitoring but health workers lack objective assessment tools. We examine the use of an infrared thermal imaging camera as a novel non-invasive point-of-care tool for filarial lower-limb lymphoedema in 153 affected adults from
Belnacasan in vivo
Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma.
Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family wi
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F. proliferatum, F. oxysporum and F. redolens showed pathogenicity to asparagus and were the main species associated to ADS. Fusarium oxysporum was the species with the highest genetic diversity displaying 14 sequence-based haplotypes with no geographic differentiation. This work contributes to understanding the Fusarium complex associated to ADS for developing accurate integrated disease management strategies.Pseudomonas
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A review of the structure of the center cerebral artery for that age of thrombectomy: a radiologic application according to CT angiography as well as perfusion CT.
With exceptionally large RI changes, the evanescent field of cladding mode in ZIF-8 is greatly enhanced to sense the vapor-MOF interactions. As a proof-of-concept, a LPFG sensor with ZIF-8 coating showed a
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volution and ecology. By evaluating several decades of surveillance data from wild aquatic birds sampled along North American migratory flyways, we discovered an annual trend of increasing subtype diversity during southbound migration, peaking on southern wintering grounds. Winter sampling revealed the highest proportion of mixed and rare infections which suggest higher opportunity for spillover. These findings all
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17, p = .05) and a moderate correlation between the number of macrophages and wear particles and wear volume. There was no statistically significant correlation between wear and any other feature including lymphocytic inflammation or necrosis. Strong correlations between combined cup and ball wear volume and histological characteristics were not observed, although the number of macrophages was more closely correlated
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Among a selected population at high risk for developing BM, PCI significantly decreased CBM in addition to increasing progression-free survival and OS. To our knowledge, this is the first study to evaluate PCI in epidermal growth factor rece
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Herein we briefly review the in vitro prediction methods that serve to identify drugs with a potential to induce hyperbilirubinemia. In vitro assays can be deployed early in drug development and may help to minimize late-stage attrition. Based on current evidence, drugs that behave as mono- or multispecific inhibitors of OATP1B1, UGT1A1, and BSEP in vitro are at risk of causing clinically significant
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We aim to highlight the importance of timely diagnosis and further management in such clinical scenarios, where permanent vision loss can compromise someone’s quality of life.Hepatosplenic T-cell lymphoma is a rare but highly aggressive form of T-cell malignancy. As cases are not routinely seen in practice, the malignancy can be confused with other hematologic conditions that have a similar presentation. H
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© FEMS 2020.Aerobic methane-oxidizing bacteria of the Alphaproteobacteria have been found to express a novel ribosomally synthesized post-translationally modified polypeptide (RiPP) termed methanobactin (MB). The primary function of MB in these microbes appears to be for copper uptake, but MB has been shown to have multiple capabilities, including oxidase, superoxide dismutase, and hydrogen peroxide reductase activitie
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Physiological measurements are informative in assessing the relative importance of stressors that potentially impact the health of wildlife. Kelp Gulls, Larus dominicanus (KG), resident to the region of Península Valdés, Argentina, have developed a unique behavior of landing on the backs of southern right whale adults and calves, Eubalaena australis (SRW), where they feed on their skin and blubber
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Results Immune profiling revealed that HT40 upregulated a variety of inflammatory markers in the tumors. Immunologically, HT40 treated tumors showed an increased population of granzyme B+ expressing functional CD8+ T cells (~4-fold) as well as an increased M1 to M2 macrophage ratio (~2-3-fold) and CD8+ T regulatory T cell ratio (~5-fold) compared to the untreated control. Systemically, the p
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with OCD conducted during the current COVID-19 pandemic. Factors such as quarantine length, location, overlapping society-level challenges, and differing measurement and sampling choices may help to explain this difference across studies.
Our study of online OCD support community members found a much higher rate of OCD symptom worsening than did other studies on people with OCD conducted during the current
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A total of 750/2,871 participants had MetS. Among the six types of machine learning methods investigated, multiplayer perceptron and support vector machine exhibited the same performance as the conventional regression method, based on the areas under the receiver operating characteristic curves. The naive-Bayes method exhibited the highest sensitivity (0.49), which was higher than that of the conventional
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Oral mucositis refers to mucosal damage and occurs in the oral, pharyngeal, and laryngeal cavities. When patients with cancer get oral mucositis, the painful condition can cause difficulties in eating, drinking, and swallowing and may compromise the patient’s nutritional status. It also may be drastically associated with infections, resulting in longer hospitalizations.
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volution and ecology. By evaluating several decades of surveillance data from wild aquatic birds sampled along North American migratory flyways, we discovered an annual trend of increasing subtype diversity during southbound migration, peaking on southern wintering grounds. Winter sampling revealed the highest proportion of mixed and rare infections which suggest higher opportunity for spillover. These findings all
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hiHep cells were also found to spread farther and have better hepatocyte-specific functions (albumin secretion and urea) in the liver microtissue when liver dECM was added to the GelMA bioinks. Our results provide a promising liver dECM-based cell-laden bioink for liver microtissue fabrication, which would be a potential liver tissue engineering product to help restore hepatic functions. Implantable medical
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These measures include social distancing, intensive surveillance and quarantining of cases, contact tracing and isolation, cancellation of mass gatherings, and community containment. The virus is the third zoonotic coronavirus, after SARS-CoV and MERS-CoV, but appears to be the only one with pandemic potential. However, a number of important properties of the virus are still not well understood, and there is an u
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After simulation training the emergency physicians judged their knowledge, skill, and safety to be greater when they used the barrier during airway management in patients with COVID-19. The combined use of a laryngoscope and the Intubox barrier resulted in less particle dispersion during intubation.
After simulation training the emergency physicians judged their knowledge, skill, and safety to be gr
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To assess if habitual sleep duration/quality was associated with appetite in individuals with obesity, and if the association was modulated by sex.
Sleep duration/quality was measured with Pittsburgh Sleep Quality Index score in 95 healthy adults with obesity (BMI 36.6±4.2kg/m
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A 7-year-old castrated male domestic shorthair cat was presented for evaluation of decreased appetite and respiratory signs. A CBC run on presentation revealed severe nonregenerative anemia, thrombocytopenia, and leukocytosis characterized by a prominent population of blasts, having morphologic features suggestive of a monocytic lineage. The cat tested positive for FIV, FeLV, Mycoplasma haemominutum, and only mild abnor
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Safeguarding the home or company from criminals is critical for maintaining reassurance and guaranteeing the protection of your family members and workforce. Nevertheless no technique is infallible, there are various real-world steps an individual can take to be able to vastly decrease the risk of the break-in. Here are our best techniques for securing your own home against burglars and bad guys
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The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” and changes to clinical practice worldwide; there is no comparative information emerging from the United Kingdom with regard to major trauma.
This observational study from a UK Major Trauma Centr
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The increasing mandate for fresh-like food products and the possible hazards of chemically preserved foods necessitate the search for alternatives. Bacteriocins represent a promising food biopreservative. In the present study, one hundred enterococci isolates recovered from Egyptian raw cow milk and homemade dairy products were screened for bacteriocin production. The overall detection rate was 10%. Three isolates,
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These results open up a broad range of opportunities for the engineering of metasurfaces and strongly enhanced light-matter interactions.The patterning of polydimethylsiloxane (PDMS) into complex two-dimensional (2D) or 3D shapes is a crucial step for diverse applications based on soft lithography. Nevertheless, mould replication that incorporates time-consuming and costly photolithography proces
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The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients wit
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Although cyanobacteria absorb blue light, they use it less efficiently for photosynthesis than other colors absorbed by their photosynthetic pigments. A plausible explanation for this enigmatic phenomenon is that blue light is not absorbed by phycobilisomes and, hence, causes an excitation shortage at photosystem II (PSII). This hypothesis is supported by recent physiological studies, but a comprehensive
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Despite a number of studies linking family and marriage factors with health behaviour, the effects of children on the health behaviour of parents are still understudied. This study explored the association between the presence of children and adults’ smoking behaviours.
This study used panel data from the China Family Panel Studies 2010 and 2012, and the da
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Some of the constituents, which have not been tested yet, were predicted to involve mitochondrial membrane potential, caspase-3 stimulation, and AhR activity. Since Nrf2 activation could be favorable for prevention of hepatotoxicity, we also suggest that these compounds should undergo testing given that they were predicted not to be activating Nrf2. Among the major constituents, alkaloids appear to be the least stu
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KMUP-1 prevented CCI-induced neuropathic pain and BKCa current inhibition in a peripheral nerve injury model, suggesting that KMUP-1 could be a potential agent for controlling neuropathic pain.A porcelain insulator is an important part to ensure that the insulation requirements of power equipment can be met. Under the influence of their structure, porcelain insulators are prone to mechanical damage and cr
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These results indicate that ELP nanoparticles, regardless of chain length, particle diameter, or amino acid hydrophobicity, may have the potential to stimulate a humoral immune response via immunoglobulin G and activated complement factor 3 despite the large amounts of albumin adsorbed at the blood-material interface.The EpiData Center (EDC) has provided routine blood lead level (BLL) surveillance for Departm
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Flooding and extreme heat interact with socioeconomic conditions to impact physical infrastructure and disrupt community health as well as health facility operations. Community members and health facilities make infrastructural and operational adjustments to reduce extreme weather stress and improve healthcare provision to clients. These measures include mobilisation of residents to clear rubbish and unclog drains;
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Lactate is a universal metabolite and energy source, yet the mode of lactate metabolism in many strictly anaerobic microorganisms is still enigmatic. This sparked us to investigate the biochemistry and bioenergetics of lactate metabolism in the model acetogenic bacterium Moorella thermoacetica. Growth and metabolism were dependent on CO2 and the chemiosmotic gradient. We discovered a l-lactateNAD+ ox
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Malignant conditions of the gastrointestinal tract and accessory organs of digestion, including the oral cavity, esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus, are referred to as gastrointestinal cancers. Curcumin is a natural compound derived from turmeric with a wide range of biological activities. Several in vitro and in vivo studies have inve
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Through a single administration, we found that iPSCs trafficked to allograft lesions, differentiated into ECs within 1 week, and survived for 4-8 weeks. The therapeutic effect of a single administration was moderate. Thus, Intgβ1 and pluripotency are essential for iPSCs to treat allogeneic vasculopathy. This article is protected by copyright. All rights reserved.Getah virus (GETV) is a mosquito-borne virus th
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At the applied level, this could be of interest with a view to conducting training programs in face recognition.This paper formulates a new problem for the optimal placement of Unmanned Aerial Vehicles (UAVs) geared towards wireless coverage provision for Voice over WiFi (VoWiFi) service to a set of ground users confined in an open area. Our objective function is constrained by coverage and by VoIP speech quality a
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A new species of Acrotaeniostola Hendel, A. connexa sp. n. of tribe Gastrozonini, is described from India. Acroceratitis incompleta Hardy of tribe Gastrozonini and Ceratitella sobrina (Zia) of tribe Ceratitidini have been recorded for the first time from India. The genus Ceratitella Malloch and tribe Ceratitidini are recorded for the first time from India.Larvae of the Notacanthella Jacobus McCafferty, 2008 species
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Endometriosis is responsible for pain symptoms with great impact on the patient’s quality of life. Several medication lines have been studied aiming at its definitive treatment. Among them, angiogenesis inhibitor factors may be effective given that angiogenesis has fundamental role in the establishment and growth of endometriotic lesions. In this study, we investigated the influence of bevacizumab, anti-factor drug
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An accurate surgical template for guided implant surgery is essential for the success of an implant restoration. However, reports on the accuracy of digitally designed and computer numeric controlled (CNC) machine-milled surgical templates are sparse.
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The codon optimization and mRNA secondary structure prediction revealed that the chimera is suitable for high-level expression and cloning. Overall, the constructed recombinant chimeric vaccine candidate demonstrated significant potential and can be considered for clinical validation to fight against this global threat, COVID-19.In our previous study, we found that VPS28 (vacuolar protein sorting 28 homolog) could alt
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증명 아이디를 구입하는 절차는 간단하지만 몇 가지 신경 써야 할 부분이 있죠. 우선, 신뢰 가능한 상인을 찾아내는 것이 중요해요. 인증된 상인은 이전 거래의 평가나 평가를 통해 그리고 확인할 수 있습니다, 이를 통해 보안이 보장된 보장받을 수 있죠. 또한, 판매자가 제공하는 가입과 인증 절차를 정확히 알아야 합니다.
구매하고자 하는 네이버 과정의 사용료는 다양한 편입니다. 시장에서의 상황에 따라 변화가 있을 수 있으며, 아이디의 활성 상태나 종류에 따라 다르게 결정됩니다. 그래서 다양한 판매자의 가격을 비교하여, 구체적인 혜택이나 서비스도
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ical target for the antidepressant mechanism of minocycline. Impaired hippocampal neurogenesis was observed in diabetic mice; however, this may not be involved in the pathogenesis of depression.The voltage-dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane potential, cell volu
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To analyze the biomechanics of cystic lesions in the mandibular body in a three-dimensional (3D) finite element model.
A 3D finite element model of cystic lesion of the mandibular body was constructed based on the CT images of the mandible of a healthy adult female volunteer with normal occlusion. The size of the cyst and the residual bone wall were analyzed
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Victim-offender contact has been studied extensively in prisons, but research on contact between victims and mentally disordered offenders in forensic mental health settings is lacking. Therefore, an exploratory study was conducted on contact between victims and offenders in four Dutch forensic psychiatric hospitals. These offenders have committed serious (sexually) violent offenses, for which they could not be held fully resp
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g characteristics and enabling conditions are more important in China, while perceived needs are more significant in the US. Such differences might reflect possible US-China differences in job environment (eg, job pressure) and culture (individualism vs collectivism and family structure).
High levels of psychosocial distress are correlated with worse glycemic control as measured by glycosylate
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The majority of freshwater ecosystems worldwide suffer from eutrophication, particularly because of agriculture-derived nutrient sources. In the European Union, a discrepancy exists between the scale of regulatory assessment and the size of research catchments. The Water Framework Directive sets water quality objectives at the mesoscale (50-500 km2), a scale at which both hillslope and in-stream processes influence carbo
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(1) Background Developmental Language Disorder (DLD) is diagnosed when the child experiences problems in language with no known underlying biomedical condition and the information required for its correct evaluation must be obtained from different contexts. The Children’s Communication Checklist (CCC-2) covers aspects of a child’s communication related to structural language and pragmatic skills, which are linked to soci
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Therefore, such PFP nanodroplets with phase/size tunable properties enable site-specific drug delivery efficiently and exhibit their potent in cancer theranostics.Although the manufacturing processes of contact lenses are well established, the use of additive manufacturing for their fabrication opens many new possibilities to explore. The current study demonstrates the fabrication of p
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infection and variety V2-49-17 with yellow endosperm and partial resistance to Fusarium sp. infection. In this manner, we were able to compare potential effects of inductors upon defence gene expression among three varieties with different susceptibility to infection but also between inoculated and non-inoculated seedlings of a single variety. The lowest infection levels were detected in th
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Mental Disorders among Refugees Abstract. Children and adolescents with migration and refugee backgrounds are subject to various health-related, psychosocial, sociocultural, and economic burdens that may influence the prevalence, manifestation, course, and treatment as well as prognosis of mental disorders. In addition, they are particularly disadvantaged by numerous barriers to accessing the mental healthcare and treatm
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A total of 17 and 433 FRE crashes and near-crashes, respectively, were included in this study. It was found that (1) FRE crashes were associated with the sequential and combined effects of those factors above; (2) certain types of speed oscillations were identified as precursors to sudden braking when vehicles ahead decelerated or stopped-and-went; and (3) many factors were identified as being associated with driver
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Moreover, AP sites located ≤10 base pairs to the cdPu on its 5′-end side were repaired less efficiently than AP sites located ≤10 base pairs on the 3′-end side of cdPu. The strand with an AP site placed opposite cdPu or one base in the 5′-end direction was not reconstituted for cdA nor cdG. CdPus affect the repair of the other lesion within the CDL. It may translate to a prolonged lifetime of unre
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Interaction between MALAT1 and miR-146b-5p was predicted via bioinformatics and validated using Dual-luciferase reporter assay and Ago2-RIP.
MALAT1 was aberrantly downregulated in the intestine mucosa of CD patients and mice with experimental colitis. MALAT1 knockout mice were hypersensitive to DSS-induced experimental colitis. MALAT1 regulated intestinal mucosal
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Autoimmunity increases with age and is often commonly evaluated in women of the reproductive age group. Prevalence of thyroid antibodies is common even in euthyroid pregnant women. We aim to compare the association of thyroid antibody status on the maternal and neonatal outcomes in pregnant women with hypothyroidism.
We conducted a cross-sectional retrospective study on 718 cases in
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The overall mortality was recorded as 23 (4.0%) in six months, with a median (interquartile) age of 65 (20) years. Majority of the patients (dead or alive) had partial anterior circulation infarct, PACI (43.5%; 34.0%) and total anterior circulation infarct, TACI (26.1%; 8.8%). In addition, DVT prophylaxis (82.8%), anticoagulant for atrial fibrillation (AF) patients (48.8%) and rehabilitation (26.2%) were con
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The incremental cost-effectiveness ratio (ICER) for providing surgical care to patients of all ages was $215 (SD $3,666) per disability-adjusted life-year (DALY), which is below the willingness-to pay-threshold (WTP) of $1,170 per DALY and highly cost-effective at a WTP threshold of $390. Each surgeon is estimated to avert approximately 5,570 DALYs during their career when performing operation
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Special-purpose classical force fields (FFs) provide good accuracy at very low computational cost but their application is limited to systems for which potential energy functions are available. This excludes, e.g., most metal-containing proteins or those containing cofactors. In contrast, the GFN2-xTB semi-empirical quantum chemical method is parameterized for almost the entire Periodic Table. The accuracy of GFN2-xTB is assessed
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rectomy.Familial Mediterranean fever (FMF) is a rare autoinflammatory disorder of the innate immune system. Patients with innate immune system defects are at a high risk of meningococcal disease, although it is unclear if patients with FMF also have increased susceptibility to invasive infection. Herein, we present a diagnostically challenging case of a male adolescent with a past medical history of FMF stabilize
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ion between nurses and physicians in truth disclosure.
National standards are commonly used as an improvement strategy in healthcare, but organisations may respond in diverse and sometimes negative ways to external quality demands. This paper describes how a sample of NHS hospital trusts in England responded to the introduction of national standards for 7-day services (7DS), from an
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The effect of different bearings on synovial white blood cell (WBC) count and polymorphonuclear percentage (PMN%) in aspirations remains unclear. Therefore, this study investigates the impact of aseptic Metal-on-Metal (MoM) bearing on synovial fluid.
We searched our arthroplasty registry for aseptic painful THAs with MoM bearings between 2011 and 2018. Then, a case-matched
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A 70-year-old male was referred to our hospital for marked thrombocytosis without anemia. The patient simultaneously presented with an MPL W515L mutation, one of the major driver mutations in essential thrombocythemia (ET), and deletion of 5q, a characteristic cytogenetic abnormality in myelodysplastic syndrome (MDS). Bone marrow examination showed a combination of both mature hyperlobulated megakaryocytes, as f
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Folic acid-doxorubicin-double-functionalized-lipid-core nanocapsules (LNC-CS-
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Genome comparison revealed a high level of similarity among isolates both within and between units. All isolates showed resistance to chloramphenicol and carried identical catP gene with other Southeast Asian isolates, suggesting a common lineage. Their antigenic
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For different tumour types (bronchial versus advanced laryngeal) sensitivity and specificity were 100% and 80% respectively. VOCs isolated from in-situ cancers included some previously demonstrated in advanced cancers and some novel VOCs. In-situ bronchial and laryngeal cancer can be detected by VOC analysis. Distinction from normal controls and between the two tumour types could allow screening in high risk groups for thes
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ther clarification in prospective longitudinal studies.[This corrects the article doi 10.1590/s0102-865020200090000003].Since the beginning of the COVID-19 pandemic, publications have highlighted the disproportionate impact of the COVID-19 pandemic on academic mothers, mostly focusing on the impact of social distancing and quarantine. A few months later, despite the lack of effective vaccines or therapeutics in sight, many
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Palm oil production chain generates a greasy residue in the refining stage, the Palm Oil Deodorizer Distillate (PODD), mainly composed of free fatty acids. Palm oil is also used industrially to fry foods, generating a residual frying oil (RFO). In this paper, we aimed to produce lipase from palm agro-industrial wastes using an unconventional yeast. RFO_palm, f
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사업을 성장시키기 위해서는 여러 온라인 플랫폼을 효율적으로 이용하는 것이 필수적입니다. 특별히 네이버는 블로그 서비스, 카페, 지식인 등 여러 기능를 제공하여 비즈니스가 고객과 연락하고 관계를 더욱 돈독히 하는 데 큰 지원을 줍니다. 그러나 그러한 서비스를 최대한 활용하기 위해서는 알맞은 네이버 계정가 필요합니다. 그래서 안전하게 네이버 아이디를 구입하는 방법에 대해 조사하는 것은 아주 의미가 있습니다.
네이버 계정을 구입할 때는 보안과 신뢰성을 최우선으로 생각해야 합니다. 불법 거래되는 계정나 사기성 판매자를 막는 것이 사업의 안전을 지키는 길입니다. 이번 글에서는 사업 성장을 위한 네이버 아이디를 어떤 방법으로 신뢰성 있게 구입할 수 있는지를 또한 그 과정에서 염두에 두어야 할 사항들
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Nonetheless, at the histological level, internalization into tumor cells was strongly enhanced for the riboflavin-targeted peptostars. Based on these results, we conclude that passive accumulation is dominating the accumulation of peptostars, while tumor cell internalization is strongly promoted by riboflavin targeting.A sensitive and fast method for simultaneous determination of gaseous ammonia
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Requirements for safety pharmacology testing have been in place since the issue of initial regulatory guidance over 20 years ago. An evaluation of such testing, supporting first clinical entry of 105 small molecule drug candidates over the last decade, showed that a “core battery” of in vitro electrophysiological (hERG), conscious non-rodent telemetry cardiovascular, rodent central nervous system (CNS) (modified Irwin
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The incremental cost-effectiveness ratio (ICER) for providing surgical care to patients of all ages was $215 (SD $3,666) per disability-adjusted life-year (DALY), which is below the willingness-to pay-threshold (WTP) of $1,170 per DALY and highly cost-effective at a WTP threshold of $390. Each surgeon is estimated to avert approximately 5,570 DALYs during their career when performing operation
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To monitor a state of disease freedom and to ensure a timely detection of new introductions of disease, surveillance programmes need be evaluated prior to implementation. We present a strategy to evaluate surveillance of Mycobacterium avium subsp. paratuberculosis (MAP) using simulated testing of bulk milk in an infectious disease spread model. MAP is a globally distributed, chronic infectious disease with substantial a
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low JOA score increased the risk of developing depression. It is necessary to evaluate mental status and related risk factors before surgery.OBJECTIVE To explore the predictive values of the combination of preoperative data, including medical history and physical examination, and results of sleep oximetry performed early after the surgery (one week) in predicting the treatment outcomes of uvulopalatopharyngoplasty (UPP
Metabolism inhibitor
Nurses and other healthcare providers can be trained to provide reflexology during painful, anxiety-producing procedures to increase patient tolerance of these treatments and overall quality of life.
To examine the effects of a legacy intervention for children with advanced cancer and their parents on parental coping strategies.
The authors recru
PIK-90 ic50
All the studied methylamines are found to favor the hydrophobic collapse of the polymer thus stabilizing the globular state of PVCL. Sarcosine is observed to cause the maximum decrease in lower critical solution temperature (LCST) of PVCL followed by TMAO and then betaine. The differences observed in the LCST values of PVCL in the presence of these molecules can be attributed to the different polymer-osmolyte interaction
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Treatment guidelines are primarily based on randomized clinical trials (RCTs). RCTs tend to some extent to exclude older adults despite the fact that physicians need guidance when treating this patient group. By summarizing existing literature, we aimed to (a) quantify the proportion of RCTs and other clinical studies (CTs) that did not adequately include older adults; (b) identify the main barriers for this n
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The predictive capabilities of deep neural networks (DNNs) continue to evolve to increasingly impressive levels. However, it is still unclear how training procedures for DNNs succeed in finding parameters that produce good results for such high-dimensional and nonconvex loss functions. In particular, we wish to understand why simple optimization schemes, such as stochastic gradient descent, do not end up trapped in loc
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93; p 30%) is a potential pitfall for the detection of metastases in HP.Sweet potato (Ipomoea batata) is considered a superfood among vegetables and has been consumed for centuries. Traditionally, sweet potato is used to treat several illnesses, including diarrhea and stomach disorders. This study aimed to explore the protective effect of sweet potato on intestinal barrier function, and to identify the active compounds o
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nd defect morphology in patients with peri-implantitis.Infants’ oculomotor tracking develops rapidly but is poorer when there are horizontal and vertical movement components. Additionally, persistence of objects moving through occlusion emerges at 4 months but initially is absent for objects moving obliquely. In two experiments, we recorded eye movements of thirty-two 4-month-old and thirty-two 6-month-old infants (
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Seasons Visual appeal, Abundance, as well as Web host Choice of Philaenus spumarius and Neophilaenus campestris (Hemiptera: Aphrophoridae) inside Olive Groves inside Portugal.
The global COVID-19 pandemic has brought numerous challenges for conducting the human subjects research needed to advance science and improve health.
The purpose of thi
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The previously proposed Ansatz for density cumulant theory that combines orbital-optimization and a parameterization of the 2-electron reduced density matrix cumulant in terms of unitary coupled cluster amplitudes (OUDCT) is carefully examined. Formally, we elucidate the relationship between OUDCT and orbital-optimized unitary coupled cluster theory and show the existence of near-zero denominators in the stationarity conditions for bot
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This is mainly attributed to the effect of temperature on the hydrogen-bond interaction. Ag nanoparticles (Ag NPs) can be prepared above the PTT and facilely separated below PTT. The Ag NPs obtained from the current SFME showed higher catalytic activity than that obtained from a common surfactant-based ME.A novel method of iodine-catalyzed aerobic oxidation with spirovinylcyclopropyl oxindoles under mild co
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Best Car Locksmiths in Wellingborough: Ensuring Your Safety and Convenience
In the dynamic town of Wellingborough, the need for dependable and effective car locksmith services is more important than ever. Whether you’ve lost your car keys, need a key duplication, or require emergency lockouts, having access to an experienced and reliable car locksmith can make all the distinction. This short article
CBD3063
In pregnant women with type 1 diabetes, the average total intake was 218 ± 19 g/day, which was 20% (53 g/day) lower than in healthy pregnant women. Mean intake of dietary fiber in women with diabetes was lower than the recommended adequate intake for healthy women. With the limitations of pronounced heterogeneity across the included studies, pregnant women with type 1 diabetes reported a mean total carbohydrate intake, whic
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low JOA score increased the risk of developing depression. It is necessary to evaluate mental status and related risk factors before surgery.OBJECTIVE To explore the predictive values of the combination of preoperative data, including medical history and physical examination, and results of sleep oximetry performed early after the surgery (one week) in predicting the treatment outcomes of uvulopalatopharyngoplasty (UPP
ADT-007 mw
Lower dehydroepiandrosterone-sulfate (DHEA-S) levels have been inconsistently associated with coronary heart disease (CHD) and mortality. Data are limited for heart failure (HF) and association between DHEA-S change and events.
Assess associations between low DHEA-S/DHEA-S change and incident HF hospitalization, CHD, and mortality in older adults.
E-616452 in vitro
Over the last few years, several attempts have been made to replace petrochemical products with renewable and biodegradable components. The most challenging part of this approach is to obtain bio-based materials with properties and functions equivalent to those of synthetic products. Various naturally occurring polymers such as starch, collagen, alginate, cellulose, and chitin represent attractive candidates as the
Seliciclib clinical trial
Sepiapterin reductase deficiency (SR) is a rare inborn disorder of neurotransmitter metabolism. The early diagnosis of SR disease should be achieved through the determination of the sepiapterin level in body fluids of suspected patients. Here, we report the selection, identification, and characterization of DNA aptamers against sepiapterin. The aptamer selection was achieved via the systematic evolutio
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The growth performance and photosynthetic activities of M. aeruginosa were significant with IAA (p less then 0.01) and BSL (p less then 0.05) compared to ZT and ABA, as TPN concentrations increased. Hormones stimulated the MCs production significantly BSL (p less then 0.05) at various levels and protected the cells against TPN-induced oxidative stress and expression of mcyB and mcyD genes involve in MCs synt
HRO761 clinical trial
nt, and palpation of the stylohyoid complex to avoid potentially serious complications from conceivably hazardous interventions.
Epididymal anomalies are common in boys with undescended testis. Epididymo-testicular non-union with a nubbin in the scrotum is a rare anomaly and may be confusing during management of cryptorchidism. The non-fused epididymis and vas deferens which are descended to
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In this introduction article, we summarize the 2020 International Conference on Intelligent Biology and Medicine (ICIBM 2020) conference which was held on August 9-10, 2020 (virtual conference). We then briefly describe the nine research articles included in this supplement issue. ICIBM 2020 hosted four scientific sections covering current topics in bioinformatics, computational biology, genomics, biomedical informatics,
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This chapter will address the issue of risk for HIV-associated neurocognitive disorder (HAND), focusing on HIV-associated dementia (HAD), among persons living with HIV in relationship to the risk for other dementias. Advances in effective antiretroviral therapy (ART) have led to an increase in the prevalence of older persons surviving with HIV – in addition to older persons who become infected by HIV later in life. Hence, HIV
네이버 계정 판매
네이버 가계정은 다양한 이용자들에게 필수적인 수단으로 알려져 있습니다. 특별히 블로깅, 카페, 지식인 등 다양한 채널에서 이용하는 비즈니스들에게는 더욱 가치 있는 중요한 요소입니다. 하지만 이러한 계정들을 안전히 구매하고 판매하는 과정에서 생각하지 못한 다양한 위험 요소가 있습니다. 계정들을 사고 파는 과정에서 잘못된 절차를 절차를 밟거나, 신뢰할 수 없는 상대 파트너와 접촉하게 되면 아이디가 멈추거나 제한될 수 있습니다.
이번 시간에는 글에서는 네이버 아이디를 안전하게 구매하고 매각하는 방법을 알아보겠습니다 살펴보겠습니다. 계정의 거래를 고려하고 있는 회사들과 개인들이 좀 더 신뢰
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The ExpTra-S was associated with the positive dimension of the psychosis phenotype but not with the negative or affective dimensions, or subjective experiences. No items displayed differential functioning for sex and age. The ordinal alpha for the total score was 0.96. The patients with psychosis had a higher score for early traumatic experiences in comparison with the non-clinical group. The results obtained showed that th
네이버 아이디 구매
네이버 블로그는 한국 내 정보 공유와 소통의 핵심적인 플랫폼으로 정착하고 있습니다. 수많은 기업과 개인이 이곳을 브랜드를 홍보하며, 고객과의 관계를 증진시키며, 궁극적으로는 비즈니스 성과를 개선하고자 합니다. 그러나 블로그와 카페 운영에서 성공을 거두기 위해서는 적절한 계정 관리와 전략 수립이 중요합니다.
최근에는 네이버 아이디 판매와 같은 방법이 주목받고 있습니다. 이 전략은 특정한 목적이나 필요에 의해 구매된 네이버 계정을 통해 더 많은 유입과 더 나은 상호작용을 유도하는 것입니다. 이러한 계정 전략이 어떻게 비즈니스 성과를 향상시키는지에 대한 이해는 블로그 운영자들에게 필수적인 통찰을 제공합니다. 이 글에서는 네이버 아이디 판매의 역할과 그 효과을 상세히 살펴보겠습니다.
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Capsazepine
These results suggest that facial trauma in infants causes hyperactivation of microglia in the trigeminal spinal nucleus following AFI, leading to the prolongation of the facial mechanical pain hypersensitivity.
These results suggest that facial trauma in infants causes hyperactivation of microglia in the trigeminal spinal nucleus following AFI, leading to the prolongation of the facial mechanical
Cyclopamine nmr
RESULTS In the literature, results for ACI in the knee are reported to be good, especially for larger cartilage defects. Arthroscopic techniques should lead to a decrease of complications and perioperative morbidity. No technique-specific complications occurred in our cohort. From 2012-2015, 98 patients were treated using the above mentioned technique, whereby 62 patients were retrospectively eval
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In order to evaluate dominance/implantation of starter cultures for wine fermentation, both commercial starters and wild strains were monitored during the fermentation of Greco di Tufo (GR) and Aglianico of Taurasi (AGL) musts. Preliminary characterization of commercial strains was carried out by several molecular markers. Five fermentations-four starter-inoculated and one spontaneous-were carried out in duplicat
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ups 2 and 3 (p=0.888). The mean foreign body reaction score was 0, 2.5, and 2.44 in groups 1, 2, and 3, respectively. No difference was present between groups 2 and 3 (p=0.743). Conclusion Primary nerve repair using the cyanoacrylate adhesive may provide similar electrophysiological and histopathological results as compared to the conventional microsuture repair.Objective This study aimed to determine the effects of a natur
ZVADFMK
7% times. ‘Percent rank’ function analysis for SC doses also indicates the same.
This study supports MRI fusion for GTV and OAR delineation for non-spinal metastasis. Our study showed that the dosimetric analysis is vital for observer variation studies and the addition of the MR data set is significant to improve the confidence of Stereotactic treatments.
This
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Based on the relative abundance of sensitive microbial taxa and predicted functions, bioindicators [Bacteroidia], 1/[Nitrospira], 1/[Nitrification], and 1/[Aerobic nitrite oxidation] were established to reflect and predict the contamination status of heavy metals in sediments. Our in-depth research on the effects of heavy metals on microorganisms and the establishment of bioindicators provide references and new perspectives
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WP1130
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression, which play fundamental roles in cancer development. In this study, we found that homeobox A11 antisense RNA (HOXA11-AS), a highly expressed lncRNA in cell lines derived from prostate cancer bone metastases, promoted the cell invasion and proliferation of PC3 prostate cancer cells. Transcription factor homeobox B13 (HOXB13) was identified as
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His dizziness was improved when Propafenone dose was reduced, and resolved after sotalol replacement, with ECG recovered to nearly normal state of QRS. Propafenone may lead to QRS widening and increase the risk of ventricular tachycardia, and it may not reduce ARVC associated mortality. This report may serve as a precaution for clinicians when providing cares for ARVC patients.Aim Neonates are notably vulnerable,
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We can style it different ways. We can color it like the rainbow. We can cut it and curl it. Our hair is something that makes us unique, and the vast majority of people love having it on top of their heads. That’s why people are willing to go to the ends of the earth to fight hair loss. Don’t travel that far. Just check out some of these tips.
Make sure to brush or comb every day. This is of course n
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1). Post-operative CRP was higher in patients with CD on day 1 (P=0.011), day 2 (P=0.001), day 3 (P=0.001) and day 4 (P=0.007), but no leak or intra-abdominal abscess occurred in either group.
CD patients experience increased post-operative pain, require more post-operative analgesia and have an enhanced post-operative inflammatory response. Further studies to elucidate the mechanism
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Car locksmiths occupy an essential position in the daily lives of car owners. In the dynamic town of Wellingborough, located in Northamptonshire, UK, these competent experts supply vital services that help people restore access to their automobiles, enhance their security, and guarantee that their driving experience remains uninterru
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Device learning-driven recognition of story affected person aspects for conjecture associated with major difficulties following posterior cervical vertebrae fusion.
Indeed, the number of isolated cases in the Veneto region was the highest among all the Italian regions at the beginning of the epidemic. Moreover, the implementation of molecular diagnostic tools, which were initially absent, enabl
PCO371 mouse
fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by the inability of keratinocytes to control cutaneous β-H
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The Role and Importance of Auto Locksmiths in Wellingborough
In the bustling town of Wellingborough, located in Northamptonshire, England, the need for dependable and effective auto locksmith services is as vital as ever. Whether it’s a locked car, a lost key, or a broken ignition, auto locksmiths play an important role in guaranteeing that residents can quickly an
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However, heterologous expression of rha1/2 in Bacillus subtilis significantly increased bacterial resistance to 4-HNE in vitro and promoted bacterial survival following phagocytosis by murine macrophages in an ROS-dependent manner. Thus, Rha1 and Rha2 are not necessary for 4-HNE resistance in L. monocytogenes but are sufficient to confer resistance to an otherwise sensitive organism in vitro and in host cells. Our work dem
Piperlongumine in vitro
Ophthalmic examination (OE) is a common part of preclinical studies. Pupillary dilation to facilitate OE may affect results of other planned testing. The purpose of this study was to determine the duration of mydriasis produced by commercially available 0.5% and 1% tropicamide in ophthalmologically normal albino rats. Twelve female Sprague-Dawley rats were used. A single drop of 1% tropicamide was app
네이버 계정 구매
네이버 플랫폼는 대한민국에서 선호되는 온라인 플랫폼 중 하나입니다. 많은 사용자들이 이 플랫폼에서 정보를 공유하고 소통하며, 비즈니스들은 이들 커뮤니티를 통해 제품과 서비스를 홍보할 수 있는 경우를 모색하고 있습니다. 특히 Naver ID를 구매한 계정이 이 플랫폼에서 더욱 강력한 파급력을 미치게 수 있습니다. 기존의 계정에 비해 많은 팔로워 수와 높은 신뢰성을 통해, 회사의 수익 증가에 구체적인 기여를 수 있습니다.
현재 디지털 마케팅 전략에서 계정의 아무리 강조해도 과장할 수 없습니다. 특별히, 효율적으로 관리되는 네이버 블로그와 카페는 브랜드 인지도를 향상시키고 고객들과의 관계를
네이버 아이디 판매
네이버 카페는 기업이 블로그 솔루션을 강화하며 커뮤니티 활동을 강화하는 데 아주 중요한 플랫폼이죠. 이런 카페의 활동을 촉진하기 위해서는 신뢰할 수 있는 네이버 계정 판촉이 필요합니다. 계정을 사고 싶어 하는 많은 회사는 보안 상의 이유로 주저하게 됩니다. 올바른 방법으로 계정을 구매하면 카페 내 활동을 더 활발하게 하고, 지식의 제공을 극대화할 수 있는 가능성이 증가합니다.
안전하게 계정을 구매하는 프로세스는 자체로 주의가 필요합니다. 여러 인터넷 마켓과 판매처가 있지만, 이들 중에서 신뢰성 있는 곳을 찾기란 어렵습니다. 네이버 아이디 판매 글을 통해 회사가 네이버 커뮤니티를 활동을 활성화하는
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Results Over the 8 years period of time injury has contributed about 7 % of the total deaths. Majority of injury related deaths were among males. Traffic accidents were the major injury related deaths for both sexes; intentional self-harm was highly observed among males compared with females. The findings of this study showed that the proportion of injury related deaths decreased with increasing age. Conclusio
네이버 아이디 구매
웹사이트와 온라인 커뮤니티 운영 운영하는 데 있어 네이버야말로 중대한 장소 중 하나입니다. 사용자 수가 많고, 다양한 기능을 제공하는 제공하는 네이버는 콘텐츠 광고하며 사용자와 의사소통하는 데 매우 편리합니다. 적극적으로 네이버를 이용하기 위해서는 인증 계정을 보유하는 것이 중요합니다. 확인된 계정은 사용자에게 신뢰도를 부여하고, 더 많은 기회 노출 제공합니다.
그런데 네이버의 인증 계정을 구매하는 방법은 무엇일까요? 이 가이드에서는 네이버의 계정 거래 정보를 설명하고, 블로그 온라인 커뮤니티 비즈니스를 위한 인증 계정을 잘 활용하는 팁을 알려드리겠습니다. 이 과
Tasocitinib
quivalent to that of CE-CT and liver MRI. Moreover, [68Ga]Ga-FAPI-04 PET/CT is better at identifying liver lesions than [18F]-FDG PET/CT, and its use may improve tumor staging, recurrence detection, and implementation of necessary treatment modifications.Autism is strongly associated with sensory processing difficulties. We investigate sensory habituation, given its relevance for understanding important phenotypic tra
Selleckchem CPI-455
Cooler mean annual temperatures towards the range limit were associated with increased resistance to gene flow in both sexes. Sex ratios became increasingly male biased towards the range limit, and there was evidence for a changed sexual selection regime shifting from favouring larger males in the south to favouring smaller males in the north. Our findings suggest sex-specific spatial phenotype sorting at the ra
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Wiley & Sons Ltd.Selective cleavage of the β-O-4 ether bond of lignin to produce aromatics is one of the most important topics for the sustainable production of chemicals from biomass. A simple system has been developed for Cα -Cβ bond cleavage of a β-O-4 ketone-structured lignin model compound (LMC) by H2 O2 in formic acid under metal catalyst-free conditions. By using this simple system, with H2 O2 , formic acid, a
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Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need for rescue morphine to treat unacceptab
Cilofexor mouse
Nelarabine is effective in inducing remission in patients with relapsed and refractory T-cell acute lymphoblastic leukemia (T-ALL) but has not been fully evaluated in those with newly diagnosed disease.
From 2007 to 2014, Children’s Oncology Group trial AALL0434 (ClinicalTrials.gov identifier NCT00408005) enrolled 1,562 evaluable patients with T-ALL age 1-31 years wh
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In cell proliferation assay, Circ_0058063 and GLUT1 overexpression resulted in the increased, while Circ_0058063 knockdown resulted in the decreased rate of ESCC cell proliferation. Moreover, GLUT1 overexpression reduced the effects of Circ_0058063 knockdown. Conclusions Circ_0058063 upregulates GLUT1 expression and promotes glucose-uptake in ESCC to promote cell proliferation. 2020 Journal of Thoracic Disease. All rights r
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12- to 24-month follow-up.Osteoradionecrosis (ORN) is considered one of the most severe complications of radiotherapy (RT). Treatment modalities for ORN may vary considerably, including conservative or surgical procedures. Recently, alternative managements such as the combination of photobiomodulation therapy (PBMT) and antimicrobial photodynamic therapy (aPDT) have also yielded promising results
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comes. The overall mortality rate was 11.4%, and the mean in-hospital length of stay was 2.07 ±1.54 days. Smoking increased mortality in all cases. Conclusions AMI is complicated by several types of arrhythmia. SA is the most common arrhythmia in AMI. Mortality in AMI is largely due to AV nodal blocks and VT. Smoking increases mortality in all cases.
Measuring plant productivity is critical to understan
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res remained similar in the studied time periods, indicative of insufficient pain relief. This points out a pressing need to further investigate alternative opioid and narcotic sparing strategies for patients with SAH.The reconstruction of anterior skull base defects after carcinologic surgery is challenging. Large defects can require the use of autologous free tissue transfer. Currently, most reconst
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The native-like structures of protonated glycine and peptide Gly3H+ were elucidated using cold ion IR spectroscopy of these biomolecules hydrated by a controlled number of water molecules. The complexes were generated directly from an aqueous solution using gentle electrospray ionization. Already with a single retained water molecule, GlyH+ exhibits the native-like structure characterized by a lack of in
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There are a lot of people that have lost hair that want to learn how they can go about getting it back. There are ways to go about getting some hair back but you need to educate yourself, as much as possible, in order to hope for success. This article is geared towar
DNA Repair inhibitor
The UCSC database was used to predict that acetylation of histone H3 at lysine 27 (H3K27ac) induces binding to the PSTPIP2 promoter, and this prediction was validated by a ChIP assay. Interestingly, an HDAC-specific inhibitor (TSA) was sufficient to potently upregulate PSTPIP2 in epithelial cells. Histone acetylation-mediated silencing of PSTPIP2 may contribute to cisplatin nephrotoxicity. PSTPIP2 may serve a
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To compare the efficacy of continuous positive airway pressure (CPAP) versus usual care for prehospital patients with severe respiratory distress.
We conducted a parallel group, individual patient, non-blinded randomised controlled trial in Western Australia between March 2016 and December 2018. Eligible patients were aged ≥40 years with acute severe respiratory distress
Sabutoclax
Alkaline phosphatase activity was assessed in fecal samples and was negatively correlated with HbA1c and positively correlated with bacterial diversity. The results of this study reinforce that MD adherence results in a better glycemic control in subjects with T2D. Changes in gut bacterial richness caused by MD adherence may be relevant in mediating the metabolic impact of this dietary intervention.Chinese green tea i
Oxythiamine chloride clinical trial
MicroRNAs (miRNAs) are desirable targets for the diagnosis, prognosis and treatment of diverse human diseases. In this study, we developed a universal and enzyme-free signal amplification approach for the quick, sensitive and specific electrochemical detection of diverse miRNAs from tumor cells using a catalyzed hairpin assembly (CHA) and the DNA three-way junction (DNA
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Losing your car keys is an universally dreaded experience. That minute of panic when you pat your pockets, rummage through your bag, and frantically search every surface area, only to realize they are truly gone, is something most chauffeurs have actually co
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Moose (Alces alces americanus) populations in many areas along the southern extent of the North American moose range, including Minnesota, have experienced decline. Ascertaining neonate health and cause-specific mortality is critical where calf survival is low and understanding underlying causes of population dynamics is important. To investigate moose neonate health
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d confirmatory biopsy at relatively low PSA levels and long PSA doubling time (1). Additionally, undetectable PSA levels after salvage therapy supports the role of early treatment in ILF (1). Further research is needed to determine appropriate patient selection and salvage modality in this population.Meningioma (MEN) is a common central nervous system disease. Accumulating evidence indicated that long non-coding RNA matern
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Copyright © 2020 Manangeeswaran, Lewkowicz, Israely, Ireland and Verthelyi.Systemic lupus erythematosus (SLE) patients exist an imbalance between regulatory T (Treg) and T helper 17 cells (Th17), which might be contributed by defective immune regulation of bone marrow derived mesenchymal stem cells (BM-MSCs) from SLE patients. Our microRNA array analysis showed markedly down-regulated expression levels of micr
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Signal Transducer and Activator of Transcription (STAT) 3 emerged rapidly as a high-value target for treatment of cancer. However, small-molecule STAT3 inhibitors have been slow to enter the clinic due, in part, to serious adverse events (SAE), including lactic acidosis and peripheral neuropathy, which have been attributed to inhibition of STAT3’s mitochondrial function. Our group developed TTI-101, a competitive inhibito
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Infections caused by the opportunistic pathogens Scedosporium/Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium/Lomentospora cell wall com
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Epileptic seizures are considered to be a brain network dysfunction, and chronic recurrent seizures can cause severe brain damage. However, the functional brain network underlying recurrent epileptic seizures is still left unveiled. This study is aimed at exploring the differences in a related brain activity before and after chronic repetitive seizures by investigating the power spectral density (PSD), fuz
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Naver는 한국에서 가장 인기 있는 인터넷 플랫폼 중 하나로, 블로그 및 카페 수많은 사용자들에게 지식과 공간을 제공합니다. 최근에 회사들이 네이버의 여러 기능을 활용하여 브랜드 인식 높이고, 고객과의 연결을 강화하는 방법에 대해 큰 관심을 보이고 있어 왔습니다. 이 글에서는 네이버 계정을 구매함으로써 기업들이 블로그와 카페를 효과적으로 활용할 수 있는 수단에 대해 살펴보겠습니다.
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Background Up to 33% of women report a negative or traumatic childbirth experience. Given this high prevalence and its consistent association with adverse postpartum and child outcomes, it is essential to identify predictive factors and to improve the management of the childbirth experience. Objective This systematic review explores and identifies risk and protective factors for women’s subjective childbir
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This study was performed to elucidate the uptake and bioaccumulation of polystyrene microplastics (PS-MPs) in Japanese medaka (freshwater fish) and Java medaka (marine fish), and to assess its impacts on the survival, reproduction, and gene expression of Japanese medaka. Both species were exposed to 2-μm fluorescent PS-MPs (107 beads/L) for 3 weeks. The bioaccumulation factor of PS-MPs for Java medaka wa
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The overexpression of glutathione peroxidase 4 (GPX4; an enzyme that suppresses peroxidation of membrane phospholipids) is considered a poor prognostic predictor of diffuse large B-cell lymphoma (DLBCL). However, the mechanisms employed in GPX4 overexpression remain unknown. GPX4 is translated as a complete protein upon the binding of SECISBP2 to the selenocysteine insertion sequence (SECIS) on the 3’UTR of GPX4 mRNA
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The large changes in mean arterial blood pressure (MABP) and cerebral blood flow velocity (CBFV) induced by squat-stand maneuvers (SSM) make this approach particularly suited for studying dynamic cerebral autoregulation (CA). However, the role of other systemic determinants of CBFV has not been described and could provide alternative physiological interpretations of SSM results. In 32 healthy subjects (16 female), conti
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88 pg/mL using a minimum sample volume of 30 µL with a shorter assay time of 15 min for each ELISA step. The limit of detection (LOD) thus obtained was significantly improved than the conventional 96-well platform.Far field superlensing of light has generated great attention in optical focusing and imaging applications. The capability of metamaterials to convert evanescent waves to propagative waves has led to numerous propo
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This study reports the differences in the protein composition of salivary pellicles formed under in situ conditions on two Titanium (Ti) surfaces, with different roughness and wettability. Smooth pretreatment Ti surfaces (Ti-PT) with an average roughness (Ra) of 0.45 μm and a water contact angle (WCA) of 92.4°, as well as a more rough sandblasted, large grit, acid-etched treatment Ti surfaces (Ti-SLA
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The seed MC of the 61 accessions was uniformly very low (0.10-0.12%), and 97 to 100% of the seeds were viable. Thus, all 61 wheat accessions collected in this study have the initial requirements to remain viable for long periods of time in ex-situ conservation in the gene seed bank.Azurin protein of Pseudomonas aeruginosa is an anti-tumor agent against breast cancer and mammaglobin-A (MAM-A) protein is a specific antigen o
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Postoperative early recurrence after hepatic resection for hepatocellular carcinoma (HCC) poses a challenge to surgeons, and the effect of a surgical margin is still controversial. This study aimed to identify an ideal margin to prevent early recurrence.
A total of 226 consecutive patients who underwent primary curative hepatic resection for solitary a
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This framework provides a possible method to risk stratify children prior to a disaster to better inform planning and responses in the future.
This framework provides a possible method to risk stratify children prior to a disaster to better inform planning and responses in the future.
The aim of this study is to evaluate challenges to disaster preparedness of families with chil
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SCA differs from other branch-generating algorithms in that the geometry generated depends to a great extent on its perception of the “external” space available for branching, uses few rules and, importantly, can be easily translated into a realistic “biological patterning algorithm”. We identified a gene in the C. dipterum genome (Cd-bnl) that is orthologous to the fibroblast growth factor branchless (bnl)
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We estimated mean difference using linear regression and prevalence ratios using modified Poisson regression accounting for the clustered design. All analyses were intention-to-treat. RESULTS Children in the LNS groups (T2 and T3) had ∼40% lower prevalence of anemia and iron deficiency anemia and 25% lower prevalence of iron deficiency than children in the control group (T0) (P less then 0.05
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Cycling downhill accelerates heat loss and requires lower work rates leading to cold discomfort. Historically, cyclists have behaviorally thermoregulated prior to cycling downhill by inserting newspapers into their jerseys. Yet, there is no experimental data to support such a method showing improvements in thermal perception and profile; we hypothesized it would.
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The coronavirus disease 2019 (COVID-19) has a tremendous influence in general public’s behaviors; however, changes in the status of regularly scheduled outpatient visits in Japan during COVID-19 pandemic are still unknown.
This cross-sectional study was conducted in May 2020. Participants were recruited by an Internet-based survey company. A total of 659 patients (54% male, aver
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Pharmacological and non-pharmacological therapies are simultaneously prescribed when treating hypertensive individuals with elevated cardiovascular risk (ie, metabolic syndrome individuals). However, it is unknown if the interactions between antihypertensive medication (AHM) and lifestyle interventions (ie, exercise training) may result in a better ambulatory blood pressure (ABP) control. To test this hypothesis, 36 hyp
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To develop a classification of sexual partner types for use in partner notification (PN) for STIs.
A four-step process (1) an iterative synthesis of five sources of evidence scoping review of social and health sciences literature on partner types; analysis of relationship types in dating apps; systematic review of PN intervention content; and review of
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However, ACh levels show no significant difference with respect to the control group. The data indicate that diazoxon directly alters elements in the cholinergic system of SMNC by AChE inhibition or indirectly through the interaction with AChR, which is likely related to the immunotoxic properties of diazinon and its metabolites.This study was conducted to explore the beneficial role of taurine against chronic high c
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Palaeoenvironmental proxies suggest that the Tràng An water deer occupied cooler, but not necessarily drier, conditions than today. We consider if the specimens represent extirpated Pleistocene populations or indicate a previously unrecognized, longer-standing southerly distribution with possible implications for the conservation of the species in the future.Flapping wings have attracted significant interest for
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Variation within the HLA locus been shown to play an important role in the susceptibility to and outcomes of numerous infections, but its influence on immunity to P. falciparum malaria is unclear. Increasing evidence indicates that acquired immunity to P. falciparum is mediated in part by the cellular immune response, including NK cells, CD4 and CD8 T cells, and semi-invariant γδ T cells. HLA molecules expressed by
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The emergence of the SARS-CoV-2 infection and its potential transmission through touching surfaces in clinical environments have impelled the use of conventional and novel methods of disinfection to prevent its spreading. Among the latter, pulsed light may be an effective, non-chemical decontamination alternative. Pulsed light technology inactivates microorganisms and viruses by using high intensity polychrom
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Although this is a promising genetic engineering topic in the field of nanopharmacogenomics or targeted nucleic vaccines, there are limited but continuously enriched in vivo data in depth of time regarding their safety, efficacy, and immune response. In the current paper we expand the limited published data in the field of ribosome machinery and SARS-CoV-2 mRNA fragment vaccin
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Background There is a limited evidence base to support the volume-outcome relationship in patients undergoing percutaneous coronary intervention (PCI) for unprotected left main coronary artery disease (UPLMD). This study aimed to evaluate the relationship between institutional and operator volume and in-hospital outcomes in patients undergoing PCI for unprotected left main coronary artery disease. Methods and Results We
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We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI-induced heart failure. Three months after MI induction, Wistar rats were divided into four groups Sham; sedentary MI (S-MI); aerobic exercised MI (A-MI); and resistance exercised MI (R-MI). Exercised rats trained three times a week for 12 weeks on a treadm
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Biofield therapy has shown positive results over a broad range of pathology from preclinical research to human studies. However, biofield therapy investigation is limited by an inability to quantify the therapeutic effect. This study aimed to measure the effects Reiki had on mice intervertebral disc (IVD) cells compared with sham and to quantify Reiki by measuring photon emission. We treated mice IVD cells with ten-minute sessi
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However, comparability studies are not always an option, especially for the introduction of a method to a new laboratory. Access to original validation data and suitable reference sample panels then becomes essential to provide evidence that the assay remains ‘fit for the intended purpose’.Any modification to a validated assay must be evaluated in terms of the impact on the assay’s performance characteri
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0-39.6) of all examined faecal samples from raccoons, including animals sampled in buildings. We did not detect genetic assemblage A in any of the samples. Sequences obtained from the glutamate dehydrogenase and beta-giardin gene fragments from a selection of three of the positive samples showed that raccoons carried a zoonotic G. duodenalis genotype belonging to sub-assemblage BIV, which is commonly found in humans and
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The information provided in this study can serve for effective management of sand steppes, and antlions should be considered important indicators for conservation monitoring and planning.Time-lapse fluorescence imaging of live cells at super-resolution remains a challenge, especially when the photon budget is limited. Current super-resolution techniques require either the use of special exogenous probes, high illumina
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The imago and soldier castes of a new Tauritermes Krishna, 1961 species, Tauritermes bandeiraisp. nov. are described. It is the fourth species of Tauritermes and occurs from the Caatinga and Atlantic Forest of Brazil. Unlike its congeners, the soldier of T. bandeirai has prominent frontal horns.A new fossil genus and species is described from the Middle Jurassic of China. The type of Sinoelcana mi
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02). In patients with cath volume of 300 mL or more, decisions to catheterize patients were accurate more often when based on bladder scanning measurements (94%-100%) than when based on horizontal US measurements (50%-56%; P = .001).
Bladder volume can be measured accurately with bladder scanning or US, but abdominal fluid remains a confounding factor limiting accurac
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microRNAs are powerful regulators of growth, development, and stress responses in plants. The Arabidopsis thaliana microRNA miR167 was previously found to regulate diverse processes including flower development, root development, and response to osmotic stress by controlling the patterns of expression of its target genes AUXIN RESPONSE FACTOR 6 (ARF6), ARF8, and IAA-Ala RESISTANT 3. Here, we report that miR1
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Generally, our study uncovered the mechanism by which serine metabolism regulates YAP via USP7 and identified the crucial role of YAP in the regulation of cell proliferation and tumor growth; thus, VP may be a new treatment for colon cancer.With multipotent differentiation potential and paracrine capacity, mesenchymal stem cells (MSCs) have been widely applied in clinical practice for the treatment of ischemic hea
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Background Approximately 10% of all Graves’ disease cases are triiodothyronine (T3)-predominant. T3-predominance is characterized by higher T3 levels than thyroxine (T4) levels. Thyroid stimulating hormone receptor autoantibody (TRAb) levels are higher in T3-predominant Graves’ disease cases than in non-T3-predominant Graves’ disease cases. Treatment with oral drugs is difficult. Here, we report a ca
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ative and palliative treatment of gastrointestinal neuroendocrine tumors.
Patients with cirrhosis frequently require sedation for elective endoscopic procedures. Several sedation protocols are available, but choosing an appropriate sedative in patients with cirrhosis is challenging.
To conduct a systematic review and meta-analysis to compare propofol an
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Development was delayed in all surviving infants, most with additional neurological sequelae.
DMJD may be identified by prenatal MRI as early as 18weeks gestation. We propose three distinct phenotypic forms of DMJD, Types A-C. Next-generation sequencing provides an underlying molecular diagnosis in some patients, but further studies on associated genetic diagno
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Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses
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Electrical stimulation of the subthalamic nucleus (STN) is clinically employed to ameliorate several symptoms of manifest Parkinson’s Disease (PD). Stimulation parameters utilized by chronically implanted pulse generators comprise biphasic rectangular short (60-100 μs) pulses with a repetition frequency between 130 and 180 Hz. A better insight into the effect of electrical stimulation parameters could potentially revea
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Eleven percent of respondents admitted not following recommendations regarding disposal of lenses and 18% would not consider ceasing lens wear if unwell (with flu/cold) during the pandemic.
Respondents reported wearing their contact lenses less than usual. Good compliance with handwashing was observed but soft reusable lens wearers showed a statistically significant lower com
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well-being. Further special focus should be on attendings to counteract their lacking identification with the job. Hereby, the provision of feedback and professional perspectives might foster the process of re-identification.(1) Background There has been various reports on the potential impact of anesthetic agents used during oocyte retrieval (OR) on the impairment of the capacity of the oocyte for fertilization and s
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In pear, sucrose was mainly distributed in vacuole; and the alternation of sucrose abundance was associated the change of vacuolar invertase (VI) activity during fruit storage. However, the molecular mechanism beneath such phenomenon has not been clarified until recently. For this, a combination of metabolite, enzyme activity, transcriptome, quantitative real-time PCR (qRT-PCR), bioinformation, subcellular local
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The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the accompanying rise of its complications, including cardiovascular disease, necessitates our understanding of the metabolic disturbances that cause diabetes mellitus. Metabolomics and proteomics, facilitated by recent advances in high-throughput technologies, have given us unprecedented insight into circulating biomarkers of T2D even
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The specificity of engineered EVs and artificial EV-mimetics can be improved through peptide or polymer decoration. However, apart from therapeutic RNA, EVs naturally carry many molecules. This may lead to unpredictable effects and thus should be applied with caution.Objectives To assess the efficacy and safety of a methylphenidate hydrochloride extended-release capsule (MPH-MLR) formulation in treating attention-def
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We present prenatal diagnosis of low-level mosaicism for a small supernumerary marker chromosome (sSMC) derived from chromosome 9q (9q13-q21.33) in a pregnancy with a favorable outcome, and cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes.
A 36-year-old, primigravid woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age.
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sequential yeast and LAB combination could be an advisable practice.Baijiu (Chinese liquor) is a type of traditional distilled alcoholic beverage produced through spontaneous solid-state fermentation with sorghum as the primary material. Material processing, including sorghum soaking, steaming and cooling which is carried out in an open environment, is an integral part of Baijiu manufacturing. However, the
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Extrapolation of our results allows to state that in the human oral cavity, virtually all β-D-glucosides would follow this type of hydrolysis. Additionally, a new method was developed for an in vivo rapid test of glucosidase activity in the human mouth on the tongue using fluorescein-di-β-D-glucoside as substrate. The results presented in this study serve as a proof of concept for the hypothesis that microbial hydrolysi
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Background Recently, a large-scale novel coronavirus pneumonia (NCP) outbreak swept China. As of Feb. 9, 2020, a total of 40,260 patients have been diagnosed with NCP, and 23,589 patients were suspected to have infected by the 2019 novel coronavirus (COVID-19), which puts forward a great challenge for public health and clinical treatment in China. Until now, we are in the high-incidence season of NCP. Thus, the analysis
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Our data suggest that CD169+ resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.Anti-epidermal growth factor receptor (EGFR) monoclonal antibody is a standard treatment of metastatic colorectal cancer (mCRC) and its most common adverse effect is a papulopustular acneiform rash. The
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In contrast, timing and extent of anticipatory grip forces were impaired in patients, although anticipatory control was generally preserved. These deficits were correlated with decreasing Mini-Mental State Examination scores. Apraxia scores, assessed by pantomime of tool-use, did not correlate with performance in the catching task.
We interpreted the decreased grip force in AD
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In a condition of dysfunctional visceral fat depots, as in the case of obesity, alterations in adipokine levels may be detrimental for the cardiovascular system. The proinflammatory leptin and resistin adipokines have been described as possible links between obesity and atherosclerosis. The present study was aimed at evaluating whether proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of low-density l
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R-loops are tripartite structures consisting of an RNADNA hybrid and a displaced single-stranded DNA [1]. They are widespread and occupy up to 5 % of the mammalian genomes [2]. R-loops have a key role in genome stability, and known functions associated with gene regulation, DNA replication, chromatin patterning, immunoglobuline gene recombination and DNA Double-strand break repair [3-7]. Novel methodology, including th
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The depletion in the acetylcholinesterase (AChE) level reveals altered neurotransmission in brain cells. Resultant cellular degeneration was also observed in the radiation-exposed hippocampus. Conclusively, the present study revealed that microwave radiation induces oxidative stress, depleted redox status, and causes DNA damage with the subsequent reduction in working memory in a time-dependent manner. This study provi
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Residents positively endorsed the learning tool, including design, content, and perceived impact on learning. The learning tool’s interactivity was perceived to provide increased educational value compared to other current learning methods. CONCLUSIONS We created a high-fidelity simulation platform for treatment plan evaluation linked to a curated case bank. Evaluation of the pilot deployment demonstrated
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The photopic negative response results suggest that there are no
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Infections occurred mainly between 2016-2018 corresponding to a period of high circulation of these viruses in Europe. In mammalian species, antibodies against WNV were detected in one dama gazelle (Nanger dama) whereas serological evidence of USUV infection was observed in several Canidae, especially in African wild dogs (Lycaon pictus). Our study helps to better understand the exposure of captive specie
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The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra h
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DNA damage and repair have been shown to be associated with carotid artery restenosis and atherosclerosis. The proliferation and migration of vascular smooth muscle cells (VSMCs) is the main cause of artery stenosis. This study aims to define the relationship between DNA damage and VSMCs proliferation.
A rat carotid artery injury model was established, and human and rat VS
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here are clinical and morphological features of the subclasses of AL amyloidosis, which may be of value for predicting the course and progression of the disease.
The retrospective analysis of nephrobiopsy specimens from of patients with AL amyloidosis revealed that kidney damage was mainly associated with the development of λ-associated AL amyloidosis. The clinical and labor
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Nicorandil fixed the disturbed HIF-1α/VEGF/eNOS signaling. Nicorandil corrected the renal functions confirmed by improved the histological glomerular tuft retraction that was obvious in the cyclosporine group, without significant influence by glibenclamid. Proper protection from CsA-induced nephrotoxicity was achieved by nicorandil. Nicorandil reversed the disturbed HIF-1α/VEGF/eNOS pathway created by cyclosporine.T
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BACKGROUND AND PURPOSE The idiopathic normal pressure hydrocephalus (iNPH) Radscale was developed to standardize the evaluation of radiological signs in iNPH. The purpose of this study was to estimate the diagnostic accuracy of the iNPH Radscale in a sample of “true positive” and “true negative” cases. METHODS Seventy-five patients with definite iNPH, i.e. who had improved at clinical follow-up one y
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When both Gpr56 and Gpr97 are deleted in ESCs, no or few hematopoietic PCs (HPCs) are generated upon ESC differentiation. Together, our results reveal novel and redundant functions for these 2 G-protein coupled receptors in normal mammalian hematopoietic cell development and differentiation.Ancestral sequence reconstruction provides a unique platform for investigating the molecular evolut
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The classical surgical anatomy of the female pelvis is limited by its gynecological oncological focus on the parametrium and burdened by its modeling based on personal techniques of different surgeons. However, surgical treatment of pelvic diseases, spreading beyond the anatomical area of origin, requires extra-regional procedures and a thorough pelvic anatomical knowledge. This study evaluated the feasibility
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Of the 49 eyes, 18 eyes (36.7%) were classified as IIOP group and 31 (63.3%) as nIIOP group. Significant differences in mean CST reductions over baseline one week after DEX implantation were observed between the groups. The degree of CST reduction from baseline to 1 week was significantly correlated with the degree of IOP change from baseline at 1 week and 1 month afte
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The past decade has witnessed the preliminary development of pre-hospital emergency. We analyzed the scientific output related to pre-hospital emergency in the past two decades, aiming to evaluate the publication status of the literature related to pre-hospital emergency through bibliometrics analysis, and hope to provide enlightenment of trends and hotspots for the development of pre-hospital emergency.
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Even though aberrant mechanistic target of rapamycin (mTOR) signaling is known to cause cardiomyopathy, its underlying mechanism remains poorly understood. Because augmentation of αB-crystallin and hspB2 was presented in the cortical tubers and lymphangioleiomyomatosis of tuberous sclerosis complex patients, we deciphered the role of αB-crystallin and its adjacent duplicate gene, hspB2, in hyperactive mTOR
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Porous organic polymers (POPs) constructed through covalent bonds have raised tremendous research interest because of their suitability to develop robust catalysts and their successful production with improved efficiency. In this work, we have designed and explored the properties and catalytic activity of a template-free-constructed, hydroxy (-OH) group-enriched porous organic polymer (Ph-POP) bearing functional Pd n
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Introduction Ketamine is being increasingly utilized in a variety of patient care settings, ranging from high acuity inpatient scenarios to the outpatient management of select mental health diagnoses. Postoperative patients are at an increased risk of developing a depressed state, and though ketamine’s ability to improve mood is well documented in the literature, the relationship between perioperative keta
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Sulfur particles with a conductive polymer coating of poly(3,4-ethylene dioxythiophene) “PEDOT” were prepared by dielectric barrier discharge (DBD) plasma technology under atmospheric conditions (low temperature, ambient pressure). We report a solvent-free, low-cost, low-energy-consumption, safe, and low-risk process to make the material development and production compatible for sustainable technologies. Different coating proto
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A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate (1), was isolated from marine filamentous cyanobacterial mats associated with apparent ingestion-related intoxications of captive bottlenose dolphins in the Florida Keys. Sequencing of 16S rDNA revealed that mats were composed of closely related Oscillatoriacean species including a previously undocumented species of Neolyngbya. The structur
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in vivo pharmacokinetic analysis demonstrated 1.3-fold higher AUC than Fungizone® even at a 4.5-time lesser dose via the oral route and a ∼15-fold rise in the bioavailability in contrast to the native AmB. The hemolytic study revealed that the developed formulation exhibited 8-fold lesser hemolysis than Fungizone®. Furthermore, the biosafety profile of AmB-EC-NPs was ensured by the significantly lesser level of blood u
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Chitosan is an antimicrobial, biodegradable and biocompatible natural polymer, commercially derived from the partial deacetylation of chitin. Currently modified chitosan has occupied a major part of scientific research. Modified chitosan has excellent biotic characteristics like biodegradation, antibacterial, immunological, metal-binding and metal adsorption capacity and wound-healing ability. Chitosan i
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Unsafe Abortion is one of the leading causes of maternal death. The unhygienic and dangerous practice has been encountered in various geographical areas of Nepal. Despite its legalization, many women are still being not concerned and well informed regarding safe abortion and become victims of it. The main aim of this study was to assess the knowledge and practice regarding safe abortion among married women
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Purpose of review This article provides an overview and update on the neurologic manifestations of sarcoidosis. Recent findings The 2018 Neurosarcoidosis Consortium diagnostic criteria emphasize that biopsy is key for diagnosis and determines the level of diagnostic certainty. Thus, definite neurosarcoidosis requires nervous system biopsy and probable neurosarcoidosis requires biopsy from extraneural tissue. Without b
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This Comment raises concerns about the article “Therapeutic target and molecular mechanism of vitamin C-treated pneumonia a systematic study of network pharmacology”.We demonstrate that a force microscope operated in a bimodal configuration enables the mapping of magnetic interactions with high quantitative accuracy and high-spatial resolution (∼30 nm). Bimodal AFM operation doubles the number of observables with respect to c
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STUDY DESIGN Quality improvement evaluation with retrospective analysis. OBJECTIVES To compare a technique to place pedicle screws (PS) using a novel detachable pedicle marker and probe (DPMP) and pulsed fluoroscopy (PF) vs. conventional technique utilizing PF with standard instruments (SI) and O-arm. Spinal fusion with pedicle screw instrumentation (PSI) is the mainstay in treatment of spinal deformities. Re
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CRISPR-Cas systems are a form of prokaryotic adaptive immunity that employs RNA-guided endonucleases (Cas effectors) to cleave foreign genetic elements. Due to their simplicity, targeting programmability, and efficiency, single-effector CRISPR-Cas systems have great potential for application in research, biotechnology, and therapeutics. While DNA-targeting Cas effectors such as Cas9 and Cas12a have become
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In addition, the adsorbents were successfully applied in dealing with the practical industrial wastewater. The results indicate the potential of rationally designed sulfydryl-functionalized graphene oxide for high performance Hg(II) removal.Perfluoroalkyl acids (PFAAs) are a focus of scientific and regulatory attention nowadays. However, PFAAs dynamics in the environment and the factors that determine wildlif
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FE possessed the most bile duct-like mechanical properties based on its elastic moduli, percent elongations at break, and changes in mass under all liquid exposure conditions. EHBD models printed in FE sustained no functional damage during biliary stent deployment or when tube connectors were inserted, and provided a high level of visualization of deployed stents. These results demonstrate that our 3D printed EHBD model
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Invasive species-species that have successfully overcome the barriers of transport, introduction, establishment, and spread-are a risk to biodiversity and ecosystem function. Introduction effort is one of the main factors underlying invasion success, but life history traits are also important as they influence population growth. In this contribution, we first investigated life history traits of the Barbary
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in English, German ZIEL Das Frankfurter Netzwerk für Suizidprävention (FRANS) dokumentiert die Entwicklung der Suizidzahlen in Frankfurt a. M., um gezielt Präventionsbedarfe zu erkennen. METHODE Auswertung der Leichenschauscheine mit Todesursache „Selbsttötung“. Die Suizidstatistik erhebt Geschlecht, Alter, Suizidmethode, Wohn- und Geburtsort, die Meldeadresse sowie Ort und Datum des Suizides
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Unlike the other local travel modes, bicycling did not decrease during the pandemic and is anticipated to significantly increase. Investment in bicycle-safe infrastructure could sustain the anticipated increase in bicycling.
Unlike the other local travel modes, bicycling did not decrease during the pandemic and is anticipated to significantly increase. Investment in bicycle-safe infrastructure coul
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Calcium channel blockers (CCBs) are commonly used agents in the treatment of hypertension as part of monotherapy or combination therapy. Peripheral edema is the most common side effect that requires discontinuation or replacement of treatment. Some studies in the literature have shown that long-acting dihydropyridine type CCBs lead chylous ascites in peritoneal dialysis patients. However, amlodipine-associ
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In conclusion, multiple pupil measures showed similar effects of SNR, suggesting that effort may be reflected in multiple aspects of TEPR. Moreover, a direct analysis of the pupil time course seems to provide a more holistic view of TEPRs, yet further research is needed to understand and interpret its measures. Further research is also required to find pupil measures less sensitive to changes in luminance.Epid
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8% men and 56.2% women) from the Andalusian universities of Granada, Malaga, and Jaen, all of them located in areas of medium socio-cultural context. Moderate mediation and factorial ANCOVA analyses have been carried out. The results point to the fact that the profile of the post-adolescents with the best score in reading competence also scores better in emotional intelligence and their mothers are those who score
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Many toxicity investigations have evaluated the potential health risks of ingested engineered nanomaterials (iENMs); however, few have addressed the potential combined effects of iENMs and other toxic compounds (e.g. pesticides) in food. To address this knowledge gap, we investigated the effects of two widely used, partly nanoscale, engineered particulate food additives, TiO2 (E171) and SiO2 (E551), on the
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These results will provide new insights for the study and application of PRFUs. KEY POINTS • First report of bioinformatic mining and systematic analysis of Phage recombinase function unit (PRFU) in Corynebacterium genomes. • Recombineering ability of the representative PRFUs was experimentally verified in Corynebacterium glutamicum ATCC 13032 strain. • PRFU with the highest recombineering efficiency a
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future studies to explore the pathogenesis of constipation.
The overall composition of the gut microbiota changed in constipated women of reproductive age, characterized by a loss in Proteobacteria and an increase in Bacteroidetes. Furthermore, the abundance of some butyrate-producing bacteria also reduced. These changes may reflect the u
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Conclusion The SOS-moral trial will provide data necessary to determine whether to open concurrent CTOs among MVD patients with CMR-detected necrotic myocardial tissue.Introduction The glucagon-like peptide-1 receptor agonists (GLP-1 RAs) class agent has grown rapidly in the last decade due to its effects on lowering HbA1c and weight and the low possibility of hypoglycemia. However, GLP-1 RAs are not devoid of adverse effects a
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Failures to reproduce research findings across scientific disciplines from psychology to physics have garnered increasing attention in recent years. External replication of published findings by outside investigators has emerged as a method to detect errors and bias in the published literature. However, some studies influence policy and practice before external replication efforts can confirm or challenge the
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These are the situations where visual aids for increasing conspicuity after dark have the greater potential for reducing motorcycle RTCs.The 402-mile of Interstate 80 in Wyoming was selected by the U.S. Department of Transportation to develop, test, and deploy a suite of Connected Vehicle (CV) applications (WYDOT CV Pilot). It is expected that after full deployment of CV technology
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Excessive intake of nutrients can result in decreases in the reproductive efficiency of goat bucks and increase production costs in goat e nterprises. In this study, the aim was to compare the reproductive features of young bucks fed diets for maintenance of growth or were fed ad libitum. Ten bucks were used (n = 5/group), with a completely randomized design. Blood and semen were collected from each animal every 2
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During the current pandemic, COVID-19 has been detected in patients using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) that confirms the presence of SARS-CoV-2 RNA. The demand for increased testing, particularly for asymptomatic individuals required alternative approaches to single-patient RT-PCR testing, such as pooling.
This study explored the impact of dilution o
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es of temperate grassland may have attained saturation of C sink activity more than one century ago. Increasing N fertilizer supply may not be an effective climate change mitigation strategy in many grasslands, as it promotes the expansion of grasses at the disadvantage of the more CO
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Nanostructured surfaces are known to provide excellent optical properties for various photonics devices. Fabrication of such nanoscale structures to germanium (Ge) surfaces by metal assisted chemical etching (MACE) is, however, challenging as Ge surface is highly reactive resulting often in micron-level rather than nanoscale structures. Here we show that by properly controlling the process, it is possible to confine t
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Given the essential involvement of parts of PFC in contextual fear responses and that of BLA in fear responses in general, the observed remodeling of VH-to-PFC afferents and the accumulation of intracellular Aβ in BLA and PFC pyramidal cells might exercise critical influences on enhanced avoidance behavior in 3xTg mice.
Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant
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To investigate factors contributing to pre and postoperative urethral function in male patients who underwent robot-assisted radical prostatectomy (RARP) using the urethral pressure profile (UPP).
Study A A total of 313 patients who underwent RARP between April 2013 and March 2015 were prospectively investigated. UPP was performed preoperatively in all patients. Correlation
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This disruption is associated with an inhibition of inflammatory interleukin 17 secretion. CONCLUSION The data highlights the major involvement of Th17 immune cells in the biological effects of an RWE. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia-inducible factor-1 alpha (HIF
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Selenium (Se) deficiency is a widespread and seasonally chronic phenomenon observed in Tibetan sheep (Ovis aries) traditionally grazed on the Qinghai-Tibet Plateau (QTP). Effects of the dietary addition of Se-enriched yeast (SeY) on the bacterial community in sheep rumen and rumen fermentation were evaluated with the aim of gaining a better understanding of the rumen prokaryotic community. Twenty-four yearli
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Sickle cell disease (SCD) is the most common inherited hematological disorder and a well-described risk factor for end-stage kidney disease (ESKD). Mortality and hospitalizations among patients with SCD who develop ESKD remain understudied. Furthermore, prior studies focused only on SCD patients where ESKD was caused by SCD. We aimed to describe mortality and hospitalization risk in all SCD patients initiating dialysis
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Kisspeptin, neuropeptide involved in puberty beginning and regulation of pituitary-gonadal axis, has been shown to stimulate antioxidant defenses in murine models. Its levels are greater in females than males and also in obese prepubertal girls. Therefore, our aim was to evaluate sex-related differences in prepubertal obese patients and the relationships of Kisspeptin with metabolic/hormonal parameter
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Nephron cilia disruption in male, but not female, mice 1) reduces BP prior to cyst formation; 2) increases NOx production that may account for the lower BP prior to cyst formation; and 3) induces polycystic kidneys that are associated with hypertension and reduced renal NO production.
Nephron cilia disruption in male, but not female, mice 1) reduces BP prior to cyst formation; 2) increases NOx produ
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In the busy town of Wellingborough, nestled in the heart of Northamptonshire, the development of car keys has actually mirrored the more comprehensive technological advancements of the automobile market. From the basic metal keys of the past to the sophisticated wise keys these days, the journey of car type in Wellin
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The adsorption rate for the trans-isomers on both surfaces is similar, but the desorption rate of the trans-isomers is faster at the glass-water interface than at the Teflon-water interface. This result demonstrates that the trans-isomers have higher affinity for the glass surface, so the trans-to-cis ratios on glass and TeflonAF are 80/1 and 2/1, respectively, with similar trends for all th
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Background Cancer survivors experience on average a 20% reduction in peak exercise capacity (VO2 peak) post-cancer treatment. Intermuscular fat (IMF) is a strong predictor of reduced exercise capacity in heart failure (HF) patients; however it is unknown whether increased IMF is related to reduced VO2 peak in cancer survivors. Methods and results Twenty eight individuals 14 cancer survivors > 12-months post-c
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The belief in conspiracy theories and paranoid ideation are often treated as almost synonymous. However, there is to date no research concerning shared underlying cognitive underpinnings of belief in conspiracy theories and paranoid ideation. One potential underlying factor could be the well-known jumping to conclusion (JTC) bias, the tendency of persons with delusions to perform hasty decisions that
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Lidocaine (LDC) is a local anesthetic widely used to relieve intubation-related airway responses. However, low drug concentration and short effective duration of LDC is inadequate to provide a satisfactory anesthetic effect on the surface of the airway. The present study sought to develop a LDC-delivery endotracheal tube (ETT) to achieve high local drug concentration and sustained drug release with the aim of attenuatin
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We present a classic case of AML with t(8;16)/KAT6A-CREBBP occurring in a patient with both a germline NF1 mutation and recent cytotoxic therapy for embryonal rhabdomyosarcoma.
Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. Ho
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The results of this study demonstrate that US is a feasible method of evaluating the efficacy of OMT. These results show good intra- and interobserver reliability of US acquisition and landmark measurement. Our study suggests that US assessment correlated closely with palpatory diagnosis. Our results also suggest that OMT can significantly improve lumbar rotational asymmetry, but did not improve side-bendi
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Mouse challenge studies with death as an endpoint remain the gold standard in assessing the potency of ricin toxin, a Category B biothreat agent derived from the castor bean (Ricinus communis). However, animal studies are expensive, time consuming and ethically concerning. In an effort to reduce reliance on animals in vaccine development, we developed a monoclonal antibody (MAb)-based ricin competi
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Pulmonary atresia with intact ventricular septum (PA/IVS) is a rare lesion with wide anatomic variability. A rare variant exists, marked by right-sided dilatation, an Ebsteinoid tricuspid valve (TV), and severe tricuspid regurgitation. Neonatal cone valvuloplasty allows for a biventricular circulation and avoids complications of prosthetic valves; however, this technique inevitably requires reintervention to exchang
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001) and oral formulation (+ 25-29%, p ≤ 0.003) without and with adjustment for CYP2D6 genotype. The doses were lower in older versus younger patients (oral – 30%; LAI – 20%; p < 0.001). Compared with the younger LAI users without reduced CYP2D6 function, a higher C/D ratio was observed in the older LAI users with reduced CYP2D6 function (+ 104%, p < 0.001).
The present
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This exploratory study assessed postural control and muscle activity in children with cerebral palsy while standing barefoot (BF), in prescribed ankle-foot orthoses (AFOs) and in distal control orthoses (DCOs), which stabilized foot-ankle and deliberately aligned the shank.
This within-subject study evaluated 10 participants, Gross Motor Functional Classification System level
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5min (98min and 147min). Patients tolerated a liquid diet on postoperative day (POD) 0 and were discharged on POD 1 after tolerating a low residue diet and having bowel function. Pathology showed two adenomas with negative margins. There was no immediate or delayed morbidity or mortality.
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74; 95% CI 1.17, 2.58; vs. ≥15 μmol/L; HR, 0.91; 95% CI 0.57, 1.46, P interaction = 0.042) at baseline or time-averaged mean arterial pressure (MAP) ≥102 mmHg (median) (HR, 1.92; 95% CI 1.27, 2.89; vs. less then 102 mmHg; HR, 0.89; 95% CI 0.57, 1.41, P interaction = 0.015) during the treatment period. However, no such association between neutrophil counts and first hemorrhagic stroke was found. In summary, h
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The other couple decided to continue the twin pregnancy and gave birth to two living newborns weighing 2580 g and 2060 g at 37
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Although ribosomes are generally known to be a translational machinery, some ribosomal proteins also have accessory functions involving early development and differentiation. Previously, we reported that ribosome incorporation into human dermal fibroblasts generated embryoid body-like cell clusters, altered cellular fate, and differentiated into cells of all 3 germ layers. However, the molecular phenomena
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The Percepta genomic classifier has been clinically validated as a complement to bronchoscopy for lung nodule evaluation.
The goal of this study was to examine the impact on clinical management decisions of the Percepta result in patients with low- and intermediate-risk lung nodules.
A prospective “real world” registry was institute
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Thermoset polymers show favorable material properties, while bringing about environmental pollution due to non-reprocessing and unrecyclable. Diels-Alder (DA) chemistry or reversible exchange boronic ester bonds have been employed to fabricate recycled polymers with covalent adaptable networks (CANs). Herein, a novel type of CANs with multiple dynamic linkers (DA chemistry and boronic ester
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Patients who declined and enrolled were of similar age (median age, 74 vs 75 years old; p = 0.27), sex (32% vs 36% female; p = 0.49), and race/ethnicity (p = 0.26). In multivariable analysis, patients were significantly more likely to decline if they initially presented at the community hospital compared to the academic medical center (53% vs 42%; adjusted OR, 2.2 [95% CI, 1.2 to 4.2]) and if single (37% v 2
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Understanding on the complex correlation between esophageal hypomotility and esophageal symptoms as well as the limited evidence of prokinetic agents is necessary for physicians to appropriately manage patients with Ineffective Esophageal Motility (IEM).Objective To investigate the effect of ethyl acetate extract from Celastrus orbiculatus (COE) on gastric cancer cell apoptosis and reveal its underlying molecular mec
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In the patients with an impaired G8, a significantly prolonged hospital stay, higher rate of delirium, and higher 1-year mortality rate were seen.
The G8 is a simple and useful screening tool for identifying deficits in CGA in older patients with cancer requiring surgery. Second, we concluded that patients with an impaired G8 are more at risk for a complicated reco
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oss-species reactivity of L1ORF2p antibody due to the conserved epitope will be useful to study the retrotransposon biology in mice and rat germ tissues.
We report exceptionally high L1ORF1p and L1ORF2p expression in post-operative oral cancer samples. The novel L1ORF2p antibody reported in this study will serve as a useful tool to understand why L1 activity is deregulated in OSCC and how it contribu
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An ethnobotanical study was conducted to document indigenous medicinal plants and their usage from knowledgeable and elderly persons in Razzar and Gadoon valley of Swabi and Allai and Tanawal valley of Hazara region of Pakistan during 2016-2019. Several systematic field visits and questionnaire surveys were carried out in selected sites of the study area to gather relevant information from the local community.
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A new strategy for the wastewater treatment was proposed by combining polyvinylpyrrolidone-functionalized silver nanoparticles with reduced graphene oxide (AgNPs-PVP@rGO) as a visible light-triggered photoactive nanocomposite. The nanocomposite with enhanced photocatalytic degradation and photothermal antibacterial activity can simultaneously decrease the content of organic pollutants and bacteria in the wastewater under
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Moreover, stiff substrate induced activation of extracellular signal-regulated kinases (ERKs), which was inhibited by treatment with TRAM34 or BAPTA-AM. Stiff substrate-induced cell proliferation was suppressed by treatment with PD98059, an ERK inhibitor. Taken together, these results show that substrates with pathologically relevant stiffness upregulate the IKCa channel expression to enhance intracellular C
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The study aimed to assess affecting structural factors on the entrepreneurship behavior of the academic members of healthcare in Qazvin University of Medical Sciences, Central Iran.
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Little is known about genomic alterations of gestational choriocarcinoma (GC), unique cancer that originates in pregnant tissues, and the progression mechanisms from the nonmalignant complete hydatidiform mole (CHM) to GC. Whole-exome sequencing (20 GCs) and/or single-nucleotide polymorphism microarray (29 GCs) were performed. We analyzed copy-neutral loss-of-heterozygosity (CN-LOH) in 29 GCs t
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The microbial electrosynthesis is a platform to supply protons and electrons to improve the conversion efficiency and production rate for the valorization of C1 gas. This study examined proton migration and electron transfer of the electrode and microbe by using various external parameters in the electrosynthesis of CO. The CO electrosynthesis achieved almost double of coulombic efficiency than the c
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Serum adropin and apelin-12 levels can be useful biomarkers for predicting MetS in obese children. Our findings could provide a novel approach for the treatment and prevention of MetS.
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Morel-Lavallée lesions (MLL) create pre-fascial space by shearing the subcutaneous tissues away from the underlying fascia, in a patient with trauma. Necrosis of the overlying skin can develop over a wide area of the lesion. The lesion might be contaminated by the surgical site due to careless intrusion when treating the combined arteriopathy. A 70-year-old woman presented with avulsion of the skin over the rig
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The ability to perform routine structure-guided drug design for selective BACE inhibitors has been limited because of the lack of robust platform for BACE2 expression, purification, and crystallization. To overcome this limitation, we developed a platform that produces 2-3 mg of pure BACE2 protein per liter of E. coli culture, and we used this protein to design macrocyclic compounds
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Furthermore, these two genes are expressed higher in the testis and ovary of domesticated silkworm compared to wild silkworms, and correlations between their expression pattern and meiosis of the sperm and ova were observed.
The domestication of silkworm has induced artificial selection on epigenetic modification markers that may have led to phenotypic changes during do
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This minimally sufficient condition had the highest coverage (5/7 practices scoring higher on the outcome) and best performance across solutions; all included leadership priority for patient safety. Other key factors included self-efficacy and job satisfaction and quality improvement climate. The most common factor whose absence was associated with the outcome was a well-functioning process for behav
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51 ± 9.11% of the whole-cell GAD activity was inhibited. D101 MAR exhibited excellent properties in stabilizing the pH of the conversion reaction system, supplementing free L-Glu and removing excess GABA. Comparison of the biotransformation only in acetate buffer, the GABA production, with 50 g/100 mL of D101 MAR, was significantly increased by 138.71 ± 5.73%. D101 MAR with pre-adsorbed L-Glu could significantly
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Objective The objective of this study is to evaluate fatigue in cancer outpatients receiving chemotherapy using an objective system and to clarify the type of nursing support needed after a disaster. Methods Based on the diagnostic criteria for chronic fatigue syndrome, the degree of subjective fatigue, autonomic function, and amount of physical activity were measured in cancer outpatients undergoing chemotherapy fr
selleck compound
Although DNA of high quality can be easily prepared from cultured cells with commercially available kits, many studies involve a large number of samples which increases the cost drastically. We optimized two simple and inexpensive methods for preparing DNA suitable for digital PCR from a small number of cells directly from wells of 96-well plates.
Cells (number 10
TPX-0005 mouse
Recent data support a role for endoscopic radiofrequency ablation (RFA) in unresectable cholangiocarcinoma by improving stent patency and overall survival.
We describe 3 patients with inoperable cholangiocarcinoma with jaundice and cholestasis who were recommended palliative chemotherapy. They underwent endoscopic retrograde cholangiopancreatography with single-operator cholan
Adavivint
When value and prevalence were inversely related, some observers showed particularly strong preferences for high-valued target types, while others showed a preference for high-prevalent, albeit low-value, target types. In younger adults, individual differences in the selection choices correlated with a personality index, suggesting that avoiding selections of low-value targets may be related to reward-seeking behaviour.
Review AdaKami
Dalam rangka evaluasi pengelolaan keuangan daerah dikembangkan sistem informasi keuangan daerah yang menjadi satu kesatuan dengan sistem informasi pemerintahan daerah. 1. Menerapkan sistem kerja yang profesional berlandaskan semangat kekeluargaan. Bermain catur membutuhkan latihan yang sering dan berkala. Pemain catur yang handal butuh waktu yang lama untuk belajar langkah-langkah bermain catur. Klub catur yang ini berdiri pad
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Wellingborough Auto Locksmiths: Your Solution for All Lock-Related Emergencies
In the busy town of Wellingborough, where life moves at a fast lane, the requirement for trusted and effective auto locksmith services is more vital than ever. Whether you’ve lost your car keys, locked yourself out of you
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Exploring Gotogel Super: Your Comprehensive Guide
The online gaming world has actually grown significantly over the past couple of years, drawing in the interest of millions. Amongst the variety of gaming platforms readily available today, Gotogel Super stands out. This gaming website has actually caught th
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Finding the Best Car Locksmith in Wellingborough
When it pertains to car ownership, convenience and security are essential. Nevertheless, losing your car keys or experiencing a lockout can quickly turn a day into a disaster. Locals of Wellingborough might find themselves in such a situation. Luckily, the town is home to lots of expert locksmiths focusing on automotive services. This sho
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COVID-19 can be associated with coagulopathy (CAC, COVID-19-associated coagulopathy) with a high prothrombotic risk based on an intense inflammatory response to viral infection leading to immunothrombosis through different procoagulant pathways[1]. Emerging evidence suggests that the use of heparin in these patients could be associated with lower mortality[2].Background The prevalence of gestational
CBP-IN-1
rends that may result in enhanced or repressed gene expression to regulate heterosis. Taken together, our results reveal a miRNA-mediated network that plays a key role in jointing stage heterosis via posttranscriptional regulation.
Apple (Malus ssp.), one of the most important temperate fruit crops, has a long cultivation history and is economically important. To identify the genetic relation
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We discuss possible mechanisms underlying change in gene-environment correlation over time, the advantages and challenges of including gene-environment correlation in longitudinal twin models, and recommendations for future research.
Sustainable diets are diets with low environmental impacts and high affordability which contribute to food and nutrition security. The present study aimed to develop
selleck kinase inhibitor
Electronic structure properties highlight the charge transfer from the Al atom(s) to dehydrogenated model epoxy system.Semiconducting polymer nanoparticles (SPNs) possess many special photophysical and chemical properties. However, little research has been done on the potential of SPNs in laser technology. In this work, we present the ultrafast pulses generation at 1.5 and 2 μm through prop
CID-2950007
Mesenchymal tumors of the liver are rare, and in this group, myxoid leiomyomas are even rarer. So far, only 2 cases have been reported in the literature.
We aim to report the case of a 16-year-old female with a large lesion on the right hepatic lobe, grossly composed of gelatinous and heterogeneous tissue.
Histological evaluation revealed a be
Cy7 DiC18
Multiple primary cancers in the same individuals may signal genetic predisposition. Accordingly, the association of GC with breast cancer may be related to mutations in the
gene, and clustering of colorectal, small intestinal and bladder cancers could be related to Lynch syndrome. The third line of findings supports a contribution of immune dysfunction on the increased risk of GC as SPC after sk
AY-22989
In April 2017, surveillance detected a surge in severe acute respiratory infections (SARI) in Bangladesh. We collected specimens from SARI patients and asymptomatic controls for analysis with multipathogen diagnostic tests. Influenza A(H1N1)pdm09 was associated with the SARI epidemic, suggesting that introducing vaccines and empiric antiviral drugs could be beneficial.We describe trends in acute rheumatic fever (ARF), rh
VY-3-135 solubility dmso
In-use steel stocks in China showed no clear signs of saturation or flatten off pattern although their growth rate declined recently. An increase in steel stocks productivity was found during 1978-2018, which means relative decoupling of in-use steel stocks from economic growth, but still far away from absolute decoupling. The dematerialization pattern revealed in this study deepens our understanding of ma
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Several studies have noted that the existence of comorbidities lead to an increase in the risk of premature mortality and morbidity. Most of the studies examining the effects of air pollution on comorbidity visits were from Northern American countries, with scarce literature from Asia. This study contributes to existing, yet limited understanding of air pollution-comorbidity by examining the effects of daily air pollu
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Traveling waves are commonly observed across the brain. While previous studies have suggested the role of traveling waves in learning, the mechanism remains unclear. We adopted a computational approach to investigate the effect of traveling waves on synaptic plasticity. Our results indicate that traveling waves facilitate the learning of poly-synaptic network paths when combined with a reward-dependent local syna
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Passive immunization with antibodies is a promising approach against enterotoxigenic Escherichia coli diarrhea, a prevalent disease in LMICs. The objective of this study was to investigate expression of a monoclonal anti-ETEC CfaE secretory IgA antibody in N. benthamiana plants, with a view to facilitating access to ETEC passive immunotherapy. SIgA1 and SIgA2 forms of mAb 68-81 were produced by co-expressing the light
selleck compound
In populations with distinct subgroups, synchronized interventions are less effective than targeting the interventions in each subcommunity separately.Genome-wide association studies (GWAS) explore the genetic causes of complex diseases. However, classical approaches ignore the biological context of the genetic variants and genes under study. To address this shortcoming, one can use biological networks, which model functional relations
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Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an a
BRD3308 clinical trial
The need for an autologous cell source for bone tissue engineering and medical applications has led researchers to explore multipotent mesenchymal stromal cells (MSC), which show stem cell plasticity, in various human tissues. However, MSC with different tissue origins vary in their biological properties and their capability for osteogenic differentiation. Furthermore, MSC-based therapies require large-scale
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Understanding Car Locksmiths in Wellingborough: Services, Importance, and FAQs
In today’s busy world, protecting reliable and efficient services is crucial, especially when it concerns car security. Wellingborough, a lively town in Northamptonshire, houses a number of expert car locksmiths all set to help in
selleck kinase inhibitor
001). Residents cited time constraints, lack of knowledge about available resources, and discomfort with screening questions as barriers to screening in both settings. Residents were more likely to screen for social needs when screening questions were embedded in the EHR (odds ratio = 9.6; 95% confidence interval 6.7-13.9). CONCLUSIONS Pediatric residents were more likely to screen for unmet social need
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Understanding the Vital Role of Car Locksmiths in Wellingborough
Car locksmiths inhabit an important position in the daily lives of lorry owners. In the bustling town of Wellingborough, situated in Northamptonshire, UK, these knowledgeable experts provide important services that help people gain back access to their lorries, improve their security, and ensure
Akt phosphorylation
Moreover, the total private and the total public health expenditures seem to have a bidirectional long-run relationship and significant cointegration. The same was observed regarding the public expenditure and household medical services expenditure, as well as pharmaceuticals. Furthermore, the results indicate that over the years of recession, the monthly HHE decreases, due to the confiscation of middle-class income, which l
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Best Auto Locksmith Near Wellingborough: Your Ultimate Guide to Reliable Services
In the busy town of Wellingborough, finding a reliable and effective auto locksmith can be a complicated job, specifically when you’re in a bind. Whether you’ve locked your type in the car, lost your car keys, or need a new ignition system, the right
Selleckchem GSK1210151A
be predictive for poor prognosis in patients with sudden sensorineural hearing loss.
We aimed to describe sociodemographic, comorbidities, co-medication and risk of thromboembolic events and bleeding in patients with NVAF initiating oral anticoagulants (OAC) for stroke prevention, and to estimate adherence and persistence to OAC.
Primar
Pemetrexed
However, no significant (P > 0.05) difference was observed between maxillary intrusion (MAI and MSI) and maxillary extrusion (MAE) movements.
This study shows that the nasal width varies distinctly depending on the type of Le Fort I maxillary surgical movement.
This study shows that the nasal width varies distinctly depending on the type of Le Fort
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The results of the current study indicated a similar pattern that emerged in the context of the COVID-19 pandemic the Israeli Arabs reported a higher level of distress and a lower level of resilience and well-being.Thermoelectric materials are materials that involve the coexistence of heat flux and electric current in the absence of magnetic field. In such materials, there is a coupling among electric potential
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Using cell proliferation and Western blot analysis, we demonstrated that AMACR inhibition and docetaxel treatment, under androgen deprivation conditions, significantly reduced the proliferation of ARV7 positive cancer cells and decreased the levels of AR and ARV7 expression, possibly via downregulation of heat shock protein 27.
The United States Preventative Services Task Force (USPSTF) guideli
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NONHSAT079547.2 was significantly upregulated in HT patients and was positively correlated with serum thyroid peroxidase antibody level. Further studies confirmed that NONHSAT079547.2 could promote cell growth and control IL-17 expression and secretion via the NONHSAT079547.2/miR-4716-5p/IL-17 axis.This is the first study to describe the lncRNA profile in CD4+ T cells of HT patients. The studies on t
Elenestinib c-Kit inhibitor
[This corrects the article DOI 10.1155/2020/2675940.].Background and Objectives. Several anesthesia techniques were applied to hemorrhoidectomy, but postoperative pain and urinary retention were still two unsolved problems. The aim of this prospective randomized study was to evaluate the effect of ultrasound-guided pudendal nerve block (PNB) combined with deep sedation compared to spinal an
SU056
brain activity complexity and anaesthetics. They do not support models of consciousness that propose a direct relation between brain activity complexity and states of consciousness.Attention is a central neural process that enables selective and efficient processing of visual information. Individuals can attend to specific visual information either overtly, by making an eye movement to an object of interest, or covertly, withou
CDK inhibitor
The present method highlights the potential of (co-)immobilization of ene-reductases, notorious for their poor scalability, and complements the few existing methods available for increasing productivity in asymmetric bioreduction reactions.
To improve understanding of transition from viral infection to viral clearance, and antibody response in pediatric patients with severe acute respiratory syndrome coronaviru
Desferrioxamine B concentration
Of the patients presenting with intraocular pressure (IOP) below 30 mmHg, 3/29 (10%) needed subsequent cyclodiode laser therapy compared to 35/43 (81%) patients with a baseline IOP above 30 mmHg (p less then 0.001). Conclusions In a clinical setting, many patients show evidence of NE already at the first visit. A substantial part of patients develops NE a long time after presentation, c
NEO2734 molecular weight
AIM The aims were to characterize pediatric medication errors and to identify the prevalence of known high-alert substances in these errors. METHODS All pediatric drug-related incident reports and complaints nationally reported to the Health and Social Care Inspectorate in Sweden 2011-2017 regarding inpatients were characterized by context and modal details. In addition, drug use at a university hospital wa
Lithium Chloride Antiviral inhibitor
Our results highlight that Fe(ii) exerts a beneficial effect on maintaining Ni in a metallic state, whereas the extension of the Fe oxidation is accompanied by a more extended Ni surface hydroxylation with a negative impact on the selectivity towards methane.The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinet
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Pandemics like COVID-19 warrant an urgent implementation of the one health surveillance (OHS) system to the focus on multisectoral, multidisciplinary, multi-institutional, and multispecialty coordination, in all aspects of the response to outbreaks that might involve humans, animals, and their environment. The Indian system so far has evolved in conducting surveillance and monitoring of parameters within the domain of huma
Gotogel Super
Navigating the Realm of Online Lottery: A Closer Look at Gotogel Super
In the ever-evolving landscape of online entertainment, digital platforms have transformed various traditional leisure activities. Amongst these, the world of lottery and number games has actually witnessed a substantial transformation, migrating from physical tickets and regional vendors to the large stretch of the int
LL37 Anti-infection chemical
Infections with gastrointestinal nematodes (GINs) in small ruminants are becoming increasingly harder to treat due to the development of anthelmintic resistance. Across Swedish sheep farms, Haemonchus contortus is one of the more persistent and pathogenic species encountered. Benzimidazole drugs, such as albendazole, are still widely used to control the GIN burden in small ruminants. However, the de
PF-04620110 mouse
hould be of particular importance in the context of patients without access to third-generation targeted agents. Further studies are warranted to ascertain this effect.
Among a selected population at high risk for developing BM, PCI significantly decreased CBM in addition to increasing progression-free survival and OS. To our knowledge, this is the first study to evaluate PCI in epidermal gr
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Locked Out and Stranded? Your Guide to Car Key Replacement in Wellingborough
Losing your car keys is an aggravating experience that can rapidly hinder your day. One minute you’re prepared to go, the next you’re staring blankly, pockets empty, understanding your necessary car key is no place to be found. Whether they’ve been
Pemetrexed
28, 95% CI [0.10; 0.78], P=.02). No differences in the rates of infection, cardiovascular complications, neoplasia, and deaths were observed between the 2 groups. In multivariate analysis, continuation of corticosteroid treatment had no influence on sensitization but was associated with a higher rate of infection (OR= 2.66, 95% CI [1.09; 6.46], P= .03).
Maintenance of C
selleck chemical
The follow-up time of all patients was more than 2 years. The combined group and control group were (24.3±10.2) months and (27.5±14.8) months, respectively. There were no statistically significant differences in the anterior edge height of the vertebral body and Cobb angle at 1 day after surgery between two groups (
>0.05), and there were statistically significant differences at 6, 12, 24 m
PX-478 in vivo
Referrals were more likely to be White, highly educated, older, and privately insured (all p≤0.001). Focus group participants indicated that the time required to meet other mothers was an important barrier. In the second survey we recruited 201 mothers; only 53.7% knew ≥1 mother whom they could invite to the study.
New mothers are not easily recruited using RDS because they
Desferrioxamine B concentration
Of the patients presenting with intraocular pressure (IOP) below 30 mmHg, 3/29 (10%) needed subsequent cyclodiode laser therapy compared to 35/43 (81%) patients with a baseline IOP above 30 mmHg (p less then 0.001). Conclusions In a clinical setting, many patients show evidence of NE already at the first visit. A substantial part of patients develops NE a long time after presentation, c
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ation in patients with Gerstmann-Sträussler-Scheinker disease and implies that the C-terminus of PrPSc is dispensable for infectivity and strain features for this prion strain, uncovering the central PrP domain as the minimal molecular component able to encode infectious prions. These findings are consistent with the hypothesis that non-fibrillar prion particles are highly efficient propagators of disease and provide
GSK1838705A cell line
Background/aim This study aimed to determine the anxiolytic effect of a putative glyoxalase 1 inhibitor, piceatannol, as well as its antitumor activities on the stress-induced tumor growth of Lewis lung carcinoma. Materials and methods The anxiolytic activities of piceatannol (1-30 mg/kg) were assessed using the elevated plus maze (EPM) test. We also evaluated the pharmacological modulation of stress-induc
TL12186
This paper inquires whether reindeer herders’ traditional knowledge (TK) provides a reservoir of precaution and adaptation possibilities that may be relevant to counteract climate change. As our core example, we used the milking of reindeer-which, in some areas, was practiced up until the 1950s-1960s-and the risk of getting foot rot disease (digital necrobacillosis; slubbo in North Sámi), caused by the bacterium Fusobacter
3-TYP inhibitor
In this work, magnetic wakame biochar nanocomposites for the first time had been synthesized to investigate their adsorption to methylene blue dye. As-prepared magnetic biochar samples were obtained by the impregnation method to load nickel on wakame biochar via one-step carbonization with activation agent KOH at 800 °C. The prepared samples were characterized by BET, XRD, FTIR, Raman, SEM, TEM and so on. The res
NUDIX inhibitor
It is vitally important that providers treating post-traumatic stress disorder continue to stay abreast of research advances in the treatment of this disorder. This article updates the reader about advances in research in PTSD treatment in the past four years as well as the evolving recommendations of clinical practice guidelines.
One of the most important developments is that
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Bites occurred in the owner’s yard in 356 dogs (85%) and 53 cats (26%). A snake venom detection kit was used in 172 cases (28%) and antivenom was administered in 523 cases (85%). Most animals (n = 534, 88%) survived to discharge (median hospitalisation of 25 [IQR 16, 62] hours). SnakeMap effectively collects relevant clinical data from dogs and cats with presumed snake bite and provides locally specific infor
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Understanding the Vital Role of Car Locksmiths in Wellingborough
Car locksmiths occupy an important position in the day-to-day lives of lorry owners. In the dynamic town of Wellingborough, located in Northamptonshire, UK, these skilled specialists supply necessary services that assist individuals gain back access to their lorries, enhance their
Simnotrelvir nmr
ing for unstable angina and nonacute coronary syndrome indications among national cohorts of Medicare and VA enrollees. The provision of appropriate use reporting did not appear to have a substantial impact on the proportion of PCIs coded for acute indications during this study period.
After introduction of AUC assessments and reporting, we observed comparable increases in coding for acute m
NVS-STG2
At the same time, postoperative wounds after L-HOBT healed faster and with fewer postoperative complications compared to the control group. This resulted in a shorter treatment period, terminating with an earlier skin suture removal.
There are multiple studies indicating that the Indian expat population working in the Middle East is at a significantly high risk for developing anxiety, depression, and s
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The Best Wellingborough Auto Locksmiths: A Comprehensive Guide
In an age where mobility is critical, the requirement for dependable automobile locksmiths has actually never been more essential. Wellingborough, a captivating market town in Northamptonshire, is home to numerous experienced auto locksmiths proficient a
Verubecestat inhibitor
5; 95% CI = 1.2, 1.7) and attack rate was higher among those continuously exposed to MHL (97% [268/277]) than others (38% [16/42]; RR = 2.5; 95% CI = 1.7, 3.7). The duration of exposure was associated with increased risk of bilateral photokeratitis (χ
test for linear trend = 74;
< 0.00001). During the environmental inspection, we identified the use of MHL with
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We report that SRA significantly inhibits the expression of signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase (JNK), P65, and protein kinase B (AKT) pathways. These findings depict the effective inhibition of STAT3, p38, and AKT expression by SRA, making it a potential therapeutic candidate for human OC.
This study aimed to investigate the interaction between dietary inflammatory in
PX-478 in vivo
ies the effect of sleep apnoea on cardiovascular outcomes. The findings that undiagnosed sleep apnoea impairs diastolic function in a middle-aged coronary artery disease patient underscore the importance of early diagnosis and treatment of sleep apnoea. It is recommended to train and educate cardiac rehabilitation staff on the importance of sleep disorders in this population.
Age modifies the e
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The consumption of fluoridated tap water and tea substantially increases plasma fluoride concentrations in children. Quantifying the contribution of diet and other sources of fluoride is critical to establishing safe target levels for municipal water fluoridation.The main objectives of this study were to evaluate the chemical constitution and allergenic potential of red propolis extract (RPE). They were e
Selleck GSK2830371
systemic treatment options that can potentially improve outcomes in NEC.
Cancer may be a risk factor for worse outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections. However, there is a significant variability across cancer types in the extent of disease burden and modalities of cancer treatment that may impact morbidity and mortality from coronavirus disease-19
Favipiravir inhibitor
The novel coronavirus disease 2019 (COVID-19) is a highly infectious and rapidly spreading disease. There are limited published data on the epidemiology and outcomes of COVID-19 infection among organ transplant recipients. After initial flulike symptoms, progression to an inflammatory phase may occur, characterized by cytokine release rapidly leading to respiratory and multiorgan failure. We report t
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Ambient fine particulate matter (PM2.5) data of similar continuously monitored species at two air monitoring sites with different characteristics within the City of Toronto were used to gauge the intra-city variations in the PM composition over a largely concurrent period spanning two years. One location was less then 8 m from the side of a major highway while the other was an urban background locati
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Wellingborough Auto Locksmiths: Your Solution for All Lock-Related Emergencies
In the dynamic town of Wellingborough, where life moves at a fast pace, the need for trusted and effective auto locksmith services is more important than ever. Whether you’ve lost your car keys, locked yourself out of your car, or require a
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The Role and Importance of Auto Locksmiths in Wellingborough
In the dynamic town of Wellingborough, situated in Northamptonshire, England, the requirement for trusted and effective auto locksmith services is as necessary as ever. Whether ‘s a locked car, a lost key, or a broken ignition, auto locksmiths play a cruc
MRTX849 concentration
Tuberculosis (TB) prevention through the use of preventive treatment is a critical activity in the elimination of TB. In multiple settings, limited staffing has been identified as a barrier to managing preventive treatment for TB contacts. This study aims to determine how health center staffing, service type, and TB caseload affects implementation of isoniazid preventive therapy (IPT) for TB contacts in southe
MSA-2
Unfortunately, during the period without specific oncology treatment, her disease showed an unequivocal progression. Therefore, she started on alectinib with great response, and no liver function alteration recurred.
This case suggests that alectinib, even belonging to the same drug class, could be used as an alternative agent when crizotinib is the etiology of liver damage, but more robu
TRC051384
0112). There were no significant differences in the OS after BM diagnosis between HR FM and LR FM patients. Multivariate analyses for OS after BM revealed that patients with HER2(+)and estrogen receptor(+) tumors had a significantly better survival(risk ratio[RR]=0.644, p=0.0413; RR=0.290, p=0.0251, respectively). Three patients are surviving longer than 10 years after BM, including 2 with L-type and 1 with LH-type tumo
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Navigating Car Key Programming in Wellingborough: A Comprehensive Guide
In the modern-day period of automobile technology, car keys have actually evolved from simple metal gadgets to sophisticated electronic tools. This evolution has caused a new set of difficulties and chances for car owners, particularly when it concerns car key pro
L-NAME
The use of vaping devices, including e-cigarettes, has been steadily increasing in recent years, especially among younger populations.
With many vaping devices on the market and misconceptions about the safety of vaping, there is a substantial amount of information that healthcare professionals need to know. As a response to this growing public health concern, doctor of pharmacy (Ph
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Do you want to learn more about investing in real estate? If so, you are in the right place. This article has several tips to help you begin. Once you have read it, you will have a greater understanding of the market. Use these tips to make sound choices in your investments.
It is possible to get contracts set up for free. However, always be wary of doi
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Treatment of sebaceous lymphadenocarcinoma depends on the typing and clinical staging of the cancer. Extensive resection is the first choice, and adjuvant radiotherapy should be given to patients with high-grade tumors or those at an advanced clinical stage.
Gastric mixed adenoma-neuroendocrine tumors (NETs) are quite rare. In the 2019 world health organization classification of tumors of the digesti
IKE modulator in vivo
Prevention the possibility to preserve fertility is essential, mainly in patients with bleeding disorders or undergoing anticoagulant therapy; therefore, they need estro-progestinics or GnRH analogues to prevent ovulation and avoid further episodes of HCL. This review will aid physicians in making an early diagnosis of HCL, to avoid unnecessary surgery, and use the most effective treatment.
<b
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Incidental durotomy during elective spine surgery is relatively common. While usually benign and self-limited, it can be associated with morbidity, increased cost, and medicolegal ramifications. Dural repair typically involves performing a primary closure using a suture or dural staple; repairs are then frequently augmented with a sealant, patch, or fat/fascial graft. Although primary repair of an incidental
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Alkenylphosphine oxides have a wide spectrum of practical applications. However, chemo-, regio-, and enantiocontrolled construction of this structural motif still constitutes a significant synthetic challenge. Here we show that these compounds can be efficiently accessed by using a palladium/Xiao-Phos catalytic system, which leads to the highly regioselective formation of the anti-Mar
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Bystander intervention on behalf of victims of peer aggression is credited with reducing victimization, yet little is known about how bystanders evaluate their intervention efforts. African-, European-, Mexican-, and Native-American adolescents (N = 266) between 13 and 18 years (Mage = 15.0, 54% female) recounted vengeful and peaceful responses to a peer’s victimization. For comparison, they also descri
AM1241
Furthermore, we examine the comparability of these data among respondents of different ethnoracial origins and from different regions of birth, who report few versus many years since migration, their age, gender, and the language used to respond to the interview (e.g., English vs. Spanish). We test for measurement equivalence using multigroup confirmatory factor analysis. The results reveal that health scales are comparable
Reversine cost
rhamnosus in all three bases. Diacetyl levels increased in fermented oat and coconut samples when L. rhamnosus was combined with a starter culture containing Streptococcus thermophilus and with another starter culture containing S. thermophilus, L. bulgaricus and Bifidobacterium. In all fermented oat samples, L. rhamnosus significantly enhanced fermented flavor notes, such as sourness, lemon, and fruity taste, whic
selleck compound
rgical intervention.
With the diversity of prosthetic components patients with a transtibial amputation can now expect to return to high function. Subsequently, the ipsilateral knee is at risk of developing osteoarthritis with a need for a provision of total knee arthroplasty (TKA).
We describe a novel technique for TKA in a transtibial amputee utilizing nav
LY-3475070
Restless legs syndrome (RLS), with a lifetime prevalence of up to 10%, is a frequent neurological disease and the most common movement disorder in sleep. A compulsive urge to move the legs with sensory symptoms and sleep disturbances can significantly impair the quality of life. Furthermore, RLS frequently occurs as a comorbidity to various internal and neurological diseases. #link# It is diagnosed clinically based on
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Navigating Car Key Conundrums: Your Guide to Auto Locksmiths in Wellingborough
Losing or harming your car keys can be a frustrating and bothersome experience, disrupting your day and possibly leaving you stranded. In such predicaments, the know-how of an auto locksmith becomes important. For re
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The conformational flexibility and length of the hydrophobic regions of amphiphilic excipients appears to be critical for effectiveness. This hypothesis was supported by molecular modeling studies to better understand the interactions between the excipients with the drug nanoparticle surface. Despite the increasing interest in pharmaceutical use of mesoporous silica, there is
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Trometamol clinical trial
Policymakers should take the pre-established partnerships of healthcare organizations into account before delineating the area in which regionalization is meant to take place. A better alignment of governance and accountability structures is also needed for regionalization to occur in healthcare.
This paper combines insights from valuation studies with sociogeogra
SBC-115076
s. Level of evidence Level III-systematic review of level III studies.Purpose Transphyseal humeral separations (TPHS) are rare injuries with only case reports and small series reported in the literature. This multicenter study aimed to assess the various patient characteristics, injury patterns, treatments, outcomes, and complications in a large series of these injuries. Methods A retrospective review was conducted at
Stem Cells inhibitor
ferent orthopedic subspecialties. This classification may be a useful tool for documenting complications in orthopedic surgery.
Classification systems are internationally used tools to characterize the functions of children and young people with cerebral palsy (CP), for clinical and research use. The aim of this study was to characterize the different classification systems available and desc
Ravoxertinib clinical trial
STAT3 was predicted as the target gene of miR-125b, and the high level of miR-125b inhibited STAT3 signaling pathway. High expression of miR-125b may be involved in the occurrence of PE through inhibiting STAT3 pathway to inhibit the migration and invasion of extra-villous trophoblastic cells.In patients who are successfully resuscitated after initial cardiac arrest (CA), mortality and morbidity rates a
GSK1904529A
Adolescents and young adults (AYAs; aged 15-39 years) with cancer frequently receive intensive measures at the end of life (EoL), but the perspectives of AYAs and their family members on barriers to optimal EoL care are not well understood.
We conducted qualitative interviews with 28 bereaved caregivers of AYAs with cancer who died in 2013 through 2016 after receiving treatmen
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The TargetScan analysis showed NF-kB1 to be the target of miR-322. Additionally, NF-kB1 was remarkably upregulated in all the breast cancer cells. However, miR-322 overexpression resulted in depletion of NF-kB1 expression in MCF7 cells. Silencing of NF-kB1 also decreased the proliferation rate and colony formation of the MCF7 cells. CONCLUSION To conclude, miR-322 may exhibit therapeutic implications in
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It has been reported that lncRNA growth arrest-specific transcript 5 (GAS5) interacts with miR-21, which plays critical roles in osteoporosis. The involvement of GAS5 in osteoporosis was investigated in this study.
Expression levels of GAS5 and miR-21 in plasma of both osteoporosis patients and healthy controls were determined by RT-qPCR. Diagnostic values of GAS5 and miR-21 for
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COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) on the 11th of March 2020, leading to some form of lockdown across almost all countries of the world. The extent of the global pandemic due to COVID-19 has a significant impact on our lives that must be studied carefully to combat it. This study highlights the impacts of the C
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Aortoduodenal syndrome is a rare duodenal obstruction caused by an abdominal aortic aneurysm. Current treatment involves open aneurysmal repair according to the theory that this procedure releases the duodenum from mechanical compression. However, the mechanism of duodenal blockage remains unclear and reports of endovascular aneurysm repair (EVAR) for aortoduodenal syndrome are quite rare. We report our successfu
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However as clinical suspicion of an adenocarcinoma was strong but histopathological report of colonoscopic biopsy was contradictory, intersphincteric ultra-low anterior resection with coloanal anastomosis with covering ileostomy was done. Resected specimen was sent for histopathological study and it reveals- villous adenoma with low grade dysplasia. Two months later reversal of ileostomy was done and now
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Organophosphorus compounds occupy a significant position among the plethora of organic compounds, but a limited number of paramagnetic phosphorus compounds have been reported, including paramagnetic phosphonates. This paper describes the syntheses and further transformations of pyrroline and piperidine nitroxide phosphonates by well-established methods, such as the Pudovik, Arbuzov and Horner-Wadsworth-Emmo
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Bogus Positive Costs and also Potential risk Factors about the VOMS and mBESS throughout You.Ersus. Military services Personnel.
Among programs’ 272 core faculty and 318 current residents, 10% and 21%, respectively, were identified as URMs. As faculty diversity increased, there was no difference in selection to interview for URM (OR=0.83; 95%CI0.54-1.28, per 10% increase in faculty diversity
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A reference fingerprint was established and 93 compounds of FTZ were tentatively identified. In vivo, FTZ treatment exerted antidiabetic and antidyslipidemic effects while decreased the level of corticotropin releasing hormone (CRH). 11β-HSD1 mRNA showed similar trajectory in both liver, adipose and skeletal muscle tissues, which was up-regulated in diabetic group and ameliorated in FTZ groups. Furthermore, the
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Evidence is discovered for selective constraint against the occurrence of lysine residues (which likely disrupt prion formation) in S. cerevisiae prion-forming domains as they evolve across Saccharomycetes. These results provide a case study of the absorption of mutational trends by compositionally biased domains, and suggest methodology for assessing selection pressures on the compositio
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While exposure to sulfur mustard (SM) is commonly associated with the production of vesicating dermal, ocular, and respiratory injuries, systemic damage to bone marrow and lymphatic tissue can decrease critical immune cell populations leading to higher susceptibility to life-threatening infection and septicemia. There are currently no approved medical countermeasures for SM-induced myelosuppression. An intravenous SM challe
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Gut microbiota is believed to play a crucial role in modulating obesity in humans, and probiotics affecting gut microbiota can alleviate some of the obesity-related health complications. The study was aimed to investigate changes in the composition of the gut microbiome in obese humans due to short-term (2 weeks) treatment of obese patients with a probiotic preparation containing Bifidobacterium longum. Fae
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By maintaining intact multi-protein complexes in the gas-phase, native mass spectrometry provides their molecular weight with very good accuracy compared to other methods (typically native PAGE or SEC-MALS) (Marcoux and Robinson, Structure 211541-1550, 2013). Besides, heterogeneous samples, in terms of both oligomeric states and ligand-bound species can be fully characterized. Here we thoroughly describe the an
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Response assessed by standard MRI-based Response Assessment in Neuro-Oncology criteria was associated with overall survival in the bevacizumab plus radiotherapy arm by trend only (
= 0.09). High
FET-TBR of noncontrast-enhancing tumor portions during bevacizumab therapy was associated with inferior overall survival on multivariate analysis (HR
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the expression levels of ATP7A and ATP7B, which are important proteins in the tumorigenesis and chemotherapy of lung adenocarcinoma. The present study provided evidence for the potential use of Salvia miltiorrhiza extract for treating lung adenocarcinomas in the clinic.An increasing body of evidence indicates the involvement of microRNAs (miRNAs/miRs) in the initiation and progression of colorectal cancer (CRC). miR-296-5p wa
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Plasmids remain important microbial components mediating the horizontal gene transfer (HGT) and dissemination of antimicrobial resistance. To systematically explore the relationship between mobile genetic elements (MGEs) and antimicrobial resistance genes (ARGs), a novel strategy using single-molecule real-time (SMRT) sequencing was developed. This approach was applied to pooled conjugative plasmids from c
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Surface-enhanced Raman spectroscopy (SERS) is being considered as a powerful technique in the area of food safety due to its rapidity, sensitivity, portability, and non-destructive features. This review aims to provide a comprehensive understanding of SERS applications in fast detection of toxic and harmful substances in food matrix. The enhancement mechanism of SERS, classification of active substrates, detect
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INTRODUCTION The first lineage separation in mammalian development occurs when totipotent cells of the zygote give rise to the inner cell mass and the trophectoderm. The lineages are strictly separated by an epigenetic barrier. In vitro derivatives of these lineages embryonic stem cells (ESC) and trophoblast stem cells (TSC) are used to study the requirements needed to overcome the barrier in ESC to TSC conv
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gem-Difluoroalkene bearing a carbonyl group is a challenging target to synthesize by conventional methods. Herein we report a mild and concise route to access the target compounds through the visible-light-mediated direct β-C-H gem-difluoroallylation of aliphatic aldehydes and cyclic ketones. Upon a synergistic combination of photoredox catalysis and organocatalysis, various α-CF3 alkenes were employed as the gem-di
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p skills and knowledge to support AMS.Graphical Abstract.Graphical Abstract.
We previously developed proxy indicators (PIs) that can be used to estimate the appropriateness of medications used for infectious diseases (in particular antibiotics) in primary care, based on routine reimbursement data that do not include clinical indications.
To (i)
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associated with favourable recommendations of drugs and devices in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews. However, we also stress risk of confounding in the included studies and the statistical imprecision of individual analyses of each document type. It is not certain whether non-financial conflicts of interest impact on recommendations.
We interpr
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The tocilizumab has been administered to control cytokine storms that occurred due to the release of proinflammatory cytokine including interleukin 6. Chloroquine and hydroxychloroquine were also used in hospitals, to handle severe COVID-19 patients. Currently, plasma therapy has been exercised as a therapeutic alternative, especially to handle severe COVID-19 patients. In addition, herbal medicines are expected to play sig
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Osimertinib-resistant lesions (cervical spine and brain) showed EGFR-L858R and MET amplification, but not EGFR-T790M, whereas osimertinib-sensitive lesions (lumbar spine) showed EGFR-L858R and -T790, but not MET amplification. Osimertinib decreased the association of amplified MET with L858R-mutated EGFR but increased that with human epidermal growth factor receptor 3 in KNZ_OR cells. MET knockdown or MET i
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predictive value on the adenoma recurrence after resection of LSTs. The fecal microbiome signature of LST may provide a noninvasive alternative to early detect LST and predict the adenoma recurrence risk after resections of LSTs.
Fecal microbiome signature (ETBF-P. stomatis-P. micra) can diagnose LSTs with high accuracy. ETBF, P. stomatis, and P. micra were related to malignant LST and P. stomatis exh
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Parents reported barriers in accessing care including service shortages and inaccessibility, underresourced schools, lack of clinician mental health expertise, lack of child-clinician rapport, inconsistent care, financial constraints, lack of mental health awareness among parents, and stigma. Parents want expanded and improved access to services, more respite and support services, supportive schools, and improved menta
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Durkheim suggests that the rise and fall of suicide rates will depend on the nature of social change. As society is undergoing massive social disruption resulting from the COVID-19 pandemic, suicide rates may increase unless suicide prevention measures align with the current social reconstruction process.This study examines the psychometric properties of the Illness Attitude Toward COVID-19 Scale (IATCS). The IATCS was te
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patula var. longipedunculata. We observed high genetic diversity, low inbreeding rate, and rapid linkage disequilibrium (LD) decay in the varieties. Based on outlier tests, loci showing signatures of natural selection were detected in geographically distant P. patula var. longipedunculata populations. For both varieties, we found significant correlations between climate-r
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Binge eating and binge drinking are two of the most common health-risk behaviors among young people showing to frequently co-occur in nonclinical samples of adolescent boys and girls. The present study examined the role of different dimensions of family functioning in binge behaviors among adolescents. One thousand and twenty young to late adolescents (507 girls and 517 boys) with ages ranging from 16 to 22 ye
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Sluggish cognitive tempo (SCT) is associated with-but distinct from-attention-deficit/hyperactivity disorder (ADHD). This study examined SCT rates in adult outpatients seeking an ADHD assessment, differences in rates based on ADHD status, impact of assessment method (i.e., reporting source, symptom count, and functional impairment), and age of SCT symptom onset.
Outpat
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The group of experts reached a consensus on the relevant aspects in the therapeutic management of rosacea, providing information on epidemiology, pathophysiology, triggering factors, clinical condition, classification, quality of life, and comorbidities. Consensus was defined as approval by at least 90% of the panel.
Despite the impossibility of cure, the
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eater investment in structural supports to bolster family connectedness and better evidence on how to support families affected by mass incarceration and structural racism.
To achieve health equity and maximize opportunities for all youth, we must remove the obstacles and consequences of mass incarceration. Improving the health and flourishing of Black youth who have had incarcerated parents requires greate
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531). EGFR mutation status (same mutations, different mutations, all wild-type) had no statistically significant effect on DFS of SMFLC (
=0.388). Univariate and multivariate regression analysis revealed that radiographic feature of solid nodules (hazard ratio (
)=7.4,
=0.008) and MMFLC (
=5.6,
=0.001) were
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Although much attention has been focused on individual-level drivers of burnout in primary care settings, examining the structural and cultural factors of practice environments with no burnout could identify solutions. In this cross-sectional analysis of survey data from 715 small-to-medium-size primary care practices in the United States participating in the Agency for Healthcare Research and Quality’s EvidenceNOW initiative, we foun
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Facioscapulohumeral dystrophy (FSHD) is associated with the upregulation of the DUX4 transcription factor and its target genes. However, low-frequency DUX4 upregulation in patient myocytes is difficult to detect and examining the relationship and dynamics of DUX4 and target gene expression has been challenging. Using RNAScope in situ hybridization with highly specific probes, we detect the endogenous DUX4 and target gene
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The aim of this paper was to analyse heart failure (HF) signs and symptoms, hospital referrals, and prescription patterns in patients receiving sacubitril/valsartan (sac/val) in primary care and cardiology settings in Germany.
A retrospective cohort study of electronic medical records identified 1263 adults (aged ≥18 years) in the German IMS® Disease Analyzer database who were prescri
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Routine third-trimester ultrasound is frequently offered to pregnant women to identify fetuses with abnormal growth. Infrequently, a congenital anomaly is incidentally detected.
To establish the prevalence and type of fetal anomalies detected during routine third-trimester scans using a systematic review and meta-analysis.
<b
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Coronavirus disease (COVID-19) caused by SARS-CoV-2 has spread since the end of 2019 and has resulted in a pandemic with unprecedented socioeconomic consequences. This situation has created enormous demand for the improvement of current diagnostic methods and the development of new diagnostic methods for fast, low-cost and user-friendly confirmation of SARS-CoV-2 infection. This critical review focuses on viral e
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The extremely rapid spread of the SARS-CoV-2 has already resulted in more than 1 million reported deaths of coronavirus disease 2019 (COVID-19). The ability of infectious particles to persist on environmental surfaces is potentially considered a factor for viral spreading. Therefore, limiting viral diffusion in public environments should be achieved with correct disinfection of
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2% in the 1935 cohort and 17.5% in the 1945 cohort) than the FS (13.1% and 8.8%) or FP (1.8% and 1.6%). Low financial satisfaction was associated significantly with frailty in both sexes. Low level of education was associated with frailty in women and being unmarried or divorced in men. Frailty was associated to increased mortality using all frailty definitions
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Investing is so easy, anyone can do it. But not everyone can do it well. Investing intelligently is about getting the right information and considering all your decisions thoroughly. Without the right information, you can lose money instead of earning it. Keep reading for some awesome tips about investing your money.
Remember that there are always more fish in the sea. It is ea
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avonoids eriocitrin or eriodictyol may aid in the prevention of periodontitis, representing a potential method to enhance local immunity and host defense.The managed mineralisation of CO2 on mineral substrates has significant potential to mitigate CO2 emissions to atmosphere, using processes that are analogous to the formation of limestone in nature. High-temperatures and pressures or ambient conditions can be applie
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BACKGROUND Gastric schwannomas are rare benign tumors originating from the intramuscular plexus of the stomach and account for just 2.6% of gastric mesenchymal tumors. Gastric schwannoma (GS) with a surface ulcer is very rare. Herein, we report a rare case of an ulcer-bearing GS, which in conjunction with multiple enlarged regional lymph nodes, readily mimicked gastric cancer (GC). CASE PRESENTATION A 79
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Trigger finger, or stenosing tenosynovitis, is one of the most common conditions affecting the hand, yet its pathophysiology remains poorly understood, and genetic association studies of trigger finger are lacking. The purpose of this study was to identify single-nucleotide polymorphisms associated with trigger finger through a genomewide approach.
The authors performed a
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suggests that up to 50% of the population served by fluoridated water systems may not receive its full caries-preventive benefits due to not consuming plain tap water. Our findings add support for the need to identify and address barriers to tap water consumption and promote health benefits of fluoridation.
Half of US youth consumed plain tap water on a given day. Consuming plain t
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Current follow-up results on paracetamol-exposed very preterm infants may not be alarming suggesting that paracetamol administration shortly after birth is not associated with common adverse consequences.
This study was designed to analyze the relationship between tumor metastasis and acute ischemic stroke (AIS) in Chinese cancer patients.
This retrospective study included
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IG significantly correlated with the amount of time spent using the app (Spearman’s rho=0.741, p=0.004). Conclusion When compared to conventional teaching, an app-based blended-learning approach leads to improvement in test scores, possibly as a result of more intensive preparation for and review of the clinical examination course material.Purpose The analysis of difficulties in understanding the information content of an e
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In addition, the MOEA-CRL adjusts the distribution of the cross-reference lines directly defined by the DPD indicator according to the contributing solutions. Therefore, the adaptation of cross-reference lines will not be affected by the population size and the uniform distribution of cross-reference lines can be maintained. The MOEA-CRL is examined and compared with other MOEAs on several benchmark problems.
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Thus, to partly alleviate the noise in expression estimates, they propose a new normalization method called length-rescaled CPM. Remarkably, the authors found considerable distortions at the nucleotide level, which leads to an underestimation of diversity in transcriptome assemblies. The study by Freedman et al. (Mol Ecol Resourc 2020) clearly shows that we have not yet reached “high-quality” in the field of transc
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Extra-articular manifestations of gout are common. The Achilles tendon is a frequently affected site, and uric acid deposition may have harmful effects on tendon structure and function. Advanced imaging can aid in early diagnosis, follow-up of disease activity and therapy efficacy. This case series highlights the use of dual-energy CT as a tool in diagnosing gout and in detecting extra-articular manifestations.[Th
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Aureobasidium pullulans LB83 was evaluated for cellulase production under submerged fermentation conditions. Different process variables such as carbon sources (corn cob, sugarcane bagasse, and sugarcane straw), synthetic (urea, ammonium sulfate, and peptone), and non-synthetic (soybean meal, rice, and corn meal) nitrogen sources and inoculum size were evaluated by one parameter at-a-time strategy. Aureobasidium pullu
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Thus, clinicians’ focus on psychotic symptom expression is not sufficient to achieve goal agreement. Rather, it is imperative to consider the individual subjective needs of patients as a key element for sustained therapeutic alliance.
We aim to relate the pharmacological treatment at admission of hip fracture patients with their prognosis.
We designed
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The open water phones call to adventurers, and Sea-Doo answers with a pledge of euphoria and reliability. For decades, this legendary brand has actually sculpted its name into the world of watercraft, ending up being a sign for those who yearn for water delights. Whether it’s the rush of skimming throughout a lake or the tranquility of a leisurely cruise, Sea-Doo transforms every outing into an unforgettable e
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The 2D CNN method provides fully automated segmentation of the left and right kidney and calculation of TKV in <10 s on a standard office computer, allowing high data throughput and is a freely available executable.
The 2D CNN method provides fully automated segmentation of the left and right kidney and calculation of TKV in less then 10 s on a standard office computer, allowing high data t
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The advantages of OCM, such as fine isotropic spatial resolution, fast time resolution, and low phototoxicity, make it the ideal optic tool for 3-D traction force microscopy.Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which,
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The use of oxygen in HaD improves the quality of life and survival of our patients, reducing the number of readmi
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To evaluate methods for analysis of genotoxic effects on mammalian cell lines, we tested the effect of three common genotoxic agents on Chinese hamster ovary (CHO) cells by single-cell gel electrophoresis (comet assay) and gas chromatography-tandem mass spectrometry (GC-MS/MS). Suspension-grown CHO cells were separately incubated with etoposide, bleomycin, and ethyl methanesulfonate and analyzed by an a
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Adolescent narcolepsy patients exhibited disrupted small-world network properties. Regional alterations in the caudate nucleus and posterior cingulate gyrus were associated with subjective sleepiness and regional alterations in the caudate nucleus and inferior occipital gyrus were associated with impulsiveness. Remodeling within the salience network and the default mode network was associated with
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D’altro canto, se devi fare tradurre lo stesso testo in più lingue, scegliere l’agenzia sarà sicuramente la soluzione più pratica e veloce perché comunicherai con il project manager per tutte le traduzioni di cui hai bisogno. Ti fornirò anche consigli su come ottenere un preventivo dettagliato per la tua traduzione, senza incorrere in costi aggiuntivi. Infine, discuteremo dell’importanza di investire in traduzioni di qualità e come c
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Background The aim of our study was to investigate whether metastatic patterns were associated with the prognosis of patients with FIGO stage IV high-grade serous ovarian cancer (HGSC). Methods We retrospectively investigated 83 consecutive patients with FIGO stage IV HGSC who underwent primary surgery between April 2005 and June 2013 at our institution. Metastatic patterns were defined as pleural effusion (st
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Numerous studies have been investigated the potential of biochar (BC) derived from various materials and crop straw (CS) to decrease the bioavailability of heavy metals in soil contaminated with cadmium (Cd), and thereby reduce their potential risk to human health and the ecological environment. However, little attention has been given to the comparison of heavy metal remediation efficiency using BC and CS such as
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Inspired by the active site structure of natural horseradish peroxidase having iron as a pivotal element with coordinated histidine residues, we have developed histidine coated magnetic nanoparticles (His@MNPs) with relatively uniform and small sizes (less than 10 nm) through one-pot heat treatment. In comparison to pristine MNPs and other amino acid coated MNPs, His@MNPs exhibited a considera
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cally important symptoms of PTSD in DVA survivors. Trial registration ISRCTN, ISRCTN64458065, Registered 11 January 2019. © The Author(s). 2020.Introduction Laboratory services are crucial parts of the health system having a great contribution to disease prevention and management. The importance of accurate and reliable laboratory test results is less recogni
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The detection of Δ152p53 isoform mRNA in serum is indicative of tumorigenesis. Furthermore, we showed a tissue-specific p53-dependent deregulation of the p63 and p73 isoforms in these tumours. This study highlights important species-specific differences in the transcriptional regulation of TP53. Considering the similarities of TP53 regulation between pig and human, these observations provide useful pointers for further invest
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This butanolide also complied with Lipinski’s rule of five and was not predicted as interference compound (PAINS). This is the first report on the isolation of these bioactive butanolides under the guidance of in vitro trypanocidal activity against T. cruzi. Copyright © 2020 Nunes et al.The alleged effects of serotonergic agents in alleviating levodopa-induced dyskinesias (LIDs) in parkinsonian patients are debatable. To
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Safety was assessed via spontaneous reporting and review of subject diaries. RESULTS Clinical and statistically significant superiority to no treatment in terms of enhancing moisturization and desquamation per D-SQUAME® analysis at Day 2 and Day 14 (-2.51 and -3.07 from baseline, respectively; p less then 0.0001) was achieved. Treatment success as assessed by the investigator (via the Dry Skin Scale) and subject’s self-a
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stage and may play an important role in hair morphogenesis by regulating associated gene expression. Furthermore, potential lncRNAs associated with DNA methylation on target genes were delineated. This study enriches the regulatory network and molecular mechanisms on hair morphogenesis.Assessment of heart rate variability (HRV) and cardiac ectopic beats is a clinically relevant topic. The pre
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0-fold), colon (2.5-fold), lung (3.6-fold), and liver (2.1-fold), but essentially no enhanced activity in the tumor tissues of the spleen, stomach, and pancreas and a comparable level in both the tumor and normal kidney tissues were observed. The probe offers practical means for studying GGT-associated biology in cells and tissues by one- as well as two-photon ratiometric imaging.Nitrous acid (HONO) is a major precurs
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BACKGROUND We report an unusual case of low-grade fibromatosis-like metaplastic carcinoma (LG-FLMC) of the breast. This exceedingly rare epithelial breast malignancy has been reported only 68 times in the past 20 years, and is classified as a subtype of metaplastic breast carcinoma (MBC). It is a locally aggressive tumor with a low potential for lymph node and distant metastases, but with a tendency to recur after excision. Here we describe
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© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Complex urban air quality has long been assessed by a single (or major) contaminant, e.g., fine particulate matter (PM2.5 ), but scant attention has been given to multicontaminant air pollution, especially in countries with severe air pollution, e.g., China. We thus proposed an improved method for quantifying both single- and multicontaminant air pollution. Our ap
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Militaries around the world play an important but at times poorly defined and underappreciated role in global health security. They are often called upon to support civilian authorities in humanitarian crises and to provide routine healthcare for civilians. Military personnel are a unique population in a health security context, as they are highly mobile and often deploy to austere settings domestically and inte
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More than 70% of JIA-uveitis eyes showed some WFA-evidence of posterior segment inflammation, which changed the course of therapy for a major proportion of patients with no clinically active anterior chamber inflammation.
Diffusion weighted imaging (DWI) has become important for orbital imaging. However, the echoplanar imaging (EPI) DWI has inherent obstacles due to susceptibility to magnetic f
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The median overall survival was 1.3years (95% CI 0.3-5.7) and 5.0years (95% CI 3.1-5.9) for patients with low BMI and for patients with normal or higher BMI, respectively. In the multivariate analysis, low BMI (95% CI 1.07-4.44), ECOG ≥2 (95% CI 1.02-2.89), hypoalbuminemia (95% CI 1.21-4.01), high LDH (95% CI 1.22-3.49), and light chain ratio > 100 (95% CI 1.06-2.77) were independent
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Surgical quality improvement efforts are challenging due to the multidisciplinary nature of care, difficulties obtaining reliable data, and variability in quality metrics. The objective of this analysis was to assess whether participation in a regional collaborative quality initiative was associated with decreased in-hospital surgical complication in South Carolina.
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The aim To identify the issues that arise in states that consolidate different approaches to the use of surrogacy technologies and formulate the main trends towards unification of legislation in this area.
Materials and methods The study used a complex of general scientific and special methods of cognition, in particular, dialectical, generalizing, comparative legal and o
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In some cases, similar surgical revascularization and free flap transfer can be performed in a single surgery. The aim of this study is to implement a standardized algorithm for preoperative examination and radiological diagnostics before reconstructive surgery of the lower extremity.
Delayed cerebral ischemia (DCI) is a frequent cause of morbidity and mortality in patients with cerebral vasospasm (CV) f
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The protective effect of seed-priming was explained by increasing the antioxidant defense markers including the antioxidant metabolites (i.e., total antioxidant capacity, carotenoids, phenolics, flavonoids, ASC, GSH, tocopherols) and enzymes (CAT, POX, GPX, SOD, GR, APX, MDHAR, DHAR), particularly in infected tomato seedlings. Additionally, cluster analysis indicated the differential impact of IAA- a
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Data indicated that EM tool material composition impacted the release of microorganisms (p = 0.0001), where the PUF EM tool released TV more readily than the CELL EM tool. Conversely, the decreasing inoculum levels did not statistically differ in the release of microorganisms from the EM tool matrices. In addition, no significant difference was found between the machine stomacher and manual elution by human operat
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Diagnosis of soil-transmitted helminths (STHs) in developing countries is commonly based on microscopic detection of eggs in stool samples, using the Kato-Katz (KK) method, which has a poor sensitivity for detecting light intensity infections. We compared the performance of the KK method and real-time PCR in the framework of a randomized trial, which evaluated four novel treatments against Trichuris trichiura and concomitant
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هل تساءلت يومًا كيف يمكنك الحفاظ على ثلاجتك في أفضل حالة ممكنة؟ تعتبر الثلاجات واحدة من أهم الأجهزة المنزلية، حيث تلعب دورًا حيويًا في الحفاظ على طعامنا وشرابنا طازجًا. لكن، مثل أي جهاز آخر، تحتاج الثلاجات إلى صيانة ورعاية دورية لضمان عملها بكفاءة. في هذا الدليل الشامل لصيانة ثلاجات، سنستعرض خطوات سهلة وفعّالة للحفاظ على أدائها، وسنقدم لك نص
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4%), open defecation (35.5%) and semi-extensive husbandry system (62.3%). Others are non-availability of deworming programme (54.4%), rearing pigs of different ages together (41.9%), non-disinfection of feeding or water troughs (41.2%) and early weaning (54.3%). Cognizant of the zoonotic potentials of Ascaris spp and Taenia solium cysticerci, the prevalence found for the parasites are significant fro
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ciMSCs constitutively express the immunomodulatory factors iNOS, GAL-9, TGF-β1, PTGER-2α and VEGF, and the pro-inflammatory mediators COX-2, IL-1β and IL-8. When stimulated with the canine pro-inflammatory cytokines tumor necrosis factor-α (cTNF-α), interferon-γ (cIFN-γ), or a combination of both, ciMSCs upregulated their expression of IDO, iNOS, GAL-9, HGF, TGF-β1, PTGER-2α, VEGF, COX-2, IL-1β and
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638 while that of AJCC 8th staging system was 0.613 in SEER database. Similar phenomena were observed in RJPDC database. Kaplan-Meier analyses revealed reliable internal coherences (SEER Ib P=0.26; IIa P=0.063; IIb P=0.53; IIIa P=0.11.
Ib P=0.32; IIa P=0.66; IIb P=0.76; IIIa P=0.66) and significant staging efficiency (SEER P<0.001; RJPDC P=0.002).
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The United States (US) has a complex healthcare system with a mix of public, private, nonprofit, and for-profit insurers, healthcare institutions and organizations, and providers. Unlike other developed countries, there is not a single payer healthcare system or a national pharmaceutical benefits scheme/plan. Despite spending over USD 10,000 per capita in healthcare, the US is among the worst performers compared
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003) and maximum time delay scans (p = 0.005). We found significant higher normalized ratios for minimum post-injection time delay with respect to maximum post-injection time delay (p less then 0.001). The normalized ratios demonstrated a statistically significant negative correlation with the post-injection time delay (r = – 0.31; p = 0.006). The findings of this study suggest that washout phenomena of retained
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Both preF and preF+N vaccines afforded safe, clinical, and virological protection against BRSV, with little difference between the two subunit vaccines. Analysis of immune parameters pointed to neutralizing antibodies and antibodies to preF as being significant correlates of protection. Thus, a single shot vaccination with preF appears sufficient to reduce the burden of BRSV disease in calves with MDA.Pathogens that i
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In ray-finned fishes, the sternohyoideus (SH) is among the largest muscles in the head region and, based on its size, can potentially contribute to the overall power required for suction feeding. However, the function of the SH varies interspecifically. In largemouth bass (Micropterus salmoides) and several clariid catfishes, the SH functions similarly to a stiff ligament. In these species, the SH remains
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None had
(B) or
(C) genes. F101L and G4D/K/R or T150A were the main substitutions of ribosomal protein L4, L3, respectively. We found one
isolate co-contained
and
and another
isolate co-contained
and
(D), but they were not resistant to
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5 days (IQR 9-18) for IgM and 15.0 days (IQR 12-20) for IgG; 54/62 patients (87.1%) sampled at day 14 or later seroconverted. Severe infections were associated with earlier seroconversion and higher peak IgM and IgG levels. Levels of IP-10, HGF, IL-6, MCP-1, MIP-1α, IL-12p70, IL-18, VEGF-A, PDGF-BB and IL-1RA significantly correlated with disease severity.
We found virus vi
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Low culture temperature is known to enhance the cell-specific productivity of CHO cells expressing varied recombinant (r-) proteins, but the mechanisms remain unclear. Regulation of UPR pathway genes, such as transcriptional regulatory factors and ER-resident proteins, appear to be involved in the improvements of r-protein production under low temperature conditions. We studied the transcriptional regulation of UP
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In the wake of the coronavirus disease 2019 (COVID-19) pandemic, hospital resources have been stretched to their limits. We introduced an innovative course to rapidly on-board a group of non-intensive care unit (ICU) nurse practitioners as they begin to practice working in a critical care setting.
To assess whether a brief educational course could improve non-ICU practi
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Technology advancements have driven the use of self-administered dietary assessment methods in large-scale dietary surveys. Interviewer-assisted methods generally have a complicated recipe recording procedure enabling the adjustment from a standard recipe. In order to decide if this functionality can be omitted for self-administered dietary assessment, this study aimed to assess the extent of standard recipe modifications
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BACKGROUND Menopause induces oral bone loss, leading to various oral diseases. Mastication importantly affects bone metabolism in the jawbone. OBJECTIVE To analyze the effect of enhanced masticatory force on osteoprotegerin (OPG), receptor activator of nuclear factor kappa B ligand (RANKL), and mechano-growth factor (MGF) in alveolar bone of ovariectomized rats and to study the mechanics mechanism of the alveolar
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The combined detection associated with autoantibody features within wide spread lupus erythematosus.
An additional zinc supplementation should be considered when high protein and energy intake are received by preterm newborns in the first week of life.In 2012 and 2013, the genomic sequences of two novel influenza A virus (IAV) subtypes, designated H17N10 and H18N11,
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The protective effect of seed-priming was explained by increasing the antioxidant defense markers including the antioxidant metabolites (i.e., total antioxidant capacity, carotenoids, phenolics, flavonoids, ASC, GSH, tocopherols) and enzymes (CAT, POX, GPX, SOD, GR, APX, MDHAR, DHAR), particularly in infected tomato seedlings. Additionally, cluster analysis indicated the differential impact of IAA- a
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هل تعلم أن الثلاجات تعتبر من أهم الأجهزة المنزلية التي نستخدمها يوميًا؟ فهي ليست مجرد أداة للحفاظ على الطعام طازجًا، بل تلعب أيضًا دورًا حيويًا في أسلوب حياتنا. ومع ذلك، مثل أي جهاز آخر، تحتاج الثلاجات إلى صيانة دورية لضمان عملها بكفاءة. في هذا المقال، سنتناول موضوع “صيانة ثلاجات” بشكل شامل، وسنقدم لك أفضل النصائح والخدمات المتاحة في السوق. فلنبدأ!
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The availability of blood transfusion has been a recurrent concern for medical institutions and patients. Efficient management of this resource represents an important challenge for many hospitals. Likewise, rapid reaction during transfusion decisions and planning is a critical factor to maximize patient care. This paper proposes a novel strategy for predicting the blood transfusion need, based on available informa
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TTE and DHA abrogated proteinuria and reversed urine albumin level. Testicular and renal oxidative stress and pro-inflammation were attenuated in diabetic rats treated with TTE and DHA. The diabetes-mediated histopathological damage was alleviated in the kidney and testis.
The protective effect of TTE and DHA against diabetes induced kidney and testicular damag
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This vaccine can be considered as stable and preventative to protect against brucellosis in animals and thus protect the public from this infection. Conclusion These findings will provide further insight into designing future targeted awareness interventions and adapted policies as efforts toward reducing the prevalence and prevention of brucellosis in cattle in Lebanon. Copyright © Hassan, et al.Background and Aim
ML141 in vitro
Although 62 years have elapsed since the first report of hereditary deafness in a mouse strain, the molecular mechanism of hair cell mechanotransduction remains elusive. Three recent studies present crucial insights into the molecular crux of hair cell mechanotransduction machinery.Characterizing the brain’s ability to adapt to changing environments has been at the forefront of neuroscience for decades. In of Neuron,
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The aim of this study was to estimate the burden of ischemic heart disease (IHD) and type 2 diabetes mellitus (T2DM) attributable to a diet high in sugar-sweetened beverages (SSBs) in China from 1990 to 2017.
Data from the Global Burden of Disease Study 2017 were used to assess all-age and age-standardized, risk-attributable mortality, years of life lost (YLL), years
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Strains of Echinicola, thought to play vital roles in the environment for their high enzyme production capacity during decomposition of polysaccharides, are ubiquitous in hypersaline environments. A Gram-negative, non-spore forming, gliding, aerobic bacterial strain, designated LN3S3T, was isolated from alkaline saline soil sampled in Tumd Right Banner, Inner Mongolia, northern PR China. Strain LN3S3T grew at
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This model generates mechanistic insights that help in further experiments and modeling.Wastewater-based epidemiology is a powerful tool to understand the actual incidence of coronavirus disease 2019 (COVID-19) in a community because severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, can be shed in the feces of infected individuals regardless of their symptoms. The prese
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The structure and dynamics of interfacial water in biological systems regulate the biochemical reactions. But, it is still enigmatic how the behavior of the interfacial water molecule is controlled. Here, we have investigated the effect of membrane fluidity on the structure and dynamics of interfacial water molecules in biologically relevant phopholipid vesicles. This study delineates that modulation of membrane
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The promotion of cellular uptake was evaluated by flow cytometry and the results produced 99% fluorescent stained cells. Moreover, the results from CLSM and 3D fluorescence imaging confirmed particle localization in the cells. Interestingly, NS-HSA MPs could not induce inflammation through nitric oxide production from macrophage RAW264.7 cells. This is the first study involving the loading of non-sericin extracts into
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Conclusions Although physician trainees recognize the importance of education related to FSD, the majority report little time being allocated to it in their training programs.Purpose The objective of this study was to delineate the long-term impact of pediatric convulsive status epilepticus (CSE) on health-related quality of life (HRQOL) in children recently diagnosed with epilepsy. Methods Children with
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Conclusion For the first time, we found the region of β6 core promoter and demonstrated the binding sites for transcription factors such as Ets-1 and STAT3, which are important for integrin β6 promoter transcription activity. These findings are important for investigating the mechanism of integrin β6 activation in cancer progression.Background Colorectal cancer (CRC) is a worldwide problem, which has been associated wit
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Pulses (e.g., lentil, common bean, chickpea, and dry pea) are linked to a myriad of positive human and environmental health impacts, making them an ideal food for wise and conscientious global citizens. In addition, pulses are affordable and shelf-stable. The combination of these factors, an elevated consumer interest in plant-based diets, and the COVID-19 pandemic resulted in increased purchasing
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هل سئمت من مشاكل الثلاجة التي تؤثر على جودة الطعام في منزلك؟ هل تبحث عن طرق فعالة لصيانة ثلاجاتك؟ إذاً، أنت في المكان الصحيح! في هذا المقال، سنتحدث عن كل ما تحتاج معرفته حول صيانة الثلاجات، وسنقدم لك أسرار الصيانة الاحترافية لتضمن لك أداءً ممتازًا لجهازك. كما سنشير أيضًا إلى وصيانة تكييفات لتحقيق بيئة منزلية مثالية. فلنبدأ!
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هل تساءلت يومًا لماذا تتعرض ثلاجتك لبعض المشاكل رغم أنك تعتني بها جيدًا؟ تعتبر صيانة ثلاجات المنزل من الأمور الأساسية التي تضمن لك كفاءة عالية وأداء ممتاز. عندما نتحدث عن صيانة الثلاجات، يجب أن نتذكر أن هذا الجهاز هو قلب المطبخ، حيث يحفظ الطعام ويضمن بقاءه طازجًا لفترة أطول. لذلك، في هذا المقال، سنستعرض لك 7 نصائح فعالة لصيانة ثل
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These commonalities led to a recurrence and exacerbation of initial symptoms. This finding should be shared with those involved in the care system for victims’ mental health suffering from a large-scale disaster, and we need further research about the issue.
PTSD may occur not only in those who experience the actual life-threatening like ICU admission but in those who experience the atmospheric change of so
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The surfactant adsorption at the djurleite-water interface makes the sulfide surface hydrophilic at acidic pH and hydrophobic at neutral and basic pH. In addition, ASL has strong affinity to copper sulfide and demonstrates metal leaching properties. Finally, ASL demonstrates detergenc
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هل تساءلت يومًا لماذا لا تبرد ثلاجتك كما ينبغي؟ هل تشعر بالقلق من ارتفاع فواتير الطاقة بسبب أعطالها المتكررة؟ إذا كانت الإجابة بنعم، فأنت لست وحدك! تُعتبر الثلاجات من الأجهزة الأساسية في كل منزل، وصيانتها بشكل دوري أمر ضروري للحفاظ على أدائها الأمثل. في هذا المقال، سنقدم لك 7 نصائح ذهبية لصيانة ثلاجاتك، إلى جانب بعض النصائح حول صيانة غسالات وصيانة تكيي
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recommended during hospitalization.
Initiation, promotion, progression, and metastasis of mammary tumors are mediated by dysregulation of multiple genes involved in various signaling pathways. Expressional variation of these molecules significantly influences cancer cell proliferation in breast cancer.
In the current study, tumor necrosis factor-alpha (TNF
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Combining FND cauterization with VEGF TrapR1R2 treatment prevented the undesired effect of the FND procedure alone and significantly better regressed corneal blood and lymphatic vessels at 1 week after the treatment compared to monotherapy and control group (p less then 0.01).Nonhereditary factors play an important role in the occurrence of congenital heart disease (CHD). This study was to explore the possible parental nonhereditary expos
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15 ± 0.016 N, n=3; p=0.0015). Eyelet fracture location corresponded to tensile strength. The lens in air withstood greater tensile stress.
Stress is placed on different regions of the eyelet with each suturing method. Simple pass may withstand greater tension and decrease risk for lens fracture, but the operating surgeon must consider multiple factor
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The prolonged PFS and OS were significantly associated by the clearance of HE4 after 3rd cycle chemotherapy (p< 0.0001, p< 0.0001) as well as CA125 after 1st cycle chemotherapy (p< 0.0001, p< 0.0001).
Our data suggested that the early clearance of HE4 and CA125 could predict platinum response and prognosis in patients with ovarian cancer. Monitoring
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المقدمة
هل سبق لك أن فتحت ثلاجتك لتجد أن الطعام لم يعد بارداً كما كان؟ أو هل شعرت بالقلق من أن الثلاجة قد تتعطل في أي لحظة؟ إن صيانة الثلاجات هي أمر أساسي لضمان أداء الأجهزة المنزلية بشكل فعال وطويل الأمد. في عالمنا اليوم، حيث تؤدي الثلاجات دورًا محوريًا في حياتنا اليومية، يجب أن نكون على دراية بأهمية الصيانة الدورية. في هذا المقال، سنستكشف أفضل النصائح وال
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<0.001).
The failure to show a sustained reduction in vitamin D testing is a common finding with demand management strategies to limit test requesting. More significant is the failure of the intervention to improve the detection of vitamin D deficiency. These failures highlight the need for better tools to manage test requesting including the
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The present findings suggest that DCE-integrated MR-PET provides a reliable, non-invasive, quantitative assessment of tumor angiogenesis; can guide the use of angiogenesis inhibitors toward longer survival; and will play an important role in the personalized treatment of NSC
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This compound could lead to a better understanding of how a bitopic D3 dopamine receptor selective ligand might lead to the development of pharmacotherapeutics for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease.When agricultural automation systems are required to send cultivation field images to the cloud for field monitoring, pay-as-you-go mobile communication lead
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Decreased expression of PTEN, as well as increased expression of Nox4, miRNA-214, PDK1, phosphorylated Akt, mTOR, and mTORC1, was detected. These abnormalities were partially restored by XST treatment. Thus, XST ameliorated podocyte apoptosis partly through modulating the PTEN-PDK1-Akt-mTOR pathway. These novel findings might point the way to a natural therapeutic strategy for treating DKD. Copyright © 2020 R
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ttee of the National Research Centre in Egypt (NRC) under the registration number 15225.
The authors declare no competing financial interests.
The authors declare no competing financial interests.
Mining, waste disposal, and agrochemical residues have contributed to pollution of water and soil with toxic metals in most low- and middle-income countrie
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Tumors with seizures as primary mode of presentation are collectively called Long-term epilepsy associated tumors (LEATs or Epileptomas). The overall survival is good so ‘seizure outcome’ becomes the primary goal rather than neuro-oncological outcome.
A retrospective analysis of our surgical database (2015-19) was done to find operated patients of intra-axial b
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Carotenoids color many of the red, orange and yellow ornaments of birds and also shape avian vision. The carotenoid-pigmented oil droplets in cone photoreceptors filter incoming light and are predicted to aid in color discrimination. Carotenoid use in both avian coloration and color vision raises an intriguing question is the evolution of visual signals and signal perception linked through these pigments? H
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n in these patients is related to their degree of kidney function impairment.
Osteoarthritis (OA) is a common musculoskeletal disease characterized by pain, stiffness, limited activity, occasional effusion, and local inflammation. MiR-146 is one of the noncoding RNA closely related to OA, but the role of miR-146 in OA remains controversial. The tumour necrosi
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Six compounds showed no violations as per Lipinski rule. Bioactivity prediction states that all the compounds may act through enzyme inhibition. The results of in silico studies suggest that out of the eleven selected phytochemicals isorhamnetin and pinocembrin have more drug likeliness properties and lesser in silico toxicity with more binding affinity than artemisinin on all receptors. CONCLUSION These findings indicate
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This in-vitro study evaluated and compared the effect of white henna (WH) and natural henna (NH) addition on Candida albicans adhesion and physical properties of the denture base material.
A total of 243 acrylic resin specimens (9 per group) were divided as follows 81 for flexural strength, 81 for Candida albicans adherence test, and 81 for surface roughness, translucency, and hardne
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<0.001).
The failure to show a sustained reduction in vitamin D testing is a common finding with demand management strategies to limit test requesting. More significant is the failure of the intervention to improve the detection of vitamin D deficiency. These failures highlight the need for better tools to manage test requesting including the
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Illustrate patterns of patient problem information received and documented across the home health care (HHC) admission process and offer practice, policy, and health information technology recommendations to improve information transfer.
Observational field study.
Three diverse HHC agencies using different commercial point-of-care electr
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هل سبق لك أن واجهت مشكلة في ثلاجتك، أو غسالتك، أو حتى تكييف الهواء في يوم حار؟ إذا كان الأمر كذلك، فأنت لست وحدك! تعتبر الأجهزة المنزلية جزءاً أساسياً من حياتنا اليومية، وعندما تتعطل، يمكن أن تسبب الكثير من الإزعاج. في هذا المقال، سنتحدث عن كيفية ضمان فعالة، بالإضافة إلى تقديم نصائح حول صيانة غسالات وتكييفات. دعنا نبدأ!
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The tensile crack propagated stably at ~ 0.05 times the Rayleigh wave speed cR. We observed an unstable failure pattern of the coal samples that was characterized by the ejection of small pieces from the coal specimen surface. This behavior is attributed to the strain energy that is stored in the rock specimen, which releases when the coal fails. The excessive strain energy transitions into dynamic energy during coal failur
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This study aims to examine whether miR-448 reverses the cisplatin (DDP) resistance in lung cancer by modulating SATB1. QRT-PCR and immunohistochemistry were used to examine the miR-448 and SATB1 expressions in DDP-sensitive and -resistant lung cancer patients. A microarray was used to investigate the cytoplasmic/nucleic ratio (C/N ratios) of genes in A549 cells targeted by miR-448, followed by Dual-luciferase re
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These findings indicated that wheat germ agglutinin renders ciliary beats visible, which is valuable for observing human airway ciliary movements in situ.Established electrodecarboxylative etherification protocols are based on Hofer-Moest-type reaction pathways. An oxidative decarboxylation gives rise to radicals, which are further oxidised to carbocations. This is possible only for benzylic or otherwise s
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Epilepsy is a devastating neurological condition exhibited by repeated spontaneous and unpredictable seizures afflicting around 70 million people globally. The basic pathophysiology of epileptic seizures is still elusive, reflecting an extensive need for further research. Developing a novel animal model is crucial in understanding disease mechanisms as well as in assessing the the
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The giant protein titin forms the “elastic” filament of the sarcomere, essential for the mechanical compliance of the heart muscle. Titin serves a biological spring, and therefore structural modifications of titin affect function of the myocardium and are associated with heart failure and cardiomyopathy.
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The adoption and evaluation of good practices in food handling in food service are essential to minimizing foodborne diseases. The present study aimed to evaluate food safety knowledge, attitudes, and practices of food handlers in schools in Vitória, Brazil.
A cross-sectional study was carried out in the school food services of the municipal network of Vitória-ES. The sample of
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Incubator is a medical device that provide a climatic environment for a newborn and a preterm infant. In the incubator environment, especially, the temperature significantly increases the survival rate of infants. In this study, the incubator air temperature, temperature uniformity and infant skin temperature were measured and controlled with conventional methods and FBG based temperature sensors, and their res
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With a growing global population and increased environmental concerns around animal agriculture, it is essential to humanely maximize animal performance and reduce environmental emissions. This study aims to determine the efficacy of feeding ractopamine hydrochloride (RAC), an orally active, β 1-adrenergic agonist (β1AA), to feedlot steers in the last 42 d of finishing to reduce ammonia (NH3) emissions and improve ani
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Perfluorooctanesulfonate (PFOS) as an accumulative emerging persistent organic pollutant in crops poses severe threats to human health. Lettuce varieties that accumulate a lower amount of PFOS (low-accumulating crop variety, LACV) have been identified, but the regarding mechanisms remain unsolved. Here, rhizospheric activation, uptake, translocation, and compartmentalization of PFOS in LACV were investigated in compar
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5 and 92 µg/ml respected to various Gram-positive bacteria. Similarly, the drug resistant bacteria were also inhibited by pp-Nisin (MIC ranged between 15 and 175 µg/ml). All samples of ppnisin exhibited auto induction ability. Taxonomic identification of the nisin producers was done by whole genome sequencing which reveals that cultures belongs to Lactococcus lactis ssp. lactis. Also it was found that Lactococcus lactis
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A metastatic mesenteric mass is a hallmark of small intestinal neuroendocrine tumours (SI-NETs). However, little is known on its development over time. Therefore, we conducted a study to assess the evolution of a SI-NET-associated mesenteric mass over time.
Retrospectively, 530 patients with proven SI-NET were included. The presence and growth of a mesenteric mass w
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To evaluate whether the pretreatment apparent diffusion coefficient (ADC) measured with diffusion weighted imaging (DWI) of tumor can be used as an imaging biomarker for predicting prognosis in solitary large hepatocellular carcinomas (HCCs) treated with transcatheter arterial chemoembolization (TACE) immediately combined with radiofrequency ablation (RFA).
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Rapid elimination of Plasmodium falciparum malaria in Cambodia is a goal with both national and international significance. Transmission of malaria in Cambodia is limited to forest environments, and the main population at risk consists of forest-goers who rely on forest products for income or sustenance. The ideal interventions to eliminate malaria from this population are unknown.
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Experimental measurements of NMIIA densities at the dimple and rim validate our prediction that (a) membrane forces must be non-uniform along the RBC membrane and (b) the force density must be larger in the dimple than the rim to produce the observed membrane curvatures. Furthermore, we predict that RBC membrane tension and the orientation of the applied forces play important roles in regulating this force-sha
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Various temperatures may have different effects on the distribution of paramphistomes that cause amphistomosis in cattle, including Fischoederius elongatus. Therefore, this study aimed to investigate the effects of different temperature treatments on F. elongatus hatching, with specific identification using morphological, histological, and phylogenetic analysis. All specimens were collected from two buffalo (Bubalus bub
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Tigecycline (TGC) is one of the last-resort therapeutic agents for treating infections caused by extensively drug resistant Acinetobacter baumannii isolates. Although resistance to TGC is not common, non-susceptible A. baumannii (NSAB) isolates have been described. In the current study, we aimed to assess the molecular mechanisms mediating TGC non-susceptibility in 5 clinical isolates of A.
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Typhoid fever is endemic in developing countries like India. An increasing prevalence of resistance to cephalosporins and fluoroquinolones by Salmonella isolates is seen. We present an 8-month-old boy with invasive Salmonella typhi disease. Blood culture showed S. typhi sensitive to ampicillin-sulbactam and cotrimoxazole but resistant to fluoroquinolones and third-generation cephalosporins
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We propose that, after the non-skeletogenic commitment, the EMM is divided into dermis and meninges by E11.5 in normal development. Two distinct responses of the EMM, chondrogenesis and osteogenesis, to Dlx5-augmentation in the NCCDlx5 strongly support this idea.Host plant attributes are essential factors determining the population dynamics of herbivorous insects. The developmental
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Multiple regression modelling was used to determine the association between HLS-14 and CSHQ-J scores.
Of the 354 parents, 255 (72%) were in the high HL group and 99 (28%) in the low HL group. The mean CSHQ-J score was significantly lower in the high HL group than in the low HL group (45.3 ± 6.0 points vs. 46.8 ± 5.9 points, p = 0.043). In multiple regression analyses, par
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Fasciola hepatica has been shown to have a high capacity for immunomodulation of the host response, making the development of protective vaccines extremely difficult. One of these immunomodulation mechanisms is the impairment of dendritic cells (DC) maturation and, therefore, suppression of antigenic presentation. The aim of this study was to evaluate the pathological changes as well as the characterization of two
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s, negative MRI finding, and inability to modify the surgical plan when indicated.
Intraoperative ECoG serves as a reliable tool to guide resection and may inform the prognosis for seizure freedom in pediatric patients undergoing epilepsy surgery. ECoG-based modification of the surgical plan is associated with a higher rate of minor complications. Children in whom ECoG-based mod
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This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13 years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7.5 years) were studied at baseline and multiple time points over 13 years. The incidence of TKR and THR was determined by data linkage to N
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Left ventricular assist devices (LVADs) have changed the landscape of treatment options for patients with end stage heart failure. Due to the limited availability of donor hearts for transplantation, LVADs have become an important option for many of these patients. Much progress has been made in the device industry since then, and newer devices continue to improve patient outcomes. In this review,
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Given the high participation of Black/African American individuals in high school sports, especially high-risk sports for concussion, it is important to note if racial and socioeconomic status (SES) differences exist in baseline performance on clinical measures of concussion.
To explore the association between race and SES on baseline concussion assessments of neurocognit
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Nipple sparing mastectomy with free tissue transfer for breast reconstruction offers excellent aesthetic outcomes but poses a challenge in monitoring the buried flap. Venous anastomotic flow couplers directly monitor buried flaps without the need for monitoring skin paddles. In a two year period we used the Synovis GEM™ flow coupler on 24 DIEP flaps. In our practice, flow couplers are effective in monitoring buried fre
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TP may be associated with epidemiological, environmental and systemic disorders of patients suffering from this condition. Conservative surgical removal continues to be the first choice treatment when the TP must be removed. Further studies are considered necessary to elucidate the etiological factors.
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The mean distribution of preoperative obstruction level could be divided into the following 38% velar, 46% multilevel, and 16% infravelar obstructions. Patients with a good treatment response (defined as AHI < 15/h and AHI reduction of 50%) had fewer preoperative velar obstructions compared to non-responder (17% vs. 54%, p-value = 0.006). In patients measured after sHNS implantation, a significantly higher rate of mul
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ation in patients with Gerstmann-Sträussler-Scheinker disease and implies that the C-terminus of PrPSc is dispensable for infectivity and strain features for this prion strain, uncovering the central PrP domain as the minimal molecular component able to encode infectious prions. These findings are consistent with the hypothesis that non-fibrillar prion particles are highly efficient propagators of
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The current study examined the concentrations of ten trace elements (TE) (nickel, chromium, cadmium, iron, zinc, manganese, aluminum, copper, selenium and lead) in the edible tissue of the Ark shell Arca noae (L. 1758) from a Mediterranean coastal lagoon, the Bizerte lagoon during 2013-2014. The analysis of several redox status biomarkers, metallothioneins (MTs), malondialdehyde (MDA), glutathione peroxidase (GP
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Retrospective and single-arm prospective studies have reported clinical benefit with neoadjuvant imatinib for GISTs. In the absence of randomized Phase III data, the impact of neoadjuvant systemic therapy (NAT) on survival compared to upfront resection (UR) remains unknown. We identified N = 16 308 patients within the National Cancer Database (2004-2016) who underwent resection of localized GIST of the stomach
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Compound fault diagnosis is challenging due to the complexity, diversity and non-stationary characteristics of mechanical complex faults. In this paper, a novel compound fault separation method based on singular negentropy difference spectrum (SNDS) and integrated fast spectral correlation (IFSC) is proposed. Firstly, the original signal was de-noised by SNDS which improved the noise re
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Given the high participation of Black/African American individuals in high school sports, especially high-risk sports for concussion, it is important to note if racial and socioeconomic status (SES) differences exist in baseline performance on clinical measures of concussion.
To explore the association between race and SES on baseline concussion assessments of neurocognit
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Introduction Understanding and meeting the patients’ preoperative expectations for anterior cruciate ligament (ACL) reconstruction (ACLR) is critical for achieving successful patient-centered outcomes. There is currently no standardized method to assess preoperative expectations of ACLR based on the patient-derived methods. The purpose of this study was to develop and test a patient-derived patient expectations sur
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More research is needed to better elucidate both the OIT-related and patient-related factors that may predispose individuals to develop EoE. The presence of comorbid conditions and/or preexisting subclinical esophageal eosinophilia may account for some of cases of EoE identified during OIT.
EoE is a rare but concerning side effect of OIT. More research is needed to better elucidate both the OIT-related and patient-r
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Our work highlights the role of MTase as a unique intra-molecular initiation factor specifically only through the JEV-mode conformation, providing an example of conformation-based crosstalk between naturally fused protein functional modules.Susceptibility of plants to abiotic stresses, including extreme temperatures, salinity and drought, poses an increasing threat to crop productivity worldwide. Here the drought-induce
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This study evaluates the effects of light irradiation on the profiles of headspace volatiles, such as formaldehyde and acetaldehydes, which are harmful chemicals. Generally, the levels of total headspace volatiles decreased during storage, while those of acetaldehyde and formaldehyde increased markedly in white wine. This increase in aldehyde levels suggests that wines should not be exposed to light irra
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Huntington’s disease (HD) is a devastating neurodegenerative disorder caused by an aberrant expansion of the CAG tract within the exon 1 of the HD gene, HTT. HD progressively impairs motor and cognitive capabilities, leading to a total loss of autonomy and ultimate death. Currently, no cure or effective treatment is available to halt the disease. Although the HTT gene is ubiquitously expressed, the striatum appears to be th
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How well could one predict the growth of a leafy crop from reflectance spectra from the soil and how might a grower manage the crop in the light of those predictions? Topsoil from two fields was sampled and analysed for various nutrients, particle-size distribution and organic carbon concentration. Crop measurements (lettuce diameter) were derived from aerial-imagery. Reflectance spectra were obtained in the
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m flap and dermofat graft transplantation. The lower lip and mandible defects of the second patient were reconstructed with a combination of submental flap and fat grafting. The transplanted dermofat graft, fat graft, the microvascular free flap, and the submental flap survived completely and maintained adequate tissue volume and facial contour during the follow-up time of 2 years. Both patients were satisfied
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Microcystins (MCs) produced by cyanobacteria pose serious threats to human health. However, the contribution of long-term exposure to MCs to the development of nonalcoholic fatty liver disease (NAFLD) remains poorly documented. In this study, we estimated the environmental uptake of MCs by a small population of fishers who have lived for many years on Meiliang Bay of Lake Taihu, where cyanobacterial blooms
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81mg/L are predictors for preoperative DVT. More attention is warranted to prevent preoperative DVT when two or more predictors are present.Background Endovascular clot retrieval (ECR) is the standard of care for acute ischaemic stroke caused by large vessel occlusion. Reducing stroke symptom onset to reperfusion time is associated with improved functional outcomes. This study aims to develop a computat
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0 and 24.5 months, respectively, for upfront surgery. OS was significantly improved with -SM compared with +SM in both groups (p=0.006). When resection yielded +SM, NACRT patients had improved OS compared with upfront surgery patients (p<0.001). On multivariable analysis, +SM in the upfront surgery group (hazard ratio [HR] 2.94, 95% confidence interval [CI] 2.04-4.24; p<0.001) and older age (HR
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stigation in prospective studies to validate this particular association. The study was registered in OSF registries DOI’s 10.17605/OSF. IO/D95GN.
Stroke is responsible for the largest proportion of neurological disorders causing a significant morbidity. Gamma-glutamyl transferase (GGT) enzyme has an active involvement in atherosclerosis through its role in oxidative and inflammatory mechanis
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Values of DDx, Hg, Pb, and Cu above the PECs in lake sediments and/or in the outlet show potential risk for aquatic organisms. Results highlight the key role of tributaries in driving contamination from the watershed to the lake through sediment transport.A long-duration laboratory study spanning more than 6 months was conducted to evaluate the effect of operating mode on the performance of sand filt
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The rationale for this document is to outline a systematic approach describing how to apply the existing guidelines to questions on cardiac structure and function specific to the intraoperative environment in open, minimally invasive, or hybrid cardiac surgery procedures.The grave clinical context of the coronavirus disease 2019 (COVID-19) pandemic must be understood. Italy is immer
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BACKGROUND Long non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy. However, the vast majority of lncRNAs have not been tested as potential therapeutic targets, particularly in the context of currently used cancer treatments. Malignant glioma is rapidly fatal, and ionizing radiation is part
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Since sexual health education (SHE) is not mandatory in Italian schools, we conducted a survey on freshmen of four Italian university campuses in 2012 to investigate the respective level of sexual health knowledge (SHK) in relation to birth control, with the aim to inform public health policy makers. A convenience strategy was employed to sample 4,552 freshmen registered with various u
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Cell lines are powerful tools for research into liver function at the molecular level. However, they are generally unsuitable for rigorously assessing the effects of amino acid composition, because many lines require serum-containing medium for their maintenance. Here, we aimed to investigate the effects of ornithine and arginine, which are included in the characteristic metabolic process in hepatocyte, on a human h
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The experimental results show that our approach significantly overcomes the accuracy of the original TSN and TSM algorithms by keeping real-time performance.In recent years, there has been rapid progress in the development of photonic devices based on lead halide perovskite nanocrystals since they possess a set of unique optical and charge transport properties. However, the main limiting factor for their subsequent applicat
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This study analyses the deterioration of mechanical properties in lightweight concrete after exposure to room temperature (20 C) and high temperature, i.e., up to 1000 C, including changes in visual appearance, loss of mass, and compressive strength. All-lightweight shale ceramsite aggregate concrete (ALWAC) and semi-lightweight shale ceramsite aggregate concrete
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Study groups were comparable with respect to all outcome measures at entry (P > 0.05). Within group comparison showed significant improvements in all measured variables. Further, between groups comparison revealed significant higher improvements (P < 0.05) in right and left feet Staheli’s arch index, navicular drop as well as the radiographic indexes in favor of the intervention group.
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mbolysis was significantly associated with favorable clinical outcome and successful recanalization in the group with a medial ICAC pattern, but not in the group with an intimal ICAC pattern.
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79 ± 1.58 Hounsfield units) than group A (4.81 ± 1.53 Hounsfield units). Radiation dose and contrast media were lower in group B (1.98 ± 0.92 mSv) (89.51 ± 15.49 mL) compared with group A (2.77 ± 1.03 mSv) (100 ± 1.00 mL). Receiver operating characteristic curve demonstrated increased reader in group B (95% confidence interval, 0.524-1.0) than group A (95% confidence interval, 0.545-1.0). Group B had increased reven
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The present study was performed to explore the immunotoxicological effects of the lambda cyhalothrin (LCH) insecticide and evaluate the efficiency of Thyme powder (TP) as a fish supplement in attenuation of LCH impact on Oreochromis niloticus (O. niloticus) fish. Fish was sampled following 30-days exposure to LCH (1/6 LC50 0.48 μg/L) and TP (2%) supplementation, individually or in combination. The
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Membrane proteins play important roles in health and disease. Despite their importance, the study of membrane proteins has been significantly limited by the difficulties inherent to their successful expression, purification, and stabilization once they have been extracted from the cell membrane. In addition, expression of human membrane proteins commonly requires the use of expensive and/or time-consumi
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Sleeping under an ITN reduces contact with mosquitoes through the combination of a physical barrier and an insecticidal effect, which reduces the incidence of malaria. The 2016-2020 Burkina Faso National Malaria Strategic Plan aims to have at least 90% of the population, 100% of children under age 5, and 100% of pregnant women sleep under an ITN.
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In subcellular accumulation and distribution of castor seedlings, Cd (27.1%-69.4%) and Zn (39.6%-66.6%) in the cell wall was the highest. With the increase of Cd addition, the accumulation of Cd increased in cell wall while decreased in organelle and soluble fraction. Hydroxyl, amino, amides and carboxyl functional groups on cell wall might provided the main binding sites for Cd and Zn. OBJECTIVE Neurocysticercos
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Alpha-lipoic acid (ALA)-containing dietary supplements are widely used in clinical practice, although their safety assessment is under-inves
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043; P=0.040; and P=0.011, respectively). Blood eosinophilia showed positive correlations with FeNO (P=0.004) and spirometry variables (FEV₁ [% predicted], P=0.003; FEV₁, P less then 0.001; and FVC, P less then 0.001). An FeNO level of 22.5 ppb was the best cutoff value to predict blood eosinophilia (P=0.000). CONCLUSIONS Blood eosinophil count is a likely biomarker that can predict positive relationship with FeNO values and pulm
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74 [95% CI 1.71-4.37]). Preadolescents who reported PEs had higher average total healthcare costs over the following 5 years. The costs for individuals with PEs were higher for mental healthcare services across primary to tertiary care, but not for somatic care. After adjustments, PEs remained independently associated with higher costs and poorer HRQoL, but not with poorer school performance. In conclusion, PEs
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Primitive neuroectodermal tumours (PNETs) are rare malignant small round cell tumours. Notably, despite widespread reports of PNET in multiple parts of the body, it is extremely rare in the pelvis. Here, a rare case of giant PNET of the pelvis, that was treated with surgical intervention comprising hemipelvectomy and amputation, is reported. A 42-year-old female patient presented with an enlarged mass on the left
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Computed tomography (CT) and magnetic resonance imaging (MRI) are both capable of predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC). However, which modality is better is unknown.
To intraindividually compare CT and MRI for predicting MVI in solitary HCC and investigate the added value of radiomics analyses.
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I. Conclusion Taken together, our study revealed an up-regulated circRNA, circTLK1, could exacerbate myocardial IRI via targeting miR-214/RIPK1-mediated TNF signaling pathway, which may provide therapeutic targets for treatment.Cd2+ is one of the most widespread environmental pollutants and its accumulation in central and peripheral nervous systems leads to neurotoxicity as well as aggravation of common
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damicornis corals, indicating that this is a promising technique for administering coral probiotics in situ. Studies to track the delivery of probiotics through carriers such as B. plicatilis, and the provision or establishment of beneficial traits in corals are the next proof-of-concept research priorities.Production of volatile fatty acids (VFAs), fundamental building blocks for the chemical industry, depends on fossil fuel
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In the modern-day era of automotive innovation, car keys have actually developed from simple metal devices to advanced electronic tools. This development has caused a new set of obstacles and chances for car owners, particularly when it pertains to ca
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This study investigated the damage prevention potential range of anodized 5083-H321 aluminum alloy under a cavitation-erosion environment in seawater. Various applied potential conditions were determined through the cathodic polarization experiment. Then cavitation-erosion experiments were conducted with the applied potentials and the current density, weight loss, and surface damage depth were analyzed. The results pre
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CONCLUSIONS The TRA can be considered a safe alternative to the TFA for neurointerventional procedures in the pediatric population and provides potential advantages. However, as pediatric patients require special consideration due to their smaller-caliber arteries, routine use of ultrasound guidance is advised when attempting the TRA.Small-bowel obstruction (SBO) and volvulus as a result of ventriculoperitoneal shunt
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The LMs internalization and immune activation of BMDCs were blocked in the presence of cytochalasin, filipin III and chlorpromazine, which demonstrated that internalization of LMs by BMDCs is a key process for the LMs induced immune activation of BMDCs.
The results obtained support the further evaluation of LMs as a mycobacterial vaccine, adjuvant, and in immunotherapy
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Here, we present measurements on some simple metallic systems an unconsolidated aggregate of aluminum beads under a confining pressure, an aluminum bead confined between two aluminum plates, and a steel bead confined between steel plates. Ultrasonic waves are used as probes of the systems, and changes are assessed with coda wave interferometry. Three different methods of low-frequency conditioning are applied; all r
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Candida albicans (C. albicans) infection shows a growing burden on human health, and it has become challenging to search for treatment. Therefore, this work focused on the antifungal activity, and cytotoxic effect of biosynthesised nanostructures on human ovarian tetracarcinoma cells PA1 and their corresponding mechanism of cell death. Herein, the authors fabricated advanced biosynthesis of uncoated α-Fe2O3 and coated
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No differences in carriage of methicillin resistant Staphylococcus aureus were detected. This study showed that patients with declared β-lactam allergy had a higher risk of ESBL carriage in ICU at admission and discharge. V.OBJECTIVES In the “REWIND” study, we sought to describe the real world clinical and prescribing practice of urinary tract infections (UTI) management in Italy, Belgium, Russia, and Brazil, in orde
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This generic mechanism serves as a paradigm for finding topological quasiflat bands in 2D crystalline materials and metamaterials.We study dispersive optical nonlinearities of short pulses propagating in high number density, warm atomic vapors where the laser resonantly excites atoms to Rydberg P states via a single-photon transition. Three different regimes of the light-atom interaction, dominated by eithe
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Eria corneri is a perennial epiphytic orchid distributed in southeastern China with high value of ornamental and medicinal. In this study, the complete chloroplast genome sequence of E. corneri was determined from Illumina pair-end sequencing data. The complete chloroplast genome sequence of E. corneri is 150,538 base pairs (bp) in length, including one large single-copy region (LSC, 85,941 bp), one small single-copy region (
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Birmingham, the dynamic heart of the West Midlands, is known for its rich commercial heritage and diverse architectural landscape. Amongst its numerous trades, glazing stands out as an important service, using both aesthetic and useful opti
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Objective To confirm the direct projection pathway between the medial vestibular nucleus (MVN) and vestibular efferent (VE) neurons and explore its electrophysiological characteristics. Methods Newborn [(9±1) day-old] male and female Wistar rats were used in the study. The postsynaptic currents of VE were recorded after stimulating neurons in MVN by the whole-cell patch clamp recording technique. The action pote
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Tacrolimus (TAC), a calcineurin inhibitor, and everolimus (EVL), an mTOR inhibitor, have been used as immunosuppressive (ISS) drugs in post-kidney transplantation therapy. The objective of this study was to compare the efficacy of EVL vs TAC in the ISS maintenance triple therapy. Ninety-seven kidney transplant patients, who received triple maintenance therapy with TAC, mycophenolate mofetil (MMF), and methyl prednisone (PRED)
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r and extension of time, the demineralized collagen fibrils were destroyed in varying degrees. The collagen fibrils were curled, fractured, fused, and even disappeared. Conclusions NTAPP could significantly increase the surface temperature, modify dentine wettability and alter the micro structure, which was significantly influenced by input power, gas flow rate and treating time.Objective To investigate the relationship between pa
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Microcomputed tomography and morphometric analysis revealed that a four-week oral administration of LLEP notably decreased trabecular bone loss. Taken together, our results suggest that LLEP can mitigate estrogen deficiency-induced bone loss by suppressing osteoclastogenesis, which makes it an excellent candidate for combating osteoporosis.Objective Finger systolic blood pressure measurement (FSBP) has been shown h
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Introduction Over the past decades, a large amount of both adult and pediatric data has shown relationship between Nonalcoholic Fatty Liver Disease (NAFLD) and chronic kidney disease (CKD), resulting in an overall increased cardiometabolic burden. In view of the remarkable role of the genetic background in the NAFLD pathophysiology, a potential influence of the major NAFLD polymorphisms (e.g. th
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First contemporary individual negotiation registered from the Iberian hinterland took place through Heinrich Stadial Two inside of unpleasant environment situations.
BACKGROUND Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found
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The absorption-enhancing effects of MA on DTX-PLip-MS were further confirmed by in vivo imaging. The above findings suggest that MA served as a new and efficient absorption enhancer for DTX-PLip-MS.HIGHlIGHTSIn this study, malic acid as a new absorption enhancer for DTX in polymer-liposome (PLip) embedded in pH-sensitive microspheres (MS) was found for the first time.The malic acid could significantly enhance oral bi
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Personnel with predeployment psychiatric diagnoses had a statistically significant higher risk for both postdeployment long-term sickness absence, hazard ratio (HR) = 2.06, 95% CI [1.52, 2.80]; and postdeployment MHPs, HR = 2.38, 95% CI [1.73, 3.27], than personnel without a predeployment psychiatric diagnosis. Personnel with a predeployment psychiatric diagnosis demonstrated a higher risk of reporting high levels of
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I. Conclusion Taken together, our study revealed an up-regulated circRNA, circTLK1, could exacerbate myocardial IRI via targeting miR-214/RIPK1-mediated TNF signaling pathway, which may provide therapeutic targets for treatment.Cd2+ is one of the most widespread environmental pollutants and its accumulation in central and peripheral nervous systems leads to neurotoxicity as well as aggravation of common
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Bones are the third most common site of metastasis, although bone metastasis (BM) incidence varies widely. This study investigated the incidence of BM in the most common cancers in Taiwan to present the recent treatment landscape in patients with organ-specific cancers.
Data from the National Health Insurance Research Database of Taiwan were used to identify a
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SurA is thought to be the most important periplasmic chaperone for outer membrane protein (OMP) biogenesis. Its structure is composed of a core region and two peptidylprolyl isomerase domains, termed P1 and P2, connected by flexible linkers. As such these three independent folding units are able to adopt a number of distinct spatial positions with respect to each other. The conf
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This study describes a double-blind randomized placebo-controlled phase I clinical trial in healthy adults of a new potential pandemic H7N9 live attenuated influenza vaccine (LAIV) based on the human influenza virus of Yangtze River Delta hemagglutinin lineage (ClinicalTrials.gov Identifier NCT03739229). Two doses of H7N9 LAIV or placebo were administered intranasally to 30 and 10 subjects, respectively. Th
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Over the past decade, there has been increasing evidence highlighting the implication of the gut microbiota in a variety of brain disorders such as depression, anxiety, and schizophrenia. Studies have shown that depression affects the stability of gut microbiota, but the impact of antidepressant treatments on microbiota structure and metabolism remains underexplored. In this study, we investigated the in vitro antimicr
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Matrix metalloproteinase 9 (MMP-9) is an extracellularly operating zinc-dependent endopeptidase that is commonly expressed in the brain, other tissues. It is synthesized in a latent zymogen form known as pro-MMP-9 that is subsequently converted to the active MMP-9 enzyme following cleavage of the pro-domain. Within the central nervous system, MMP-9 is localized and released from neurons, astrocytes and microglia where i
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Background Several studies have linked type 2 diabetes (T2D) to an increased risk of developing Alzheimer’s disease (AD). This has led to an interest in using antidiabetic treatments for the prevention of AD. However, the underlying mechanisms explaining the relationship between T2D and AD have not been completely elucidated. Objective Our objective was to examine cerebral 18F-fluorodeoxyglucose (FDG) uptake during
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It requires research in our country and development of programs in Spanish, or adaptation of those of other countries, to test the effectiveness in our health system and to study, in turn, the cost-efficiency. But it is proven to be effective in reducing depressive symptoms and must be study as a possible tool to be introduced in the management of depression in non-specialized care.The intravaginal route of admin
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Results Disappearance of pain and/or swelling, gaining chewing ability, absence of complications, post-operative appearance, and tidiness and organisation of the clinic were found to be significantly associated with patients’ assessment. None of the factors related to the treating dentist were significant.Conclusions Patients may share the same perception about their treatment outcome as their dentists. A
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This article focuses on the amino acid sensing pathways through which host cells sense the availability of amino acids and reprogram the host translation machinery to mount an effective antiviral response. Besides, how SARS-CoV-2 hijack and exploit amino acid sensing pathway for its replication and pathogenesis is also discussed.Paragangliomas in the diaphragm are extremely rare. We report the case of a 27-year-old wo
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Gingival hyper-pigmentation is an esthetics problem in patients with excessive gingival display. Laser ablation has been suggested recently as the most effective, pleasant, and reliable technique for gingival depigmentation compared to blade surgery.
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Twelve of the 20 patients who underwent treatment using Gelfoam showed improvement in hearing (measured as a reduction in hearing threshold), while only 7 of the 20 patients who underwent intratympanic injection showed such improvement. Among adverse reactions, the most common was pain (88%) which typically did not last beyond 3 days. Other adverse reactions observed were dizziness (24%) and headache (20%).
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More importantly, the rapid self-inflating characteristic of the scaffold in water, that is, the volume of hydrogel scaffold can increase to about 8 times that of their own in an hour and can generate a slight compressive stress on the surrounding host tissue, thus stimulating the reconstruction and growth of new bone tissues. The in vitro experiment indicates that the scaffold is nontoxic and biocompatib
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1-85.7%, 86.1-97.7%, 40.0-85.7%, 92.5-97.7% and 82-96%, respectively. The overall Kappa Cohen coefficient of agreement varied between 0.349-0.638 for EPE and between 0.507-0.668 for SVI. Conclusions Our results showed that 1.5T mp-MRI is a reliable method for local staging of prostate cancer, with good diagnostic performance in detecting EPE and SVI. The overall interobserver agreement rates between readers with the s
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Lifecourse, conditional change and change score growth models yield complementary inferences when appropriately interpreted. Future longitudinal studies of associations of early-life growth with later outcomes would benefit from adopting a causal mediation framework to integrate inferences from multiple complementary growth models.
Lifecourse, conditional change and change score growth model
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Gaining patient trust has been shown to improve health outcomes. Trust between the patient and the clinician starts with the clinician demonstrating empathy and positive attributes such as kindness and approachability. The advent of COVID-19 and the need for clinicians, patients, and caregivers to wear masks at all times has unintentionally limited nonverbal communication and potentially affected the ability
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Genetic engineering of human-induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC) may increase the risk of genomic aberrations. Therefore, we asked whether genetic modification of hiPSC-NSCs exacerbates chromosomal abnormalities that may occur during passaging and whether they may cause any functional perturbations in NSCs in vitro and in vivo.
The transgenic cassette wa
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Overall, our preliminary data highlight the underlying mechanism of TLE-HSTI, providing a new perspective for guiding treatment of TLE.
There are limited data on the risks and benefits of using andexanet alfa (AA) in comparison with four-factor prothrombin complex concentrate (4F-PCC) to reverse factor Xa inhibitors (FXi) associated intracranial hemorrhage (ICH). We sought to describe our e
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Rhodococcus spp. strains are widespread in diverse natural and anthropized environments thanks to their high metabolic versatility, biodegradation activities, and unique adaptation capacities to several stress conditions such as the presence of toxic compounds and environmental fluctuations. Additionally, the capability of Rhodococcus spp. strains to produce high value-added products has received considerable attentio
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However, the dropout rate was decreased for women, but not men, with low blood pressure and triglycerides. An improved understanding of the characteristics of participants and the cardiac rehabilitation dropout rate are expected to contribute to the development of cardiac rehabilitation strategies that decrease patient dropout.We characterized the gut microbial composition and relative abundance of gut bacteria in the
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Using IL-10 as a model protein, we successfully achieved nanomolar sensitivity. We confirmed that the shift of the extinction peak was improved by 450% due to plasmon coupling between AuNC and Au strip. We expect that the AuNC-assisted LSPR sensor platform can be utilized as a diagnostic tool by providing convenient and fast detection of the LSPR signal.Introduction Implementation science frameworks have helped advan
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Left-truncation poses extra challenges for the analysis of complex time-to-event data. We propose a general semiparametric regression model for left-truncated and right-censored competing risks data that is based on a novel weighted conditional likelihood function. Targeting the subdistribution hazard, our parameter estimates are directly interpretable with regard to the cumulative incidence function. We compare differen
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Long-term primary culture of mammalian cells has been always difficult due to unavoidable senescence. Conventional methods for generating immortalized cell lines usually require manipulation of genome which leads to change of important biological and genetic characteristics. Recently, conditional reprogramming (CR) emerges as a novel next generation tool for long-term culture of primary epithelium cells derived from
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The decrease in the level of GSH was measured on Cu + Pb exposure via both routes. Thus, all these enzymatic and non-enzymatic responses are sensitive to the metals tested and could serve as early warning indicators for assessing the effects of metal pollution in these species.Bisphenol-A is one of the most studied endocrine-chemicals, which is widely used all over the world in plastic manufacture. Because of
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To describe the first “arcuate sign” case series in the pediatric population, radiologic features of the associated injuries, management, and how they compare with the adult population.
Retrospective study included patients under 18 years of age wit
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RESULTS 44 (13%) patients had radiographic non-union and 301 (87%) were fused at 24 months post-op. At 24 months, PROs were similar between the two groups. Seven patients in the Nonunion group (16%) and 10 (3%) in the Fused group had additional surgery at the index level prior to the 24 -follow-up (p = 0.003). Over the 84-month follow-up a total of 9 patients in the Nonunion group (21%) and 22 (7%) in the Fused group
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11 cm and 0.01 cm respectively (p<0.001). Excellent rotation/lateral movement was observed in subjects at popliteal region and good rotation/lateral movement was observed at midthigh level.
Sciatic nerve movement can be observed with ankle dorsiflexion and plantar flexion in the transverse plane at popliteal and midthigh locations under real time ultrasound. This preliminary stud
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Evidence-based methods to lose weight are important in tackling increasing obesity trends in adult populations. More knowledge about persons who want to lose weight and do not/do need weight loss support is necessary to design effective preventive practices. Thus, the aim of the study was to investigate the prevalence of desire to lose weight in the general population and the prevalence of health problems and healt
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Approximately a quarter of patients admitted to ICU with AECOPD died during hospitalization, and these patients accrued significant costs. This study identifies important factors associated with poor outcome in this at-risk population, which has value in risk stratification and patient or family discussions addressing goals of care.
Approximately a quarter of patients admitted to ICU with AEC
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Due to their roles in controlling the COVID-19 epidemic, PCPs in China faced a series of barriers that affected them physically and mentally. Support for PCPs should help them to overcome these barriers and work efficiently. The current findings provide insight into the challenges and potential solutions for strengthening the pre
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Six years after pregnancy the prevalence of MS was 10.0%; the prevalence was higher for women with a previous placental syndrome (13.5%). Gestational triglycerides and remnant cholesterol in the highest quartile and HDL-c in the lowest quartile were associated with the highest risk for future MS, independent of smoking and body mass index.
Gestational lipid levels provide an insight i
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Na análise de regressão multivariada, quando se considerou a gravidade do caso pelo maternal severity score (pontuação de severidade materna, MMS, na sigla em inglês), houve uma grande redução da força de associação entre utilização de UTI e morte materna, além da inadequação do cuidado e não disponibilidade de UTI na instituição. Na avaliação considerando apenas os casos de maior gravidade (desfecho materno g
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The tests showed that the pozzolanic activity or R-MUD after three days is at the same level as silica fume and after 28 days it is twice as high as the activity of fly ash. Beyond the 180th day of curing, R-MUD had the same level of activity as fly ash. The summary is supplemented by calorimetric tests, which confirm the high reactivity of R-MUD compared to other commonly used concrete additives, already in the in
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There were discrepancies in the willingness by physicians to practice early SCD diagnosis and its uptake by mothers (p less then 0.0001). The commonest reason given by both the physicians and mothers for not practicing SCD prenatal diagnosis was the high cost of the procedure. Conclusion The perceptions and practice of early SCD diagnosis was suboptimal in the study locality. Scaling up awareness and universal c
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In 2016, World Health Organization guidelines conditionally recommended standardised shorter 9-12-month regimens for multidrug-resistant (MDR) tuberculosis (TB) treatment. We conducted a prospective study of a shorter standardised MDR-TB regimen in Karakalpakstan, Uzbekistan.
Consecutive adults and children with confirmed rifampicin-resistant pulmonary TB were enrolled between Septe
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An alternate strategy for measuring sepsis incidence, outcomes, and trends is to use objective and consistent clinical criteria rather than administrative codes or registries to identify sepsis. This is feasible using data routinely found in electronic health record systems, such as blood culture draws and sustained courses of antibiotics to identify infection and laboratory values, vasopressors, and mecha
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Good agreement between in vitro and FE-results was found for the changes in ROM before and after instrumentation. Good agreement for changes in ROM was obtained when varying the number of instrumented levels as well, indicating that the model can be a useful tool to evaluate the effects of construct composition variations. The present study was limited by the fact that only normal spine curvatures were analyzed and the fact t
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Next, wLSSVM optimized by LDWPSO forecasts each sequence separately. Finally, the final prediction result is obtained by adding all prediction results. For the purpose of verifying the effectiveness and superiority of the EEMD-LDWPSO-wLSSVM model, a total of 12 models were built to compare their performance in three regions of Guangdong, Hubei, and Shanghai respectively from three eva
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Leptospirosis, caused by pathogenic Leptospira species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production. Scavenger receptor A1 (SR-A1), one of the critical receptors mediating this process, plays a complicated role in innate immunity. However, the role of SR-A1 in the immune response against pathogenic Leptospira invasio
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Here, we conduct a comprehensive review and discussion of the bibliography available regarding the role of polyP in the mitochondrial dysfunction present in AD and PD. Taking into account the data presented in this review, we postulate that polyP could be a valid, innovative and, plausible pharmacological target against mitochondrial dysfunction in AD and PD. However, further research should be conducted to better un
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With the emergence of several new epidemics of viral infections – SARS, MERS, EBOLA, ZIKA, Influenza A (H1N1) pandemic,Covid-2019 – over the past 3 decades we suggest that a world-wide programme of stratospheric surveillance and space weather monitoring should be urgently put in place without further delay.
To evaluate the first-attempt success rates and complica
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Coleoptera is a mega-diverse order, but only about 1% of its species have been analyzed cytogenetically. In this order, the subfamily Alticinae presents many identification problems, mainly due to the occurrence of mimicry. The objective of this work was to cytogenetically characterize 3 very similar species of the genus Alagoasa (A. pantina, A.areata, and A.scissa). We used classical and molecular cytogenetic as
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The results show that AXT can be used to study lipids distribution in EC at various locations, suggesting its use as a universal probe for studying cellular lipids using Raman spectroscopy. The use of labeled Raman imaging of lipids in the EC of various organs could contribute to their easier identification and to a better understanding of the development and progression of various vascular diseases, and it co
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5%) as APPs. The individual clinician median focus was 92.8% (interquartile range [IQR] 87.0, 100.0) for EM physicians, 45.2% (IQR 5.1, 97.0) for non-EM physicians, and 100.0% (IQR 96.3, 100.0) for APPs.
EM physicians have twice as much clinical focus in comparison to non-EM physicians providing emergency care to Medicare fee-for-service beneficiaries. These
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Several examples of ‘active failures’ were also described. DISCUSSION AND CONCLUSIONS Safety issues appear broader than those recorded and reported by health services and inspectorates. Many safety issues have also been identified in other care settings supporting the notion that there are overlaps between service users and carers’ perspectives of safety in mental health services and those of users in other settings. Areas for furthe
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The Joule heating characteristics of functional nanoparticle decorated nanocarbon aerogels are systemically investigated in terms of electrical-thermal responses. Studies verify that nanocarbon aerogels are exceptional supporting and electric-conducting monolithic frameworks for nanoparticles, enabling stable and accurate aerogel temperature control via direct electrical heating of the nanocarbon supp
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Bovine tuberculosis (bTB) is an important disease for dairy productivity, as well as having the potential for zoonotic transmission. Previous prevalence studies of bTB in the dairy sector in central Ethiopia have suggested high prevalence, however, they have been limited to relatively small scale surveys, raising concerns about their representativeness. Here we carried out a cross sectional one-stage cluster sampl
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Five groups were defined based on OM-exposure and the presence of VTI. Baseline characteristics were analysed, and comparison of mean SDQ-scores for the five exposure groups was conducted. Means were adjusted for à priori defined confounding factors. RESULTS Data from 52,877 children in the DNBC showed an association between OM and poorer SDQ-scores. VTI was associated with an additional increase, i.e. worsening, of the SD
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The semiterrestrial isopod, Ligia exotica represents one of the oldest documented species introductions of marine organisms and is known as an intermediate form between marine and strictly terrestrial isopods. In order to explore the potential value of Ligia as an animal food source, this study focused on the growth rate under laboratory rearing conditions and conducted a detailed analysis of the overall nutrient co
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Patients with atrial fibrillation are increasingly prescribed a direct oral anticoagulant (DOAC) over warfarin and seek to avoid anticoagulation even without a history of major bleeding. This study explores the outcomes of patients implanted with a Watchman device in relation to anticoagulation choice (warfarin versus DOAC) in the post-procedure period and a history of bleeding.
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5%) as APPs. The individual clinician median focus was 92.8% (interquartile range [IQR] 87.0, 100.0) for EM physicians, 45.2% (IQR 5.1, 97.0) for non-EM physicians, and 100.0% (IQR 96.3, 100.0) for APPs.
EM physicians have twice as much clinical focus in comparison to non-EM physicians providing emergency care to Medicare fee-for-service beneficiaries. These
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096). 43.6% were directly admitted to hospital care.CART analysis identified the variables oxygen saturation (<95%), dyspnoea and history of cardiovascular (CV) disease to distinguish between high and low-risk groups. If all three variables were negative, most patients were discharged from ED, and the incidence of the clinical endpoint was 0%. The validation cohort confirmed the safety of discharge us
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atients were identified as at risk for non-adherence with the CQR. Medication adherence is influenced by the patient’s beliefs about medicines and illness perceptions, and these may be key targets for future interventions to improve medication adherence.
This study aims to investigate whether fibromyalgia (FM) and work-related musculoskeletal disorders can be diff
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To seek out the effect of curcumin on cholesterol efflux in THP-1 macrophages and clarify its specific mechanism.
THP-1 macrophages were cultured with curcumin at different concentrations, followed by detection of the toxicity of curcumin to cells utilizing CCK-8 assay. Following culturing with serum-free ox-LDL, THP-1 macrophages were transfected with mi-miR-125a-
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Coleoptera is a mega-diverse order, but only about 1% of its species have been analyzed cytogenetically. In this order, the subfamily Alticinae presents many identification problems, mainly due to the occurrence of mimicry. The objective of this work was to cytogenetically characterize 3 very similar species of the genus Alagoasa (A. pantina, A.areata, and A.scissa). We used classical and molecular cytogenetic as
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with immunity acquired from repeated, low-level exposure to the parasite, generating transient subclinical infections or mild disease. Should this be the case, the use of tick control, particularly in adult dogs in free-roaming populations in B. rossi endemic regions, should be carefully considered. Our preliminary research revealed that metformin, a classic anti-diabetic drug, could rescue
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The concentration of natalizumab in breast milk and serum of infants was low; B cells normal in infants breastfed under anti-CD20. CONCLUSION More data on the effect of Mab exposure during pregnancy are needed. Otherwise, our data suggest that treatment with natalizumab, ocrelizumab, or rituximab during lactation might be safe for breastfed infants. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc
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We report here an overview of current trends and a selection of recent results regarding the characterization of emulsions by Diffusing Wave Spectroscopy (DWS). We provide a synopsis of the state of the art of the DWS technique, and a critical discussion of experiments performed on samples in which Brownian and ballistic dynamics coexist. A novel analysis scheme is introduced for DWS experiments on creaming o
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The seven papers in this issue address a variety of challenges that parents in several different cultural places encounter as they do their best to ensure their children’s safe, happy, and successful development from infancy through middle childhood infant sleep, developmental agendas, temperament, preschools, academic success, and learning to be a parent in a new cultural environment. The authors use a varied of meth
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COVID-19 has led to global dramatic shifts in daily life. Following the biopsychosocial model of health, the goal of the current study was to predict people’s psychological well-being (PWB) during the initial lockdown phase of the pandemic and to investigate which coping strategies were most common among people with low and high PWB. Participants were 938 volunteers in the United States who responded to an online s
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They may also show efficacy in treating patients with milder symptoms such as patients with schizotypal personality disorder and attenuated psychosis syndrome. Their utility may also expand outside the spectrum of schizophrenia to encompass Parkinson’s Disease psychosis, major depression, bipolar depression, and dementia-associated apathy.Background Optic neuritis (ON) and multiple sclerosis (MS) are com
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Therefore, in addition to the proven capability of HT to regulate reactive oxygen species (ROS) levels, through both direct scavenging properties and indirect antioxidant efficacy, our results revealed that HT promotes angiogenesis, arguing in favor of great pharma-nutritional potential in ischemic injuries.The evolution of implant dentistry since the discovery of the osseointegration concept has been remar
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A 61-year-old man who stretched in the morning presented a rupture of the tibialis anterior tendon treated by extensor hallucis longus transfer. Rupture of the tibialis anterior tendon is rare. Surgical treatment seems to be more efficient in improving the function.LIA is an emerging alternative for patient-con- trolled epidural analgesia(PCEA) after total knee arthroplasty(TKA). LIA allows faster mob
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Anastomotic leak in hollow digestive organs is 1.36 times more common in carriers of homozygous CC genotype of the MMP-2 gene and twice less common in minor homozygotes of TT (5.9% vs. 10%, p>0.05). It is statistically significant that in the group of patients with anastomotic leak in hollow digestive organs the GG variant of the TIMP-2 gene was detected 1.6 times more often. Carriers of minor homozygotes of AA ge
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atients were identified as at risk for non-adherence with the CQR. Medication adherence is influenced by the patient’s beliefs about medicines and illness perceptions, and these may be key targets for future interventions to improve medication adherence.
This study aims to investigate whether fibromyalgia (FM) and work-related musculoskeletal disorders can be diff
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5%) as APPs. The individual clinician median focus was 92.8% (interquartile range [IQR] 87.0, 100.0) for EM physicians, 45.2% (IQR 5.1, 97.0) for non-EM physicians, and 100.0% (IQR 96.3, 100.0) for APPs.
EM physicians have twice as much clinical focus in comparison to non-EM physicians providing emergency care to Medicare fee-for-service beneficiaries. These
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Tibial dyschondroplasia (TD) is the common leg disease in commercial broilers. However, the effects of TD on meat quality and the protective of Morinda officinalis polysaccharide (MOP) are largely unknown. Three hundred broiler chicks (one-day-old) were equally allocated into control (CON), TD and MOP-treated groups for 15 days. The results indicated that TD influenced morphology and meat quality-related parameters of t
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While obtaining such data in vivo is not possible, these in vitro data show proof of concept for likely significant cell- and progestogen-specific PR-B effects.Central administration of L-arginine was reported to attenuate stress responses in neonatal chicks. The present study aimed to elucidate the differential effects of centrally administered L-arginine and its enantiomer, D-arginine, on the stress response in
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The cumulative mortality rate (CMR) of O. niloticus following the P. aeruginosa challenge was decreased in the SYN group compared to other groups. The results emphasize that synbiotic could be used as a norfloxacin alternative to enhance the related immunological parameters, including antioxidant activity and disease resistance against P. aeruginosa infection of O. niloticus.Background Angiogenesis is well known to
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In doing so, it will consider preparations from low- to high-solids and the effect of structural transformation via gelation, phase separation and vitrification on protein functionality as a delivery vehicle or heterologous complex. Applications for the design of novel functional foods and nutraceuticals will also be discussed.Brain Breaks videos are web-based structured physical activity (PA) videos that aim at s
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However, the size of supramolecular FEL-βRA better matched that of active cavity of BSA; the cocrystal is closely bound to BSA through hydrogen bonding with ASN390 residue and intermolecular hydrophobic interactions with LEU429, VAL432, LEU452 and ILE387 residues. This change on binding affinity of FEL to BSA induced by cocrystallization with βRA provided theoretical basis to evaluate the transportation, distribution a
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among pregnant women in this sub-urban population of Nepal was high compared to few cases of CT and no cases of NG, syphilis, and HIV. The WHO standard protocol provided a valuable framework for conducting STI surveillance that can be adapted for other countries and populations.Despite a total prohibition on the practice of female genital mutilation (FGM), young girls continue to be victims in some African countr
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This implies that algal PUFA were selectively retained or were produced internally via enzymatic PUFA conversion by aquatic consumers. This field study demonstrates the nutritional importance of algal PUFA for neural organs in aquatic consumers of headwater regions.Some authors have evaluated the unconstrained optimum and decorrelated multistage linear phenotypic selection indices (OMLPSI and DMLPSI,
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Measurements on native particles with reduced polydispersity have allowed us to refine the particle morphology, which is well described by a hairy particle (core-chain) geometry with short chains decorating the surface of the particles. The isotopic variants of OSA-modified particles enhanced the scattering contrast for neutrons, revealing lightly modified hairy chains for small degrees of substitution (DS) of OSA, and a r
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Compared with the SA group, SFI significantly improved cerebral MFI after HS. SFI up regulated cerebral endothelial NOS expression, but down regulated interleukin-6, TNF-α, inducible NOS and aquaporin-4 expression compared with the SA group. The cerebral microvascular endothelial injury and interstitial edema in the SFI group were lighter than those in the SA group.
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Findings show that although the victim-offender overlap exists among prisoners, the majority of prisoners were neither a victim nor an offender. Victim-offenders and victims-only comprise only a small proportion of the sample. Findings also indicate that there are few unique factors across the groups. Results of the study have implications policy and future research.Objective The Hopkins Verbal Learning T
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Our experiments show that both the structure of the physical situation as well as expectations about what will happen affect people’s judgments.
With advances in cancer disease diagnosis and treatment, the trends of cancer survival continue to increase, but cancer survivors usually experience disease- or treatment-related problems (including both physiological and psychological
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The associations between client satisfaction and veterinarian mental health measures were non-linear and complex; in several of the models, relatively higher client satisfaction was unexpectedly associated with poor veterinarian mental health states, while lower client satisfaction was associated with mental health scores suggesting wellness. Given that client satisfaction may impact client adherence to medical recommenda
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v/l) and very profound ECG alterations, characterized by lengthening waves and intervals, were seen as early as 30 min after intragastric administration of KCl in rats. In addition, a transient increase in arterial blood pressure and time-dependent bradycardia were also seen after the KCl administration. No metabolic acidosis was present in the animals, and the potassium ion did not increase proportionally to chloride
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atients were identified as at risk for non-adherence with the CQR. Medication adherence is influenced by the patient’s beliefs about medicines and illness perceptions, and these may be key targets for future interventions to improve medication adherence.
This study aims to investigate whether fibromyalgia (FM) and work-related musculoskeletal disorders can be diff
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Experimental results on real-world data sets demonstrate the effectiveness of the proposed method.This study examines which management methods are the most recent and advanced in managing rejected brine generated from desalination plants. It also provides up-to-date information regarding the most adequate technologies that generate a minimum quantity of rejected brine via the use of minimization techniques and
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While obtaining such data in vivo is not possible, these in vitro data show proof of concept for likely significant cell- and progestogen-specific PR-B effects.Central administration of L-arginine was reported to attenuate stress responses in neonatal chicks. The present study aimed to elucidate the differential effects of centrally administered L-arginine and its enantiomer, D-arginine, on the stress response in
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umorigenesis through cell cycle arrest and inducing apoptosis in HER2/neu mice.The purpose of this study was to establish the diagnostic reference levels (DRLs) for paediatric head computed tomography (CT) in Morocco and to assess the effective doses received during head CT examinations. The data of 1007 patients were collected retrospectively from Moroccan university children’s hospitals. The sample was classif
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96; 95%CI, 1.29-19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574-0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in
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CONCLUSION Anterior arthroscopic acromioplasty significantly reduced CSA overall, notably in case of high CSA. LEVEL OF EVIDENCE IV, retrospective study. INTRODUCTION Hinged knee megaprostheses are mainly used for reconstruction after tumor resection. They may incur complications, but this has not been assessed in the French literature, except in small series at short follow-up. We therefore conducted a large-scale nation
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Analgesia within the intensive care unit (ICU) is often achieved via the utilization of opioids in alignment with current guidelines. Recent evidence has not only demonstrated the potential impact of opioids in suppression of immune function, but also the potential harm of immunosuppression of patients within the ICU. Despite the potential immunosuppression seen with opioids in this at-risk population, their use remains f
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[This corrects the article DOI 10.2147/CMAR.S203082.].
This study aimed to establish and evaluate the usefulness of a simple, practical, and easy-to-promote machine learning model based on ultrasound imaging features for diagnosing breast cancer (BC).
Logistic regression, random forest, extra trees, support vector, multilayer perceptron, and XG Boost models were dev
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Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders. Full understanding involves genomics, neurochemistry, electrophysiology, and behavior. The scientific issues are daunting but important for human health because of the
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As a major activator of transforming growth factor β (TGF-β), the RGD receptor αvβ8-integrin is involved in pathogenic processes related to TGF-β dysregulation, such as tumor growth, invasion, and radiochemoresistance, metastasis and tumor cell stemness, as well as epithelial-mesenchymal transition. The novel positron emission tomography (PET) radiopharmaceutical Ga-68-Triveoctin for in vivo mapping of αvβ8-integrin expres
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ed a similar virulence gene profile. To our knowledge, this study represents the first report of complete phenotypic and genomic characterization of the emerging Streptococcus pneumoniae, serotype 24F, in the Middle East and North Africa region.The global increase of community-associated (CA) infections with methicillin-resistant Staphylococcus aureus (MRSA) is a major healthcare problem. Although sequence type
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Cancer stem-like cells (CSCs) contribute to the high rate of tumor heterogeneity, metastasis, therapeutic resistance, and recurrence. Histone lysine demethylase 4D (KDM4D or JMJD2D) is highly expressed in colon and liver tumors, where it promotes cancer progression; however, the role of JMJD2D in CSCs remains unclear. Here, we show that JMJD2D expression was increased in liver cancer stem-like cells (LCSCs);
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Despite similar accessibility in a health care system, completion varied by race/ethnicity, socioeconomic status, health status, and care seeking behavior, suggesting areas to target for improvement.Chlamydia infection remains a problem for the world. Hundreds of millions of people suffer from Chlamydia-related diseases, but the specific infection mechanism is still unclear. Studies have shown that int
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knowledge, gender, and marital variables. Color variable had an overall positive effect on the tendency to do the bleaching.
Various species of candida contribute to oral candidiasis. It is the time to shift from conventional rigid antimicrobial therapies to more patient specific and safer ones.
The present study aimed to investigate antifungal e
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Chiral noble metal nanoparticles has recently gained great interest due to their potential applications including ultrasensitive chiral recognition and asymmetric synthesis. We anticipate that they could be utilized to induce asymmetric photo-polymerization reactions with high enantioselectivity and reactivity. Here, we report such a system. By employing silver nanoparticles modified with cysteine as the chiral indu
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02). Incidence of complete satisfaction after injection (35%; 95% CI, 21-50%) was significantly lower than neurolysis (63%; 95% CI, 50-74%) and neurectomy (57%; 95% CI, 47-67%) (P less then 0.01). The need to proceed to further surgery was significantly greater following injection (15%; 95% CI, 9-23%) versus neurolysis (2%; 95% CI, 0-4%) or neurectomy (5%; 95% CI, 3-7%) (P less then 0.01). Incidence of procedural compl
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Background There is renewed focus on the complement system in the pathogenesis of schizophrenia. In addition to providing aetiological insights, consistently dysregulated complement proteins in serum or plasma may have clinical utility as biomarkers. Methods We performed a systematic literature review searching PubMed, Embase and PsycINFO for studies measuring complement system activity or complement protein
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BACKGROUND The severe inflammatory state secondary to Covid-19 leads to a severe derangement of hemostasis that has been recently described as a state of disseminated intravascular coagulation (DIC) and consumption coagulopathy, defined as decreased platelet count, increased fibrin(ogen) degradation products such as D-dimer as well as low fibrinogen. AIMS Whole blood from 24 patients admitted at the intensive care un
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Prostate cancer has a high incidence in men and is the second cause of cancer death among americans male. microRNA (miR) is becoming a potential new prognostic factor for prostate cancer. Single nucleotide polymorphisms (SNPs) are common polymorphisms, characterized by a single exchange of nitrogen based in the DNA. This polymorphism is present in the miRs, altering their function.
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Il traduttore di termini tecnici deve avere quindi una buona conoscenza del settore di riferimento, insieme a solide competenze sulle strategie di scrittura più efficaci per trasferire le informazioni da una lingua all’altra. Le traduzioni tecniche e industriali sono curate da esperti del settore in grado di comprendere ogni sfumatura del testo e renderla fedelmente nella propria lingua madre. Aumentate la fiducia dei vo
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In the Gangetic plains of India, including Delhi, cholera is endemic. On 10 May 2018, staff at the north Delhi district surveillance unit identified a laboratory-confirmed cholera outbreak when five people tested positive for Vibrio cholerae O1 Ogawa serotype in Bhadola. We investigated to identify risk factors and recommend prevention measures.
We defined a case as ≥3 loose s
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Dietary Fat Archipelago Period, Vividness, and PUFA Source Really Impact Diet-Induced Thermogenesis but Not Fullness in older adults in a Randomized, Crossover Trial.
arktos habitats. Habitat characteristics were related to capture records of A. arktos to determine potential fine-scale structural habitat requirements. Percentage of rock cover and leaf litter were the strongest predictors
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Infrared thermography has great value of clinical application in daily pressure injury assessment. It is of great significance to make a faster and more objective clinical judgement for patients at risk of pressure injury.
Contemporary treatments for functional dyspepsia have limitations. Herbal medicine has been suggested as adjunctive treatment
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Bilateral acoustic hearing in cochlear implant (CI) recipients with hearing preservation may allow access to binaural cues. Sensitivity to acoustic binaural cues has been shown in some listeners combining electric and acoustic stimulation (EAS), yet remains poorly understood and may be subject to limitations imposed by the electrical stimulation and/or amplification asymmetries. The purpose of this study was to invest
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We aimed to compare the performance of the recent CASTLE score to J-CTO, CL and PROGRESS CTO scores in a comprehensive database of percuta
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OBJECTIVE The aim of the work was to study the origin of the idea that herpes labialis (HL) in patients with pneumonia and meningitis was believed to be of prognostic importance. BACKGROUND HL is caused by a primary infection or reactivation of herpes simplex type I. In the past, it has been related to pneumonia and meningitis; moreover, HL was believed to be of prognostic importance. METHODS A selection of 19t
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Moreover, there was a significant negative indirect effect from cumulative media use at 18 months to focused attention at 26 months via focused attention at 22 months. Finally, the cumulative media index appeared to be a better predictor of focused attention than any of the singular media use indicators. Children’s focused attention did not predict subsequent cumulative media use across time, providin
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Our results show that as expected more complex grammars are generally more difficult to learn.This scoping review of UK evidence aimed to describe what is known about Lesbian, Gay, Bisexual, and Trans (LGBT+) health inequalities in relation to cancer, mental health, and palliative care to inform research, policy and public health interventions. Using a scoping review methodology, we identified studies from database
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We investigate whether an educational intervention of GPs increases patient-centeredness and perceived shared decision making in the treatment of patients with poorly controlled type 2 diabetes mellitus?
We
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Health technology assessments (HTA) rely on head-to-head comparisons. We searched for intraindividual comparisons (IIC) qualifying as head-to-head design to develop comparative evidence.
Gemeinsamer Bundesausschuss (G-BA) appraisals between January 2011 and April 2020 were reviewed for inclusion of IIC. Identified IIC were grouped according to disease characteristics into nonprogressive, progres
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URL http//www.clinicaltrials.gov. Unique identifier NCT02306616.
No clear guidelines or available studies exist regarding the effects of intensity-modulated radiotherapy (IMRT) of esophageal cancer (EC) on the cardiovascular system. We therefore analyzed a wide range of cardiac vascular dosimetric parameters and clinical characteristics to assess the prognostic factors for EC patients treated with IMRT.
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We concluded that IFI27, IFI44, IFITM3, FCER1A, and ISG15 may play a role in RSV. Our finding may contribute to the development of new potential biomarkers, reveal the underlying pathogenesis and also identify novel therapeutic targets for RSV.
We concluded that IFI27, IFI44, IFITM3, FCER1A, and ISG15 may play a role in RSV. Our finding may contribute to the development of new potential biomarkers, re
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This article discusses central nervous system vasculitis, a clinical and MRI mimic of multiple sclerosis (MS). There is a paucity of discussion of vasculitis in the radiology literature, and many MS neurologists believe that vasculitis is underdiagnosed. Therefore, the authors hope that the readers will find this paper increases their knowledge about CNS vasculitis and improves their ability to differentiate MS from vascul
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Microorganisms surrounding plant roots may benefit invasive species through enhanced mutualism or decreased antagonism, when compared to surrounding native species. We surveyed the rhizosphere soil microbiome of a prominent invasive plant, Phragmites australis, and its co-occurring native subspecies for evidence of microbial drivers of invasiveness. If the rhizosphere microbial community
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Thalidomide is an old well-known drug that was first used as morning sickness relief in pregnant women before being withdrawn from the market due to its severe side effects on normal fetal development, However, over the last few decades, the interest in this old drug has been renewed because of its efficacy in several important disorders for instance, multiple myeloma, breast cancer, and HIV-related disease
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Finally, ratios of CorynebacteriumLactobacillus and StaphylococcusLactobacillus are elevated in the intact skin of individuals with a history of SCD leg ulcers, while the ratio of LactobacillusBacillus is elevated in that of individuals without a history of ulcers. Investigations of the skin microbiome in relation to SCD ulcer pathophysiology can inform clinical guidelines for this poorly understood chronic wound, as we
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The wwPDB partners are committed to following the FAIR (Findability, Accessibility, Interoperability, and Reproducibility) principles and have implemented a DOI resolution mechanism that provides access to all the relevant files for a given PDB entry. On average, >250 new entries are added to the archive every week and made available by each wwPDB partner via FTP area. The wwPDB partner sites also deve
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The premature MPF destabilization and defects in other cell cycle regulators possibly cause meiotic instability in ovum soon after ovulation. The meiotic instability results in a pathological condition of abortive SOA and deteriorates ovum quality. These ova are unfit for fertilization and limit reproductive outcome in several mammalian species including human. Therefore, global attention is required to identify the underlying causes i
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6 months. There was significant difference in age between two groups (P0.05). CONCLUSION Under the multi-disciplinary diagnosisand treatment mode, the method of PFNA operation is safe and feasible, the patients with local anesthesia are older, and the proportion of patients with ASA≥grade Ⅲ is higher, which is better for some elderly high-risk patients than general anesthesia.OBJECTIVE To explore the feasibility
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Oculomotor decision making can be investigated by a simple step task, where a person decides whether a target has jumped to the left or the right. More complex tasks include the countermanding task (look at the jumped target, except when a subsequent signal instructs you not to) and the Wheeless task (where the jumped target sometimes then quickly jumps to a new location). Different instantiations of the LATER (Linear
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annulata parasites in India. Conclusion High genetic variation between the parasite populations in the country suggests their successful spread in the field and could hamper the disease control programs. Our findings provide the baseline data for the diversity and population structure of T. annulata parasites from India. The low diversity in the vaccine advocates improving the current vaccine, possibly by increasing its het
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To evaluate the antitumor activity of the raw extract from biopolymers isolated from the Vibrio sp. marine bacteria in breast cancer induced by N-Methyl-N-nitrosourea (MNU) in rats.
The Vibrio sp. marine bacteria was cultured for seven days, then the raw supernatant was filtered, precipitated and concentrated. MNU was administered in a single dose of 50 mg/kg to 39 Holtzman rats
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Worldwide cardiovascular disease is the major cause of disability and premature death. This is due to the ascending trend of consuming an unhealthy diet and obesity which increases the risk of hypertension and type 2 diabetes mellitus. Thus this study aimed to determine the pooled prevalence of the cardiovascular disease in Ethiopia.
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Tetrahydrofolic acid and formaldehyde are key human metabolites but their physiologically relevant chemistry is undefined. Our NMR studies confirm formaldehyde as a product of tetrahydrofolic acid degradation but also reveal their reaction regulates the stability of tetrahydrofolic acid. These observations identify a novel non-enzymatic feedback mechanism regulating formaldehyde and folate metabolism that has i
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The ICP-MS data revealed that the release of K and Na mainly takes place during the stage of devolatilization. During devolatilization, almost all potassium and sodium are released from wood samples, while only 65-90% of K and 74-90% of Na are released from straw samples. Based on the results, the flame emission spectroscopy technique is capable to fully detect released alkali metals in the gas phase during combustion
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Despite calls for improved accountability in global health systems, and a set of clear and consistent theoretical accountability frameworks, empirical descriptions of how accountability is experienced and enacted in low- and middle- income country (LMIC) settings is limited. Therefore, we sought to characterize how managers at all levels of Ethiopia’s primary healthcare system experience accountability in t
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Experience of violence or abuse from an intimate partner (intimate partner violence, IPV) can result in a variety of psychological and mental health impacts for which survivors may seek psychotherapy or other mental health services. Individuals experiencing IPV may have specific needs and preferences related to mental health care, yet the question of how to best provide client-centered mental healt
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After accounting for the potential additional mortality from collisions, and assuming that the death of a parent also led to the loss of its offspring, the breeding population was projected to increase by 3.57% (95% CI 2.16-5.15%) per year, compared with 6.56% (95% CI 4.59-8.73%) in the absence of turbines, suggesting a negligible effect on population viability. However, additional mortality could result in greate
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The human genome harbors numerous structural variants (SVs) which, due to their repetitive nature, are currently underexplored in short-read whole-genome sequencing approaches. Using single-molecule, real-time (SMRT) long-read sequencing technology in combination with FALCON-Unzip, we generated a de novo assembly of the diploid genome of a 115-year-old Dutch cognitively healthy woman. We combined this assembly with two previously publ
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Tumor-associated macrophages (TAMs) play a crucial part in cancer evolution. Dynamic imaging of TAMs is of great significance for treatment outcome evaluation and precision tumor therapy. Currently, most fluorescence nanoprobes tend to accumulate in the liver and are difficult to metabolize, which leads to strong background signals and inadequate imaging quality of TAMs nearby the liver
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Germline mutations in the DNA mismatch repair (MMR) genes cause Lynch syndrome (LS). In this study, we identified and characterized a novel SINE-VNTR-Alu (SVA) insertion in exon 12 of MSH2 in an individual with early-onset colorectal cancer and a very strong LS family history. RT-PCR analysis indicated a larger aberrant MSH2 transcript in one of the family members. MSK-IMPACT next-generation sequen
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Mauritia flexuosa palms inhabit wetland environments in the dry, seasonal Brazilian savanna (Cerrado) and produce mucilaginous secretions in the stem and petiole that have a medicinal value. The present study sought to characterize the chemical natures of those secretions and to describe the anatomical structures involved in their synthesis. Chemical analyzes of the secretions, anatomical, histochemical analyses, and
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Furthermore, SnRK1.1 migrates from cytoplasm to nucleus under high-NH4+/low-pH conditions. The translocation of SnRK1.1 from cytosol to nucleus under high-ammonium stress releases the inhibition on SLAH3, which allows SLAH3-mediated NO3- efflux leading to alleviation of high-NH4+/low-pH stress. Our study reveals that the C-terminal phosphorylation also plays important role in SLAH3 regulation and provides additional i
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This case highlights the potential role of ECMO, convalescent plasma and immunomodulatory therapies in the management of cardiogenic shock associated with COVID-19 myopericarditis.
Secondary tricuspid regurgitation (sTR) is frequent in patients with heart failure with reduced ejection fraction and is associated with adverse outcomes despite guideline-directed therapy. However, little is known about
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[This corrects the article DOI 10.34133/2019/7108494.]. Copyright © 2020 Zhicheng Xiao et al.Most regulatory chromatin interactions are mediated by various transcription factors (TFs) and involve physically interacting elements such as enhancers, insulators or promoters. To map these elements and interactions at a fine scale, we developed HIPPIE2 that analyzes raw reads from high-throughput chromosome conformation (Hi-C) exp
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In response to the COVID-19 pandemic, the NHS has implemented significant workforce changes to manage the increased and changing demand on healthcare services. We aimed to investigate the impact of redeployment on the wellbeing of doctors as well as highlighting ways to improve.
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Biological research and many cell-based therapies rely on the successful delivery of cargo materials into cells. Intracellular delivery in an in vitro setting refers to a variety of physical and biochemical techniques developed for conducting rapid and efficient transport of materials across the plasma membrane. Generally, the techniques that are time-efficient (e.g., electroporation) suffer from heterogeneity and low
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Patients undergoing elective knee or hip replacement surgery for osteoarthritis improve their emotional status during hospitalization, with fewer negative emotions at discharge. Good emotional status, feeling of higher health status at baseline, and shorter hospitalization were independ
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Glucose homeostasis is maintained in large part due to the actions of the pancreatic islet hormones insulin and glucagon, secreted from β- and α-cells, respectively. The historical narrative positions these hormones in opposition, with insulin primarily responsible for glucose-lowering and glucagon-driving elevations in glucose. Recent progress in this area has revealed a more complex relationship between
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To describe the quality of life and caregiver burden of family caregivers of cancer patients at the beginning of palliative care.
Cross-sectional descriptive study in the CUIDPACOSTASOL cohort of family caregivers of palliative phase cancer patients, included between February 2017 and December 2019 from health centres of the Costa del Sol and Malaga-Valle del Guadalhorce P
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Nurse managers can be aware of transition shock and job satisfaction changes, assess their severity and implement solutions in their hospitals. Thus, retention strategies should differ according to the changing needs of nurses at different stages of their career.
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Solar ultraviolet radiation (UVR) exposure is a known risk factor for the development of skin cancer. Heterogeneity in solar UVR exposure may explain the diversity in skin cancer incidence between men and women. This, however, has not previously been investigated in Danish outdoor workers using UVR dosimetry. The aim of this study was to evaluate sex differences in solar UVR dosimetry in Danish outdoor workers on w
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After three intramuscular doses, the only changes observed were those commonly related to a vaccine-elicited inflammatory reaction. Subsequently, the effects of unadjuvanted RSVPreF3 vaccine on female fertility, embryo-fetal, and postnatal development of offspring were evaluated in rats and rabbits. There were no effects on pregnancy, delivery, lactation, or the pre- and postnatal development of offspri
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Automated detection of normal, unclear and tumor images from colonoscopy videos is possible by using a deep learning framework. This is expected to provide an invaluable decision suppor
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Premature luteinizing hormone (LH) surge is one of the causes for assisted reproductive technology cycle cancellation, and it is needed to find novel approaches with improved efficacy and safety profile.
To compare the effects of Duphaston and Cetrotide on the prevention of premature LH surge and characteristics of retrieved follicles and embryos in women undergoing intracy
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Members of the IL-6/IL-12 cytokine family are critical regulators of innate and adaptive immunity and have emerged as key players controlling inflammatory and autoimmune disorders. This cytokine family comprises of IL-12, IL-23, IL-27, and IL-35, each consisting of distinct α- and β-cytokine subunits that form heterodimers. A new member of this family, IL-39, was identified in the murine species and was
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OBJECTIVE This study aims to establish the typical population, safety, and outcomes of pediatric thyroidectomies, specifically identifying surgical complication rates. Furthermore, the study compares management and complication differences between the two specialties that most often manage these patients – Pediatric General Surgery and Otolaryngology. METHODS National Surgical Quality Improvement Program – Pediatrics
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Anterior cruciate ligament graft diameter is of concern to every orthopaedic surgeon who’s ever performed an anterior cruciate ligament reconstruction. The current standard is to obtain a graft of at least 8 mm in diameter. The 5-bundle construct is an option to increase the graft diameter in the situation in which a smaller diameter 4-strand hamstring autograft is encountered. The question is whe
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Co-occurring emotional and behavioral problems (EBPs) frequently exist in young autistic children. There is evidence based on parental report that parenting interventions reduce child EBPs. More objective measures of child EBPs should supplement parent reported outcomes in trials. We describe the development of a new measure of child and parenting behavior, the Observation Schedule for Children with Autism-Anxiety, Behaviour
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These results indicate that RNF2 is oncogenic in colorectal cancer and may promote disease progression by inhibiting EGR1 expression. RNF2 is thus a potential prognostic marker and therapeutic target in colorectal cancer.We conducted a randomized controlled trial to examine choral singing’s effect on cognitive decline in aging. Older Singaporeans who were at high risk of future dementia were recruited 47 were assigned to ch
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Herein, we will provide an overview and discussion of the current status of GA including advances in mechanism of pathogenesis, diagnosis, classification and current treatment modalities.
Herein, we will provide an overview and discussion of the current status of GA including advances in mechanism of pathogenesis, diagnosis, classification and current treatment mod
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We aimed toassess the efficacy of lactulose as prophylaxis against hepatic encephalopathy (HE) in cirrhotic patients with acute upper gastrointestinal bleeding (AUGIB).
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Motor vehicle accidents (MVAs) are the leading cause of death and have also been proven debilitating for their survivors. In India, with poor road infrastructure and low maintenance, MVAs are quite apparent. With a significant focus of treatment on physical health, psychological consequences linked to these traumas are often neglected.
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Mesenchymal stem cells (MSCs) have gained attraction not only in the field of regenerative medicine but also in the field of autoimmune disease therapies or organ transplantation due to their immunoregulatory and/or immunosuppressive features. Dendritic cells (DCs) play a crucial role in initiating and regulating immune reactions by promoting antigen-specific T cell activation. In this study, we investigated the effect of hum
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The chemokine receptor CXCR4, a G protein-coupled receptor (GPCR) capable of heteromerizing with other GPCRs, is involved in many processes, including immune responses, hematopoiesis, and organogenesis. Evidence suggests that CXCR4 activation reduces thrombin/protease-activated receptor 1 (PAR1)-induced impairment of endothelial barrier function. However, the mechanisms underlying cross-talk between CXCR4 and PAR1 are not
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The use of antithrombotic therapy may increase morbidity and mortality in patients with infective endocarditis (IE). This study evaluated the use of oral anticoagulant and antiplatelet agents on the development of embolic complications and bleeding episodes within 30 days of IE diagnosis.
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We report a severe case of Chromobacterium haemolyticum pneumonia associated with near-drowning and detail the investigation of the pathogen and river water. Our genomic and environmental investigation demonstrated that river water in a temperate region can be a source of C. haemolyticum causing human infections.Most H1 influenza A viruses (IAVs) of swine are derived from past human viruses. As human population im
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In contrast, only black race, liver insufficiency, cancer, and pulmonary hypertension were predictive of ED return following TKA. The primary risk factors for ED return differ for THA and TKA, and this is not currently reflected in the medical severity diagnosis-related group system. Specifically, black patients with multiple comorbidities are at high risk for unplanned ED visits following THA. This should be considered i
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technique using custom-made devices is technically feasible with a low mortality and morbidity, and a high rate of aortic remodeling. Both, the original design (CP I) and newer designs with a self-closing central sleeve (CP II and CP III) showed similar excellent outcomes.Background. Hepatocellular carcinoma, among the most common malignant digestive system tumorsworldwide, is most effectively treated with precise surgical re
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This study provides the first evidence that novel yolk-shell bio-ceramic granules, on account of their adjustable porous microstructure, have great potential in alveolar bone repair.Paper has been a popular material of choice for biomedical applications including for bioanalysis and cell biology studies. Regular cellulose paper-based devices, however, have several key limitations including slow fluid flow; large sample
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Dedicated thyroid surgeon could visually identify EBSLNs. IONM contribution significantly increases the identification rate. Systematic classification of identification and electrophysiological integrity of EBSLNs may increase comprehensive knowledge about its motor function that is crucial for complication-free thyroidectomy.
Dedicated thyroid surgeon could visually identify EBSLNs. IONM contri
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Multilamellar bodies (MLBs), structures composed of concentric membrane layers, are known to be produced by different protozoa, including species of ciliates, free-living amoebae, and Dictyostelium discoideum social amoebae. Initially believed to be metabolic waste, potential roles like cell communication and food storage have been suggested for D. discoideum MLBs, which could be
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Medical articles covering adverse drug events (ADEs) are systematic
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Infective endocarditis (IE) is the infection of the endocardial surface (innermost layer – valves, chordae tendineae, and papillary muscles) of the heart. It usually refers to infection of one or more of the heart valves which may be native or prosthetic. The definition also includes infection on indwelling cardiac devices. Over time, the etiology, as well as causes of IE, h
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Obesity is a chronic low-grade inflammatory condition, and β2-adrenergic agonists as well as exercise have been proposed as anti-inflammatory strategies in obesity, so it is critical to accurately determine the effects of β2-adrenergic stimulation, especially when combined with other non-pharmacological therapies. The aim of this investigation was to determine the effect of β2-adrener
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Cortical demyelination is a relevant aspect of tissue damage in multiple sclerosis (MS). Microstructural changes may affect each layer in the cortex differently.
To evaluate the sensitivity of quantitative magnetic resonance imaging (qMRI) measurements on cortical layers as clinically accessible biomarkers of grey matter (GM) pathology.
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The transitions were accelerated by elevating the Ca2+ concentration, temperature, and osmotic pressure, which demonstrates an increased capability of PTP to accommodate to large molecules (plasticity). Cyclosporin A inhibited the transitions between states. The analysis of PTP size dynamics in osmotically shocked mitochondria and mitoplasts confirmed the importance of the MOM for the stabilization of PTP structure. Thus, t
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8% (95% CI 0.8%-3.5%). The majority of the misdiagnosed patients had distal DVT. In analyses restricted to proximal DVTs, the failure rate was 0.6% (95% CI 0.1%-1.8%). D-dimer as a stand-alone approach reduced the proportion of required ultrasounds from 81.8% to 72.2%. Conclusion D-dimer as a stand-alone test may be safe for excluding proximal DVT and reduce the proportion of required ultrasounds. Prospective management s
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In the humerus, pain is a poor guide for differentiating between benign enchondromas and malignant well-differentiated chondrosarcomas. Radionuclide bone scans often are used, and chondrosarcomas reliably show increased uptake. However, it remains to be seen whether enchondromas consistently have negative findings on bone scans, which would provide reliable differentiation f
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Exposure to repeated concussive traumatic brain injury (TBI) and to blast-induced TBI has been associated with the potential development of the neurodegenerative condition known as chronic traumatic encephalopathy (CTE). CTE is characterized by the accumulation of hyperphosphorylated tau protein, with the resultant tau tangles thought to initiate the cognitive and behavioral manifestations that appear as the conditi
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Social and interpersonal factors impact the trajectory of chronic pain. We previously developed and validated a 2-factor, 7-item measure to assess interpersonal factors, including relationship guilt and worry and difficulty prioritizing self-care in chronic pain. Here, we confirm the factor structure and examine the sex invariance of the two-factor structure of the CARE Scale-7.
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thailandensis. Mice immunized intranasally with individual AuNP-protein-LPS conjugates, showed variable degrees of protection against intranasal Bm infection, while an optimized combination formulation (containing protein antigens OmpW, OpcP, and Hemagglutinin, along with LPS) showed complete protection against lethality in a mouse model of inhalational glanders. Animals immunized with different nano-glycoconju
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Knockdown of YAP prevented the upregulation of pYAP, cell migration and invasion induced by the ASPP2 suppression. Treatment with a specific antibody against ASPP2 downregulated ASPP2 and LSR, affected F-actin at tricellular contacts, upregulated expression of pYAP and claudin-1, and induced cell migration and invasion via YAP. In normal human endometrial epithelial cells, ASPP2 was in part colocalized with LSR at tr
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ict resistance to treatment.BACKGROUND Car accidents due to unexpected forward or backward runaway by older drivers are a serious social problem. Although the cause of these accidents is often attributed to stepping on the accelerator instead of the brake, it is difficult to induce such pedal application errors systematically with usual drive simulators. We developed a simple personal computer system that induce
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Our novel and interactive tendon atlas highlights previously underappreciated heterogeneity between and within tendon cell populations. The atlas also serves as a resource to further the understanding of tendon extracellular matrix assembly and maintenance and in the design of therapies for tendinopathies.This paper reports on a mixed-methods study that utilized a convergent parallel design to examine Chinese graduate
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The resulting lyophilized drug product was stable for at least two years at -20 °C ± 10 °C, 5 °C ± 3 °C and 22.5 °C ± 2.5 °C and maintained its vaccine potency, as evaluated in a murine protection assay. This manufacturing process thus enables further clinical and commercial development of BPZE1.The production of extra virgin olive oil (EVOO) in Brazil developed quite recently
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인어베가스 신뢰할 수 있는 시스템으로, 평판 좋은 도박 사이트 사이트에 대한 인포를 전달하는 데 헌신하는 시스템입니다. 이 플랫폼은 고객들이 오직 정통한 그리고 합법적인 도박 인터넷 사이트에 접속할 수 있도록 보장하는 데 중점을 둡니다. 다양한 온라인 카지노를 광범위하게 검증함으로써, 인어베가스 플레이어가 교육된 결정을 내릴 수 있도록 도와주는 랭킹 시스템을 제시합니다. 목표는 안전하고 그리고 유쾌한 도박 경험을 제안된 시스템을 통해 보장하는 것입니다. 이 시스템들은 검사되고 검증된 신뢰할 수 있는 서비스입니다.
중요한 측면 중 하나는 인어베가스 정확한 검증 정보를 공급하는 데 전념하고 있다는 점입니다. 많은 온라인 베터들이 신뢰할 수 있는 카지노와 불법적인
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In conclusion, slope aspect had significant effect on vegetation attributes, which was significantly influenced by local climate (aridity) in terms of both strength and direction depending on the specific attributes investigated.A method for rapid and objective assessment of ocular lens density and transmittance is needed for research and clinical practice. The aim of this study was to d
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The number of people that have one or multiple condition(s) with a chronic course is rising, which consequently challenges healthcare systems. Healthcare geared to long-term care should focus on patient-centredness, shared decision making and self-management. The Assessment of Burden of Chronic Conditions (ABCC) tool was develope
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In addition, myeloid-derived suppressor cells are strongly elevated in the transgenic model used and normalized by combination treatment, indicating restoration of brain immune homeostasis. Overall, our results suggest that revitalizing brain immunity by combining IV with moderate-dose PD-1 inhibition may represent a therapeutic immunotherapy for AD.Frontotemporal dementia (FTD) describes a group of clinically het
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The facile synthesis of highly active and stable bifunctional electrocatalysts to catalyze water splitting is attractive but challenging. Herein, we report the electrodeposition of Pt-decorated Ni(OH)2/CeO2 (PNC) hybrid as an efficient and robust bifunctional electrocatalyst. The graphite-supported PNC catalyst delivers superior hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities over th
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Five main barriers to guideline utilization were expressed by providers 1) disagreement between recommendations and patient expectations; 2) guidelines not specific to individual patients; 3) unfamiliarity with “non-specific” term, or with the bio psychosocial model of MSDs; 4) time consuming; and 5) heterogeneity in guideline methods. Four main facilitators to guideline utilization were cited 1) clinician’s interest in evidenc
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Moreover, the current review discusses the challenges and prospects regarding the application of chitosan-based nanofibers in enzyme immobilization, towards maximizing catalytic activity and lifetime.Bioplastics have been an interesting area of research and development in the last few decades. Normal plastics are made out of petroleum products, which is a non-renewable resource. Apart from that, its non-biodegradable
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INTRODUCTION A recent analysis derived from the PAMPer trial dataset demonstrated no significant independent plasma survival benefit in those who required massive transfusion ( ≥10 units of red cells in 24 hours). The definition of massive transfusion has evolved over time to minimize bias and predict those at highest risk of death. We sought to characterize the definition of massive transfusion, their asso
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Самые знаменитые духи Армани Джио – один из красивейших гимнов туберозе, белому цветку женственности.
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Microbes release a wide variety of metabolites to the environment that benefit the whole population, called public goods. Public goods sharing drives adaptive function loss, and allows the rise of metabolic cross-feeding. However, how public goods sharing governs the succession of communities over evolutionary time scales remains unclear. To resolve this issue, we constructed an individual-based model, where an autonom
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Given its short acquisition time, the PVS can be implemented in a pediatric clinic with minimal impact on workflow.
The PVS detected amblyopia with high sensitivity in a nonenriched pediatric population. The device would allow children with amblyopia and/or strabismus to be referred to an eye care specialist as early as 2 years old. Given its short acquisition time, the PVS can be implement
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Thickness control is a critical process of automated polishing of large and thin Si wafers in the semiconductor industry. In this paper, an elaborate double-side polishing (DSP) system is demonstrated, which has a polishing unit with feedback control of wafer thickness based on the scan data of a laser probe. Firstly, the mechanical structure, as well as the signal transmission and control of the DSP system, are discus
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We propose that applying newly developed quantitative molecular and neuroscience technologies will advance our understanding of the unique neurobiology of each disorder and enable the development of personalized therapy.The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortal
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Generalized tonic-clonic seizure (GTCS) is a condition that is characterized by generalized spike-wave discharge in bilateral cerebral hemispheres during the seizure. #link# Although previous neuroimaging studies revealed functional abnormalities in the brain activities of children with GTCS, the topological alterations in whole-brain networks remain poorly understood.
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Researchers primarily used KDIGO (Kidney Disease Improving Global Outcomes) guidelines to define AKI. All of these studies excluded patients with CKD. The range of time for long-term renal outcomes was 28 days to 3 years, with the majority being 1 year. Renal outcomes ranged from recovery to renal replacement therapy to death.
To better understand the long-term renal outcomes after
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Statistical significance was set at P less then 0.05. The overall prevalence of MetS was 20.6%, with men having greater prevalence than women (24.9% vs. 18.3%). Prevalence of MetS increased with age. Factors contributed to MetS in the overall sample were BMI, hypertension, diabetes and physical activity of moderate intensity. Diabetes and hypertension were significantly associated with MetS in men, whereas BMI, diabetes
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We have provided a systematic review of the literature of this new and challenging entity of cutaneous IgG4-RD.Macular arteritis (MA) has a striking discordance between the clinical presentation of hyperpigmented macules and the histopathologic findings of a lymphocytic arteritis with intraluminal hyalinized fibrin ring and thrombosis. It has been proposed that MA represents the chronic, indolent, lymphocytic form of the ne
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The data presented in this review is compiled by searches of PubMed, database of American Cancer Society (ACS). We have included article from September 1994 to March 2020 as covering all article in chronological order is not fissile so we included relevant article with substantial information in this specific area of research by using the search term (alone or in combination) estrogen, hematopoietic stem cell, immune ce
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38; p less then 0.001) and Hispanics (OR = 0.64; p = 0.039) had lower odds of having bathroom modifications than non-Hispanic Whites. Fear of falling and activities of daily living limitations had incremental impacts on having bathroom modifications. This study highlights the need to improve disparities in bathroom modifications for non-Hispanic Black and Hispanic Medicare beneficiaries, including those with rep
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Coral-associated microorganisms are likely to play an important role in host defense by the production of antimicrobials. Six new chromanones, namely, phomalichenones H-M (5, 6, and 8-11), and ten known analogues (1-4, 7, and 12-16) were isolated from the coral-associated fungus Parengyodontium album sp. SCSIO 40430. Their structures were elucidated by comprehensive spectroscopic analyses. In addition, the struc
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Birmingham, the second-largest city in the United Kingdom, is known for its rich commercial history and dynamic cultural scene. Nevertheless, the city likewise faces challenges such as sound pollution and varying climate condition. One reliable option to these c
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Nanocyl induced, in general, a less pronounced reaction than Mitsui-7, and the cultures with human monocyte-derived macrophages (MDMs) showed the proinflammatory response at later time points than those without MDMs. In conclusion, we present a robust alveolar model to predict inflammatory and fibrotic responses upon exposure to MWCNTs.We report the synthesis of long narrow gold nanocrystals and the study of their vi
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HLA genes play a pivotal role for successful hematopoietic stem cell transplantation (HSCT). There is an increasing need for sophisticated screening of donor HLA genotypes for unrelated HSCT. Next generation sequencing (NGS) has emerged as an alternative for classical Sanger sequence for HLA typing. In this study, HLA-A, -B, and -DRB1 alleles were genotyped at the allelic (6-digit) level using MiSe
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In response to the increasing rates of childhood obesity, the United States and countries across Latin America have invested in research that tests innovative strategies and interventions. Despite this, progress has been slow, uneven, and sporadic, calling for increased knowledge exchange and research collaboration that accelerate the adapt
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No superiority of any technique was noted in our analysis. Self-reported outcomes were the most frequently improved.
There seems to not exist a one-fits-all treatment for this clinical picture and no clear decision-making pattern. A recent trend toward sequential approaches, starting with less invasive procedures, can be observed. Laryngoscope, 2021.
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The spectral changes due to chlorination of the CuPc molecule were mainly attributed to an increase of the threshold energy of the C atoms bonded to chlorine, and the influence of the change in the PDOS by chlorination was not significantly large.An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic an
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Cancer patients’ belief about prognosis can heavily influence medical decision making and goals of care. It is known that parents of children with cancer tend to be optimistic regarding their child’s prognosis; however, little is known about pediatric patients’ prognostic beliefs, how physicians’ prognostic communication is perceived, and how these perceptions are compared with actual prognoses.
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Of the 64 participants that took part, 46 participants were classified as public sector participants and 18 as industry participants. Participants indicated that they predominantly (80%) rely on subjective comparisons when comparing AEs between treatment groups. Thirty-eight per cent were aware of specialist methods for AE analysis, but only 13% had undertaken such analyses. All participants believed guidan
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The guideline-based decision support system (GL-DSS) of the DESIREE project and OncoDoc are two clinical decision support systems applied to the management of breast cancer. In order to evaluate the DESIREE GL-DSS, we decided to reuse a sample of clinical cases previously resolved by the multidisciplinary tumor board (MTB) of the Tenon Hospital (Paris, France) when using OncoDoc. Since we ha
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Acute kidney injury (AKI) is a common and serious complication after cardiac surgery, and current strategies aimed at treating AKI have proven ineffective. Levosimendan, an inodilatating agent, has been shown to increase renal blood flow and glomerular filtration rate in uncomplicated postoperative patients and in patients with the cardiorenal syndrome. We hypothesized that levosimendan through its specific effects on r
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The seven papers in this issue address a variety of challenges that parents in several different cultural places encounter as they do their best to ensure their children’s safe, happy, and successful development from infancy through middle childhood infant sleep, developmental agendas, temperament, preschools, academic success, and learning to be a parent in a new cultural environment. The authors use a
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This paper evaluated the unique challenges of Australians in relation to the global novel coronavirus (COVID-19) pandemic. The 2019-2020 bushfires and COVID-19 outbreak have increased rates of anxiety and distress in Australia. On the contrary, unprecedented spending by the Australian Government on health care, employment, and housing has potentially lowered anxiety and stress for some Australians. Research is required to mon
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ticle is protected by copyright. All rights reserved.
Cardiology pharmacists are in a unique position to work with other pharmacists and health care professionals to implement safe and effective practice changes during the COVID-19 pandemic. Ongoing and adjustments are necessary in rapidly changing times.This article is protected by copyright. All rights reserved.The roles and contribut
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Perceived organizational support was found to have both main and buffering effects on the emotional attachment of nurses toward their organizations. The findings support the importance of creating supportive work settings to alleviate the adverse effects on nurses of workload and work-family interference.
Perceived organizational support was found to have both main and buffering effects on the emo
https://canvas.instructure.com/eportfolios/3672632/entries/13475596
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People with mesothelioma and their families have palliative care needs throughout the relatively short trajectory of their illness.
To describe the palliative care needs and experiences of people with mesothelioma and their family carers.
Integrative systematic review with narrative synthesis (PROSPERO
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The overall cost of the evaluation process was €97 per person screened, €17 834 per cardiovascular disease detected, and €29 588 per cardiovascular disease associated with SCD detected. Inclusion of ECG was associated with a 36% cost reduction per diagnosis of diseases associated with SCD compared with the health questionnaire alone.
The inclusion of an ECG to a health questionnai
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Birmingham, a dynamic city in the heart of England, is known for its abundant history, diverse culture, and dynamic neighborhood. However, it is likewise a city that experiences a series of weather condition conditions, from cold winter seasons to mild s
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Bioinformatic analysis of these differential proteins revealed a central network of interacting molecular species, providing a rationale to the concomitant modulation of different plant physiological processes following the microbial inoculation. These findings indicated that the application of Trichoderma-based products exerts a positive impact on strawberry, integrating well with previous observat
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BACKGROUND Breast cancer is a collection of multiple tissue pathologies, each with a distinct molecular signature that correlates with patient prognosis and response to therapy. Accurately differentiating between breast cancer sub-types is an important part of clinical decision-making. Although this problem has been addressed using machine learning methods in the past, there remains unexplained heterogene
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Venous thromboembolism (VTE) concomitant to acute limb ischemia (ALI) is rarely reported. The aim of the study was to investigate characteristics and identify clinical indicators of VTE in patients with ALI.
Electronic medical record was used to identify patients diagnosed with ALI from January 2013 to June 2019. Eligible patients were categorized as VTE or non-VTE base
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Charcot foot (CF) is a rare complication of diabetes associated with foot deformities and foot ulcers. Peripheral arterial disease (PAD) is a factor of poor prognosis in patients with diabetic foot ulcers (DFUs). However, PAD has infrequently been studied in CF. We aimed to determine the prevalence, the characteristics and the prognosis of PAD in a large group of patients with diabetic CF. We retrospectively compared
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The results of the study allow us to conclude that in order to regulate the functional activity of lymphocytes during various diseases, it is necessary to take into account an autoregulatory mechanisms that ensure the interaction of immune cells with the mediators of the nervous and endocrine systems, maintaining the homeostasis of these systems and regulating the immune response.The aim of the study was to det
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The spectral separation of differently colored food dyes was achieved by the fully addressable driver controlled RGBW LEDs. The software was newly written in R to speed-up the processes, supported by the new Raspberry Pi 4B computer with 4 GB RAM. The analysis of Stevia leaves for steviol glycosides yielded results comparable to the status quo. Different water samples were analy
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Sacral Neuromodulation with the InterStim System for Over active Vesica: 3-Year Results from french Potential, Multicenter, Observational Seems Research.
t of age-associated changes to immunity.A combination of decision tree (DT) and fuzzy logic techniques was used to develop a fuzzy model for differentiating peanut plant from weeds. Color features and wavelet
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Clinical case formulations (CCFs) can be organized and communicated in several ways but one of the most effective is through CCF causal diagrams (CCFCDs). Haynes et al., Psychological Assessment, 2020, 32, 541 illustrated how the psychometric evaluation of CCFCDs could be facilitated by assigning quantitative values to the clinician’s judgments in a CCF. Although quantification could facilitate the psychometr
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We conclude that failing to account for demographic variation across climatic gradients can lead to erroneous conclusions about species’ capacity to spatially track suitable climate.AbstractMany organisms are specialized, and these narrow niches are often explained with trade-offs-the inability for one organism to express maximal performance in two or more environments. However, evidence is lacking that trade-offs are
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Decompressive hemicraniectomy (DHC) is a treatment of space-occupying hemispheric infarct. Current surgical guidelines use criteria of age <60 years and surgery within 48 hours of stroke onset.
The purpose of this study was to evaluate the neurologic outcome after DHC and evaluate the relationship of stroke volume and outcomes.
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Anxiety disorders are among the most prevalent mental disorders. While it is known that a majority of individuals with anxiety disorders remains untreated, actual treatment rates for adolescents and young adults in Germany remain largely unknown.
As part of the Behavior and Mind Health (BeMIND) study, examining a random community sample of 14-21-year-olds (Dresden; Germany; N
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To analyze risk factors for death in individuals with severe acute respiratory syndrome due to COVID-19.
This was a retrospective cohort study, comprised of adult individuals with COVID-19, from March to September 2020, notified by the Epidemiological Surveillance System in the state of Acre, Brazil. Cox regression was used.
Among 57,700 indivi
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Notably, through simple modification of the feed solution configuration, composite/structured micromaterials can also be produced, including quantum-dots-labeled fluorescent particles, magnetic particles, core-shell particles, microcapsules, and necklace-like microfibers. This method, with general applicability and facile control, is envisioned to have great prospects in the field of polymer microprocessing.Chronic f
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A responsive and well-functioning newborn referral system is a cornerstone to the continuum of child health care; however, health system and client-related barriers negatively impact the referral system. Due to the complexity and multifaceted nature of newborn referral processes, studies on newborn referral systems have been limited. The objective of this study was to assess the barriers for effective funct
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Migraine headache is a common cause of pain and disability in children and adolescents and is a major contributor to frequently missed school days and limitations in activities. Of children and adolescents with migraine headache, approximately one-third have migraine with aura (MA). MA is often considered to be similar to migraine without aura (MO), and thus, many studies do not stratify patients based on the pres
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Also, the proposed method was applied to pedestrian impact simulations with various impact speeds to estimate the probability of death with respect to the impact speed. The probability of death from the proposed method was compared with those from epidemiological studies. The proposed method accurately estimated WBIMs such as ISS and WBFCI using either for a given distribution of injury risk or MAIS levels. The pred
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We find that the tensile modulus of the polymers increases with increase in strain rates, which shows that polymers show a strain-dependent behavior. The tensile modulus of the polyester-ether is higher than polyester but reaches yield stress faster than polyester. This makes polyester more ductile than polyester-ether.An asymmetric α-regioselective allenylation reaction of activated ketimines with 3-butynoates is disclosed
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This study aims to clarify the mechanisms underlying transcriptional regulation and regulatory roles of lncRNAs in skeletal muscle cell differentiation.
We analysed the expression patterns of lncRNAs via time-course RNA-seq. Then, we further combined the ATAC-seq and ChIP-seq to investigate the governing mechanisms of transcriptional regulation of diffe
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The neurobiology of Parkinson’s disease and its progression has been investigated during the last few decades. Braak et al. proposed neuropathological stages of this disease based on the recognizable topographical extent of Lewy body lesions. This pathological process involves specific brain areas with an ascending course from the brain stem to the cortex. Post-mortem studies are of i
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All clusters had significantly more difficulties in EF, ToM, socialization and adaptive behavior compared to TD. Social and adaptive trajectories between the ASD subgroups were relatively different; Cluster 3 showed poorer socialization and daily living skills than the other two subgroups. These findings highlight the importance of fully assessing social, cognitive, and adaptive profiles to develop care
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ion of transposon families paired with expression evidence paves the way for additional work seeking to link epigenetics with the important trait variation seen in this homoploid hybrid system.Fusarium head blight (FHB) is a serious fungal disease affecting wheat and other cereals worldwide. This fungus causes severe yield and quality losses from a reduction in grain quality and contamination of grain with mycotoxins. Inte
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Together, these findings establish a HMGB2-TOP1cc-cGAS axis that enables cytoplasmic chromatin recognition and response to immune checkpoint blockade.Seasonal mismatches between electricity supply and demand is increasing due to expanded use of wind, solar and hydropower resources, which in turn raises the interest on low-cost seasonal energy storage options. Seasonal pumped hyd
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Due to its intranasal mode of delivery, etripamil has a rapid onset of action, and could feasibly be administered by the patient themselves. Clinical Phase II trials of etripamil in moderate to high doses demonstrated efficacy comparable to the standard of care, and took an average of 3 minutes from drug administration to conversion to sinus rhythm. In this article, we have conducted an extensive literatur
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Ganoderma boninense (G. boninense) infection reduces the productivity of oil palms and causes a serious threat to the palm oil industry. This catastrophic disease ultimately destroys the basal tissues of oil palm, causing the eventual death of the palm. Early detection of G. boninense is vital since there is no effective treatment to stop the continuing spread of the disease. This review describes past an
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Rheumatic heart disease (RHD) still affects more patients globally than degenerative valve disease. The vast majority of these patients live in low- to middle-income countries. Once symptomatic, they will need heart valve surgery. Unfortunately, prosthetic valves perform poorly in these patients given their young age, the high incidence of multi-valve disease, late diagnoses and often challenging socio-economic ci
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From then on, each time a new processis wanted, the father or mother process connects to the server and requeststhat it fork a brand new course of. The fork server course of is single threadedunless system libraries or preloaded imports spawn threads as aside-effect so it’s typically secure for it to use os.fork().No pointless sources are inherited. The effectiveness of these safety practices depends heavily on constant applicati
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The spectral separation of differently colored food dyes was achieved by the fully addressable driver controlled RGBW LEDs. The software was newly written in R to speed-up the processes, supported by the new Raspberry Pi 4B computer with 4 GB RAM. The analysis of Stevia leaves for steviol glycosides yielded results comparable to the status quo. Different water samples were analy
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These findings demonstrate that ZMK1 together with ZmCIPK23 plays important roles in K+ uptake and homeostasis in maize.Carotenoids are essential in human diet, so that the development of programs toward carotenoid enhancement has been promoted in several crops. The cereal tritordeum, the amphiploid derived from the cross between Hordeum chilense Roem. et Schulz. and durum wheat has a remarkable carotenoid content in the endosperm. B
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Migraine headache is a common cause of pain and disability in children and adolescents and is a major contributor to frequently missed school days and limitations in activities. Of children and adolescents with migraine headache, approximately one-third have migraine with aura (MA). MA is often considered to be similar to migraine without aura (MO), and thus, many studies do not stratify patients based on the pres
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To compare postoperative outcomes in patients with diabetic nephropathy receiving haemodialysis and undergoing isolated coronary artery bypass grafting (CABG) using bilateral or single skeletonized internal thoracic artery (ITA).
Among 1441 consecutive patients undergoi
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The polarization splitter-rotator (PSR) plays a significant role in telecom, Datacom, and quantum circuits to meet significant requirements for polarization processing and multiplexing. We design an ultracompact PSR based on a silicon asymmetrical directional coupler (ADC). One waveguide of the ADC is gradually etched in two levels along the coupling region and the S-bend. A trapezoidal taper on the top of the dual-etc
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The fungal genus Alternaria was distributed widely and found in different habitats such as plant or indoor environment. During an investigation into this genus in China, two new Alternaria species, Alternaria vulgarae and A. divaricatae were respectively isolated from diseased leaves of Foeniculum vulgare and Saposhnikovia divaricata, which both belonged to Umbelliferae. Phylogenetically, they were determined as new spec
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Impetigo is a common superficial bacterial infection of the skin, with a global disease burden of greater than 140 million. Children are more affected than adults and incidence decreases with age. Principal pathogens implicated include Staphylococcus aureus and Streptococcus pyogenes. There are two common variants of impetigo nonbullous (70%) and bullous (30%). Nonbullous impetigo is caused by S. aureus and S.
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we applied a thematic analysis approach to analyze qualitative data. Results Timeliness of report, registration completeness, report completeness, and data accuracy level of the selected facilities were 70, 78.2, 86, and 48%, respectively. All results are below the expected national standards. Commonly reported reasons for the poor practice of data quality were; poor support of management, lack of accountability f
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Our study indicates that the GLP-1 pathway plays a critical role in microglia-reactive astrocyte associated neuroinflammation in AD and the effects of NLY01 are primarily mediated through a direct action on Aβ-induced GLP-1R+ microglia, contributing to the inhibition of astrocyte reactivity. These results show that targeting upregulated GLP-1R in microglia is a viable therapy for AD and other neurodegenerativ
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The spectral separation of differently colored food dyes was achieved by the fully addressable driver controlled RGBW LEDs. The software was newly written in R to speed-up the processes, supported by the new Raspberry Pi 4B computer with 4 GB RAM. The analysis of Stevia leaves for steviol glycosides yielded results comparable to the status quo. Different water samples were analy
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In addition, overexpression of human AR produced no benefit to disease onset and progression in SOD1G93A mice. In conclusion, the disease course of SOD1G93A mice is independent of AR expression levels, implicating other mechanisms involved in mediating the sex differences in ALS. Our findings using Nestin-Cre mice, which show an inherent metabolic phenotype, led us to hypothesise that targeting hypermetabolism assoc
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Osteopontin (OPN), a phosphorylated sialoprotein, has been shown to overexpress in a variety of cancers and to contribute tumor progression and metastasis by increasing cell migration and adhesion. In the current study, we aimed to investigate the prognostic and predictive role of OPN in patients with advanced gastric cancer.
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Although the genetic factors associated with hypertension remain unknown, genetic variations in genes related to ion channels, inflammation, and the cell cycle may affect susceptibility to hypertension. In the present study, the association between hypertension and 10 candidate single-nucleotide polymorphisms (SNPs) was evaluated among Chinese Dai people, who have a smaller gene pool than Han individuals.
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In 2020, there seems to be less and less reasons justifying that elder women with cervix cancer may not receive the appropriate treatment. The sorption behaviour of three perfluoroalkyl substances (PFASs), namely perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexane sulfonic acid (PFHxS), was determined on 28 tropical soils. Tropical soils are often highly weathered, ri
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ose most likely to benefit.Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is the most prevalent non-viral sexually transmitted infection that affects over 170 million people worldwide. The only type of drug recommended for the therapeutic control of trichomoniasis is the 5-nitroimidazoles, although there have been reports of some undesirable side effects and clinical resistance. Hence, the need for the se
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Cerebral ischemia-reperfusion injury is pivotal in the development of multiple-subcellular organelle and tissue injury after acute ischemic stroke. Recently, the Golgi apparatus (GA) has been shown to be a key subcellular organelle that plays an important role in neuroprotection against oxygen-glucose deprivation/reperfusion (OGD/R) injury. PAQR3, a scaffold protein exclusively localized in the GA, was origin
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PURPOSE To determine whether there is an association between external match load and contextual factors on subjective wellness in the days before and after Australian Rules football match play. METHODS A total of 34 elite male Australian football players completed a subjective wellness questionnaire in the days leading into the match (-3, -2, and -1 d), the day of (match day), and the days after each match (+3, +
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The article provides an overview of the opinions and attitudes of a selected group of experts on the introduction of electronic healthcare in the Czech healthcare system. The research used the DELPHI method, the first wave of which took place in the first quarter of this year and the second wave is planned for the second half of this year. A total of forty respondents assessed the relevance of the individual steps o
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The results did not replicate the original study such that younger adults showed slightly more priming from distractors than older adults. The results provide converging evidence that although older adults have more difficulty inhibiting irrelevant information in the Stroop task, distractor information does not seem to disproportionately influence later memory for older adults compared with younger adults. These studies sug
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Three different sources of FSH (porcine pituitary, pFSH; recombinant bovine, rbFSH; and recombinant human, rhFSH) were compared during in vitro culture of preantral and early antral follicles of goats for 18 days. Treatments were base medium supplemented with no FSH (control), 10, 50, or 100 mIU/mL pFSH (pFSH10, pFSH50, and pFSH100, respectively), 100 ng/mL rbFSH (rbFSH), and 50 mIU/mL rhFSH (rhFSH). There were ev
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After 12 months of follow-up, 41 (25.5%) cardiovascular complications were detected in the group of ACS patients with ADD and 20 (13.0%) in the group of ACS patients without ADD. According to the results of the analysis of the neural network based on NAD(P)-dependent dehydrogenases of platelets activity in ACS patients with ADD, indicators were obtained that are informative for predicting the development of recurren
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cervical cancer is an illness that causes 250,000 deaths worldwide. Data on Health professional’s skills is highly important for the elaboration of prevention strategies. Objective assess the knowledge, attitudes and practices (KAP) among Brazzaville midwives on cervical cancer screening.
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Coronavirus disease 2019 (COVID-19) is a novel infectious disease that started in Wuhan, China, and has rapidly spread all across the world. With limited ability to contain the virus and relatively high transmissibility and case fatality rates, governmental institutions and pharmaceutical companies are racing to find therapeutics and vaccines that target this novel coronavirus. However, once again, pregna
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Immunoglobulin A vasculitis (IgAV), the most common childhood vasculitis, is associated with gastrointestinal (GI) involvement in 50-75% of cases. The aim of this study was to describe the characteristics of GI involvement in a cohort of hospitalized children with IgAV.
We retrospectively evaluated patients hospitalized for IgAV at Meyer Children’s University Hospital, from J
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Altogether, we demonstrate the diagnostic value of pHLuc as a bioluminescent reporter for pH variations across the tumor microenvironment. The pHLuc reporter plasmids constructed in this work are available from Addgene.The Graves’ disease is an autoimmune disease highly associated with thyroid cancer. The Graves’ ophthalmopathy (GO) is a special Graves’ disease with inflammatory ophthalmopathy being a typical extrathy
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In glioblastoma U87 and U251 cells treated with EP, the viability, proliferation, migration, invasion abilities were inhibited in a dose-dependent manner. EP inhibited EMT and the activation of NF-κB (p65) and ERK. With NF-κB (p65) and ERK activated, EMT, migration and invasion of U87 and U251 cells were promoted. However the activation of NF-κB (p65) and ERK were decreased, EMT, migration and invasion abilities wer
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Registry ClinicalTrials.gov; Name Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia; URL https//clinicaltrials.gov/ct2/show/NCT01348542; Identifier NCT01348542.
The aim of this study was to characterize older adult Medicare beneficiaries seen by board-certified sleep medicine providers (BCSMPs) and identify predictors of being seen by a BCSMP.
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Do dopaminergic reward structures represent the expected utility of information similarly to a reward? Optimal experimental design models from Bayesian decision theory and statistics have proposed a theoretical framework for quantifying the expected value of information that might result from a query. In particular, this formulation quantifies the value of information before the answer to that query is known, in situations wh
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We integrate a biocompatible plant virus-based nanotechnology (tobacco mosaic virus, TMV) with S100A9-targeting peptides for its application in imaging and diagnosis of atherosclerosis. S100A9-targeted TMV nanoparticles exhibit remarkable specificity to S100A9 and targeting of atherosclerosis lesions in ApoE-/- mice.Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery systems
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Knockdown of circ_0008039 suppressed BC cell proliferation, migration, invasion, and glycolysis. Moreover, miR-140-3p could bind to circ_0008039 and its inhibition reversed the inhibitory effect of circ_0008039 interference on proliferation, migration, invasion, and glycolysis in BC cells. SKA2 was verified as a direct target of miR-140-3p and its overexpression partially inhibited the suppressive effect of miR-140-3p
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Pain has a significantly greater effect on pre-frontal-cortex and sensory-motor areas than nonpainful stimulation on oxyhemodynamics. The effect of pain on sensory-motor areas was greater than the effect of pain on the prefrontal-cortex. There was an effect of centralized pain in the CPP group on oxyhemodynamics f
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Oxytocin has drawn significant research attention for its role in modulating mammalian social behavior. Despite generally conserved roles, oxytocin can function differently even in closely related species. Previous studies have shown that bonobos and chimpanzees, humans’ two closest relatives, demonstrate considerable behavioral differences, including that bonobos look more at others’ eyes than chimpanzees. Oxytocin is kno
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The 116 women with RIF after the OPTIMUM treatment strategy were 38.3±3.8years old and had an implantation failure history over 5 (3-19) ET cycles. Implantation testing identified impaired intrauterine circumstances in 75 women (64.7%), an aberrant elevated Th1/Th2 cell ratio in 56 women (48.3%), and thyroid abnormalities in 33 women (28.4%). Cumulative ongoing pregnancy rates including spontaneous pregnancy in the pa
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Mandible displacement is known to correlate with otological conditions such as pain in the ear canal, hearing loss, or tinnitus. The present work aimed to determine the association between the displacement of the condyle in a temporomandibular joint, the structure and position of the petrotympanic fissure (PTF), and comorbid tinnitus in patients affected by temporomandibular joint and muscle disorder (TMD).
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Microbial communities are ubiquitous and play crucial roles in many natural processes. Despite their importance for the environment, industry and human health, there are still many aspects of microbial community dynamics that we do not understand quantitatively. Recent experiments have shown that the structure and composition of microbial communities are intertwined with the metabolism of the species that in
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The present study focuses on an innovative approach in measuring the mechanical oscillations of pre-loaded Achilles tendon by using Mechanotendography (MTG) during application of a short yet powerful mechanical pressure impact. This was applied on the forefoot from the plantar side in direction of dorsiflexion, while the subject stood on the ball of the forefoot on one leg. Participants with Achilles tendinopathy (AT; n = 10) were com
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Re-analysis of several translatome datasets was performed to compare the translatomes of glioma models with those of their non-tumor counterparts and to document glioma cell responses to radiotherapy and MNK modulation. The role of recurrently altered genes in the context of translational control and tumorigenesis are discussed.Parkinson disease (PD) is the second most common age-related neurodegenerative disease in the
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The use of the growth factors for the long-term culture of stem cells can be beneficial. However, to promote germ cell differentiation, the growth factors might be used by other meiosis inducer factors, such as RA.
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Hematopoietic adaptor containing SH3 and SAM domains-1 (HACS1) is a signaling protein with two juxtaposed protein-protein interaction domains and an intrinsically unstructured region that spans half the sequence. Here, we describe the interaction between the HACS1 SH3 domain and a sequence near the third immunoreceptor tyrosine-based inhibition motif (ITIM3) of the paired immunoglobulin receptor
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Recent advances in the treatment of breast cancer (BC) have been related to the personalization of therapy. The methylation status of the promoter regions of tumor suppressor genes such as BRCA1and BRCA2is supposed to be useful as a prognostic factor in BC patients.
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Enteral feeding in community settings is becoming increasingly common, and this article aims to help nurses and other healthcare professionals to refresh their knowledge of the important concepts in the community-based care of patients receiving enteral nutrition via a percutaneous endoscopic gastrostomy (PEG) tube. The article provides an overview on the management and care of the patient, the
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Safety-net health systems are a primary source of care for socioeconomically disadvantaged individuals who may be eligible for HIV pre-exposure prophylaxis (PrEP) and are priority groups under the Ending the HIV Epidemic (EHE) initiative. Nevertheless, little evidence is available about barriers to PrEP implementation in safety-net settings. We aimed to assess the association between PrEP knowledge and prescrib
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Post-exercise HG inhalation attenuated the increase in urinary 8-hydroxydeoxyguanosine excretion rate (P less then 0.05), a DNA oxidation marker, and the reduction in the countermovement jump height (P less then 0.05), compared with Placebo inhalation. Other exercise performances and blood oxidative stress and muscle damage markers did not differ between HG and Placebo inhalation. Moreover, the increase in urinary
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Rural practitioners who develop a sense of belonging in their community tend to stay; however, belonging means neighbours become patients and non-clinical encounters with patients become unavoidable. Rural clinical experiences expose students to overlapping personal and professional relationships, but students cannot be duly prepared to navigate them because ethical practice stand
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Resourcefulness theory has been developed and applied for nearly four decades in the West and been recommended by scholars in Taiwan for almost two decades. Research into the concept and theory of resourcefulness has been conducted in the nursing profession, especially in psychiatric and mental health nursing, in Taiwan, making the country the earliest Chinese and Taiwanese culture to adopt and use this theory.
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Matrix targeting sequences (MTSs) direct proteins from the cytosol into mitochondria. Efficient targeting often relies on internal matrix targeting-like sequences (iMTS-Ls) which share structural features with MTSs. Predicting iMTS-Ls was tedious and required multiple tools and webservices. We present iMLP, a deep learning approach for the prediction of iMTS-Ls in protein sequences. A recurrent neural network has bee
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4 ± 125.4 vs. 258.3 ± 220.4 mL; p less then 0.001). The PDQ-J score and preoperative NRS scores (NRS-BP, NRS-LP, and NRS-LN) did not differ significantly between groups. Less improvement in the NRS-BP (ΔNRS-BP) was observed in the DP group than in the IDP group (p less then 0.05). Although pain improved after surgery in both groups, IDP surgery was advantageous in minimizing bleeding and preserving poste
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This review covers recent research progress in bioadhesives as focused on their applications in musculoskeletal tissue repair and regeneration. We also discuss the advantages and outstanding challenges of bioadhesives, as well as the future perspective toward regeneration of connective tissues with high mechanical demand.
Determining factors that predict a career in academic neurosurgery can help to i
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This finding was further supported by significant moderating effect (assessed using ANCOVA and sub-sample analysis) of BP on valence-startle amplitude relationship. The comparison BP group also showed slower latencies to response onset for pleasant stimuli compared to neutral and unpleasant, with no effect of valence in the elevated BP group. However, BP did not moderate the valence-onset latency relationship. Our findin
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Inactive ovaries (IOs) affect the estrus cycle and timed artificial insemination (TAI) efficiency in dairy cows during early lactation. The objective of the experiment was to determine metabolic changes in the serum and milk whey of dairy cows with IO and estrus. Twenty-eight healthy postpartum Holstein cows in similar age, milk production, and body condition were selected at 30 days postp
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5 ± 14) as well as the social impairment (+21 ± 7) at 1 year postoperatively. Patients were followed for a median of 2 years (range 2-6 years). Conclusions The use of tendon slings for static facial paralysis reconstruction is a reliable technique with no functional sequelae and good long-term results.Introduction Although patients are able to easily record electrocardiograms using consumer devices, these are typi
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Inside vitro along with vivo usefulness of thiacloprid towards Echinococcus multilocularis.
Nanocolloids having directional interactions are highly relevant for designing new self-assembled materials easy to control. In this article we report stochastic dynamics simulations of finite-size pseudo-dipolar colloids immersed in an implicit dielectric solvent using a realistic continuous description of the
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In addition, derrone inhibited glycoprotein IIb/IIIa (αIIb/β3) affinity. Thus, in the present study, derrone suppressed human platelet aggregation and thrombin-induced clot formation.Heat-related diseases have long been known to damage the structure and function of essential macromolecules such as proteins, lipids, and nucleic acids, thereby compromising the integrity of cells and tissues and the physiological funct
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spitals in the Amhara Region. Early age sexual contact, high parity, and being uneducated/low level of education were independently associated factors with HR-HPV infection and development of cervical lesions, highlighting the importance of prioritizing the limited HPV testing to those risk groups.
There was a relatively low prevalence of oncogenic HPV 16/18 and VIA-p
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Therefore, this study demonstrates that PAG may potentially be used as an adjuvant for influenza vaccines.Systemic infections due to Fusobacterium may originate in the tonsillar/internal jugular veins or from the abdomen. We encountered a patient who presented with bacteremia, fulminant septic shock, and extensive soft tissue pyogenic infection due to Fusobacterium necrophorum. In addition, there was widespread
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The Polycomb system is essential for stable gene silencing in many organisms. This regulation is achieved in part through addition of the histone modifications H3K27me2/me3 by Polycomb Repressive Complex 2 (PRC2). These modifications are believed to be the causative epigenetic memory elements of PRC2-mediated silencing. As these marks are stored locally in the chromatin, PRC2-based memory is a cis-ac
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001). Biliary leakage is the most common complication after OCJ; no complication was experienced in the LCJ group.
LCJ is a feasible and safe option for patients undergoing choledochojejunostomy.
LCJ is a feasible and safe option for patients undergoing choledochojejunostomy.Schizophrenia is a chronic mental disorder with marked symptoms of hallucination
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579 and 1.431, P = 0.020 and 0.049, respectively) after adjusting age, hypertension and diabetes. However, rs11536889 polymorphism had no significant influence on serum TLR4 levels. Regarding rs1927914, luciferase activity of the C allele construct was significantly increased in comparison with the T allele construct (0.589 ± 0.004 vs. 0.340 ± 0.014, P less then 0.001). Our results provided evidence that rs1927914 polymorp
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9, 95% CI 0.2-4, p = 1). One hundred percent (33/33) of the available follow-up data confirmed PET/MRI findings.
PET/MRI significantly changed PDAC management, consistently across the different SCI modalities it was compared to. These findings suggest a role for PET/MRI in the management of PDAC.
PET/MRI significantly changed PDAC management, consistently acro
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The inbreeding coefficient calculated based on ROH showed an average value of 0.026 for the whole population. In addition, the inbreeding coefficient of each generation subpopulation initially increased and then decreased. In the pedigree of the whole conserved population, the error rate of paternal information was more than 11.35% while the maternal information was more than 2.13%.
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We believe that this technique should be considered in pediatric patients with open fractures of the lower limbs and extensive soft tissue injuries.The reimplantation of small or large extruded bone segments is one of the most complex clinical management scenarios in the treatment of open fractures. No consensus exists regarding the efficiency of this technique. The aim of the study was to analyse the clinical and
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The effective design and implementation of the nursing interventions to evaluate the patients’ readiness for ventilator weaning will reduce their connection time to the ventilator and the complications of their connection to it. This study was conducted to examine the effect of nursing interventions based on the Burns Wean Assessment Program (BWAP) on successful weaning from Mechanical Ventilation (MV).
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Elevated amounts of reactive oxygen species (ROS) including hydrogen peroxide (H2O2) are observed in the epidermis in different skin disorders. Thus, epidermal sensing of H2O2 should be useful to monitor the progression of skin pathologies. We have evaluated epidermal sensing of H2O2 in vitro, by visualising H2O2 permeation through the skin. Skin membranes were mounted in Franz cells, and a suspension of Prussian wh
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While their specific roles and duties have changed to include naloxone administration to reverse opioid overdoses and providing referrals, officers felt that this was just part of their job in responding to the needs of the community. Officers reported that they have learned how to use (99%) and carry naloxone (87%) to reverse opioid related overdoses. The majority (92%) reported providing referrals (e.g., treatment a
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In the current study, 16 congeners of PAHs were measured in 32 surface sediment samples to determine their pollution status in the Jiangsu coastal zone, East China. The total concentrations of the 16 PAHs ranged from 2.2 to 46.6 ng g-1 with an average of 8.36 ng g-1 in surface sediments and were significantly lower than those of PAHs in other coastal areas of China. The spatial distribution of PAHs revealed an
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It is expected that the incidence of cerebrospinal fluid (CSF) shunt malfunctions would remain unchanged during the shelter-in-place period related to the COVID-19 pandemic.
To examine the number of shunt surgeries performed in a single institution during this time interval in comparison to equivalent periods in past years.
The nu
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In addition, a wealth of available knowledge on mechanotransduction is curated to generate an integrated signaling network encompassing the central components of the focal adhesion, cytoplasm and nucleus that act in concert to promote durotaxis, proliferation, and differentiation in a stiffness-dependent manner. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Graft allocation rules for heart transplantation are
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Exercise can significantly improve the balance function of patients with osteoporosis and osteopenia, and balance combined with strength training has the best effect, followed by TCM exercises.
Exercise can significantly improve the balance function of patients with osteoporosis and osteopenia, and balance combined with strength training has the best effect, followed by TCM exercises.
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The most common investigations were X-ray and CT (pre-operatively), and X-ray and contrast swallow (post-operatively). Standardized guidelines focused upon the frequency and type of radiological imaging for children with EA are lacking. Children with EA are subjected to more radiation exposure than the general population. Implementation of non-radiating imaging (ultrasonography, manometry) is recommended.Aging is
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In Argentina, the mosquito Aedes aegypti (L.) (Diptera Culicidae) is distributed from subtropical to temperate climates. Here, we hypothesized that the expansion of Ae. aegypti into colder regions is favoured by high-phenotypic plasticity and an adaptive inhibition of egg hatching at low temperatures. Thus, we investigated the hatching response of eggs of three populations one from a subtropical region (Resistencia) and two
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Cockayne syndrome (CS) is a rare premature aging disease, most commonly caused by mutations of the genes encoding the CSA or CSB proteins. CS patients display cachectic dwarfism and severe neurological manifestations and have an average life expectancy of 12 years. The CS proteins are involved in transcription and DNA repair, with the latter including transcription-coupled nucleotide excision repair (TC
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Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken macrophage cell line. Chicken AvBD8 stimulated the expression of proinflammatory cytokines (IL-1β, interferon gamma, and IL-12p40) and chemokines (CCL4, CXCL13, and CCL20)
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The optimal timing to administer a P2Y12 inhibitor in patients presenting with a non-ST elevation acute coronary syndrome remains a topic of debate. Pretreatment with ticagrelor before coronary anatomy is known as a widely adopted strategy. However, there is poor evidence on how this compares with administration of a P2Y12 inhibitor after defining coronary anatomy (i.e., downstream administration). Moreover, there
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Vaccination is a key strategy to prevent the pandemic caused by the coronavirus disease 2019 (COVID-19). This study aims to investigate the willingness of Chinese adults to be vaccinated against COVID-19 and further explore the factors that may affect their willingness. We used a self-design anonymous questionnaire to conduct an online survey via the Sojump. A total of 1009 valid questionnaires were analyzed. T
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Elevated amounts of reactive oxygen species (ROS) including hydrogen peroxide (H2O2) are observed in the epidermis in different skin disorders. Thus, epidermal sensing of H2O2 should be useful to monitor the progression of skin pathologies. We have evaluated epidermal sensing of H2O2 in vitro, by visualising H2O2 permeation through the skin. Skin membranes were mounted in Franz cells, and a suspension of Prussian wh
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Acid catalyzed carboxymethylation of alcohols is an emerging organic transformation that has grabbed the attention of scientific community in recent years. In the present study, sulfonated mesoporous polymer (MP-SO3H) is presented as a highly active solid acid catalyst to convert a wide range of alcohols into alkyl methyl carbonates. The remarkable catalytic activity of MP-SO3H is comparable to that of report
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es fiscal policies, social protection, labor market, and employment policies need to improve education and wealth status for women from poor households. This might be the first step toward achieving universal maternal health coverage.Intimate and sexual relationships provide opportunity for emotional and sexual fulfillment. In consensually non-monogamous (CNM) relationships, needs are dispersed among multiple partners
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Assessment regarding dairy excess fat globule membrane as well as whey proteome among Dromedary and Bactrian camel.
Purpose To describe presence of neurotrophic growth factors and histopathologic characteristics of internal limiting membrane (ILM) specimens obtained from large idiopathic full-thickness macular holes (FTMH).Methods In 24 eyes of 24 patients with FTMH of diameter > 400 µm, ILM specimens w
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In addition, correlations among FA groups were in line with correlation among individual FA. Moderate negative genetic correlations between FA and milk yield and moderate to strong positive correlations with fat, protein, and casein percentages suggest that actual selection programs are currently affecting all FA groups, not only the desired ones (e.g., polyunsaturated FA). The absence of association with d
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The anxiety and depression scales of the patients decreased after 3 months (p < 0.001). PSQI and itssubgroups ratings significantly improved after treatment (p < 0.001). Similarly, ISI, ESS, PSAS, and DBAS test scores also improved after treatment (p < 0.001).
This study provides evidence as to the applicability and acceptability of GON-B in CM treatment in terms
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Environment degree bisphenol A boosts modifications in the reno-cardiac axis through the MAPK cascades inside men person suffering from diabetes subjects: An analysis depending on transcriptomic profiling and also bioinformatics.
The primary outcome is the proportion of participants who achieve ≥ 4-fold RPR titer decrease at 3 or 6months post-treatment.
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© 2020 The Author(s).We previously reported dysregulated expression of liver-derived messenger RNA (mRNA) and long noncoding RNA (lncRNA) in patients with advanced fibrosis resulting from nonalcoholic fatty liver disease (NAFLD). Here we sought to identify changes in mRNA and lncRNA levels associated with activation of hepatic stellate cells (HSCs), the predominant source of extracellular matrix production in
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We found no evidence of a trade-off between fossorial and surface locomotion. This may be either because Lerista employed kinematic strategies that took advantage of both axial- and limb-based propulsion. This may have led to the differential occupation of their habitat, facilitating diversification of intermediate forms.The clarification of the genetic origins of present-day Tibetans requires an understanding of their
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Offer some recommendations or guidelines during the evolution of the COVID-19 pandemic in terms of diagnosis, treatment and follow-upin the field of Reconstructive Urology. MATERIAL AND METHOD The document is based on the evidence on SARS/Cov-2 and the authors’ experience in managing COVID-19 in their institutions, including specialists from Andalusia, Madrid, Cantabria,the Valencian Community and Catalonia. A we
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Assessment regarding dairy excess fat globule membrane as well as whey proteome among Dromedary and Bactrian camel.
Purpose To describe presence of neurotrophic growth factors and histopathologic characteristics of internal limiting membrane (ILM) specimens obtained from large idiopathic full-thickness macular holes (FTMH).Methods In 24 eyes of 24 patients with FTMH of diameter > 400 µm, ILM specimens w
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This situation shows that they can be bound to DNA with the groove-binding mode, with Kb value in the range of 2.0 × 103 -2.2 × 105 M-1 . Studies on human Gram(+) and Gram(-) pathogenic bacteria showed that the substituted quinolines exhibited selective antimicrobial activities with MIC values of 62.50-250 μg/ml. All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and
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Degradation and metabolism of chlorfluazuron and flonicamid from tea garden to cup were simultaneously investigated by a modified QuEChERS method coupled with UPLC-MS/MS quantification. The dissipation half-lives of chlorfluazuron, flonicamid, and total flonicamid (the sum of flonicamid and its metabolites TFNG, TFNA, and TFNA-AM) in fresh tea leaves during tea growth were 6.0 d, 4.8 d, and 8.1 d, respe
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The spinopelvic relationship in regard to total hip arthroplasty has become a topic of increasing interest in recent years. Hip arthritis and a stiff lumbar spine create a situation where the spinopelvic junction has decreased mobility, which in turn increases the risk of instability after total hip arthroplasty as the femoral acetabular joint must undergo increased motion. Regardless of the approach, surgeons should be
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Identification of optimal hand positions and development of a formal nomenclature has the potential to help trainees adopt hand positions in an informed manner, influence instrument design, and improve surgical outcomes.
To compare the corneal outcome in Fuchs’ endothelial dystrophy (FED) patients between femtosecond laser-assisted cataract surgery (FLACS) and conventional phaco surgery (CPS).
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Poor collaboration between health districts and local governments, the control of certain resources by the state and the health districts constrain the implementation of health resources and skills transfer policy at grassroots level. Careful attention should be given to the country’s political context and institutional design.Background Limbal stem cell deficiency (LSCD) is a refractory ocular surface disorder characte
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The threat of Coronavirus Disease 2019 (COVID-19) to health systems in sub-Saharan Africa (SSA) can be compared metaphorically to a lake in Africa infested with a bask of crocodiles and the saying “the eye of the crocodile.” In the lake, only the eyes of the crocodile appear on the surface while the rest of the body is submerged in water. In this Viewpoint, the eyes and the body of the crocodile represent the public health
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We analyzed data of 13 brain tissues from the Genotype-Tissue Expression (GTEx) project, and identified trios with cis-mediated transassociations across brain tissues, many of which showed evidence of trans-association in two replication studies. We also identified trans-genes associated with schizophrenia loci in at least two brain tissues.
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Infection with Streptococcus pneumoniae is the leading cause of death in children and burden of disease is greatest where helminth infections are also common. We investigated the impact of intestinal helminth co-infection on pneumococcal carriage; a risk factor for invasive disease. We used a mouse co-infection model and clinical data to assess the impact of co-infection on carriage density. Co-infection in mice was associated w
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4%) late acute genitourinary grade 3 toxicity. With a median follow-up of 63.5 months, 5 and 7-years relapse-free survival were 70% and 60.7%, respectively. CONCLUSION With a median follow-up of 5 years the present study confirms that high-dose salvage radiotherapy to a biological target volume is feasible, with low rate of late toxicity and promising activity.Laparoscop
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OBJECTIVE Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel and colon. Here we assessed the importance of the distal gut in the acute L cell response to diverse secretagogues. METHODS Circulating levels of glu
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Thus it seems that CG6709 orthologs occur only in insects undergoing on metamorphosis.The use of untreated or partially treated wastewater reuse for urban and peri-urban agricultural irrigation is a common practice in developing countries like Ethiopia. Such practices, however, pose significant environmental and public health risks. The objective of this study was to evaluate the irrigation suitability of anaerobic dig
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The history of vitamin A goes back over one hundred years, but our realization of its importance for the brain and cognition is much more recent. The brain is more efficient than other target tissues at converting vitamin A to retinoic acid (RA), which activates retinoic acid receptors (RARs). RARs regulate transcription, but their function in the cytoplasm to control nongenomic actions is also crucial. Controlled synthesis o
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Objective To explore the prognostic factors for primary gastric diffuse large B cell lymphoma (PG-DLBCL). Materials and Methods This retrospective study analyzed 72 PG-DLBCL patients between January 2012 and December 2017 in Shanxi Cancer Hospital of Shanxi Medical University, so as to identify the different prognostic factors in PG-DLBCL. The clinical features, treatment and follow-up information were analyzed
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Heart failure resulting from ischaemic heart disease is associated with a poor prognosis despite optimal medical treatment. Despite this, patients with ischaemic cardiomyopathy have been largely excluded from randomised trials of revascularisation in stable coronary artery disease. Revascularisation has multiple potential mechanisms of benefit, including the reversal of myocardial hibernation, suppression o
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It is hypothesized that unrealistically positive attitudes toward women may lead to rejection and frustration, which may influence sexual offending.
To review the therapeutic strategy in Merkel cell carcinoma (MCC) treated with radiotherapy (RT) discussed in a multidisciplinary tumour board.
Clinical records of patients with a diagnosis of MCC and with an
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01). The two groups did not demonstrate significant differences on psychosocial outcomes.
We identified a group of T1D adults reporting a consistent preference for hypoglycemia over hyperglycemia. These individuals achieve significantly greater %TIR and less %TAR, but at the cost of greater %TBR and more frequent severe hypoglycemia episodes.
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After kidney transplantation, withdrawal of calcineurin inhibitors (CNI) and conversion to sirolimus (SRL) may reduce the occurrence of new non-melanoma skin cancer (NMSC). Conversely, a reduced CNI exposure with everolimus (EVR) is an alternative strategy that has not been thoroughly evaluated. We retrospectively compared the occurrence of newly diagnosed NMSCs in two cohorts of kidney transplant recipients (KTR) with at
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48 to -0.85). The current study suggests that faster rates of acceleration and the ability to exhibit greater stroke lengths at relatively high stroke rates are determinants of 200-m kayak race performance.A growing body of research illustrates that working memory capacity is a crucial limiting factor in our ability to follow spoken instructions. Despite the ubiquitous nature of instruction following throughout the
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The objective of this systematic review and meta-analysis was to summarise the literature regarding the immunogenicity of pneumococcal conjugate vaccines (PCV) and pneumococcal polysaccharide vaccines (PPSV) in adult people living with HIV (PLWH) in the era of advanced combination antiretroviral therapy (cART).
The systematic review protocol was published online (PROSP
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28 ± 0.35 D for study and -0.57 ± 0.52 D for control group patients (p = 0.02). A significantly lower increase in axial length was found in the study group (0.13 ± 0.12 mm) compared to control (0.22 ± 0.14 mm) patients (p = 0.03). Compared to control group patients, there was less myopia progression in the study group 51 and 41 per cent in terms of cycloplegic autorefraction and axial length, respec
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Bat is the only mammal in the nature that can fly. Compared with birds and insects, bats are quite special in that their wings are formed by an elastic membrane, which renders that the airfoil deforms greatly during downstroke and upstroke. Due to the compliant skin of a bat, the movements of its wings are three-dimensionally complex during diverse flight behaviors. To understand the maneuverability and flight performan
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In-vivo ocular pharmacokinetics indicated a significant improvement in ophthalmic bioavailability of epinephrine (active form of DV). F8 was non-irritant to the eyes and showed a successful, continuous and superior ability to reduce IOP compared to DV-AqS in rabbits. In conclusion, our developed system could be an appropriate substitute to the conventional DV eye preparations in the management of elevated IOP.The prev
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These results indicate that the alterations in these factors may be related to the process of plant resistance to pathogens, and better performance against adverse conditions. This study demonstrates that the anatomical study of plants is an important tool to show the effects that are induced by biological control agents.Infections with emerging and re-emerging arboviruses are of increasing concern for global health. Tick-tr
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In the laboratory, factor VIII can be measured by three different methodologies, such as one-stage clotting assay, two-stage clotting assay, and chromogenic assay. These assays differ in ease of use, variety of reagents available, sensitivity to mild hemophilia A, and interference from lupus anticoagulants (LACs). Certain factor VIII gene mutations can cause discrepancy in results between one-stage act
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49%) > 4 wt % (77.72%) > 0 wt % (29.64%)]. Arabinose, xylitol, gluconic acid, and formic acid were found as the high-value chemicals with the photocatalytic reaction of TiO2 and Ag-doped TiO2 nanofibers under UVA irradiation. Product yields of each converted chemicals from different photocatalysts from different Ag loading contents showed relatively same trends with the glucose conversion. From a
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To evaluate cup-positioning accuracy in total hip arthroplasty (THA) using a novel angle-adjusting alignment guide with laser pointer and determine whether level of surgical experience affects accuracy of cup placement or not.
We included 117 hips in 104 patients who underwent THA using the novel guide. We retrospectively reviewed 44 hips in 40 patients who underwent THA before the n
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Several rare copy number variants have been identified to confer risk for neurodevelopmental disorders (NDD-CNVs), and increasingly NDD-CNVs are being identified in patients. There is a clinical need to understand the phenotypes of NDD-CNVs. However due to rarity of NDD-CNVs in the population, within individual countries there is a limited number of NDD-CNV carriers who can participate in research. The pan-european MINDDS
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ostic workup.Radical trachelectomy (RT) is a method of fertility preservation for patients with early invasive uterine cervical cancer stage IA2 or IB1 with a tumor diameter of ≤2 cm. However, women who have undergone RT have high risks of abortion and premature birth. To prevent premature birth, cervical cerclage is performed in patients with an ultra-short cervix, but the portio vaginalis is not visible in these patient
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< 0.001) and one’s partner (
= -0.24,
< 0.001). Actor effects-how one’s own perceptions of support associate with one’s own depressive symptomology-were stronger for care recipients than for caregivers (
= -0.83,
< 0.001 v.
= -0.26,
< 0.05). Hig
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In conclusion, this study may provide validated evidence that the introduction of IFN-γ into HUMSCs would help ameliorate GVHD after allo-HSCT.Cationic compounds have been described to readily penetrate cell membranes. Assigning positive charge to nanosystems, e.g. lipid nanoparticles, has been identified as a key feature to promote electrostatic binding and design ligand-based constructs for tumour targeting. However, t
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. Importantly, this demonstrates the high plasticity of hiPSC-CMs even in isolation. The ability of multiple biophysical cues to significantly influence isolated single hiPSC-CM phenotype and functionality highlights the importance of fine-tuning such cues for specific applications. This has the potential to produce more fit-for-purpose hiPSC-CMs. Further understanding of human cardiac development is enabled by
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Abnormalities in bone development in humans and non-humans can lead to impaired physical and psychological health; however, evidence is lacking regarding the role of individual psychosocial factors in the development of poor bone conditions. Addressing this lack of knowledge, we used low-productive laying hens (n = 93) and assessed behavioral responses to an open-field test [at 17, 18, 29, 33 weeks of age (wa
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= 0.793).
T2 mapping can be used to evaluate changes in the intervertebral disc water content. Ten sessions of traction resulted in a significant increase in quantitative T2 measurements of the NP in discs for Pfirrmann grade II-IV degeneration and remission of the patients’ clinical symptoms in the following 6 months. Ch
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85, positivity rate RR = 1.14; P less then .0001). CONCLUSIONS Determining concordance of testing and positivity rate of a laboratory test can be used for assessing testing appropriateness for other diseases in other jurisdictions. This study demonstrated some at-risk patients may be missed for H pylori testing. © American Society for Clinical Pathology, 2020. All rights reserved. For permissions, please e-mail journal
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Introduction Acute pelvic pain is an important cause of morbi-mortality. The purpose of this study was to describe the epidemiological, clinical and therapeutic features of acute pelvic pain in Yaoundé. Methods We conducted a cross-sectional, descriptive study with collection of prospective data in the Department of Gynecology and Obstetrics at the Yaoundé Gynaecology-Obstetrics and Pediatrics Hospital over the perio
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Furthermore, after generating a receiver operating curve (ROC) and calculating the area under curve (AUC), we found that DLG2-AS1 expression showed high sensitivity and specificity (AUC = 0.726) for the classification of LUAD and normal samples, determining its value as a potential lung cancer biomarker.The aim of this study was to evaluate the effects of mannan oligosaccharides (MOS) on gut health and performance in post
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Neoantigens resulting from shared mutations represent promising vaccine candidates for prevention of MSI cancers.Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor
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Within the provision of education, teachers typically have the closest contact and play a key role in meeting the needs of refugee children through effective communication to achieve culturally qualified education and the provision of more humanistic approach. This descriptive cross-sectional design study is aimed to explore the relationships among psychological resilience, intercultural sensitivity and empath
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Subgroup analysis in studies targeting the hemoglobin gene revealed a significant reduction in the persistence of gene-edited cells whether homology-directed repair or nonhomologous end-joining were used. No adverse side effects were reported. Significant heterogeneity in study design and outcome reporting was observed and the potential for bias was identified in all studies. CRISPR-Cas9 gene edited cells engraft si
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In addition, conductor embedding and post-printing heating of the conductive material are researched. The experimental results helped us to understand the mechanisms of the conductive network’s formation and its degradation. With the insight gained, the optimal printing strategy resulted in a resistivity that was approx. 40% lower than the nominal value of the filament. With a new insight into the electrical beha
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001) despite staying lower than baseline (MMDs and AMDs P < 0.001, NRS score P = 0.005). Over the same time frame, 18 (56%) patients maintained a ≥ 50% reduction from baseline in MMDs. At week 4 after treatment completion, 10 (31%) patients restarted treatment due to disease rebound to baseline levels.
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Self-compassion has been associated with less distress, particularly when people face stressful and negative events. This study analyzed the mediation role of coping and affect in the relation between self-compassion and negative emotional symptoms during the quarantine decreed by Portuguese Health Authorities in the first phase of the coronavirus outbreak. A total of 428 Portuguese adults (75%
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Knowing where our limbs are in space is crucial for a successful interaction with the external world. Joint position sense (JPS) relies on both cues from muscle spindles and joint mechanoreceptors, as well as the effort required to move. However, JPS may also rely on the perceived external force on the limb, such as the gravitational field. It is well known that the internal model of gravity plays a lar
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The aim of this work was to analyze clinical features and laboratory findings of children with adenovirus pneumonia and guide clinical diagnosis, treatment, and assessment of disease severity.
. Retrospective analysis of clinical data of 285 children with adenoviral pneumonia who were hospitalized in Wuhan Children’s Hospital from December 2018 to October 2019. According to the assessment criteria for s
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Arguably, AGPs and the AGP-Ca2+ capacitor plays a decisive role in phyllotaxis periodicity and its evolutionary origins.The Cow’s Milk-related Symptom Score (CoMiSSTM) was created as an awareness tool for cow’s milk allergy. The aim of the present study was to analyze the inter-rater variability between a pediatrician, parents, and day to day variability. A Health Care Professional (HCP) and parent filled in the
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To examine infertility-related fund-raising campaigns on a popular crowdfunding website and to compare campaign characteristics across states with and without legislative mandates for insurance coverage for infertility-related care.
Retrospective cohort study.
Online crowdfunding platform (GoFundMe) between 2010 and2020.
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002). The incidence of perioperative hypothermia according to age in the ISBPB group was 9.2% and 9.1% in the elderly and young groups, respectively, and there was no significant difference between the two groups (P = 0.983). Conclusions The incidence of perioperative hypothermia during arthroscopic shoulder surgery under ISBPB with propofol sedation is lower than that under general anesthesia. Fur
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Toll-like receptors (TLRs) play a crucial role in the innate immune system, which is the first line of defence against pathogens and pathogenic products in fish. In the present study, we cloned the full-length cDNA and genome sequences of two TLR13 s (OnTLR13a, OnTLR13b) from Nile tilapia (Oreochromis niloticus). TLR family motifs, i.e., the leucine-rich repeat (LRR) domains and Toll/interleukin (IL)-1 receptor (TIR
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The distribution of Crimean-Congo hemorrhagic fever (CCHF), a tickborne arboviral disease, is not well known in West Africa. We report 2 recent human cases of CCHF with infectious syndrome and severe bleeding in Mauritania. CCHF was diagnosed by ELISA and real time reverse transcription PCR. No secondary CCHF cases were found.We isolated Brucella melitensis biovar 3 from the spleen of an Asian badger (Mele
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016, 95% CI- 3.663 to 9.883) were found to affect compliance with fasting instructions. Conclusion To avoid risks of prolonged or inadequate fasting in day care surgical patients, good coordination between the anaesthetist and the surgeon and an updated knowledge about the preoperative fasting instructions among the health-care providers is essential. Separate written fasting instruction
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There was no 90-day operative mortality and no significant morbidity. Oncological surgical margins were free. Overall and disease-free 5-year survival were 59 and 37%. Conclusion Regardless of frequent anatomical variations of the right portal pedicle, the hanging liver maneuver, and intrahepatic extra-Glissonian approach can be combined, being useful for anatomical right hepatectomies in a safe and re
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Antibiotics are widespread in the environment with notable ecological risk, for which efficient and green removal technologies are demanded. As a kind of g-C3N4-based material with remarkable photocatalytic property, OCN is an oxygen- and nitrogen-linked carbon nitride organic polymer which can be synthesized through a single-step thermal polymerization method. In this study, OCN was applied for the vi
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We report the correlation between the size of these FCDs and their eccentricities with the morphology of the interface. This work paves the way for creating new procedures to control the assembly of functional nanomaterials into tunable assemblies that may find relevance in the field of energy technology including in optoelectronic and photonic applications.Formate dehydrogenase from Candida boidinii (EC.1.2.1.2; CbFDH)
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re compared to their younger counterparts. However, a larger proportion of older adults that went to theatre had a skin graft (where skin is removed from an uninjured part of the body and placed over the injured part).This research provides important information about a unique and growing group of patients to the local burn care community. It also highlights potential avenues for injury prevention initiatives.
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Sporadic amyotrophic lateral sclerosis (sALS) and FTLD-TDP are neurodegenerative diseases within the spectrum of TDP-43 proteinopathies. Since abnormal blood vessels and altered blood-brain barrier have been described in sALS, we wanted to know whether TDP-43 pathology also occurs in blood vessels in sALS/FTLD-TDP. TDP-43 deposits were identified in association with small blood vessels of the spinal cord in 7 of
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Study findings can provide insight into deformation characteristics of new materials and how to mitigate thermal distortions.The aim of the study was to characterize antioxidant and textural property differences of edible films prepared with the addition of lapacho extract (LE). The experimentally produced edible films also contained different carrageenans (ι- and κ-carrageenan). The κ- and ι-carrageenan, glycerol and the diff
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th gender and a pronounced inflammatory response in the NAFLD group.
To determine the structure and demographic of medical teams working in Rural General Hospitals (RGHs) in Scotland, and to gain insight into their experiences and determine their opinions on a remote and rural medical training pathway.
Structured face-to-face interviews. Interviews were p
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Nanostructured lipid carriers (NLC) have become a research hotspot, wherein cancer-targeting effects are enhanced and side effects of chemotherapy are overcome. Usually, accelerated blood clearance (ABC) occurs after repeated injections, without changing the immunologic profile, despite PEGylation which prolongs the circulation function. To overcome these problems, we designed a red blood cell-membrane-coated
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Quantification regarding m6A RNA methylation modulators design would have been a prospective biomarker pertaining to diagnosis and also associated with tumour immune microenvironment involving pancreatic adenocarcinoma.
Using our observational static balance score, the quality of the balance performance remarkably changed. [Conclusion] The quality domain of our new scale seems to be a useful tool in d
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Aqueous solutions of sodium l-glutamate (NaGlu) in the concentration range 0 less then c/M ≤ 1.90 at 25 °C were investigated by dielectric relaxation spectroscopy (DRS) and statistical mechanics (1D-RISM and 3D-RISM calculations) to study the hydration and dynamics of the l-glutamate (Glu-) anion. Although at c → 0 water molecules beyond the first hydration shell are dynamically affected, Glu- hydration is
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mmatory cytokines induce expansion and dysfunction of adipose tissue via angiogenesis and collagen turnover in premature and mature adipocytes.
Postoperative cognitive dysfunction (POCD) may be related to brain injury. S100B protein and neuron-specific enolase (NSE) have been investigated as potential biochemical markers of neural cell injury in animals and humans. This study aimed to investigate the ass
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The iconic Miller’s pyramid, proposed in 1989, characterizes 4 levels of assessment in medical education (“knows,” “knows how,” “shows how,” “does”). The frame work has created a worldwide awareness of the need to have different assessment approaches for different expected outcomes of education and training. At the time, Miller stressed the innovative use of simulation techniques, geared at the third leve
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High levels of social cohesion have been shown to be beneficial both for social entities and for their residents. It is therefore not surprising that scholars from several disciplines investigate which factors contribute to or hamper social cohesion at various societal levels. In recent years, the question of how individuals deal with the increasing diversity of their neighborhoods and society as a whole has
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Although the administration of single-allergen extracts is recommended, there are polysensitized patients who require a different strategy. This study evaluates the effectiveness of an extract containing a mixture of house dust mites (HDM) and mold allergens in polysensitized patients with asthma and/or rhinitis.
Using validated questionnaires, we assessed asthma and rhinitis control and quality
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PHGDH inhibitors administered as single-agent therapy to NOG mice harboring patient-derived MYCN-amplified neuroblastoma xenografts slowed tumor growth. However, combining a PHGDH inhibitor with the standard-of-care chemotherapy drug, cisplatin, revealed antagonism of chemotherapy efficacy in vivo. Emergence of chemotherapy resistance was confirmed in the genetic PHGDH knockout model in vitro
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Four (4.3%, 4/92) cases receiving the extensive intralesional curettage developed the local recurrence, respectively two at the proximal tibia, one at the pelvis and one at the calcaneus. Time to local recurrence were respectively 14.5, 8.8, 27.0 and 5.6 months, with the average 14 months. Kaplan-Meier estimated survivorship curve of local recurrence-free survival rates of one, two and five years were respectively 9
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Autophagy is an evolutionarily conserved lysosomal-dependent pathway for degrading cytoplasmic proteins, macromolecules, and organelles. Autophagy-related genes (Atgs) are the core molecular machinery in the control of autophagy, and several major functional groups of Atgs coordinate the entire autophagic process. Autophagy plays a dual role in liver cancer development via several critical signaling pathways, including th
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Studies have shown that high-risk PCas are associated with germline mutations and such mutations are prevalent in blacks and Asians than in whites. Thus, testing for germline mutations in patients with GS of ≥ 7, GG ≥ 3, high prostate density, low prostate volume, and PSA levels of >4.0 ng/mL may identify those at risk of developing lethal PCa and could reduce the mortality rates in Asia and West Africa.Obesity
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In addition to the general interest connected with investigations on biodiversity in natural contexts, more recently the scientific community has started considering occurrence of endophytic fungi in crops in the awareness of the fundamental role played by these microorganisms on plant growth and protection. Crops such as olive tree, whose management is more and more frequently based on the paradigm of sustainable agric
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High levels of social cohesion have been shown to be beneficial both for social entities and for their residents. It is therefore not surprising that scholars from several disciplines investigate which factors contribute to or hamper social cohesion at various societal levels. In recent years, the question of how individuals deal with the increasing diversity of their neighborhoods and society as a whole has
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Hypersensitivity reactions are suspected to cause premature aseptic loosening in susceptible patients after total knee arthroplasty. In response, metal-free implants have been developed. The aim of this prospective, observational midterm study was the assessment of a completely metal-free ceramic knee replacement system as a concise follow-up of a previous report.
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Flavin oxidases are valuable biocatalysts for the oxidative synthesis of a wide range of compounds, while at the same time reduce oxygen to hydrogen peroxide. Compared to other redox enzymes, their ability to use molecular oxygen as an electron acceptor offers a relatively simple system that does not require a dissociable coenzyme. As such, they are attractive targets for adaptation as cost-effective biosenso
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The most closely related species pair showed the highest relative over-representation of shared adaptation signatures. Moreover, the identified genes of convergent adaptation were enriched for nonsynonymous mutations, suggesting functional relevance of these genes, even though many of the identified candidate genes have hitherto unknown or poorly described functions based on comparison with Arabidopsis thaliana. We conclude that adapt
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Indeed, the co-cultivation of Actinobacteria with other bacteria is known to lead to the production of compounds that are not produced in monoculture. Furthermore, the production of specific antibiotics is linked to the composition of the growth media that, in our co-culture conditions, exclusively consisted of the components of the prey living cells. Interestingly, our strategy led to the isolation of bac
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It was also found that the proliferation and invasion ability as well as the Ras-MAPK pathway activity of HTR-8/SVneo cells were inhibited when treated with histone methyltransferase inhibitor DZNep. RASA1 gene was abnormally activated in unexplained recurrent spontaneous abortion villi due to the decreased enrichment of H3K27me3 in the gene promoter. High expression of RASA1 could inhibit the activity of the Ras-MAPK pa
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CaLCuV-based VIGS effectively works in cabbage and contributes to efficient functional genomics research in Brassica crop species. Virus-induced gene silencing (VIGS), a posttranscriptional gene silencing method, is an effective technique for analysing the functions of genes in plants. However, no VIGS vectors have been available for Brassica oleracea until now. Here, tobacco rattle virus (TRV), pTYs and cabbage le
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CRISPR/Cas9 is a preferred genome editing tool and has been widely adapted to ranges of disciplines, from molecular biology to gene therapy. A key prerequisite for the success of CRISPR/Cas9 is its capacity to distinguish between single guide RNAs (sgRNAs) on target and homologous off-target sites. Thus, optimized design of sgRNAs by maximizing their on-target activity and minimizing their po
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However, building performance is found having little impact on humanistic environment. The findings of this study could provide useful information for the construction of healthy dormitories.Minimal hepatic encephalopathy is associated with changes in the peripheral immune system which are
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05) and significantly higher OSDI scores (P less then 0.001), corneal fluorescein staining results (P less then 0.05), eyelid abnormality scores (P less then 0.05), meibography scores (P less then 0.05), and areas of meibomian gland loss (P less then 0.05). Ocular Surface Disease Index scores were significantly positively correlated with eyelid abnormality scores (P=0.025), meibography scores (P less then
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f students matched overall. However, the student-centric algorithm matched a significantly higher percentage of students to their preferred programs. The program-centric algorithm was associated with a lower program’s last matched student rank. Further research is needed on the algorithms’ associations with cost and time demands in the match, postmatch resident and program performance, and fit with a changing environ
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Chirally doped ferroelectric nematics in antiparallel-rubbed cells produce Grandjean textures of helical twist that can be unwound via field-induced polar surface reorientation transitions. Fields required are in the 3-V/mm range, indicating an in-plane polar anchoring energy of w P ∼3 × 10-3 J/m2.Recombinant influenza virus vaccines based on hemagglutinin (HA) hold the potential to accelerate production timelines and i
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Mental well-being can contribute to cigarette smoking and negatively impact disease progression among people living with HIV (PLWH). This study examined potential associations between cocaine use (COC), depression, and HIV status in predicting cigarette smoking; hypothesizing that depression would be highest in cocaine users and predict cigarette smoking. An exploratory analysis including stress was also examined as a
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AIM To identify the highest-ranked pharmacological and nonpharmacological interventions for pain relief during outpatient hysteroscopy. METHODS We conducted an online bibliographic search in different databases from inception till July 2019. We included randomized controlled trials assessing effect of pharmacological and nonpharmacological interventions on pain relief during outpatien
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It was also found that the proliferation and invasion ability as well as the Ras-MAPK pathway activity of HTR-8/SVneo cells were inhibited when treated with histone methyltransferase inhibitor DZNep. RASA1 gene was abnormally activated in unexplained recurrent spontaneous abortion villi due to the decreased enrichment of H3K27me3 in the gene promoter. High expression of RASA1 could inhibit the activity of the Ras-MAPK pa
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A tandem Bischler-Napieralski/semipinacol rearrangement reaction has been developed for the purpose of assembling a bis(spirocyclic) indole framework, a privileged structural unit of aspidofractinine-type monoterpenoid indole alkaloids, and was used in combination with a subsequent Mannich reaction to expeditiously construct the central bridged bicyclo[2.2.1]heptane ring system of these molecules with contiguous quater
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An important and often unexplored factor shaping life satisfaction is one’s perception of the world as a “just” place. The “just world hypothesis” is predicated on the idea that the world works as a place where people get what they merit, an idea that often serves as a means for people to rationalize injustices. The research addressing just world beliefs has expanded into a four-factor model that categorizes just wo
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34 m3 m-3. Given the relatively consistent climate at this site, the large range in mean monthly R s (~7 μmol CO2 m-2 s-1) was surprising and suggests that even small changes in climate can have large implications for ecosystem respiration. The strong positive relationship of R s with temperature at monthly timescales particularly stands out, as moisture is usually considered a stronger control of R s in tropi
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Background Child maltreatment induces significant health problems, both during childhood and into adulthood. To prevent child maltreatment, it is important to detect perinatal risk factors for earlier intervention. The aim of this study was to evaluate the perinatal risk factors associated with child maltreatment during pregnancy. Methods A case-control study was conducted to compare perinatal data from the Maternal and C
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Recognizing material categories is one of the core challenges in robotic nuclear waste decommissioning. All nuclear waste should be sorted and segregated according to its materials, and then different disposal post-process can be applied. In this paper, we propose a novel transfer learning approach to learn boundary-aware material segmentation from a meta-dataset and weakly annotated data. The proposed meth
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The ongoing pandemic of the novel coronavirus disease 2019 (COVID-19) originated in Wuhan, China, in December 2019. Various manifestations of coronavirus (SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2]) have been reported since the pandemic began. Some articles have reported acute pancreatitis in several patients due to COVID-19 infection. In this case report, we introduc
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Finally, we intend to provide a much better understanding of why Coronavirus induces AKI and its subsequent progression to CKD in the coming years and further discuss the acute and long-term renal consequences.
Coronary vasomotor dysfunction can be diagnosed in a large proportion of patients with angina in the presence of non-obstructive coronary artery disease (ANOCA) using comprehensive protoc
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Intolerance to high pacing rates was reported in only one patient (1.6%) and was easily resolved by reprogramming the maximum CLS pacing rate.
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With rapid global urbanization, massive anthropogenic inputs of organic matter and inorganic nutrients are resulting in severe pollution of urban rivers and consequently altering the structure and function of their aquatic microbial communities. In contrast to nutrient-induced eutrophication of freshwaters, water blackening and odorization of urban rivers, as well as their microbial communities, are
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Compared to postcontrast CTHU, serum IgG4 levels had a larger area under the ROC curve (0.847 [95% confidence interval (CI) 0.674-1.000,
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ASc-d789M produces D-lactic acid at a titer of 17.09 g/L in shake-flasks (yield of 0.89 g/g glucose consumed or 89% of the theoretical yield). Fed-batch fermentation resulted in D-lactic acid titer of 40.03 g/L (yield of 0.81 g/g glucose consumed). Altogether, our work represents progress towards efficient microbial production of D-lactic acid.Classical Bordetella species are primarily isolated from animal
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05). This analysis revealed that HI bulls harbored a higher percentage of narrow-head sperm as opposed to the higher percentage of large- and round-headed sperm detected in LI. A further genomic characterization revealed 23 regions differentially affected by inbreeding in both groups, detecting six genes (SPAG6, ARMC3, PARK7, VAMP3, DYNLRB2, and PHF7) previously related to different spermatogenesis-associated processes
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Intimate partner violence (IPV) is a maladaptive conflict behavior, and IPV is both a precipitant and consequence of drug use problems among couples. It is unknown how drug use problem severity modulates the association between IPV and observed conflict behaviors. As part of a larger clinical trial, a sample of 30 different-sex substance-misusing couples completed self-report questionnair
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The high specificity for Hp of the antimicrobials developed may be of help to reduce damage to the gut microbiota and to slow down the development of resistant Hp mutants.Background Many countries have clinical practice guidelines (CPG) for asthma that serve as an important resource for healthcare professionals and inform the development of policies and practices relevant to asthma care. The purpos
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The ongoing pandemic of the novel coronavirus disease 2019 (COVID-19) originated in Wuhan, China, in December 2019. Various manifestations of coronavirus (SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2]) have been reported since the pandemic began. Some articles have reported acute pancreatitis in several patients due to COVID-19 infection. In this case report, we introduc
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We functionally assessed the HERC1 mutation by investigation of patient and control fibroblasts under normal and nutrient starving conditions. During catabolic state, mTORC1 activity remained high in patient fibroblasts, which stands in stark contrast to its downregulation in controls. This was corroborated by an abnormally high phosphorylation of S6K1-kinase, a direct downstream target of mTORC1, in patients. Moreo
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Reported herein is a direct and efficient route to 1-bromo-1-fluoroalkanes through the reaction of unactivated alkenes with dibromofluoromethane under photoredox catalysis. The key to the success of these addition reactions is the employment of a suitable photoredox catalyst. In particular, hydro- and bromo-bromofluoromethylated products were chemoselectively formed using THF and DMF/H2O as solvents, respecti
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Copyright © 2020 Milla, Hudiyana, Cahyono and Muluk.Mothers can recognize their own children by body odor. Besides signaling familiarity, children’s body odors may provide other information relevant to maternal caregiving behavior, such as the child’s developmental status. Thus, we explored whether mothers are able to classify body odors on pre- vs. postpubertal status above chance levels. In total, 164 mothers were presented with bo
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Pathogen identification in blood cultures was achieved in 48% of the cases. The most common causative microorganisms were S. aureus in 12%, coagulase-negative Staphylococcus in 11%, S. viridans in 10% and Enterococcus in 7%. Hospital mortality was 20.4% and ten-year survival was 65%. Conclusions Patients with severe IE requiring surgical treatment still have high perioperative and late mortality.Background L
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Inactivation of genes within the arn operon led to increased susceptibility of P. aeruginosa to AZM and great increases in synergy between AZM and other antimicrobial agents, indicating that dysregulation of the arn operon might explain increased AZM uptake and synergy in host-like media. Furthermore, genes involved in central and energy metabolism and ribosome biogenesis were dysregulated more in
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Acute lung injury (ALI), manifested by progressive hypoxemia and respiratory distress, is associated with high morbidity and mortality, which lacks the effective therapies in clinics. Our previous studies demonstrated that maresin1 (MaR1), a specialized proresolving mediator, could effectively mitigate the inflammation of lipopolysaccharide (LPS)-induced ALI. However, whether MaR1 impacts the macrophage polarization t
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criteria for clinical trials in carriers with very subtle signs.Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Recently, a missense mutation, Asp620Asn (D620N), in VPS35 (PARK17) has been identified as a pathogenic mutation for late-onset autosomal dominant Parkinson’s disease (PD). Although PD
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The patients’ characteristics were similar among phases. Changes in eGFR were similar among phases, but the incidence of RD increased in phase III (phase I 228 [10.3%]; phase II 260 [11.4%]; phase III 296 [13.0%],
= 0.02). However, the differences in incidences of RD were not statistically significant after adjusting for eGFR at baseline and age. The incidences of HD were a
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Purpose A contour propagation study has been conducted to benchmark three algorithms for Deformable Image Registration (DIR) freely available online against well-established commercial solutions. Methods ElastiX, BRAINS and Plastimach, available as modules in the open source platform 3DSlicer, were tested as the recent AAPM Task group 132 guidelines proposes. The overlap of the DIR-mapped ROIs
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This research project focused on the clinical effectiveness of crisaborole ointment as a treatment for vulvar leukoplakia.
To assess the clinical efficacy of crisaborole ointment versus vitamin E, a randomized controlled trial was conducted on 100 patients diagnosed with vulvar leukoplakia. Fifty patients were assigned to each group: crisaborole (n=50) and vitamin E (n=50). Symptom improvement and vulvar leukoplakia s
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05) was observed. A statistically highly significant mean intergroup and intragroup difference was seen for all the clinical parameters at different stages of study.
The study revealed that the Illicium verum/star anise has potent antibacterial, anti-inflammatory, and astringent properties.
The study revealed that the Illicium verum/star anise has potent antiba
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There is limited research on the role of flavors in nicotine vaping products (NVPs) in relation to smoking. We examined patterns of flavor use in NVPs in relation to progression toward quitting.
Data come from 886 concurrent users of NVPs (at least weekly) and cigarettes who were first surveyed in 2016 and then successfully recontacted in 2018 as part of the ITC
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Voxel-Wise Investigation associated with Architectural as well as Well-designed MRI regarding Lateralization involving Handedness in College Individuals.
However, induction of IκBζ and the resultant cytokine and chemokine productions were significantly inhibited by pretreatment with an NF-κB inhibitor. The deletion of IκBζ did not affect the phosphorylation of ERK, p38 MAPK, or JNK by IL-33, and the
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Lastly, HARPs were functionalized with fibroblast growth factor 2 (FGF2) to highlight their use for growth factor delivery. FGF2-HARPs increased fibroblast proliferation through a combination of 3D scaffold assembly and growth factor delivery. Taken together, these studies demonstrate the development and diverse uses of high aspect ratio particles as tunable injectable scaffolds for applications in regenerative engineering.Fe
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Utilization of oral health services has been low among rural populations in Thailand, especially for minority ethnicity populations living along the borders. The aim of this study was to increase understanding of the determinants of the underutilization of oral health services among these populations.
A qualitative study using in-depth interview and semi-structured intervie
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Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability a
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The dopamine (DA) system has a profound impact on reward-motivated behavior and is critically involved in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Although DA defects are found in autistic patients, it is not well defined how the DA pathways are altered in ASD and whether DA can be utilized as a potential therapeutic agent for ASD. To this end, we employed a phenoty
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When interviewing a patient presenting with dizziness, it is imperative to both diagnosis and treatment for the clinician to identify the impact dizziness has on the patient’s productivity, general function level and cognition. and cognition. Psychiatric comorbidities and concurrent sleep disturbances are common in this patient population and identification of these additional factors is important in implementing a holist
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This ‘Gold Standard’ will facilitate the processing of data sets independent of the facility at which they were collected and enable data archiving according to FAIR principles, with a particular focus on interoperability and reusability. This agreed standard builds on the NeXus/HDF5 NXmx application definition and the International Union of Crystallo-graphy (IUCr) imgCIF/CBF dictionary, and it is compatible w
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5 ± 2.1%) in macrophages. High polyphenolic content (193 µg gallic acid/mL) was determined in the sap. The FT-IR spectrum of NFCIS revealed the presence of several phytochemicals indicate its pharmaceutical and nutritional value. Cisplatin-induced hike in urea, creatinine and lipid peroxidation was significantly decreased to 65.16, 87.74 and 53.41% by NFCIS, respectively. Hb (42.37%) and total count (72.81%) were also found
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Understanding Male Masturbation: A Comprehensive Guide
Masturbation, the act of self-stimulation for sexual satisfaction, is a prevalent and typical human behavior practiced across genders, cultures, and throughout history. While typically talked about in hushed tones or surrounded by false information, understanding male masturbation properly and honestly is important for sexual health, self-awareness, and total well
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rsely related to severity of sleeve stenosis (β= -.08, P= .01). Patients with stenosis were also more likely to have fluid pooling (96.2% vs 25%, P< .001). There was no significant difference in the trajectory of endoscope passage between the 2 groups.
Endoscopic criteria for diagnosis of GSS are lacking. Our data suggest the ratio between the narrowest
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s inhabiting shallow-water sand. Surprisingly, sulfur oxidation genes were upregulated under anoxic relative to oxic conditions. Furthermore, under anoxia, the ectosymbiont appeared to be less stressed and to proliferate more. We propose that animal-mediated access to oxygen, rather than enhancing sulfur oxidation, would facilitate assimilation of carbon and nitrogen by the ectosymbiont.The basic leucine zip
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Fucoidan has a variety of pharmacological activities, but the understanding of the mechanism of fucoidan-induced apoptosis of colorectal cancer cells remains limited. The results of the present study demonstrated that the JNK signaling pathway is involved in the activation of apoptosis in colorectal cancer-derived HT-29 cells, and fucoidan induces apoptosis by activation of the DR4 at the transcriptional
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Conspicuously more heterogeneous, the population of HA-MRSA clones observed in the 1980s, including the ST30-SCCmec I clone, has shifted to the current homogeneous population of imipenem-resistant ST5-SCCmec II clones, probably due to the introduction of new antimicrobials.Partial hepatectomy (PHx) is the gold standard for the treatment of colorectal cancer liver metastases. However, after removing a substantial amoun
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7%), PC was combined with MPA. A significant improvement in responses for the ADVS (p < .0001) and EAT-10 (p < .0001) was observed, whereas the VHI-30 score did not change significantly post-operatively. All nine patients with a tracheostomy were successfully decannulated within 18months after the surgical procedure.
For patients affected by BAVCP, PC ± MPA by tran
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On February 25, 2020, the first 2 patients were tested positive for severe acute respiratory syndrome coronavirus‑2 (SARS-CoV-2) in Tyrol, Austria. Rapid measures were taken to ensure adequate intensive care unit (ICU) preparedness for asurge of critically ill coronavirus disease-2019 (COVID-19) patients.
This cohort study included all COVID-19patients admitted to an ICU with c
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No consensus exists regarding the optimal choice of control specimen for CRS research. We present statistically significant quantitative differences in biomarker levels between paired inferior turbinate and sphenoid mucosa samples. This confirms the presence of heterogeneity between different subsites of sinonasal mucosa and highlights the need for standardization
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The bilayered hydrogel’s antiwear properties are confirmed by using a knee simulator, following ISO 14243. Finally, in vitro tests with human chondrocytes confirm the absence of cytotoxicity effects. The results shown in this paper open the way to a multilayered synthetic injectable or surgically implantable filler for restoring AC defects.
Cervical cancer is a gynecological health problem, affec
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51, 95% CI 1.44-1.58) and in participants without diabetes mellitus (aHR 1.36, 95% CI 1.33-1.39), hypertension (aHR 1.38, 95% CI 1.34-1.42), or dyslipidemia (aHR 1.35, 95% CI 1.32-1.38).
Compared with the control population, patients who underwent cholecystectomy exhibited an increased incidence of MDD. Thus, physicians should implement an enhanced program of MDD
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Peripheral sympathetic nervous system tumors are the most common extracranial solid tumors of childhood and include neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Surgery is the only effective therapy for ganglioneuroma, which may be challenging due to the location of the tumor and involvement of surrounding structures. Thus, there is a need for well-tolerated presurgical therapies that could reduce
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Mammography is the diagnostic imaging practice used in screening to detect early lesions suspected of malignancy. It uses a low energy X-ray beam in which a low dose in the order of 2-3mGy is delivered to patient breast cells. However, it has been speculated that it could lead to significant cell damage, when compared to conventional X-ray. We investigated the biological effects of low doses, with mean glandular dos
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Impact statement This study is the first to incorporate disease-specific, diabetic macrophages into a three-dimensional (3D) model of human skin. We show how to fabricate skin that incorporates macrophages with disease-specific fibroblasts to guide macrophage polarization. We also show that monocytes from diabetic patients can differentiate into macrophages directly in this skin disease m
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Agriculture is an important contributor to N2O emissions – a potent greenhouse gas – with high peaks occurring when soil mineral nitrogen (N) is high (e.g., after mineralization of organic N and N fertilizer application). Nitrogen dynamics in soil and consequently N2O emissions are affected by crop and soil management practices (e.g., crop rotation and tillage), an effect mostly assessed in the literature through compar
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Aim The purpose of this experimental study was to evaluate the existence of adrenergic receptors in ketamine-induced corneal blood vessels in rat pups. Methods The study of corneal neovascularization motricity was performed on 45-day-old Wistar rats in which, starting from the 15th day of life, corneal blood vessels were obtained by injecting intraperitoneal ketamine at a dose of 150 mg/ kg body weight, a total
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Reconstruction failure rate was 2.2% (3 patients had explantation); however, all benefited from prosthesis reconstruction a year after the initial procedures. The average satisfaction score was 4.7 out of 5 as evaluated by patients, 4.8 out of 5 by surgeons, and 4.8 out of 5 by nurses.
Primary lipofilling combined with prosthesis placement after radiotherapy is a reconstructive method
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Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs), are essential for cell-autonomous immunity against a wide variety of intracellular pathogens including Toxoplasma IRGs comprise regulatory and effector subfamily proteins. Regulatory IRGs Irgm1 and Irgm3 play important roles in anti-Toxoplasma immunity by globally controlling effector IRGs and GBPs. Th
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At the 24-month follow-up, the cumulative proportions of trabeculotomy success in the SEVAN and MEVAN groups were 89.7% and 36.0%, respectively. Patients with MEVAN and larger preoperative corneal diameter (per 0.5 mm) were more likely to experience failed trabeculotomy (hazards ratio [HR], 7.997 [95% CI, 1.640-38.996], p = 0.010; 1.853 [95% CI, 1.128-3.042], p = 0.015). CONCLUSION
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Triterpenoid saponins constitute a diverse class of bioactive compounds in medicinal plants. Salicylic acid (SA) is an efficient elicitor for secondary metabolite production, but a transcriptome-wide regulatory network of SA-promoted triterpenoid saponin biosynthesis remains little understood. In the current study, we described the establishment of the hairy root culture system for Psammosilene tunicoides, a triterpenoid sa
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Context This study is a quanti-qualitative analysis of all contacts to a helpline service for hospital workers during the COVID-19 crisis. Our aim was to describe the nature of mental burden in hospital workers and factors subjectively associated to this burden from the workers’ perspective. Methods We included all 50 contacts from 25 different workers and 10 different professions over the course of 1 month. We
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Postoperatively, patients reported a significant improvement in body image perception and safety was no longer their foremost concern.
Preoperatively, patients are most concerned with safety (e.g. risk) with secondary concerns of cost and pain but they were less concerned with their appearance. Postoperatively, safety is much, much less of an
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The COVID-19 pandemic has forced the cancellation of planned surgery and led to significant surgical service reductions. Early intervention in aortovasc
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We utilized 2300 wheat accessions including worldwide landraces, cultivars and primary synthetic-derived germplasm with three Australian cultivars Annuello, Yitpi and Correll, to investigate field-based resistance to leaf (Lr) rust, stem (Sr) rust and stripe (Yr) rust diseases across a range of Australian wheat agri-production zones. Generally, the resistance in the modern Australian cultivars, synthetic deriv
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Nitrogen deposition may affect forest soil traits and metabolic activity. We would like to further understand the mechanisms of soil biochemical processes and habitat interactions under conditions of nitrogen deposition in forests and to investigate the characteristics of soil enzyme activities and soil environmental factors in response to nitrogen deposition in Picea schrenkiana fore
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Myocarditis is a disease characterized by localized or diffuse inflammation of the myocardium without efficient treatment. This study explored the regulatory mechanism of microRNA-133 (miR-133) secreted from bone marrow mesenchymal stem cell-derived exosome (BMSC-Exo) on myocardial fibrosis and epithelial-mesenchymal transition (EMT) in viral myocarditis (VMC) rats through regulating mastermind-like 1 (MAML1). BMSC
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DNA methylation is an epigenetic modification involving the transfer of a methyl group to cytosine residues of a DNA molecule. Altered DNA methylation of certain genes is associated with several diseases including cancer. Nanomaterials, such as graphene oxide (GO), offer great potential as sensing elements for methylated DNA (mDNA) detection due to their distinct properties. Understanding molecular interacti
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Article Understanding Article Spin Rewriter: A Comprehensive Guide
In the large and ever-evolving landscape of content production, the need for top quality, distinct content has actually never been more critical. With the rise of search engine algorithms that focus on originality and the increasing demand for fresh content, content de
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Among departments conducting headache research 57% had to halt ongoing projects. Overall, 54% reported that the standard of care was worse for headache patients during the pandemic.
Hospital-based headache care and research was impacted in Denmark and Norway during the initial phase of the Covid-19-pandemic.
Hospital-based headache care and research was impacted
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A phylogenetic tree including 74 sequences of the genus confirmed this trend, since Borrelia genotypes detected in bats from Macaregua formed a monophyletic group basally positioned to Bbsl. Our results suggest that Borrelia genotypes characterized from bats roosting in the Macaregua cave might constitute a new taxon within the genus. This is the first molecular characterization of a Borrelia sp. in Colo
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This study describes the first palladium-catalyzed, site-selective α- and γ-arylation of α,β-unsaturated ketones with (hetero)aryl halides. A wide range of hetero(aryl)halides coupled with α,β-unsaturated ketones, and transformation into the arylated products proceeded with excellent to good yields. The site selectivity of the reaction is switchable by simply changing the phosphine li
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Several clinical trials investigated the effects of enteral lactoferrin supplementation on the prevention of sepsis and necrotizing enterocolitis (NEC) in preterm infants, but the efficacy and safety remain disputed. Therefore, we systematically evaluated the effect of enteral lactoferrin supplementation in preterm infants through a meta‑analysis with trial sequential analysis (TSA).
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Atherosclerotic cardiovascular disease is increased on average 2-3-fold in people with diabetes as compared to their non-diabetic counterparts and is the major cause of the increased morbidity and mortality in this disease. There is however heterogeneity in cardiovascular risk between individuals based on demographic, cardiometabolic and clinical risk factors in the setting of hyperglycemia, insulin r
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eking fertility care have greater disparities in fertility knowledge and lower health literacy compared to women from high resource clinical settings. Further studies are needed to understand these barriers and to develop targeted inventions to lower disparities and improve care for these vulnerable populations.
New-onset psychosis in an immunosuppressed patient post-kidney transpl
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In the rapidly evolving world of home innovation, robotic hoovers, likewise referred to as robotic vacuums or robovacs, have actually ended up being a popular choice for those looking to streamline their cleaning routines. advice here provide a hassle-free option for keeping a clean home with very little effort. This post looks into the ver
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Exploring the World of Men’s Masturbation Toys: A Guide to Enhanced Self-Pleasure
For centuries, people have looked for ways to explore their sexuality and experience enjoyment. As societal norms develop and discussions around sexual health become more open, the world of sexual health has actually broadened considerably. Amongst read he
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High levels of LDL cholesterol (LDL-C) represent a causal factor for cardiovascular diseases on an atherosclerotic basis, with a direct correlation between these and mortality or cardiovascular events, such that the reduction of both is associated proportionally and linearly with the reduction of LDL-C.Statins and ezetimibe are used for LDL-C lowering but may not be sufficient to achieve the targets defined by the ESC/EAS gu
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Lithium is widely used to treat bipolar disorder. However, the efficacy and vulnerability as to its side effects are known to differ. Although the specific biochemical mechanism of action is still elusive, lithium may influence mitochondrial function, and consequently, metabolism. Lithium exposure in this study was conducted on a unique set of mito-nuclear introgression lines of Drosophila subobscura to disenta
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The Growing Market for Realistic Sex Dolls: A Comprehensive Guide
In recent years, the marketplace for realistic sex dolls has actually seen a substantial rise in popularity, driven by advancements in technology and a more comprehensive acceptance of varied sexual orientations. These dolls, often crafted with precise attention to information, offer a level of realism tha
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Fifty of seventy-six (66%) owners pursued at least one staging recommendation and 69/140 (49%) owners pursued some kind of adjuvant treatment recommendation. Overall, 16/76 (21%) were adherent to staging recommendations with 20 adherent for the first year following surgery (26%). Forty-seven of 140 (34%) were adherent to treatment recommendations with 54 (39%) adherent for the first year. Owners that w
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The Brazilian version of Hypertension Knowledge-Level Scale is a reliable instrument, which had its construct and criterion validated to measure knowledge about hypertension among Brazilian people. It can help health professionals with planning educative actions.Outbreaks of a vesiculopustular disease in dairy cattle and milkers have been frequently reported in Brazil since 1999 when the vaccinia virus strain Cantagalo was
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Furthermore, we studied the sural nerve of our patient by terminal deoxynucleotidyl transferase dUTP nick end labeling and electron microscopy. A number of apoptotic cells were observed in the endoneurium of the nerve by transferase dUTP nick end labeling. Chromatin condensation was confirmed in the nucleus of non-myelinating Schwann cells by electron microscopy. These findings suggest that E61K TTR is low amyloidogenic, in
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Deep learning has achieved many successes in different fields but can sometimes encounter an overfitting problem when there are insufficient amounts of labeled samples. In solving the problem of learning with limited training data, meta-learning is proposed to remember some common knowledge by leveraging a large number of similar few-shot tasks and learning how to adapt a base-learner to a
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Spectroscopic ptychography is a powerful technique to determine the chemical composition of a sample with high spatial resolution. In spectro-ptychography, a sample is rastered through a focused X-ray beam with varying photon energy so that a series of phaseless diffraction data are recorded. Each chemical component in the material under investigation has a characteristic absorption and phase contrast as a function
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The pad2 mutant accumulated ascorbate at a wild-type level under high light; however, when the pad2 mutation was combined with ∆dhar, there was near complete inhibition of high light-dependent ascorbate accumulation. The lack of ascorbate accumulation was consistent with a marked increase in the ascorbate degradation product threonate. These findings indicate that ascorbate recycling capacity is limited in ∆dhar
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Interactive microbial communities are ubiquitous, influencing biogeochemical cycles and host health. One widespread interaction is nutrient exchange, or cross-feeding, wherein metabolites are transferred between microbes. Some cross-fed metabolites, such as vitamins, amino acids, and ammonium (NH4+), are communally valuable and impose a cost on the producer. The mechanisms that enforce cross-feeding of communally valuable metabol
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Since the outbreak of coronavirus disease 2019 (COVID-19), a growing number of cases of acute transverse myelitis associated with COVID-19 have been reported. Here, we present the case of a patient who developed sensory ataxia after COVID-19 with MR lesions suggestive for longitudinal myelitis and in the splenium of the corpus callosum. The patient was successfully treated with immunoadsorption.
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Global metabolomic profiling showed that conventional mice had greater variability in their metabolic response to injury, and a more distinct joint metabolome compared to their corresponding controls. Furthermore, differences in the response to injury in GF compared to conventional mice were linked to mouse metabolic pathways that regulate inflammation associated with the innate immune system.
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In the bustling town of Wellingborough, nestled in the heart of Northamptonshire, the evolution of car keys has mirrored the broader technological advancements of the automobile industry. From of the past to the sophisticated clever keys of today, the jour
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However, hrHPV type 35 may account for a greater contribution to the cervical cancer burden in La Libertad. Further research, specifically on cervical tumor specimens, is needed.
The prevalence of hrHPV genotypes in Peru may differ from those observed in North America and Europe. Loreto appears to follow the prevalence trend observed in North America, with hrHPV type 16 accountin
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Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are considered to be benign or have low malignant potential, and be prone to local recurrence. Malignant transformation has been associated with homozygous deletion of CDKN2A or somatic mutations i
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Tumor-treating fields (TTFields) are alternating electrical fields of intermediate frequency and low intensity that can slow or inhibit tumor growth by disrupting mitosis division of cancerous cells through cell cycle proteins. In this work, for the first time, an in-house fabricated cyclo-olefin polymer made microfluidic bioreactors are integrated with Cr/Au interdigitated electrodes to test TTFields on yeast cells with fl
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This systemic review and meta-analysis aimed to investigate the burden of tuberculosis immune reconstitution syndrome (TB-IRIS) and associated mortality to highlight the importance of future direction in preventing and treatment of TB-IRIS. Randomized clinical trials (RCTs) that compared early antiretroviral therapy (ART) versus late ART were included. PubMed, EMBASE, Science Direct and Cochrane Central Register of C
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Our systematic review demonstrated that the 1-year, 3-year, and 5-year cumulative probabilities of relapse were ∼12%, 33%, and 47% in AAV patients receiving cyclophosphamide induction, respectively. Early identification of risk factors for relapse is helpful to the risk stratification of patients so as to achieve personalized treatment.
Our systematic review demonstrated that the 1-year, 3-year, and 5-
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Furthermore, the time-dependent fluorescence anisotropy measurement has been carried out to figure out the location of curcumin inside the micellar system. In order to correlate all experimental findings, density functional theory (DFT) and classical molecular dynamics (MD) simulations at neutral pH media have been performed. It has been found that the van der Waals force of interactions plays a major role in the stab
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In current years, the building and construction and home improvement sectors have witnessed a significant shift towards utilizing products that are both energy-efficient and eco-friendly. One such product making waves in Birmingham and beyond is unplastici
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5‒E13.5. These data suggested that the loss of Nr5a1 abrogates the testicular pathway and induces the ectopic ovarian pathway, resulting in postnatal partial/complete male-to-female gonadal sex reversal. Our findings provide evidence for the critical role of NR5A1 in murine gonadal sex determination in vivo.Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are positively selec
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respectively. The study points out the risk of brackish water fishes as potential carriers of this pathogen. This asks for preventive measures to mitigate health hazards associated with V. mimicus entering into the seafood production chain.
The study revealed that the prevalence of V. mimicus is 5.6% in the total samples screened. The highest occurrence was observed in brackish water fish (19%) fol
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In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation of residual beta cell function makes the disease milder, facilitates treatment, prevents complications and increase survival. So far immune interventions have had limited effect, and some serious adverse events and risks. In an open pilot trial we aimed to improve efficacy of GAD-alum treatment using lymph-node administration i
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Filamentous fungi play an important role in the production of a range of useful extracellular hydrolytic enzymes for wide industrial applications. The Western Ghats region is known for its rich microbial biodiversity and could be a potential source of several useful fungi that could be exploited for the production of industrially important enzymes. From this soil, we aimed at the isolation of multienzyme producing
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Among acute lymphoblastic leukemia (ALL), 40% of affected patients are diagnosed after the age of 20. Compared to pediatricians, adult hemato-oncologists are less familiar with complex pediatric ALL regimens and have perceived that pediatric ALL regimens are too toxic in the adult population. Meanwhile, multiple retrospective analyzes showed the superiority of pediatric regimens among the older adults and young adolescents (AYAs) grou
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Possible underlying mechanisms and implications were discussed.Purpose To explain physical activity behavior, social-cognitive theories were most commonly used in the past. Besides conscious processes, the approach of dual processes additionally incorporates non-conscious regulatory processes into physical activity behavior theories. Habits are one of various non-conscious variables that can influence behavi
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Moreover, IECs display hyperproliferation and increased antigen presentation in active CC. Further analysis revealed that genes related to the immune response (DUOX2, PLA2G2A, CXCL9), DNA transcription (CTR9), protein processing (JOSD1, URI1), and ion transport (SLC9A3) remained dysregulated even after budesonide-induced remission. Budesonide-refractory CC patients fail to restore normal gene expression, and displayed a
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The links between taxonomies and the taxonomic triangulation technique are an important tool for generating knowledge. The results of this study may guide the diagnosis and treatment of coronavirus disease, COVID-19, as well as similar processes that occur with acute respiratory distress syndrome.
The links between taxonomies and the taxonomic triangulation technique are an important tool for ge
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An unprecedented transition-metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed. This reaction was conducted under mild conditions and tolerated a wide range of coupling partners including disulfides and amines, affording the corresponding sulfinamide products in good chemical yields. Furthermore, this reaction could b
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Patients with chronic nephropathies were particularly affected during the COVID-19 pandemic. These patients suffer from multiple comorbidities and some specific treatments may put them at risk towards severe complications. Hemodialysis patients necessitating an in-center hemodialysis maintenance regimen were unable to be confined and despite strict prevention protocols suffered high infection and subsequently fatality ra
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The Rise of the Autonomous Home Helper: Exploring the World of Robot Vacuum and Mop Cleaners
In today’s fast-paced world, time is a valuable commodity. The unrelenting demands of work, family, and individual life typically leave home chores relegated to the bottom of the top priority list. Enter and mop cleaner, a marvel of contempora
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5 ± 6.0 years; 112 (53%) of whom were younger than 25 years. All were married, 183 (87%) had no formal education and up to 190 (90%) were employed. Overall, 14 (6.7%) tested positive for HBsAg; women aged ≥35 years had the highest prevalence (10%). None with tertiary education tested positive and women married before 18 years had 13 (6.2%) prevalence. CONCLUSIONS The prevalence of HBsAg among pregnant women in Gamawa LGA was 6.7% w
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Extensive validations on the hardware implementation of the new architecture using single- and multi-class machine learning datasets show potential for significantly lower energy than the existing AI hardware architectures. In addition, we demonstrate test accuracy and robustness matching the software implementation, outperforming other state-of-the-art machine learning algorithms. This article is part of the them
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Evidence about the association of high blood eosinophil count with asthma exacerbation is inconsistent and unclear. The objective of this meta-analysis was to determine whether elevated blood eosinophil count predicts asthma exacerbation.
We searched MEDLINE, EMBASE, and additional databases, without any language restriction. We also checked the reference lists of the includ
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Basic research along with adequately powered trials are urgently needed to resolve key uncertainties on metabolism and nutrient requirements in this heterogeneous patient population.
The aim of this study was to analyze if contrast-enhanced echocardiography (CEE) is as reliable as lung perfusion scintigraphy (LPS) to detect intrapulmonary shunting (IPS) in children with portal hypertension (PHTN)
c-Met inhibitor
Conventional transurethral resection of urinary bladder tumour (TURBT) using a wire loop diathermy violates the basic principle of oncological surgery, i.e. dissection through normal tissue. However, in the en bloc technique, the tumour is removed as a single specimen. We compared the quality of specimen and recurrence rate at three months (first check cystoscopy) in both the en bloc and conventional resect
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Therefore, the z2LFMC device combines high-speed with high-resolution. We demonstrate the suitability of the z2LFMC devices for carrying out fast and efficient biopharmaceutical separations through two case studies, i.e. the fractionation of monoclonal antibody charge variants, and monoclonal antibody aggregates separation.Immobilized metal affinity chromatography (IMAC) is a technique primarily used in research
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Double glazing has actually ended up being a popular option for house owners in Birmingham over the last couple of years. Understood for its energy performance, sound insulation, and possible to enhance residential or commercial property worth, double glazing is a bene
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The COVID-19 pandemic cancelled virtually all pediatric surgery activity, which caused treatment delays in severe pathologies and increased morbidity in regular urgent procedures.
The COVID-19 pandemic cancelled virtually all pediatric surgery activity, which caused treatment delays in severe pathologies and increased morbidity in regular urgent procedures.
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Subsequently, using crystal violet staining, neuron necrosis was examined in the CA3 area of the hippocampus. Diabetic rats showed cognitive impairment following an increase in the number of necrotic cells in region CA3 of the hippocampal tissue. Also, diabetes increased serum levels of lipid peroxidation and decreased total antioxidant capacity in serum and hippocampal tissue. ET + M.ch treatment prevented the
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Sclerema neonatorum (SN) is a rare form of panniculitides with an obscure incidence, aetiology, and pathogenesis. This condition is peculiar to preterm neonates, especially those with comorbidities such as sepsis, congenital anomalies, congenital heart disease, and gastrointestinal and respiratory diseases. Usually, it presents within the first seven days of life, but may develop a few weeks late
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Taken together, our results indicate that decreased KLF2 aggravates asthma progression by promoting neutrophil migration, which is associated with the transcriptional upregulation of CXCR1 and CXCR2. The KLF2 and/or CXCR1/2 expression levels may represent an indicator of asthma severity.Excessive production of immunoglobulins (Ig) causes endoplasmic reticulum (ER) stress and trigger
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Areas in the caudal brainstem showing a high density of AR-IR nuclei included the area postrema, the dorsal motor vagus nucleus and the retrotrapezoid nucleus. More cranially, the central linear nucleus in the pons contained a dense distribution of AR-IR nuclei. The mesencephalic periaqueductal gray (PAG) showed a dense distribution of AR-IR nuclei apart from the mos
Lenvatinib
Daily back washing of the filter keeps a Sb removal rate of about 80%. PRACTITIONER POINTS A novel and cheap Fe-Mn oxide was developed for Sb removal from dyeing wastewater. A self-designed filter device was designed to verify performance of the low-cost material. Optimal design and operational parameters of the filtration process were determined. © 2020 Water Environment Federation.Unsaturated charge-neutral silicon clust
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Objective To investigate the use of p16(INK4a) immuno-stained cytology as the primary screening for cervical cancer prevention. Methods From March to August 2018, 902 women from Shenzhen and surrounding area were recruited for cervical cancer screening with ThinPrep Cytologic Test (TCT), cobas4800 HPV test, and p16(INK4a) co-test. Colpo/biopsies were performed using the point of interest biopsy protocol of directed
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s regarding optimal reporting for analyses using PSM.Dietary changes during pregnancy (DP) and post-partum are essential for women’s nutrition status and the health of their offspring. We compared the diet quality DP and at 3-year post-partum (3YPP) and assessed the relationship between maternal diet quality and nutritional status using a prospective cohort design among women in East Jakarta. In total, 107 women were recruited
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The coronavirus disease 2019 (CoViD-19) caused by the novel Coronavirus strain SARS-CoV-2 is currently a pandemic. On January 30, 2020, the World Health Organization declared that the CoViD-19 outbreak is a public health emergency of international concern. The virus has already had a direct impact on the physical health of million people, and besides, it is supposed to pose a mental health threat of gre
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ROS play central roles in the activation of the NF-κB and NLRP3 signaling pathways via IκB (an inhibitor of NF-κB) and thioredoxin-interacting protein, respectively, thereby linking the molecular mechanisms of oxidative stress, inflammation and fibrosis. Elucidating these molecular pathways may pave the way for the development of therapeutic tools to interfere with specific targets.Many countries are facing the inc
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Natural transformation is a mechanism that enables competent bacteria to acquire naked, exogenous DNA from the environment. It is a key process that facilitates the dissemination of antibiotic resistance and virulence determinants throughout bacterial populations. Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that produces large quantities of extracellular DNA (eDNA) that is required
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An unprecedented transition-metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed. This reaction was conducted under mild conditions and tolerated a wide range of coupling partners including disulfides and amines, affording the corresponding sulfinamide products in good chemical yields. Furthermore, this reaction could b
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Trong văn hóa phương Đông, đặc biệt là Việt Nam, việc xem ngày tốt xấu, chọn giờ đẹp hay tránh ngày kiêng kỵ đã trở thành thói quen từ bao đời nay. Lịch vạn niên chính là công cụ không thể thiếu trong đời sống tâm linh, phong thủy và văn hóa truyền thống của người Việt.
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Sulfiredoxin 1 (SRXN1) is a pivotal regulator of the antioxidant response in eukaryotic cells. However, the role of SRXN1 in hepatocellular carcinoma (HCC) is far from clear. The present study aims to elucidate whether SRXN1 participates in tumorigenesis and metastasis of HCC and to determine the molecular mechanisms. We found that SRXN1 expression was up-regulated in HCC tissue samples and co
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H&E and immunohistochemistry results showed mild inflammation in liver tissue but no changes in the kidney, intestine and, pancreas. Thus it concluded that the increased formation of Amadori product, DPP-4 activity and low incretins (GLP-1, GIP) activity resulting high postprandial hyperglycemic response could be collectively responsible for oxidative stress-mediated toxicity of honey and ghee in the equal mixture.
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PF-05221304
PURPOSE The objective of this study was to conduct a systematic review and meta-analysis to evaluate the cancer risks among firefighters in the time course and from different geographical areas. METHOD A PubMed search was performed to identify cohort studies about cancer risk and firefighting presented with standardized incidence ratios (SIRs) or standardized mortality ratios (SMRs). Using random-effect models, meta
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In this article, a novel thruster information fusion fault diagnosis method for the deep-sea human occupied vehicle (HOV) is proposed. A deep belief network (DBN) is introduced into the multisensor information fusion model to identify uncertain and unknown, continuously changing fault patterns of the deep-sea HOV thruster. Inputs for the DBN information fusion fault diagnosis model are the control voltage, feedback cu
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We present the analytic form of the two-loop four-graviton scattering amplitudes in Einstein gravity. To remove ultraviolet divergences we include counterterms quadratic and cubic in the Riemann curvature tensor. The two-loop numerical unitarity approach is used to deal with the challenging momentum dependence of the interactions. We exploit the algebraic properties of the integrand of the amplitude in order to reduce it
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Early diagnosis of cholecystolithiasis is significant for prevention of further development of situation. Ultrasound is the best choice for the diagnosis of cholecystolithiasis with a sensitivity of >95% and specificity of practically 100%. However, ultrasound is not perfect for it is not so clear sometimes. So, MRI is needed to assist the diagnosing of cholecystolithiasis. Some studies have been conducted to inve
signaling pathway
This study aimed to compare the characteristics of patients with spontaneous thalamic hemorrhage (STH) accompanied by intraventricular hemorrhage (IVH) with those of patients without IVH.
The medical records of consecutive patients with STH admitted to our institute between January 2000 and December 2018 were reviewed retrospectively. The laboratory and radiological results, mortality, a
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ge mutli-center cohorts are needed.Soybean (Glycine max) is a species of legume native to East Asia and used in childhood diet for over 2,000 years in the East. Soy protein formulas have been available for almost a century. Nowadays, the increase in cow’s milk allergy and vegetarian dietary preferences are driving consumers toward cow’s milk alternatives. In this paper, we reviewed the nutritional com
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Almonertinib
We suggest that cholesterol levels are measured in all RTHβ patients.Placentophagia is a common mammalian behavior, and the first scientific study of the potential effects of human maternal placentophagia on lactation was in 1917. More recently, in the 1970s, human placentophagia was reported in North America with a trend toward increased consumption. There are different hypotheses about the women and nonhuman mammals
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requires only a short hospital stay, making it comfortable for patients. Compared with other uterine-sparing methods, it does not harm fertility and has positive effects on patients’ future fertility outcomes.
Eclamptic disorder during pregnancy is one of the common problems in sub-Saharan countries and forms one of the deadly triads along with hemorrhage and infection
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5 h/day) led to a 2.6-times greater risk of injuries and 3.3-times earlier occurrence of injuries than a low load ( less then 5.5 h/day). Therefore, a high load is a risk factor for shoulder and elbow injuries in high school baseball pitchers.In this paper, we propose an image compression-encryption method based on two-dimensional (2D) sparse representation and chaotic system. In the first step of this method, the input image is extended in
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An adequate surface is essential in ensuring a solid bond between the metal and dental ceramics for metal framework wettability. This work is aimed at investigating the effect of variable abrasive blasting parameters on Ni-Cr alloy surface’s ability to be wetted with liquid ceramics at elevated temperatures. One-hundred and sixty-eight samples were divided into 12 groups (n = 14), which were sandblasted using
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This article provides predictions for the spread of the SARS-CoV-2 virus for a number of European countries and the United States of America, drawing from their different profiles, both socioeconomically and in terms of outbreak and response to the 2019-2020 coronavirus pandemic, from an engineering and data science perspective. Each country is separately analysed, due to their differences in populations
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A significant drop was observed in the center of pressure amplitude, velocity and phase plane portrait parameters when the vibro-medical insole with vibration was used compared to vibro- medical insole without vibration in eyes closed condition (p less then 0.05). The use of vibro-medical insoles was found to improve the patient’s balance control, as compared to the shoe. In the eyes closed condition,
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platensis biomass. This study aimed to evaluate the potential of live and lyophilized fungi-algae pellets as biosorbents for gold recovery and their regeneration ability. The optimum conditions determined by Taguchi method were 1 g/L co-pellets, 9-10 mm size at 250 rpm of agitation speed and pH 3.5 and 2.0 for live and lyophilized co-pellets, respectively. The porous characteristics of fung
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has a robust supportive effect on developing software toward global goods maturity. ©Daniel Tom-Aba, Bernard Chawo Silenou, Juliane Doerrbecker, Carl Fourie, Carl Leitner, Martin Wahnschaffe, Maté Strysewske, Chinedu Chukwujekwu Arinze, Gerard Krause. Originally published in JMIR Public Health and Surveillance (http//publichealth.jmir.org), 29.04.2020.BACKGROUND Nursing education has evolved in line with societal
Y27632
Endoscopic enucleation of the prostate was first described by Hiraoka in 1986, using a monopolar resectoscope. His contribution was largely ignored until Gilling and Fraundorfer published their three-lobe enucleation technique with the Holmium laser in 1998 ,that ended establishing itself as a reliable option for the treatment of HBP, backed by ample scientific evidence. Later on, enucleation performed with other lasers, as
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Assessment involving Under Nutrition Employing Upvc composite List involving Anthropometric Malfunction (CIAF) amidst Toddlers Residing in Downtown Slums involving Raipur Metropolis, Chhattisgarh, Indian.
111 non-MDT patients. Overall survival and variceal rebleed was compared between the two groups. The rate of variceal rebleed was significantly higher in the non-MDT group, while no di
Myrcludex B in vitro
Adoptive immunotherapy using CAR-T cells is a promising curative treatment strategy for hematological malignancies. Current manufacture of clinical-grade CAR-T cells based on lentiviral/retrovirus transfection of T cells followed by anti-CD3/CD28 activation supplemented with IL-2 has been associated with low transfection efficiency and usually based on the use of terminally differentiated effecto
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Over the last few years, the United Kingdom has actually seen a significant surge in the adoption of robot cleaners. These automated gadgets, designed to handle a range of cleaning jobs, have become significantly popular amongst property owners and companies alike. This short article checks out the existing landscape of robot cleaners in the UK, their benef
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It has been suggested in recent research that rational beliefs as conceptualized within rational-emotive behaviour therapy (REBT) can be operationalized as strategic self-talk, but this has yet to be meaningfully investigated. The current study examines the effects of five one-to-one REBT sessions with three amateur American Football athletes to foster rational self-talk. The purpose of the intervention was to reduce the ir
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We investigated whether dogs (Canis familiaris) distinguish between human true (TB) and false beliefs (FB). In three experiments with a pre-registered change of location task, dogs (n = 260) could retrieve food from one of two opaque buckets after witnessing a misleading suggestion by a human informant (the ‘communicator’) who held either a TB or a FB about the location of food. Dogs in both the TB and FB group witnes
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ROS play central roles in the activation of the NF-κB and NLRP3 signaling pathways via IκB (an inhibitor of NF-κB) and thioredoxin-interacting protein, respectively, thereby linking the molecular mechanisms of oxidative stress, inflammation and fibrosis. Elucidating these molecular pathways may pave the way for the development of therapeutic tools to interfere with specific targets.Many countries are facing the inc
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I. Conclusion Taken together, our study revealed an up-regulated circRNA, circTLK1, could exacerbate myocardial IRI via targeting miR-214/RIPK1-mediated TNF signaling pathway, which may provide therapeutic targets for treatment.Cd2+ is one of the most widespread environmental pollutants and its accumulation in central and peripheral nervous systems leads to neurotoxicity as well as aggravation of common neurodegenera
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However, few study papers evaluate specific activities during various processes associated with cancer progression. Moreover, an attempt was made to collect the majority of substantive studies on bioactive potential of the selected flavonols, especially with regard to modulation of a range of signal transduction pathways that participate in cancer development.Hydroxycinnamic acids are one category of bioactive phenolic a
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The Evolving Landscape of Content Creation: Understanding Content Rewriters
In today’s digital age, content is king. Services, individuals, and companies around the world rely on a constant stream of fresh, interesting, and relevant content to get in touch with their audience, establish authority, and drive success. However, the sheer volume of content required can be frustrating. This is where content
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Coronavirus disease (COVID-19), detected in Wuhan City, Hubei Province, China, is a pandemic disease and affecting all people in the world. Real-time reverse transcription polymerase chain reaction (RT-PCR) test is the standard clinical tool for the diagnosis of COVID-19. Computed Tomography (CT) is an alternative method to RT-PCR test for the diagnosis of COVID-19 due to some disadvantages of the RT-PCR tes
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Characterization of lipid based (SPC/GDO/H2O) liquid crystal (LC) drug delivery system is non-trivial and highly complex, especially when multiple and intermediate phases are present. The phase behavior of such mixtures during hydration or delivery is still poorly understood and therefore, characterizing these systems is crucially important towards controlling their function and enhancing th
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However, differences in the studied populations and heterogeneity in the methods applied across the various studies limit the generalizability of these findings and their clinical application.
Physiological studies and epidemiological data suggest a potential inverse association between adult height and blood pressure. Further research is required to define the relationship
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The objective of this paper is to apply high-speed photography and schlieren method to investigate the bubble dynamics between the free surface and a rigid wall. The temporal evolution of the bubble shape and the free surface motion are recorded by two synchronous high-speed cameras. Experiments are carried out for a single bubble generated at various normalized stand-off distances from bubble center to the free surfa
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This paper proposes a concept of green institutional environment and constructs a green institutional environmental index through ordered logistic model. Based on this, taking 92 renewable energy listed enterprises in China from 2007 to 2016 as sample, it investigates the effect of green institutional environment on renewable energy investment with semiparametric method and further discusses how t
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Given the endocannabinoid signalling local tight regulation, we hypothesize the involvement of other 2-AG degradative enzymes. Indeed, THC increases the expression of the hydrolyzing enzymes alpha beta hydrolase domain-6 (ABHD6) and -12 (ABHD12), that we firstly describe in human placental tissues. The results show that THC, depending on time of exposure, induces alterations in 2-AG metabolic enzymes express
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Future studies should consider examining underlying mechanisms that contribute to these sex differences within ε4 carriers.Objectives We conducted a cross-sectional study in Hong Kong community to estimate the carriage prevalence, associated factors and genotypes of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA) and carbapen
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The prevalence of infection was higher among boys (85.18%).
Superficial fungal infections are prevalent in koranic school children and attention should be given to non-dermatophytic species that could be responsible for SFI.
Superficial fungal infections are prevalent in koranic school children and attention should be given to non-dermatophytic species that co
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Caring for youth with mental health and/or addictions (MHA) concerns is associated with caregiver strain, which may lead to negative consequences for youth and their caregivers. These consequences may be mitigated by caregivers and/or youth receiving assistance in navigating the healthcare system. Understanding what factors are associated with caregiver strain may be important in developing and impleme
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Interestingly, feeding cells with ribose-5-phosphate, a precursor for nucleotide biosynthesis that produced through the PPP, could evidently suppress the ROS level and prevent the cell enlargement related to mitochondrial biogenesis. Taken together, these results revealed an important signaling pathway between DNA damage repair and the cell metabolism, which contributed to the premature aging effects of PUVA, and
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Both groups exhibited similar inter-lobe connecting pattern. The elderly group revealed separations, sparser long association fibers, commissural fibers, and lateral inter-lobe connectivity lost effect, mainly in the right hemisphere. New wiring and reconfiguring modules may have occurred within the brain structural network to compensate for connectivity, decreasing and preventing functional loss in cerebral intra-
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Twenty-five patients had SMAD4 loss (48%). 76% of HCQ-treated patients with SMAD4 loss obtained a histopathologic response greater than or equal to 2A, compared with only 37% with SMAD4 intact (p = 0.006). Although loss of SMAD4 has been associated with worse outcomes, in the current study, loss of SMAD4 was not associated with a detriment in median overall survival in HCQ-treated patients (34.43 mont
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In this study, the looping materials of Fe2O3, CaO, mechanically mixed CaO and Fe2O3, and chemically synthesized Ca2Fe2O5 were tested for comparison of the performance and gas evolution processes. The reaction mechanism was illustrated to have an insight into the Fe2O3/CaO-based chemical looping process. Results found that the reduction from Fe2O3 to Fe3O4 trended to form CO2 while the transition of Fe3O4 to Fe happened after 650 °C wa
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Peramivir, a neuraminidase inhibitor, was approved globally and is indicated for the treatment of uncomplicated influenza in adults and children. However, the only approved intravenous formulation of peramivir limits its clinical application due to the need for the specialized dosing techniques and increases the risk of contracting influenza virus infection among healthcare professionals when dosing within
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mutans biofilms. Co-loaded NPC treatments effectively disrupted biofilm biomass (i.e., dry weight) and reduced biofilm viability by ~3 log CFU/mL versus single drug-only controls in developing biofilms, suggesting dual-drug delivery exhibits synergistic anti-biofilm effects. Mechanistic studies revealed that co-loaded NPCs synergistically inhibited planktonic bacterial growth compared to controls and reduc
Colcemid clinical trial
8. Injury was due to predominantly flame burn, with additional injury from grease, scald, contact, friction and flash. Mean time between injury and AHSC treatment was 11 days [range 5-35 days]. All patients had adequate engraftment and complete epithelialization by the end of the study. Patients required one application of AHSC and no other additional surgical procedures at the application sites. The most c
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We investigated whether dogs (Canis familiaris) distinguish between human true (TB) and false beliefs (FB). In three experiments with a pre-registered change of location task, dogs (n = 260) could retrieve food from one of two opaque buckets after witnessing a misleading suggestion by a human informant (the ‘communicator’) who held either a TB or a FB about the location of food. Dogs in both the TB and FB group witnes
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Careful consideration is needed in choosing the right modalities for diagnosis of adrenal insufficiency.BACKGROUND The aim of the present work was to evaluate FOXA2 expression in ovarian cancer and to use integrated bioinformatics analysis to correlate it with patient prognosis. MATERIAL AND METHODS FOXA2 expression was evaluated in multiple cancers in The Cancer Genome Atlas database. A protein-protein interaction (PPI
DNA Damage inhibitor
Availability and implementation The data is freely available at clue.io/data (section Contests) and the software is on GitHub at https//github.com/cmap/gene_deconvolution_challenge.
Supplementary data are available at Bioinformatics online.
Supplementary data are available at Bioinformatics online.The conventional bulk-boundary correspondence directly c
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A nurse sees that a mother of a preterm newborn needs extra support.Nonischemic cardiomyopathies encompass a broad spectrum of myocardial disorders with mechanical or electrical dysfunction without evidence of ischemia. There are five broad variants of nonischemic cardiomyopathies; hypertrophic cardiomyopathy (Variant 1), restrictive or infiltrative cardiomyopathy (Variant 2), dilated or unclassified cardiomyopathy
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Then, we briefly present challenges and perspectives on the direction of nano-confinement in terms of the preparation of optoelectronic materials with desired functionalities. Furthermore, we believe that this review can provide a basis for developing and designing next-generation optoelectronics through nano-confinement.Skin infections caused by pathogens, including bacteria, fungi and viruses, are diffi
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In the dynamic world of content development, the ability to transform existing product into fresh, engaging content is a valuable skill. , referred to as spin rewriting, has ended up being increasingly crucial in the digital age, where content saturation is a typical challenge. Spin rewriting involves taking an initial piece of c
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GW788388
The main causes of COPD are smoking (COPD-TS) and exposure to biomass smoke (COPD-BS), considered as different phenotypes. The association of COPD-TS with lung cancer (LC) is well established, but not in COPD-BS. Thus, we studied the serum concentration of cytokines that participate in inflammation, angiogenesis, and tumor progression, used frequently as LC biomarkers, in women with COPD-BS compared with COPD-TS (n = 70)
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Head movement is an important but often overlooked component of emotion and social interaction. Examination of regularity and differences in head movements of infant-mother dyads over time and across dyads can shed light on whether and how mothers and infants alter their dynamics over the course of an interaction to adapt to each others. One way to study these emergent differences in dynamics
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Dapagliflozin reduced the risk of the composite of cardiovascular (CV) death or hospitalization for heart failure (HHF) in patients with type 2 diabetes mellitus in DECLARE-TIMI 58. We hypothesized that baseline N-terminal pro B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) levels would help identify patients who are at higher baseline risk and we describe the treatment effects of dapagli
A-674563
These results indicate that NPC6 promotes membrane glycerolipid turnover to accumulate TAG production in oil seeds and that NPC6 has a great application potential for oil yield improvement. © 2020 The Authors. New Phytologist © 2020 New Phytologist Trust.BACKGROUND Blood donors receiving testosterone replacement therapy (TRT) often require therapeutic phlebotomy due to erythrocytosis. Red blood cells (RBCs) donated by eli
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Pneumomediastinum (PnM) is a rare but life-threatening complication of DM. The present study aims to characterize the long-term prognosis and prognostic factors of DM-associated PnM.
Inpatients with DM-associated PnM were retrospectively enrolled from two tertiary referral centres for rheumatic disease. The enrolled patients were divided into survivors or non-survivors. In
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Transformations of nitrogen-oxyanions (NO x – ) to ammonia impart pivotal roles in sustainable biogeochemical processes . While metal mediated reductions of NO x – are relatively well known, this report herein illustrates proton-assisted activations of NO x – anions in the presence of electron rich aromatics such as 1,3,5-trimethoxybenzene (TMB – H, 1a ) leading to the formation of oxoammonium salt [(TMB) 2 N + =O][NO 3 – ]
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To investigate the regulatory effect of the transcription factor NF-kB1 on the expression of miR-195 in prostate cancer (PCa).
We analyzed the possibility of NF-kB1 binding to the miR-195 promoter and the expression of NF-kB1 in PCa using the JASPAR and Oncomine databases, respectively, and determined the expressions of NF-kB1 and miR-195 in PCa cells by real-
PIN1 inhibitor API-1 clinical trial
Response rates were 100% for both Delphi rounds. Quality of evidence was evaluated high, moderate low and very low, for 15 (21%), 26 (36%), 29 (40%) and 2 items, respectively. Consensus was reached for 71/72(98.6%) items. Strong recommendations were defined for 37 items, No consensus could be reached regarding the preemptive use of fresh frozen plasma.
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Life history (LH) strategies explain how organisms adapt to the environment and make the best use of their resources to fulfill bodily maintenance, growth, reproduction and other functions. The K-SF-42 is a short version of the 199-item Arizona Life History Battery for assessing seven different domains of LH strategies. This article aims to evaluate the psychometric properties of a Chinese version of the K-S
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This paper is to produce different scenarios in forecasts for international tourism demand, in light of the COVID-19 pandemic. By implementing two distinct methodologies (the Long Short Term Memory neural network and the Generalized Additive Model), based on recent crises, we are able to calculate the expected drop in the international tourist arrivals for the next 12 months. We use a rolling-window testing st
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The dynamic mechanical thermal analysis (DMA) analyses demonstrated that the storage moduli of the blends decreased slightly with the PEGMA content up to 3 wt%, increased at the PEGMA content of 5 wt%, and decreased again at PEGMA contents above 7 wt%. The maximum storage moduli for the blend with 5 wt% PEGMA are interpreted to be due to the reinforcing effect of PEGMA-g-TLCP copolymers.Propolis is a natural bee product
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Long and real time imaging of cell membrane is very important for better understanding of cell performances in physiological and pathological processes. Nowadays, fluorescence probe analysis has become an indispensable tool for monitoring cell membrane. Herein, a novel fluorescent probe based on specific recognition of GABAA receptor was developed for imaging cell membrane. The probe synthesized in this work has be
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The lung has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionall
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The detection rate of psychological health was higher for males than females. The detection rate of psychological health was higher for working days per week less than 5 days than more than 5 days. The detection rate of psychological health with high school education, senior professional title, night shift, divorced, monthly income less than 3000 yuan, weight more than 75 kg, age more than 45 years, and working
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Dinitrosyl iron complexes (DNICs) are spontaneously and rapidly generated in cells. Their assembly requires nitric oxide (NO), biothiols, and nonheme iron, either labile iron or iron-sulfur clusters. Despite ubiquitous detection by electron paramagnetic resonance in NO-producing cells, the DNIC’s chemical biology remains only partially understood. In this Forum Article, we address the reaction mechanisms for endoge
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Arms’ length bodies are often seen as a tool of technocratic governance, designed to insulate decision-making from the politicizing pressures of populist influence. This article examines a subset of arms’ length bodies in the UK which challenge this convention agencies which exist to ‘champion’ the voice of patients and the public in the four NHS systems (England, Northern Ireland, Scotland and Wales). We co
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021 [95% CI 1.401-3.925]; p = 0.038), but not triple modality therapy (HR 1.700 [95% CI 0.798-3.662]) when compared with surgery with RT. Conclusion The most common treatment was surgery and RT, consistent with National Comprehensive Cancer Network (NCCN) guidelines which recommends chemotherapy (CT) only in the most concerning cases. However, we found no difference in survival among most treatment moda
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FactSage simulation, X-ray diffraction (XRD), and scanning electron microscopy (SEM) coupled to energy-dispersive spectroscopy (EDS) analyses were performed to explore the combined influence of SiO2 and O2 on the crystallization behavior of modified Ti-bearing blast furnace slag. The results of FactSage simulation showed that an increase in the added amount of SiO2 was beneficial to the conversion of Ti
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Medical advice regarding return to play and the risk of acute and/or long-term consequences is therefore problematic. It is important that the individual’s right to make their own choices regarding their health is respected. Team, coach, parental, peer or financial pressures should not influence this decision. The choice to return to play after a concussion or mild TBI injury is the athlete’s decision once they have (1) r
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The results of this qualitative analysis can complement and guide simulation-based approaches, and serve as a basis for the investigation of more complex mechanisms.In India, coal utilization in power generation, constitutes as the single largest source of mercury emissions. This study presents mercury content in Indian sub-bituminous and bituminous coals that are primarily used as fuel in large-scale electr
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To evaluate the image quality and the safety of automated carbon dioxide (CO
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Fifty patients receiving DSA for femoropopliteal peripheral arterial disease (PAD) were enrolled in this single-center prospective study. All patients received iodinated contrast media (ICM) and CO
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We propose that E107 and E132 belong to a new sub-class of AON mutants, i.e., hypo-nodulators, and that their respective gene products are acting in the AON descending branch, upstream of TML signaling.Age-related macular degeneration is an eye disease that is the main cause of legal blindness in the elderly in developed countries. Despite this, its pathogenesis is not completely known,
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Female infertility continues to increase in prevalence annually and factors causing it need to be researched. As IL-6-174 G/C polymorphism is known to alter the plasma levels of IL-6, abnormal levels of IL-6 found in infertile females could be due to genetic reasons. With the understanding of the importance of IL-6 in reproductive physiology, several individual studies done so far to find the association of
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When cropland expansion encroaches on ecological land (e.g., forest, grassland, wetland), it seriously affects carbon storage which plays an important role in global climate change. Taking Hubei as the study area, this study explored the effects of cropland expansion on carbon storage in both 2000-2010 and 2010-2030 in different scenarios by using the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) mo
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Three ethical conflicts in particular are paradigmatic of what we define as “clerkship ethics.” First, a distinction that differentiates the clerkship student from the practicing physician involves the student’s principal role as a learner. The clerkship student must skillfully balance her commitment to her own education against her commitment to patient care in a fashion that may compromise patient care. Wh
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Contraceptive pills are chemical substances used as a means to prevent pregnancy, but they have several effects, including high lipid profile and in many cases, patients with heart and blood diseases cannot use it as a contraceptive helps in increasing the risk of cardiovascular diseases (CVD). A Stevia extract with high sweetening capacity due to its content of glycosides is used to reduce lipid profile and this st
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Hot film sensors detect the flow shear stress based on the forced convection heat transfer to the fluid. Current hot film sensors have been significantly hindered by the relatively low sensitivity due to the massive heat conduction to the substrate. This paper describes the design, fabrication, simulation, and testing of a novel flow sensor with dual-layer hot film structures. More specifically, the heat conduction was in
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The sensitivity of plasma connective tissue growth factor as a diagnostic biomarker for PH was 95%, and the specificity was 90% at a cut-off value ≥650 pg/mL. The predictive value of plasma connective tissue growth factor for adverse outcome had a sensitivity of 88% and a specificity of 83% at a cut-off value ≥1900 pg/mL. CONCLUSION Connective tissue growth factor is a promising biomarker with good diagnosti
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The aim and effect of transnational terrorism today – stemming from both Islamic revivalism and ethno-nationalist resurgence – are to fragment social consensus by forcing people into opposing camps, with no room for innocents. Governments and peoples wrestle with why this is happening and what to do. At issue here Can social science, specifically psychology, be helpful? A partial answer focuses on recent
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The OM, M3, and M4 tmax and t1/2 values were similar between groups. There were no serious adverse events (AEs) or treatment-related treatment-emergent AEs. Overall, OM, M3, and M4 PK were not meaningfully affected by mild or moderate hepatic impairment, suggesting the same dosing strategy can be used in subjects with mild or moderate hepatic impairment.
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We conclude that there is a gradient organization in self-processing, through which body-environment information is integrated for the self via propagation from Interoceptive-processing to Mental-self-processing.Intestinal IgA is induced by microbes and food antigens. Peyer’s patches (PPs) are known as one of the inductive sites for intestinal IgA production. However, the precise mechanism of IgA induction is as yet u
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We demonstrated that the two-handed tec
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Chemokines may promote the formation and instability of atherosclerotic plaque, which is the most common cause of acute coronary syndrome. The aim of this study was to clarify the function of monocyte chemotactic protein-3 (MCP-3) in the stability of atherosclerotic plaque, to determine the role of tissue factor pathway inhibitor (TFPI) on the development and stability of atherosclerotic plaques, and to furthe
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Aims We aimed to investigate associations between mental health and sociodemographic characteristics among schoolchildren in Denmark. Methods We performed a cross-sectional survey from January to October 2019 among 4th to 9th graders (N=1247) based on pilot data from a nationwide research project Stress-free Everyday LiFe for Children and Adolescents REsearch (SELFCARE). We assessed m
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There is growing concern regarding human dietary exposure to arsenic (As) via consumption of rice. The concentration and speciation of As in rice are highly variable, and models describing rice As speciation as a function of environmental covariates remain elusive. We conducted a survey of paddy rice and soil in the Mekong Delta with the objective of linking patterns in rice As content to soil chemical variables or hydrogeolo
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Introduction Early Supported Discharge (ESD) is a clinical flow management service offering interdisciplinary rehabilitation, wherein patients are provided supported in-home rehabilitation treatment; in comparison to conventional hospital-based rehabilitation model of service delivery. There has been into the functional outcomes for other types of acquired brain injury (ABI). Methods In this prospective cohort study, A
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It also demonstrated a self-cleaning property and remarkable durability.Micro light emitting diodes have been grown by metal organic vapor phase epitaxy on standard GaN and partly relaxed InGaNOS substrates with the purpose of incorporating higher concentrations of indium for identical growth conditions. Green emission has been demonstrated at wavelengths of 500 nm for the GaN template and 525 and 549 nm for the In
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Furthermore, the rhizomicrobiome communities (bacteria and fungi), investigated through NGS, highlighted how α diversity increased in all treatments compared to the untreated N12 saplings. Soil compost amendment, as well as Zn pollution, strongly modified the bacterial rhizomicrobiome structure. Conversely, the variation of the fungal rhizomicrobiome was only marginally affected by soil Zn addition, and only partially impaired by compost. Nev
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Most screening tools identifying women with substance use are not validated, used once in pregnancy, and are not reflective of continued substance use. We hypothesized that serial early prenatal substance screening leads to decreased substance use by the end of pregnancy and improved outcomes.
This is a retrospective cohort study of mothers and their infants b
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The translation of evidence from clinical trials into practice is complex. One approach to facilitating thi
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= 0.048) whilst nintedanib treatment significantly increased blood GSH (486 ± 70 μmol/L vs 723 ± 194 μmol/L,
= 0.006) and reduced ADMA concentrations (0.501 ± 0.094 vs. 0.468 ± 0.071 μmol/L,
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In a multivariate analysis of 388 children, severe hypertriglyceridemia and inherited thrombophilia were independent risk factors for VTE. Routine evaluation for these risk factors in children treated for ALL may help identify candidates for intervention.Trigeminal neuralgia (TN), the most common form of severe facial pain, may be confused with an ill-defined persistent idiopathic facial pain (PIFP). Facial pain is revi
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Dalbavancin induces markedly more extensive changes in the expression of genes required for transport processes, RNA methylation, haem biosynthesis and the biosynthesis of the amino acids arginine and glutamine. Chlorobiphenyl-vancomycin exhibits specific effects on tryptophan and calcium-dependent antibiotic biosynthesis and has a stronger repressive effect on translation. Vancomycin predictably has a uniquely strong
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Immune checkpoint blockers constitute the first-line treatment for advanced non-small-cell lung cancer (NSCLC) with ≥50% PD-L1 expression. In NSCLC, PD-L1 positivity is correlated with high
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Objective Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such models are potentially biased by secondary effects related to a chronic lack of AMPK function. In an attempt to study the direct effect(s) of AMPK on muscle me
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The treatment regimen for the eradication of Helicobacter pylori may be best when therapy is susceptibility guided. However, it is unrealistic to use a strategy based on susceptibility testing to prioritize therapy for every patient in China. Empirical therapy of H. pylori is still widely used. The study was designed to discuss the best first-line treatment regimen depending on empirical therapy. The focal point of
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016 Marine Corps policy change decreased contraception use-29.6% to 24.4%, OR 0.78 (95% CI 0.70-0.88), long-acting reversible contraception use-14.6% to 7.3%, OR 0.39 (95%CI 0.31-0.48), and increased childbirth rates-8.0% to 9.6%, HR 1.26 (95%CI 1.03-1.55) among Marines compared to outcomes in the Army and Air Force over the same time period. CONCLUSION Basic training contraceptive policy influences contraception use am
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Radiographs are the first-line investigation for knee osteoarthritis (OA). Antero-posterior (AP) and Rosenberg views have demonstrated varying sensitivities in detecting severe OA. There is a multitude of radiological grading systems described. The aim of this study was to assess four commonly used grading systems in terms of inter- and intra-observer reliability and correlate the results with patient-
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In developed countries, the incidence of non-ST-segment elevation myocardial infarction (NSTEMI) has outpaced that of ST-segment elevation myocardial infarction (STEMI). However, whether this trend is observed in Japan, in which the aging of society is rapidly progressing, remains to be elucidated.Methods and ResultsThis study retrospectively investigated the trends over time in the incidence of acute coronary syndrome (AC
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WHO Regional Office for the Western Pacific (WPRO) organized an online meeting connecting WHO Collaborating Centres (WHO CCs) in the region on 25 August 2020, to share experiences and promote networking on COVID-19 response. The meeting shared regional update on situation and responses, and COVID-19 related experiences of selected WHO CCs, followed by discussions on opportunities for enhancing collaboration between WPRO
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Liver disease has been reported to associate with oral microbiota. This study aimed to identify the salivary microbial structure in liver disease patients and determine whether the disease progression influence the bacterial composition. 16S rDNA high-throughput sequencing and bioinformatic analysis were used to examine oral bacterial diversity in the different status of hepatitis patients including 6 patients with
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Background Depressive disorders often remain undiagnosed or are treated inadequately. Online-based programs may reduce the present treatment gap for depressive disorders and reduce disease-related costs. This study aimed to examine the potential of the internet intervention “deprexis” to reduce the total costs of statutory health insurance. Changes in depression severity, health-related quality of life and impairment in
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Hendra virus (HeV) and Nipah virus (NiV) are bat-borne zoonotic para-myxoviruses identified in the mid- to late 1990s in outbreaks of severe disease in livestock and people in Australia and Malaysia, respectively. HeV repeatedly re-emerges in Australia while NiV continues to cause outbreaks in South Asia (Bangladesh and India), and these viruses have remained transboundary threats. In people and sever
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They promote Aβ deposition and TAU hyperphosphorylation aggravating and increasing the progression of AD. Moreover, they affect the processing of senile plaques and produce abnormal TAU phosphorylation. CONCLUSION There is no cure for AD but the therapeutic potential of chemokines to control the development of the disease may be a field of study to consider in the future. Copyright© Bentham Science Publis
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Herein we summarize DDR signaling pathways induced by SM, HN2 and the half mustard, 2-chloroethyl ethyl sulfide (CEES). At the present time, little is known about how mustard-induced DNA damage leads to the activation of DDR signaling. A better understanding of mechanisms by which mustard vesicants induce the DDR may lead to the development of countermeasures effective in mitigating tissue injury. Autism spectrum di
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To investigate the characteristics of diabetic foot ulcer (DFU) recurrence.
A total of 573 patients with DFUs were recruited and divided into an initial group (395 patients) and a recurrence group (178 patients). The factors related to recurrence were analyzed using multivariate regression.
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The purpose of this ecological study was to explore the association of weather with severity indicators of coronavirus disease 2019 (COVID-19). Daily COVID-19-related intensive care unit (ICU) admissions and in-hospital deaths in the Paris region and the daily weather characteristics of Paris midtown were correlated with a time lag. We assessed different study periods (41, 45, 50, 55, and 62 days) beginning from
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Spinal cord astrocytomas (SCAs) account for 6-8% of all primary spinal cord tumors. For high-grade SCAs, the prognosis is often poor with conventional therapy, thus the urgent need for novel treatments to improve patient survival. Immunotherapy is a promising therapeutic strategy and has been used to treat cancer in recent years. Several clinical trials have evaluated immunotherapy for intracranial glioma
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Microbiota transplant reduced gut Th17 cells in mice colonized with a microbiota from a donor with Crohn’s disease. By culturing strains from this microbiota and screening them in vivo, we identified a specific strain that potently induces Th17 cells. Microbiota transplants reduced the relative abundance of this strain in the gut microbiota, which was correlated wi
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The effects of gluteal implants on bone mass remain unclear. Transgender women with ILS presented higher BMD in the hip compared with transgender women without implants, while no difference was observed in other sites. These results may be artifactual and suggest using spine/forearm sites for DXA in individuals with ILS.
The inappropriate use of industrial liquid silicone (ILS) injections f
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Outcomes after end-to-end epineural suture repair remain poor. Nerve wraps have been advocated to improve regeneration across repair sites by potentially reducing axonal escape and scar ingrowth; however, limited evidence currently exists to support their use.
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The emergence of the COVID-19 and its consequences has led to fears, worries, and anxiety among individuals worldwide. Recently, Ahorsu et al. (2020) developed the Fear of COVID-19 Scale (FCV-19S). The present study aimed to translate and validate the FCV-19S in Spanish university students. The sample comprised 606 Spanish´undergraduates with a mean age of 21.59 years old. We also used a six items from the State Trait Anx
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Dalbavancin induces markedly more extensive changes in the expression of genes required for transport processes, RNA methylation, haem biosynthesis and the biosynthesis of the amino acids arginine and glutamine. Chlorobiphenyl-vancomycin exhibits specific effects on tryptophan and calcium-dependent antibiotic biosynthesis and has a stronger repressive effect on translation. Vancomycin predictably has a uniquely strong
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Large-scale protein analysis may bring important insights into molecular changes following branch retinal vein occlusion (BRVO). Using proteomic techniques this study compared aqueous humor samples from patients with BRVO to age-matc
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Malignant hidradenocarcinoma is a very rare and highly aggressive primary skin neoplasm that arises in the eccrine sweat glands. Diagnosis is typically made with histopathological evaluation after excisional biopsy. Reports of this tumor are scarce in the literature, thus making its characterization and management particularly challenging. A 71-year-old male presented in the clinic with swelling of the left
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Morphine administration for 5 days (1) improved glucose homeostasis; (2) reversed cardiac depression; (3) enhanced I-R tolerance; (4) restored mitochondrial ultrastructure; (5) improved mitochondrial function; (6) upregulated Stat3 protein; and (7) preserved membrane cholesterol homeostasis. These data show that morphine treatment restores contractile function, ischemic tolerance, mitochondrial structure and
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e these findings.Purpose This study introduces a framework to produce very short versions of the MacArthur-Bates Communicative Development Inventories (CDIs) by combining the Bayesian-inspired approach introduced by Mayor and Mani (2019) with an item response theory-based computerized adaptive testing that adapts to the ability of each child, in line with Makransky et al. (2016). Method We evaluated the pe
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Similarly, surface chemical composition was not significantly affected by the treatments. Among the treatments tested in this study, air powder abrasion with glycine powder and 3 W diode laser had the lowest impact on surface physicochemical properties.The antimicrobial peptide (AMP) piscidin was identified from Epinephelus lanceolatus and demonstrated to possess antimicrobial and immune-related functions. Suppl
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Recently, attention has been paid to the impact of cigarette smoking on skeletal muscles, as its underlying pathophysiological mechanism has been gradually elucidated. In this study, we aimed to examine whether cigarette smoking is associated with muscle mass reduction and low muscle strength in elderly men.
The study participants comprised 417 community-dwelling elderly men (ag
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Depression and extraversion did not predict any differences in fEMG responses. We suggest that impairments in spontaneous “smiling back” at another – a decreased interpersonal resonance – could contribute to negative social and emotional consequences of loneliness and may facilitate loneliness contagion.Binding of calcium ion to calcium-binding proteins (CBP) triggers a large number
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instance, vegetative cover over an open-pit mining area can cause a dramatic reduction in soil moisture. Ninety-three meters was the optimal scale used for monitoring the soil moisture in the DCMA, which indicates that we can adopt the SPOT-5, SPOT-6, and Sentinel-2 images to evaluate the soil moisture conditions in the DCMA.PURPOSE OF REVIEW This manuscript aims to review (for the first time) studies describing NGS sequ
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In terms of health efficiency, upper middle income countries performed worse than lower income countries. This phenomenon might indicate there was a U-shaped relationship between health efficiency and income level. Upper income countries should pay more attention to the environmental and health problems and cross the U-shaped turning point. The contribution of this article was to consider the heterogeneous performance of ener
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Sixty knees were revised, with progression of disease in another compartment the commonest reason. Eighty eight percent were revised using a primary prosthesis. For patients over the age of 65years at the time of index procedure, 93% died with a functioning prosthesis in situ.
Medial UKA demonstrates good long-term function and survivorship, and represents an excellent surg
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Two-dimensional volumetric exercise stress echocardiography (ESE) provides an integrated view of left ventricular (LV) preload reserve through end-diastolic volume (EDV) and LV contractile reserve (LVCR) through end-systolic volume (ESV) changes.
To assess the dependence of cardiac reserve upon LVCR, EDV, and heart rate (HR) during ESE.
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561, 95% CI 1.182-5.550). Bilateral breast cancer had significantly shorter progression-free survival (Mean survival was 26.6 vs 52.5 months for bilateral and unilateral breast cancers, respectively;
=0.001) and shorter time to develop distant metastasis (Mean survival was 41.7 vs 104 months for bilateral and unilateral breast cancers, respectively;
=0.001).
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Trong cộng đồng yêu thích xổ số, cái tên Vua xổ số không còn xa lạ. Đây không chỉ là nơi cung cấp kết quả xổ số nhanh chóng, chính xác, mà còn được biết đến như một trong những “trợ thủ đắc lực” cho dân chơi lô đề với các công cụ phân tích, soi cầu và thống kê cực kỳ uy tín.
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The results of this study revealed serotonergic innervation and cell density differences among closely related macaque species, which may play a role in modulating subtle differences in emotional processing and species-typical social styles.Performing point-of-care urine drug screen testing at autopsy by a forensic pathologist may provide an early indication of the presence of analytes of interest during autopsy. An evaluation for the scree
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Harmful cyanobacterial blooms (cyanoHABs) pose threats to human and animal health due to the production of harmful cyanotoxins. Microcystis aeruginosa is a common cyanobacterium associated with these blooms and is responsible for producing the potent cyclic hepatotoxin microcystin-LR (MC-LR). Concerns over the public health implications of these toxins in water supplies have increased due to rising occurrence of these blo
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Brucella spp., are facultative intracellular bacteria notorious for their ability to induce a chronic, and often life-long, infection known as brucellosis. To date, no licensed vaccine exists for prevention of human disease, and mechanisms underlying chronic illness and immune evasion remain elusive. We and others have observed B cell deficient mice challenged with Brucella display reduced bacterial burde
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ft in resistance patterns of common bacteria responsible for device infection. Towe M, Huynh LM, Osman MM, et al. Impact of Antimicrobial Dipping Solutions on Postoperative Infection Rates in Patients With Diabetes Undergoing Primary Insertion of a Coloplast Titan Inflatable Penile Prosthesis. J Sex Med 2020;172077-2083.
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0001). Mean CT values are highest in the Mono +50 keV images in each type of clot, and they were also significantly higher than all other imaging protocols (P<0.001). Dual-energy CT with Mono +50 keV images showed the greatest difference between attenuation in each type of clot.
Mono +50 keV dual-energy CT scan may be helpful for differentiating between RBC-rich and fibrin-rich
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Against non-CRAB, the triple therapy regimen of high-dose minocycline (fAUC/MIC 84.8) with continuous-infusion meropenem (100% T>MIC) and continuous-infusion sulbactam (83% T>MIC), as well as the double therapy of high-dose minocycline (fAUC/MIC 84.8) with continuous-infusion meropenem (100% T>MIC), resulted in persistently bactericidal activity. In conclusion, triple therapy with high-dose minocycline, continuous-
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HIV pre-exposure prophylaxis (PrEP) reduces HIV transmission and is approved for adolescents aged 12-17 years. Adolescent girls and young women (AGYW) have modest PrEP uptake rates, while many receive reproductive health counseling. We sought to identify opportunities for incorporating PrEP education in contraceptive counseling delivered to AGYW.
We performed a secondary analysis of d
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In conclusion, the most frequently reported complication after an HSG with oil-based contrast is intravasation occurring in 2.7%. In total four cases with serious consequences of oil embolisms in subfertile women were published.
The purpose of this study was to evaluate the safety and oncologic efficacy of percutaneous magnetic resonance imaging (MRI)-guided cryoablation of intraparenchymal renal canc
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Furthermore, temozolomide treatment effectively suppressed gliomagenesis in these glioma zebrafish models, and the histological responses in temozolomide-treated zebrafish were similar to those observed in clinically treated glioma patients. Thus, our findings will offer a potential tool for genetically investigating gliomagenesis and screening potential targeted anti-tumour compounds for glioma treatment.
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Even as we near therapeutic translation, there remain many questions about the governance of muscle function in human health and disease. With this review, we provide a broad overview of contemporary understanding of myosin SRX, and explore the complexities of targeting this myosin state in human disease.This article has an associated Future Leaders to Watch interview with the authors of the paper.Human induced pl
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The percentages were lower for smaller workplaces, and workplaces with 29 or fewer employees had the lowest percentage for Category 3 part-timers (27.9%). The percentage of employers bearing the full cost of medical check-ups was lower for Category 1 (90.5%), 2 (87.7%), and 3 (85.0%) part-timers than that for full-time employees (93.7%).
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The molar ratio of ASC-DP/DSPE-PEG in the nanoparticle precipitates determined by 1H NMR measurements was 68.81. The rod-like nanoparticles should be composed of a core-shell structure, where a small amount of DSPE-PEG covers the lamellar structure of ASC-DP. Further increase in the ASC-DP/DSPE-PEG molar ratio over 331 no longer provided nanoparticles. Hence, to prepare a stable ASC-DP nanoparticle suspension, it is neces
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This work extends the understanding of regulating abnormal DSB repair for cancer treatment.Aims The aim of this study was to identify the immune- and locus-associated genes in pancreatic ductal adenocarcinoma and evaluate their value in prognosis. Methods The pancreatic ductal adenocarcinoma stromal and immune scores were calculated with the estimation of stromal and immune cells in malignant tumor tissues using expr
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Id regarding Center String Oily Acyl-CoA Ligase Responsible for the Biosynthesis involving 2-Alkylmalonyl-CoAs pertaining to Polyketide Device Unit.
The expression and roles of most long noncoding RNAs (lncRNAs) in non-small-cell lung cancer (NSCLC) remain poorly understood. AMI-1 inhibitor Thus, this study investigated
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Frail older adults with ongoing care needs often require post-acute care (PAC) following acute hospitalization when not eligible for specific rehabilitation. Long-term outcomes of PAC in this patient group have not been reported for Switzerland so far. In the present report, we investigated 12-month mortality in regard to frailty status upon admission to PAC in a nursing home setting. In our sample of 140 patients
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In trypanocidal tests, an LC
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This is the first study demonstrating the activity of an amyrin
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Brazil is the country with the highest social inequality in South America. This socioeconomic disparity reflects not only on the families’ income but also on their spatial localization in the city, as well as on the urban design. These urban environments can alter the urban microclimate, and consequently, interfere in dwellers’ thermal comfort. This research investigated the relationship bet
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Following the publication of this paper, it was drawn to the Editors’ attention by a concerned reader that the western blotting data featured in Figs. 4B and 6B (wherein there was also a duplicated set of data bands) were strikingly similar to data appearing in different form in other articles at different research institutes. Owing to the fact that the contentious data in the above article were already
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Vacuum bell and exercise therapy are non-invasive treatments for pectus excavatum (PE). The purpose of this study was to determine the effects of the physiotherapy programme applied in addition to vacuum bell treatment in patients with PE.
The study included 26 male patients with PE aged 11-18 years. Patients were randomly divided into 2 groups group 1 received only v
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High-enhanced serosa sign and nodular or an irregular outer layer of the gastric wall were identified as independent predictors for building the subjective finding model. High-enhanced serosa sign and heterogeneity signature were significant predictors for differentiating the 2 groups (all, P < 0.05). The area under the curve with heterogeneity nomogram was 0.932 (95% confidence interval, 0.863-0.973) in the validation
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tion compared with lower scoring peers. Understanding this relationship and using these guidelines can help identify and treat patients whose gait dysfunction may be amplified by psychologic distress.Level of Evidence 3.
30 have more underlying psychological factors that contribute to significantly worse function compared with lower scoring peers. Understanding this relationship and using these guidelines
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University students are often a sexually active group that is at risk of acquiring and transmitting HIV. This risk depends on their level of knowledge towards the disease. Hence, HIV/AIDS related knowledge represents the acquisition of scientific facts and information regarding the symptoms, way of transmission, adverse consequences, and prevention strategies of the d
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Questions related to these events are posed for use by health and spiritual care professionals to innovatively engage persons in advance care planning. Discussion This approach might be adapted for persons of other religious traditions by exploring their sacred teachings. It is proffered for others to explore, adapt, and evaluate for its utility in initiating and facilitating advance care planning.Palliat
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Engineered plant cell lines have the potential to achieve enhanced metabolite production rates, providing a high-yielding source of compounds of interest. Improving the production of taxanes, pharmacologically valuable secondary metabolites of Taxus spp., is hindered by an incomplete knowledge of the taxane biosynthetic pathway. Of the five unknown steps, three are thought to involve cytochrome P450-like hydroxylases. In the
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Comparison to other EHs from mycobacteria allows insight into the active site plasticity with respect to substrate specificity. We speculate that mycobacterial EHs may have a narrow substrate specificity providing a potential explanation for the genetic repertoire of epoxide hydrolase genes in M. tuberculosis.Formaldehyde is an environmental and occupational chemical carcinogen implicated i
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Additional investigation regarding the validity and reliability of this framework will facilitate its adoption in research that advances our comprehension of mechanisms, deliver better treatments, and help prevent the transition of acute to chronic pain after surgery in the abdominal and peritoneal region. Perspective Using AAAPT pain taxonomy, we present key diagnostic criteria for acute abdominal
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The aim of the current study was to evaluate the probabilistic health risk and the concentration of 16 polycyclic aromatic hydrocarbons (PAHs) in commercial tea and coffee samples. For determining the mentioned contaminants in sixty-four samples, a reliable and sensitive technique was validated and developed. The technique is established on magnetic solid-phase extraction and gas chromatography-mass spect
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ut causing adverse events.
Positive end-expiratory pressure (PEEP) is an important part of the lung protection strategies for one-lung ventilation (OLV). However, a fixed PEEP value is not suitable for all patients. Our objective was to determine the prevention of individualized PEEP on postoperative complications in patients undergoing one-lung ventilation.
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As the population ages, rate of total knee arthroplasty increases and thus, it is important to maximize efficiency and minimize risk. Identifying patients who are at higher risk for transfusion can help streamline care provided and minimize superfluous, costly hemoglobin monitoring in low risk patients.
Adult patients who underwent total knee arthroplasty (TKA) in 2015 were
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Sex-based eRNA term overall performance in ischemic cerebrovascular event.
The effectiveness of PTENUE is also demonstrated in a real application, where insights are presented regarding the leading forces in financial data.Many real systems are strongly characterized by collective cooperative phenomena whose existence and properties still need a satisfactory explanation. Coherently with
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The error-correction algorithms fully recover the message when individual docking sites, or entire origami, are missing. Unlike other approaches to DNA-based data storage, reading dNAM does not require sequencing. As such, it offers an additional path to explore the advantages and disadvantages of DNA as an emerging memory material.Aptamers are single-stranded nucleic acid ligands that bind to target molecules
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Hence, we can conclude that nuclear power generation is more cost-efficient than is renewable energy generation in mitigating CO2 emissions, even with the external costs of accidents and health impact risks associated with nuclear power generation.In this article, a new process for treating steel slag and CO2 simultaneously and preparing calcium carbonate, metallic iron, and glass ceramics without wastewater or gas prod
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Intrahepatic Bruton’s tyrosine kinase is mainly expressed on Kupffer cells and sinusoidal endothelial cells, and the inflammasome is activated in Kupffer cells. Our study found that inhibition of Bruton’s tyrosine kinase effectively attenuated liver I/R injury by suppressing activation of the NLRP3 inflammasome in Kupffer cells.
Inflammatory Bowel Disease (IBD) treatment may increase the risk of i
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Vitamin D3 is the precursor of the steroid hormone calcitriol (1α,25-dihydroxyvitamin D3), a potent agonist of the transcription factor vitamin D receptor (VDR). Calcitriol has received large appreciation due to the impact not only on mineral homeostasis, but also on metabolic diseases, immunological disorders, and cancer. A supraphysiological dose of calcitriol is required to reduce the proliferation of cancer cells. However
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Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin cutaneous melanoma (n = 328) was utilized. CIBERSORT was used to identify immune cell type composition, on which unsupervised hierarchical clustering was performed. Analysis of overall survival was performed using Kapl
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However, an enhancement of motor cortex excitability (latency shortening and increased size of thenar MEP) was found with active interventions (A + B + C, and B/C alone; P less then .05 for all) but not with sham. Active but not sham interventions shortened pharyngeal SEP latency in the ipsilesional hemisphere (A + B + C P2-peak, P = .039; A N2-peak, P = .034) and antagonized the physiological habituation in pharyn
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Two datasets and other SRM measures were recommended as supplemental.Conclusion There is no one single measure that can be used to assess NBB dysfunction across all clinical research studies. Clinical and diagnostic tools are here recommended based on specific medical needs of the person with SCI/D. Following the CDE for SCI studies guidelines, we recommend both the SF-Qualiveen for bladder and the NBDS for
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Coupling devices have become commonplace in performing venous anastomoses during microvascular free tissue transfer (FTT). However, arterial anastomoses are still most commonly performed using traditional microvascular suture techniques.
To describe the safety and feasibility of using microvascular coupling devices for free flap arteri
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Management of Hypercholesterolemia throughout Women that are pregnant using Atherosclerotic Heart problems.
The wear and fatigue behaviors of two newly developed types of high-speed railway wheel materials (named D1 and D2) were studied using the WR-1 wheel/rail rolling-sliding wear simulation device at high temperature (50 °C), room temperature (20 °C), and low temperature (-30 °C). The results showe
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The social and physical environments in which people live affect the emergence, prevalence, and severity of both infectious and noninfectious diseases. There are limited data on how such social determinants of health, including neighborhood socioeconomic conditions, affect the risk of severe acute respira
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ral. Sustainability of these panels however is subject to structural financial compensation, so a cost-effectiveness analysis is warranted.The World Health Organization (WHO) advocates for patients to play an active role in their healthcare in order to improve the quality of care delivery. However, there is limited research on provider perceptions of the role of the patient during a medical encounter in an HIV setti
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The incidence of chronic kidney disease is increasing worldwide, and the previously decreasing incidence of cardiovascular disease has now plateaued. Understanding the intersection of both heart and kidney disease is crucial.
Chronic kidney disease and cardiovascular disease share common risk factors and specific pathogenic mechanisms and impact a significant segment of the pop
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Compared with NML, PHSML-H increased IL-2 expression at 12 h, but decreased expression of both IL-2 and IFN-γ at 24 h. By contrast, PHSML-R induced significant increases in IL-2 and IFN-γ levels at 24 h. Interleukin-4 expression in CD4
T lymphocytes was reduced at 12 h, but augmented at 24 h after incubation with either PHSML-H or PHSML-R.
The result
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6vs. 15.0%; OR 4.05; p=0.042). Serum immunoglobulin G-levels (IgG) [mg/dl] were lower (894.0vs. 1446.5; p=0.023).
Higher hospitalization rate and morbidity parameters underscore the clinical importance of PCP-related paradoxical IRIS. A baseline viral load of >6Log10/ml and serum IgG may help to assess individual risks for PCP-IRIS.
6Log10/ml and serum IgG m
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Based on current findings, BMAs may function as a pivotal modulator of bone metastasis of breast cancer, therefore targeting BMAs combined with conventional treatment programs might present a promising therapeutic option.Background The chemotherapy response score (CRS) system is a reproducible prognostic tool for patients receiving neoadjuvant chemotherapy (NACT) for tubo-ovarian high-grade serous carcinoma (HGSC). Achi
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Racial and ethnic minorities in the United States report higher levels of both clinical and experimental pain, yet frequently receive inadequate pain treatment. Although these disparities are well documented, their underlying causes remain largely unknown. Evidence from social psychological and health disparities research suggests that clinician-patient racial/ethnic concordance may improve minority pati
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This study was performed to determine the role of autophagy-related 16-like 1 (ATG16L1, rs2241880) and IL10 (rs1800872) polymorphisms in the susceptibility to and early prediction of breast cancer in Egyptians. The study included 50 breast cancer patients and 50 apparently healthy controls. The PCR-RFLP technique was used to detect ATG16L1 (rs2241880) and IL10 (rs1800872) genotypes.
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Maternal and child survival is a major public health problem in haor areas in Bangladesh. Fathers feel responsible as expressed by their capability “to save the future”. Using the Capability Framework for Child Growth, we aimed to identify what contextual factors underlie a father’s real opportunities to secure a safe delivery, including social norms and beliefs. Parents from households having children less than tw
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We will concentrate on cancer, type 2 diabetes (T2DM), and neuropsychiatric disorders (focusing on mood disorders).
Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections can have serious consequences during the period of aplasia and lymphopenia following hematopoietic stem cell transplantation (HSCT). Large pediatric cohort studies examining the effect of antiviral prophylaxis aga
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In this review, we summarized all reported prediction systems, including the PASS system, the GAPP system, the COPPs system and the ASES system. Additional potential indicators that related to metastatic PPGL were also introduced. AJCR Copyright © 2020.E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription factors. E2F1 binds to DNA with dimerization partner (DP) proteins through a
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Maxillary second molars and mandibular first molars extruded in the Jones jig group and slightly intruded in the Pendulum appliance group. The nasolabial angle decreased in the Pendulum group and increased in the Jones jig group.
The correction of a Class II malocclusion was shown to be stable with similar long-term post-treatment results with Pendulum or Jo
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Global consolidation rates of unstable fractures were 85% (17/20) of treated levels. Pain score was null in 84% patients (26/31) one year after PVC. There were no significant differences between pre-PVC (0.62±0.18 [SD]; range 0.22-0.88) and post-PVC (0.60±0.18 [SD]; range 0.35-0.88) vertebral height ratios (P=0.94).
PVC conveys a high overall success rate and effectively controls pain
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Retrospective and single-arm prospective studies have reported clinical benefit with neoadjuvant imatinib for GISTs. In the absence of randomized Phase III data, the impact of neoadjuvant systemic therapy (NAT) on survival compared to upfront resection (UR) remains unknown. We identified N = 16 308 patients within the National Cancer Database (2004-2016) who underwent resection of localiz
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The need for definitive answers probably explains our natural tendency to seek simplicity. The reductionist “bulk” approach, in which a mean behavior is attributed to a heterogeneous cell population, fulfills this need by considerably helping the conceptualization of complex biological processes. However, the limits of this methodology are becoming increasingly clear as models seek to explain biological events occurring
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This study is important for orthopedic and rehabilitation physicians in treating diseases of the long head of the biceps brachii tendon. As part of management, the condition of the tendon of the pectoralis major should be confirmed using magnetic resonance imaging or echocardiography.
This study is important for orthopedic and rehabilitation physicians in treating diseases of the long head of the bi
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Our results show that the pharmacological and safety profiles of MTA are modulated by changing the methyl-thio group or the methyl group of the aminoethyl chain.There are several known cases of positioning error, leading to serious consequences, sometimes also deadly. Therefore, obtaining accurate position data by means of GPS receivers is paramount. With this perspective, the aim of this study was to test
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ed comparable effectiveness and safety in the treatment of gastric diseases in our meta-analysis. Based on the current evidence, we believe that RPLS is an efficacious surgical alternative to CMPLS in the management of gastric diseases because of the shorter hospital stay and reduced blood loss. However, large-scale, well-designed, multicenter studies are needed to further confirm the results of this study.
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Bhutan implemented a national program for human papillomavirus (HPV) vaccination in 2010 involving girls aged 12 to 18 years and achieving nearly 90% coverage.
To estimate HPV vaccine effectiveness in a city in Bhutan.
2 cross-sectional surveys, 2011-2012 and 2018.
2 hospitals in Thimphu, capital of Bhutan.
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This study found worse PS and higher age are independent predictors of overall survival in NSCLC patients with MSCC treated with short-course radiotherapy after adjusting the potential confounding factors (PS, age and target therapy).Wnt signaling plays pivotal roles during our entire lives, from conception to death, through the regulation of morphogenesis in developing embryos and the maintenance of tissue h
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Two datasets and other SRM measures were recommended as supplemental.Conclusion There is no one single measure that can be used to assess NBB dysfunction across all clinical research studies. Clinical and diagnostic tools are here recommended based on specific medical needs of the person with SCI/D. Following the CDE for SCI studies guidelines, we recommend both the SF-Qualiveen for bladder and the NBDS for
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There is a real possibility of successive COVID-19-epidemic waves with devastating consequences. In this context, it has become mandatory to design age-selective measures aimed at achieving an optimal balance between protecting public health and maintaining a viable economic activity.
We programmed a Susceptible, Exposed, Infected, Removed (SEIR) model in order to introduc
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X-ray luminescence imaging emerged for about a decade and combines both the high spatial resolution of x-ray imaging with the high measurement sensitivity of optical imaging, which could result in a great molecular imaging tool for small animals. So far, there are two types of x-ray luminescence computed tomography (XLCT) imaging. One uses a pencil beam x-ray for high spatial resolution at a cost of longer measureme
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Assess the change in sleep and vigilance of underground miners during long periods of extended shifts.
Seventy miners worked 14 consecutive 12-hour day and/or night shifts. Also, they wore an actigraph and completed a visual analog scale for vigilance four times per shift. Linear regression models with mixed effects were used.
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The remaining reported studies showed inconclusive results. Patient satisfaction was high across all studies, but this systematic review did not clearly demonstrate the value of using the botulinum toxin in the treatment of alopecia. Subsequent prospective randomized controlled studies are required.Protease-activated receptor 1 (PAR1) is known as a thrombin receptor. Recent studies have reported PAR1 exp
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The integral approach here presented seeks to shed light on Nature’s solution to the problem of size variation, which underpins the diversity of beetles and the living world.Osteoporosis, a chronic metabolic bone disease, is the most common cause of fractures. Drugs for treating osteoporosis generally inhibit osteoclast (OC) activity, but are rarely aimed at encouraging new bone growth and often cause severe system
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The content of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) increased in the roots of Salvia miltiorrhiza. The expression levels of genes encoding enzymes and the activities of key enzymes in the tanshinone biosynthesis pathway increased accordingly. The results showed that AP2/ERF TFs could positively regulate the biosynthesis of tanshinone in th
UCL-TRO-1938
of neuromodulation continues to adapt to the modern healthcare era.High entropy or multi principal element alloys are a promising and relatively young concept for designing alloys. The idea of creating alloys without a single main alloying element opens up a wide space for possible new alloy compositions. High entropy alloys based on refractory metals such as W, Mo, Ta or Nb are of interest for future high tempera
WAY-100635
The majority of prescriptions for supplemental oxygen are written when patients are discharged to home from the hospital and the evaluation of these patients is inconsistent. Respiratory Therapists receive training in the evaluation and management of patients needing oxygen. The primary goal of the study was to estimate the frequency with which respiratory therapists (RTs) evaluate the need for home oxygen in patient
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Finding the very best Car Locksmith in Wellingborough
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The Rise of Lifelike Sex Dolls: Understanding the Phenomenon
In the last few years, the world has experienced a significant shift in the method individuals view and communicate with sex dolls. Gone are the days of basic, unconvincing, and frequently absurd sex toys. Today, lifelike sex dolls have actually taken spotlight, prov
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, with MICs in the range of 0.007-2µg/mL, better than linezolid, the only clinically used agent available to date. Such results reinforce the rationale of considering existing and newly designed CAIs as antibacterials with an alternative mechanism of action.
Balancing the equilibrium between CO2 and HCO3- is essential for microbial metabolism and is regulated by at least four classes of CAs.
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iers between waste pickers and the hazards (e.g., covered stations, flat ground, etc.) or more complex engineering, administrative or work controls. Because of the breadth of health problems faced by workers, more research is needed to correctly assess health outcomes (e.g. use of health practitioners) in waste pickers across time to ensure accurate data and a focused answer to the far-reaching pro
Opicapone
Aberrant right subclavian is a rare anomaly presenting in 0.3-3.0% of the population. Kommerell’s diverticulum is an aneurysm associated with this phenomen; data relating to its incidence is sparse. Currently there are no well-established guidelines for the treatment of Kommerell’s diverticulum, limitation being the rare occurrence of disease and heterogenous population with disease presentation. This case report illust
Ruxolitinib
t patients were treated with steroids. All-cause mortality was 3.7%.
PSC and autoimmune hepatitis overlap syndrome is generally associated with inflammatory bowel disease and has low mortality and good response to treatment.
PSC and autoimmune hepatitis overlap syndrome is generally associated with inflammatory bowel disease and has low mortality and good resp
Can puppies eat eggshells
Perhaps you visit the pound and pet shops and longingly dream of having the perfect pet. What could happen may differ completely from this. No matter what the situation, you need to be a good pet owner, and the following paragraphs will help you do just that.
Make sure your house is free of doggy danger. Take the time to tour your home with an eye for safety
ACT-1016-0707
ith additional anti-fibrillatory effect beyond adrenergic blockade during sympatho-vagal stimulations. Occupational exposure to silica dust particles was the major cause of pulmonary fibrosis, and many miRNAs have been demonstrated to regulate target mRNAs in silicosis. In the present study, we found that a decreasing level of miR-411-3p in silicosis rats and lung fibroblasts induced by TGF-β1. Enlargement of mi
Vorinostat order
in response to environmental stress.BACKGROUND The process of alternative splicing provides a unique mechanism by which eukaryotes are able to produce numerous protein products from the same gene. Heightened variability in the proteome has been thought to potentiate increased behavioral complexity and response flexibility to environmental stimuli, thus contributing to more refined traits on which natural an
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Placental LEPR expression was negatively associated with high sensitivity C-Reactive Protein in umbilical cord blood, which persisted after adjustment for potential confounders.
Overall, our findings suggest that genetic variation in LEPR plays a key role in regulating placental LEPR expression, which is in turn is associated with inflammatory markers in cord blood at birth. Further s
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Climate Hazards group InfraRed Precipitation with Stations (CHIRPS) rainfall showed the least bias and error (ME ≈-0.2-0.2 mm, MAE ≈0.5-2 mm), and the best agreement (COR ≈0.8), with station rainfall data. In contrast FLDAS had the higher bias and error and the lowest agreement and Global Precipitation Mission/Tropical Rainfall Measurement Mission (GPM/TRMM) data were intermediate. This information can inform the select
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Over the last few years, the market for lifelike sex dolls has experienced substantial growth, driven by advancements in technology and changing social attitudes. These dolls, designed to imitate human look and habits, have actually ended up being a subject of both fascination and controversy. This post dives into the world of lifelike sex dolls, explori
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Hemorrhagic events such as SSEH should be considered during treatment with angiogenesis inhibitors.A male patient in his 70s underwent a right lobectomy because of a hepatocellular carcinoma(HCC)located in the right lobe(S6)of his liver. Eleven months after surgery, contrast-enhanced CT showed multiple masses in the residual liver, which were diagnosed as HCC recurrence. He was then treated with hepatic arterial i
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Driving License Subsidy: Understanding the Role of Insurance Agencies
As the world progressively shifts towards a more mobile society, the significance of driving has never been more pronounced. Not only does the capability to drive empower people by approving them the flexibility to take a trip, but it also favorably effects
Derazantinib inhibitor
In summary, a 50 kdyne contusion SCI was able to reduce body mass but was not associated with substantial muscle atrophy or alterations in gene expression profiles associated with muscle health and function 14 d post-injury. SS-31 was not associated with protection against SCI-related changes in body or muscle mass, protein synthesis or gene expression in hindlimb muscles.HLA-DPA1*0146 differs from HLA-D
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The 2011 magnitude (M) 9.0 Tohoku-oki earthquake was followed by seismicity activation in inland areas throughout Japan. An outstanding case is the M6.2 Northern Nagano earthquake, central Japan, occurred 13-h after the megathrust event, approximately 400 km away from its epicenter. The physical processes relating the occurrence of megathrust earthquakes and subsequent activation of relatively large inla
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371 mg/dL; 95% CI -15.419, -3.323, p = 0.002), triglycerides (WMD = -13.776 mg/dL; 95% CI -26.636, -0.916, p = 0.036), and low density lipoprotein cholesterol (WMD = -6.590 mg/Dl; 95% CI -13.042, -0.137, p = 0.045), as well as an increase in plasma high density lipoprotein cholesterol (WMD = 3.501 mg/dL; 95% CI 1.309, 5.692, p =&nbs
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ening of this NPS-like profile. The outcomes showed that this combined behavioral paradigm unveiled distinct features of digging signatures that can be useful to study these perseverative behaviors and their interplay with anxiety states already present in the AD scenario and their worsening by naturalistic/forced isolation.High-throughput behavioral phenotyping is critical to genetic or chemical screening approach
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Unveiling the Act: Understanding Male Masturbation and its Significance
Masturbation, a topic often shrouded in silence and misconception, is a fundamental element of human sexuality and an almost universal experience for men. Far from being a taboo topic, comprehending male masturbation is important for cultivating healthy sexual attitudes, eliminating myths, and prom
Are eggshells safe for dogs
Dogs are great fun. They can be a great pet for anyone from a small child to a very old senior citizen. However, you need to make sure that you are caring for your dog in the right way. After all, you want your dog to live with you for as long as possible, right? Here are some tips to help you have a healthy, ha
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Navigating Locksmith Services in Wellingborough: A Comprehensive Guide
In the busy town of Wellingborough, the requirement for trustworthy and effective locksmith services is a typical incident. Whether ‘ve lost your car keys, locked yourself out of your lorry, or require a new key cut, discovering an expert car
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1% versus 10.3%;
=0.22) for the IVCYC and MMF groups, respectively. Mortality rate for the IVCYC group was 5.5 per 10,000 person-days of follow-up compared to 1.5 per 10,000 person-days of follow-up for the MMF group (
=0.11), and there was no significant difference in infection-related adverse events between both groups. Estimate
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Maternal obesity was associated with increased likelihood of having high birthweight (aOR 2.54, 95% CI 1.39-4.66) and large size for gestational age (aOR 1.66, 95% CI 1.20-2.31) infants. In the subset cohort, GWG was associated with increased likelihood of spontaneous preterm delivery (aOR 4.35, 95% CI 1.55-12.21) and high birthweight (aOR 3.00, 95% CI 1.22-7.34) infants. CONCLUSION Obesity during pregnancy
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Mel-P has shown cell viability of 61.33 ± 6.58% at the concentration of 500 μg/mL proving its non-cytotoxic effect. Owing to its anti-oxidant property, melanin efficiently protected the mouse fibroblast cells from UV-B (BB) irradiation in a dose dependant manner demonstrating its potential as an active photoprotective agent.
Health-related quality of life (HRQoL) dat
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tructurally distinct BcsZ belonging to GH-8, we show CcsZ displays specificity for cellulosic materials. This specificity of the synthase-associated glycosyl hydrolase validates our proposal that these hypothetical genes are responsible for biosynthesis of a cellulose exopolysaccharide. The data we present here allowed us to propose a model for Clostridial cellulose synthesis and serves as an entry point to an
Iclepertin
© 2020 Chinese Nursing Association. Production and hosting by Elsevier B.V.The epidemic of the Coronavirus Disease 2019 (COVID-19) has presented as a grim and complex situation recently. More than 77,000 cases of COVID-19 has been confirmed in China until February 25th, 2020, which are causing great impact on economy and society, as well as seriously interfering with ordinary medical practice in the department of otor
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7/50.9%, p less then 0.001) than in women (36.5/33.6%, p less then 0.05). Among hypertensive subjects, unaware were 31.8/21.3% (EMENO/MMM, p less then 0.001), aware untreated 2.7/5.6% (p less then 0.001), treated uncontrolled 35.1/24.8% (p less then 0.001), and treated controlled 30.5/48.3% (p less then 0.001). In conclusion, the prevalence of hypertension was similar with random sampling (EMENO) and
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Wellingborough Car Locksmiths: Your Solution to Automotive Locking Dilemmas
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TKI258
Due to regional shortages some health services have proposed using surgical masks manufactured from sterilisation wrap. However, there has been little assessment of the safety of this practice. Therefore, we developed our own prototypes and evaluated whether they met regulatory standards.
Surgical mask prototypes were manufactured from two thickness grades of commercial sterilisation
Diphenhydramine antagonist
The lead-free halide double perovskite class of materials offers a promising venue for resolving issues related to toxicity of Pb and long-term stability of the lead-containing halide perovskites. We present a first-principles study of the lattice vibrations in Cs_2AgBiBr_6, the prototypical compound in this class and show that the lattice dynamics of Cs_2AgBiBr_6 is highly anharmonic, largely in
UNC2250 chemical structure
The main purpose of this study is to describe how negative emotions were investigated in the sphere of dermatological diseases, in order (1) to summarize literature trends about skin disorders and emotions, (2) to highlight any imbalances between the most studied and neglected emotions, (3) and to offer directions for future research. A computerized literature search provided 41 relevant and potentially e
(R)-Propranolol
La Pampa province is divided into two clearly distinguishable fractions a small northeastern humid sector corresponding to the Pampas ecoregion and a drier western sector, represented by the Monte de Llanuras y Mesetas (termed Monte region in this paper) and Espinal ecoregions (sensu Brown et al. 2006). These three ecoregions are visibly distinguishable from an edaphological and phytogeographic p
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Car Key Services in Wellingborough: Everything You Need to Know
In today’s hectic world, the significance of having reputable access to your car can not be overstated. After all, couple of things are more frustrating than losing or damaging your car keys. For the locals of Wellingborough, a town with a growing population an
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Only the PTSD subgroup had altered startle reactions during extinction learning. Our data do not provide evidence for general differences in associative fear or extinction learning in fear-related pathologies and thereby question the diagnostic validity of the associative fear learning model of these disorders. Recent studies have revealed that wastewater treatment p
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tiation of DCs and induction of gastric cancer.Understanding the mechanisms contributing to positive relationships between predator diversity and natural pest control is fundamental to inform more effective management practices to support sustainable crop production. Predator body size can provide important insights to better understand and predict such predator-pest interactions. Yet, most studies exploring the link
Eprenetapopt
Native Bicuspid Pulmonary Valve in D-Loop Transposition of the Wonderful Arterial blood vessels: Outcomes of the actual Neo-Aortic Device Purpose and Main Dilation Following Arterial Change Operation.
Preoperatively, the breast implants were located in a subpectoral pocket in 78.7% of the patients and, postoperatively, in a subglandular pocket in 74.8% of the patients. Within the first 2
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Glyphosate is a very effective herbicide and the main active ingredient in Roundup®-the most extensively used herbicide in the world. Since glyphosate is highly water soluble it reaches water bodies easily in surface water runoff. This prompted us to undertake an experiment to evaluate the effects of glyphosate in Roundup® on natural communities of marine microphytobenthos. Microphytobenthos communities were obtaine
MMAE
In Brazil, one of the countries most heavily affected by the COVID-19 pandemic, mortality data fail to reflect the real number of deaths from the disease. The study aimed to estimate excess deaths from respiratory causes and their trends during the first six month of the COVID-19 epidemic in adults 20 years or older in eight regional metropolises in Brazil. In this ecological study, deaths from respiratory
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OBJECTIVE To investigate serum levels of vitamin A and E in pregnant women in Huai’an and evaluate their nutritional status. METHODS Totally 2824 cases of pregnant women were chosen from the Huai’an Maternal and Child Health-Care Center during January 2017 to May 2018. The serum level of vitamin A and vitamin E in the blood was detected by high performance liquid chromatography(HPL
AZD9291
Police officers face many competing pressures and demands. Exposure to potentially traumatic incidents and significant job-related stressors can place many at higher risk of developing physical and mental health problems. The police culture exerts a pronounced influence on officers, preventing some from asking for or receiving assistance. The stigma of being perceived as weak or incompetent, concerns about being labelled un
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Chalcones are a widespread group of natural compounds characterized by the basic structure 1,3-diaryl-2-propen-1-one. In this study, we focused on the uncommon formylated chalcone 3′-formyl-2′,4′,6′-trihydroxy-5′-methyldihydrochalcone that possess interesting antimicrobial and anticancer potential. Considering the pharmacological relevance of this compound, we report its isolation and the first complete and unequi
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FTY720
No correlation was found between the depth of the demarcation line and topographic changes, which was not a direct measure of treatment effectiveness. Quality analysis of the literature reviewed yielded a mean score of 8.64, indicating that the RCTs evaluated had an overall acceptable quality.Conclusions Good-quality RCTs comparing CXL techniques have been conducted, and most of them suggest that epi-off CXL can be considered
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Navigating the World of Article Spinning Software
In today’s digital age, the need for fresh and unique content has never ever been greater. From bloggers and content marketers to organizations wanting to boost their online existence, the requirement for quality content is a continuous. As an outcome, many individuals and organizations have
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OBJECTIVE To assess whether prediagnostic metabolites were associated with incident pancreatic ductal adenocarcinoma (PDAC) in a prospective cohort study. DESIGN We conducted an untargeted analysis of 554 known metabolites measured in prediagnostic serum (up to 24 years) to determine their association with incident PDAC in a nested case-control study of male smokers (372 matched case-control sets) a
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Situs Toto Gotogel Super: Unveiling the Mystery Behind Online Lottery Games
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Protein Tyrosine Kinase inhibitor
Previous studies have demonstrated that increased aortic root diameter (ARD) is frequently associated with increased cardiovascular (CV) events and is apredictor of stroke. Two-dimensional speckle tracking echocardiography (2D-STE) provides abetter evaluation of left atrial (LA) functions. Left atrial mechanical dispersion is auseful predictor of new-onset atrial fibrillation (AF) independent of LA
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Exploring the Tassimo Coffee Machine: A Comprehensive Guide for UK Consumers
The coffee machine market has actually seen a remarkable change throughout the years, and with the surge in popularity of single-serve coffee machines, the Tassimo coffee machine stands out as a trustworthy and versatile alternative for coffee connoisseurs in the UK. Providing a distinct brewing system that promises benefit witho
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The Evolution and Impact of Robot Vacuum Cleaners
Robot vacuum cleaners have become a staple in contemporary homes, offering convenience and efficiency in the often-dreaded job of cleaning. These innovative devices have actually progressed substantially given that their intro, changing the way people preserve their home. looks into the history, technology, benef
D-Luciferin
However, there are no reports comparing the prognosis of the treatment method performing tumor hemostasis alone, tumor resection after chemotherapy, and tumor hemostasis and resection at the same time. The clinical course of the patient indicates that performing tumor hemostasis and resection simultaneously and lung resection after chemotherapy is an effective option to treat a ruptured hepatoblastoma with dissemina
Pilaralisib mouse
As gauged by the Drummond checklist, the quality of CTN published economic evaluations were found to improve over time, and recent published articles were identified as guides to cutting-edge economic research. As the CTN continues to grow and mature, it is imperative that high-quality economic evaluations are incorporated alongside trials in order to maximize the public health impact of the CTN. INTRODU
IDE397
Gemogenovatucel-T is an autologous tumour cell vaccine manufactured from harvested tumour tissue, which specifically reduces expression of furin and downstream TGF-β1 and TGF-β2. The aim of this study was to determine the safety and efficacy of gemogenovatucel-T in front-line ovarian cancer maintenance.
This randomised, double-blind, placebo-controlled, phase 2b trial involv
Cinchocaine
The presumed lost type of Arma pallipes Dallas is found and Thomas’s (1992) neotype is hereby set aside (ICZN 1999, Art. 75.8). A. pallipes is proposed as junior subjective synonym of Podisus ventralis (Dallas). A lectotype designation by inference of holotype (Gaedike 1971) is accepted for the female typical specimen of P. neniator deposited at Senckenberg Deutsches Entomologisches Institut (SDEI, Müncheberg, Germa
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Process results were comparable for cell culture-derived HCV of another major genotype (5a). This study provides proof-of-concept for establishment of an efficient and economically attractive DSP with potential application for production of an inactivated whole virus vaccine against HCV for human use.Lytic polysaccharide monooxygenase (LPMO) and copper binding protein CopC share a similar mononuclear copper site. Th
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Additionally, the overexpression of AvFLS under salinity stress resulted in an increase in total flavonoid content (1.63 mg g-1 in wild-type samples and 4.63 mg g-1 on average in transgenic samples), which accompanied the increase in the activity of antioxidant enzymes and inhibited the production of reactive oxygen species. Further, AvFLS-overexpressing transgenic tobacco plants absorbed more K+ than wild
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Last, we leveraged the modularity of our platform to achieve enhanced therapeutic efficacy in a poorly immunogenic syngeneic mouse model through effective combinations with a probiotically produced cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF). Together, these results demonstrate that our engineered probiotic system bridges synthetic biology and immunology to improve upon checkpoint blockade delivery. Copyrigh
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Seed vigor affects seed germination and seedling emergence, and therefore is an important agronomic trait in rice. Small auxin-up RNAs (SAURs) function in a range of developmental processes, but their role in seed vigor remains unclear. Here, we observed that disruption of OsSAUR33 resulted in reduced germination rates and low seed uniformity in early germination. Expression of OsSAUR33 was higher in mature grains and ear
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The inevitable side effects caused by lifelong immunosuppressive agents in kidney transplantation patients spurred the exploration of novel immunosuppressive strategies with definite curative effects and minimal adverse effects. Mesenchymal stem cells (MSCs) have become a promising candidate due to their role in modulating the immune system. Encouraging results obtained from experimental models ha
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Hedyotis diffusa plus Scutellaria barbata is a couplet of medicinal that has been commonly used to treat inflammation-related diseases and various types of tumors. However, the effect of this couplet on tumor cell migration has not been elucidated. With the aid of MCF-7-BOM, a bone-metastatic subline of ER + breast cancer MCF-7, we showed that ethyl acetate fraction extracted at an equal weight ratio of Hedyotis di
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Through poetry, I offer a creative, critical analysis of the intersections of COVID-19, structural racism, and racialized police violence-situating present COVID-19 discourse within a broader historical arc of respiratory distress within communities of color, all while centering Earth Day and climate change as both metaphor and corollary. In doing so, I enact poetry as praxis, reflecting critically on the racialized
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Finding the very best Car Locksmith Near Wellingborough: Your Guide to Fast and Reliable Service
Being locked out of your car is a discouraging and frequently difficult experience. Whether you’ve misplaced your keys, snapped them in the ignition, or are handling a malfunctioning transponder, the immediate requirement is th
Stattic
In their 1987 Nature publication, “Mitochondrial DNA and Human Evolution,” Rebecca Cann, Mark Stoneking, and Allan C. Wilson gave a new reconstruction of human evolution on the basis of differences in mitochondrial DNA among contemporary human populations. This phylogeny included an African common ancestor for all human mitochondrial DNA (mtDNA) lineages, and Cann et al.’s reconstruction became known as the “Out of Africa”
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Poly(dimethylsiloxane) is a common dispersant, modifier, and binder in the field of bioinspired wettability. Herein, the soot production when poly(dimethylsiloxane) was burning was used to directly construct a superhydrophobic coating with the water contact angle reaching 159.7°. After the lubricant was infused, its transparency was greater than 80% of air in the visible light range of the human eye. In
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Penicillium ochrochloron was used in the past for the leaching of zinc from a zinc oxide containing filter dust via excreted organic acids. Organic acid excretion by P. ochrochloron was stimulated by the addition of an extracellular buffer (2-(N-Morpholino)ethanesulfonic acid, MES; or zinc oxide, ZnO ZnO + 2 H+ → Zn2+ + H2O). It was tested if the buffer stimulated excretion of organic acid anions is due to the necessity of an anio
OPCMD
Nearer to home, he just lately invited viewers into his private playroom with an explicit new photo collection because the visitor producer for Shotbyly Classic Magazine Vol. It is a part of a plan, voted for by town council in January, to transform Amsterdam’s pink gentle district by relocating intercourse work elsewhere. Mayor Femke Halsema has additionally confused that the er
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The Best Article Rewriter: A Comprehensive Guide to Streamlining Your Content
In the digital age, content is king, and the demand for premium, distinct content has never been greater. Whether you’re a blog writer, a content marketer, or a student, the requirement to produce interesting and initial articles is consistent. However, developing fresh content from scratch
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BACKGROUND Non-adherence to immunosuppressant therapy (IST) is a major risk factor for graft rejection. Limited reports are available regarding the prevalence of non-adherence to IST in kidney transplant recipients (KTRs) as well as the predictors and barriers of non-adherence. MATERIAL AND METHODS The study included ambulatory KTRs, ≥18 years of age, with a functional kidney, from January 2017 to November 2018. The prima
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We conducted genome-wide association analyses of over 250,000 participants of European (EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health record-validated post-traumatic stress disorder (PTSD) diagnosis and quantitative symptom phenotypes. Applying genome-wide multiple testing correction, we identified three significant loci in European case-control analy
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T. gondii infection also increased the expression of vascular endothelial growth factor after the cerebral ischemia. It is suggested that chronic intracerebral infection of T. gondii may be a potential preconditioning strategy to reduce neural deficits associated with cerebral ischemia and induce brain ischemic tolerance through the regulation of HIF-1α expression.The Pacific tapeworm Adenocephalus pacifcus
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emodelling and dysfunction.Congenital heart defects are a feature of several genetic haploinsufficiency syndromes, often involving transcriptional regulators. One property of haploinsufficient genes is their propensity for network interactions at the gene or protein level. In this article we took advantage of an online dataset of high throughput screening of mutations t
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Understanding the Role of Employment Agencies in the Driver’s License Sector
Employment companies are important players in various task markets, helping individuals secure positions that line up with their skills and aspirations. In particular sectors such as transportation and logistics, the demand for competent motorists is incredibly high, and this is where employment service concentrating on dr
Benzylpenicillinpotassium
Influenza C virus is a pathogen that causes acute respiratory illness in children and results in the hospitalization of infants. The antigenicity of the hemagglutinin esterase (HE) glycoprotein is highly stable, and it is not yet known whether antigenic changes contribute to the worldwide transmission and the occurrence of outbreaks of influenza C virus. Here, we performed antigenic anal
PTC-209 clinical trial
Human papillomaviruses (HPVs) and the Epstein-Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%-15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV c
Chk2 Inhibitor II
2%). Cytology was diagnostic in 43 of 62 samples (69.4%). General sensitivity, accuracy and PPV for FNAB and TCB were 67.7%, 67.7% and 100% and 96.7%, 95.2% and 98.3%, respectively. Combining the two techniques, the overall mean accuracy for diagnosis was 98.4%. Nineteen of 62 cases showed complications (30.6%). Mild pneumothorax was seen in 16 cases, whereas mild hemorrhage occurred in three case
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Exploring the World of Male Masturbator Toys: Enhancing Solo Sexual Pleasure
For centuries, human beings have sought methods to boost their sexual experiences, both with partners and individually. In current decades, the landscape of sexual wellness has actually expanded significantly, with a higher openness and acceptance surrounding using adult toys. Among these, male masturbator toys have actua
Sunvozertinib
Despite a known benefit in the reduction of cardiovascular risk, adherence to statins remains suboptimal. A qualitative analysis was conducted within an intervention that identified trajectories of statin adherence in patients and used motivational interviewing (MoI) to improve adherence. The objective of this qualitative study was to evaluate transcripts of an MoI telephonic intervention to identify potential, past,
Metabolism activator
Mechanistically, we found that miR-92b-3p promotes the activation of HSCs and thereby the progression of liver fibrosis by activating JAK/STAT pathway via targeting CREB3L2, providing a new target for the diagnosis and treatment of liver fibrosis.
Several studies suggested that high expression of Bcl2 and/or p53 in Hodgkin/Reed-Sternberg cells is an unfavorable prognostic factor in Hodgkin l
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Inflammation is the driving force of many inflammatory and autoimmune diseases, Pyroptosis is a process of cell death in response to excessive inflammation. Punicalin has been reported to have anti-inflammatory effects. However, the anti-pyroptosis is unknown. Hence, this study was aimed to research the inhibition of MG on LPS/ATP-induced pyroptosis in vitro.
Lipopolys
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On the other hand, there were significant differences in rates of males, smoking, dyslipidemia and diabetes, diastolic blood pressure and triglyceride among the groups. The prevalence of CAD values in the Low, Middle and High LDL-C groups were similar, at 52%, 47%, and 46%, respectively. In addition, there were no significant differences in the number of VD, Gensini score or CAC score among the Low LDL-C, Middle LDL-C an
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The results showed that C. chlorophaea, D. miniatum and P. saxatilis lichens, which were found to be a rich source of phenolic compounds, might be of interest in the pharmaceutical and food industries.Pentacyclic triterpenes and cardenolides were isolated from Acokanthera oblongifolia leaves. Their chemical structures were determined based on comprehensive 1D and 2D NMR spectroscopy. Their MIC was determined agai
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Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate and frequently require noninvasive respiratory support or invasive ventilation. Optimising and standardising management through evidence-based guidelines may improve quality of care and therefore patient outcomes.
A task force from the European Respiratory Society and end
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CD19 is among the most relevant targets in cancer immunotherapy. However, its extracellular domain (ECD) is prone to aggregation and misfolding, representing a major obstacle for the development and analysis of CD19-targeted therapeutics. Here, we engineered stabilized CD19-ECD (termed SuperFolder) variants, which also showed improved expression rates and, in contrast to the wild type protein, they could be efficiently
OTSSP167
Community engagement (CE) is critical for research on the adoption and use of assistive technology (AT) in many populations living in resource-limited environments. Few studies have described the process that was used for engaging communities in AT research, particularly within low-income communities of older Hispanic with disabilities where limited access, culture, and mistrust must be navigated. We aimed to identify eff
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This review presents the history around major EWOD products that hit the market to show their winding paths to commercialization and summarizes the current state of product development to peek into the future. In providing the readers with a big picture of commercializing EWOD and digital microfluidics technology, our goal is to inspire further research exploration and new entrepreneurial adventures.In his ‘Comment’ v
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2%). A total of 80.2% of patients were discharged on antiplatelet therapy alone. Peridevice flow was less then 3 mm in 98.4% at follow-up TOE. Device-related thrombus (DRT) was seen in 1.6% of cases. Cardiovascular death or ischaemic stroke occurred in 8.7% of patients at 2 years. The ischaemic stroke rate was 2.2%/year-a 67% reduction compared to the CHA2DS2-VASc predicted rate. Major bleeding (Bleeding Academic Research Con
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Physical findings of auscultation cannot be quantified at the arteriovenous fistula examination site during daily dialysis treatment. Consequently, minute changes over time cannot be recorded based only on subjective observations. In this study, we sought to supplement the daily arteriovenous fistula consultation for hemodialysis patients by recording the sounds made by the arteriovenous fistula and evaluating the sounds u
IPA-3
CRISPR-mediated genome editing has undoubtedly revolutionized genetic engineering of animals. With the ability for virtually unlimited modification of almost any genome it is easy to forget which amazing discoveries paved the way for this ground-breaking technology. Here, we summarize the history of genome editing platforms, starting from enhanced integration of foreign DNA by meganuclease-mediated double-strand breaks to CRISP
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Title: The Ultimate Guide to Male Masturbators: Everything You Need to Know
Male masturbators have actually ended up being progressively popular in the last few years, offering men a large range of sexual experiences and pleasure. These devices are designed to replicate the sensation of real sexual relations, supplying a more intimate and satisfying e
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Navigating Car Key Programming in Wellingborough: A Comprehensive Guide
In the modern period of automotive technology, car keys have actually progressed from basic metal devices to advanced electronic tools. This advancement has brought about a new set of obstacles and opportunities for car owners, especiall
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In polymeric gene delivery systems, virial vectors and non-virial vectors for gene delivery have briefly analyzed. The systems of non-virial vectors for gene delivery are polyethylenimine derivatives, polyethylenimine copolymers, and polyethylenimine conjugated bio-reducible polymers, and the systems of virial vectors are DNA conjugates and RNA conjugates for gene delivery. Conclusion The development of polymeric dr
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The Ultimate Guide to Choosing the Best Automatic Hoover for a Spotless Home
In today’s fast-paced world, the desire for convenience has actually penetrated every element of our lives, and home cleaning is no exception. Manual vacuuming, once a required task, is progressively being relegated to the previous thanks to the rise of automatic hoovers, more typically known as robot vacuums. These smart gadge
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Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.Sarcomas are complex tissues in which sarcoma cells maintain intricate interactions with their tumor microenvironment. Tumor-associated macrophages (TAMs) are a major component of tumor-infiltrating immune cells in the tumor microenvironment and have a dominant role
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Results 23.5% of patients without subjective cognitive complaints had evidence of objective cognitive impairment on the MACFIMS (z score less then -1.5 on two or more tests). The MoCA had a sensitivity of 87% and a specificity of 68% for detecting objective cognitive impairment in this patient population using a cut-off score of 27. Conclusion A significant proportion of patients without self-reported cognitive impairm
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When it concerns home or industrial property maintenance, couple of elements are as crucial as the quality and stability of glass setups. Whether shop front door repairs birmingham , doors, or ornamental glass features, the requirement for glass replacement can emerge for various reasons, consisting of damage, wea
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AG + GG) and allelic model (A vs G), ORs (95% CI) were 1.66 (1.27-2.17) (P = .00) and 1.34 (1.05-1.71) (P = .02), respectively. But there was no statistical difference under recessive model (AA + AG vs GG), OR (95% CI) was 1.40 (0.99-1.97), P = .06.ALDH2 rs671 polymorphism was related to IS risk for Chinese population and the A allele of rs671 may be a risk factor of IS.Rationale Idarucizumab is a specific re
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Navigating the World of Car Keys in Wellingborough: A Comprehensive Guide
In the busy town of Wellingborough, car keys are more than just a way to start a vehicle; they are vital tools that keep life running efficiently. Whether you’re a resident, a visitor, or a service owner, comprehending the complexities of
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Coffee enthusiasts around the world are constantly on the lookout for the next best developing method that integrates quality, convenience, and creativity. Among the myriad of choices readily available, the Tassimo Bosch Coffee Machine sticks out as a versatile and user-friendly choice. This machine brings coffeehouse quality
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The mechanism of EBV in MS therefore is a pressing question, whose clarification may substantially advance the pathophysiological understanding, rational therapies, and prevention of MS.Introduction On June 2020, the first case of concurrent Covid-19 and Kawasaki disease (KD) was published. After this first description, further works reported new cases of children affected by KD and KD-like syndrome after
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Recent studies indicate that cellular lipid peroxidation by free radical is an underlying mechanism of acute renal failure induced by gentamicin (GM). Tinospora cordifolia (Tc) extract has been reported to have antioxidant and free radical scavenging activities that is why it is used in present study with the expectation to interrupt the toxic free radical chain reaction of lipid peroxidation in the course o
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Hospitalised patients with coronavirus disease 2019 (COVID-19) as a result of SARS-CoV-2 infection have a high mortality rate and frequently require noninvasive respiratory support or invasive ventilation. Optimising and standardising management through evidence-based guidelines may improve quality of care and therefore patient outcomes.
A task force from the European Respiratory Society and end
TL12-186
dy offer scalable predictive tools that can accurately estimate the likelihood of improved pain, function, and quality of life one year after knee arthroplasty as well as LOS and 90 day readmission. Cite this article Bone Joint J 2020;102-B(9)1183-1193.
Previous research has demonstrated increased early complication rates following total hip arthroplasty (THA) in obese patients, as defined by body mass
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BACKGROUND AND AIMS Cell walls of peri-endodermis, a layer adjacent to the endodermis in alpine pennycress (Noccaea caerulescens) roots, form C-shaped peri-endodermal thickenings (PET). Despite its specific position close to the endodermis, assumed similarity of PET to phi thickenings in many other species, and fact that N. caerulescens is a well-studied heavy metals hyperaccumulating plant, PET as a root trait i
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Communicated by Ramaswamy H. Sarma.This qualitative ethnographic study complements an epidemiological study on first episode psychosis in Vulindlela, a rural area in KwaZulu-Natal, South Africa. It focuses on two themes that emerged from our data (1) the calling of the ancestors to become a traditional health practitioner and (2) ukuthwasa, the training to become a traditional health practitioner. The purpose of this stud
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Myosteatosis is a complex condition, associated with aging and diverse pathological conditions (e.g., diabetes), that contributes to mobility disability. Improved characterization of myosteatosis is required to develop targeted interventions to maintain muscle health in aging. We first determined the associations between plasma metabolites and intermuscular fat (IMF) in a cross-sectional analysis of 313 older Black men from Hea
IDF-11774
In total, 50 men and 50 women were interviewed face-to-face and 344 people responded to the questionnaire, of which 154 were men and 190 were women. RESULTS A total of 94 medicinal plant vernacular names were documented representing 85 different plant species belonging to 37 families. Men cited 63 plants (33 plant families) and women 83 (36 plant families). Sixty-one plants were cited by both men and women, two only by
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Computed Tomography (CT) plays an important role in lung malignancy diagnostics, therapy assessment, and facilitating precision medicine delivery. However, the use of personalized imaging protocols poses a challenge in large-scale cross-center CT image radiomic studies. We present an end-to-end solution called STAN-CT for CT image standardization and normalization, which effectively reduces discrepancies in image fea
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Phosphatidylcholine (PC) is the major phospholipid in meat and influences meat qualities, such as healthiness. PC is classified into three groups based on the bond at the sn-1 position Diacyl, alkylacyl, and alkenylacyl. To investigate their composition and distribution in pork tissues, including longissimus thoracis et lumborum (loin) spinalis muscles, intermuscular fat, and transparent tissues, we performed mat
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Fig mosaic is a viral disease (FMD) that spreads in Palestinian common fig ( Ficus carica L.) orchards. Recognizing the economic value of fig plants and the harmful nature of FMD, the disease poses a significant threat to the economy of the fig production in Palestine. We applied the reverse transcription and amplification (RT-PCR) and PCR technique to leaf samples of 77 trees and 14 seedlings of 17 fig culti
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Progressive osseous heteroplasia (POH) is a rarely occurring genetic condition characterized by severe segmental ossification involving the skin and deep connective tissues including the muscles. So far, the disorder is generally described as an autosomal dominant trait. By contrast, the following arguments are in favor of the alternative concept that POH should rather be taken as a non-specific segmental manifestation of different GNAS ina
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Dengue virus (DENV), Yellow Fever virus, West Nile virus, Japanese encephalitis virus and Zika virus are medically important flaviviruses transmitted to humans by mosquitoes and circulate in overlapping geographic areas. Cross-reactive immune responses have been demonstrated among the flaviviruses, particularly the four DENV serotypes. The immunological imprint left by a flavivirus infection can therefore hav
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The bio concentration factors (BCFs) of IMI-ole and IMI-urea were higher than of IMI and 6-CNA, and the BCFs had no obvious relationship with log Kow. Furthermore, the potential dietary risk of IMI in A. bisporus was acceptable when application rates in casing soil or compost was up to 50 mg kg-1. Our study supports a safe use of IMI as agricultural pest control in A. bisporus cultivation.
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Gene Ontology analysis revealed that ‘cell chemotaxis’, ‘negative regulation of ossification’ and ‘bone development’ pathways were involved in recovery. It was further confirmed that BMSCs were suitable as seed cells for cartilage tissue engineering, and that the β-tricalcium phosphate scaffold maybe ideal as cartilage tissue engineering scaffold material. The present research provided new insights into the molec
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Window Glass Replacement in Birmingham: A Comprehensive Guide
In Birmingham, the need for window glass replacement has actually increased significantly due to different factors, including home restorations, wear and tear, and the requirement for improved energy performance. House owners and residential or commercial property man
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Similar to previous studies, these data demonstrate that migrant minors are generally healthy. However, given the relatively high prevalence of hepatitis B and latent tuberculosis, systematic screening for these diseases among immigrant minors immigrants is highly recommended for early detection and treatment of potentially transmissible diseases.Corynebacterium kroppenstedtii is an emerging cause of gran
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Impulsive behaviours are a major contributor to the global burden of disease, but existing measures of cognitive impulsivity have suboptimal reliability and validity. Here, we introduce the Cognitive Impulsivity Suite, comprising three computerized/online tasks using a gamified interface. We conceptualize rapid-response impulsive behaviours (disinhibiti
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Aromatherapy is a way that has helped people adapt to their environment and maintain a great degree of well being. After enjoying a middle position in historic civilizations, it sank into oblivion until the early twentieth Century. • Request the fuel chromatography (GC) and mass spectrometry (MS) for a detailed breakdown of the components of the oil. These analytical stra
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In the increasingly competitive labor market, people looking for employment in driving-related professions frequently find themselves facing a complicated range of requirements– including the acquisition of a driver’s license. Employment service play an es
PY-60
Meningitis is the most devastating form of coccidioidomycosis. A convenient, rapid diagnostic method could result in early treatment and avoid many meningitis complications. We studied cerebrospinal fluid (CSF) samples in patients with documented coccidioidal meningitis, and controls, with complement fixation (CF), immunodiffusion (ID) (the “classical” assays), lateral flow assays (LFA; one-strip and two-strip), and two enzyme
ISX-9
The 5-HTTLPR gene-polymorphism was found to be significantly associated with AN susceptibility with an over-transmission of the S-allele from parents to offspring.
The systematic review distinctively emphasized the genetic contribution of the brain-genes on the development of AN. Despite significant study findings, no clear and standardized genetic route was determined to be t
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In addition, myeloid-derived suppressor cells are strongly elevated in the transgenic model used and normalized by combination treatment, indicating restoration of brain immune homeostasis. Overall, our results suggest that revitalizing brain immunity by combining IV with moderate-dose PD-1 inhibition may represent a therapeutic immunotherapy for AD.Frontotemporal dementia (FTD
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Finding the Best Auto Locksmith in Wellingborough
When faced with a lorry lockout, finding a trusted auto locksmith can be a difficult task, particularly in a bustling town like Wellingborough. With so many people and companies declaring to supply exceptional locksmith services, how does one identify the best choice? bes
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The cold face test and cold pressor test were performed to physiologically activate ANS. The SKNA and aVNA can be obtained simultaneously, and they are correlated with the heart rate change during the physiological challenge. The aVNA has a high potential to be developed into a novel method to measure the PNS activity.After a stroke, individuals often exhibit upper extremity (UE) motor dysfunction, influencing the per
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Gastroesophageal adenocarcinoma (GEA) is a challenging disease; most GEA patients do not live for more than a year after a diagnosis of advanced disease. Development of effective targeted therapeutics for GEA patients lags behind other cancers. Progress in molecular biology has provided subclassifications of gastroesophageal cancer which may have prognostic and predictive utility and has identified no
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