The use of cell-penetrating peptides as medication delivery carriers has gained much attention in recent years. Researchers might use them in the creation of novel medicinal agents or cosmetics. Molecules heavier than 500Da have a difficult time penetrating biofilms. Recent research has shown that covalently joining a wound-healing peptide sequence with cellular osmotic peptides may increase the efficiency with which medications are transported through cell membranes. Conjugation of newly ingested peptides into keratin cells has the potential to enhance medication transport in the presence of excellent tolerance greatly.
The success percentage of corneal transplants may be increased with intestinal peptide.
Injecting the neuropeptide (VIP) into the eyes of mice has been shown to increase the survival rate of corneal transplants, according to a study published in the American Journal of Pathology. Other benefits of VIP include:
- A quicker healing time for wounds.
- Better protection for the corneal endothelial cells.
- A cleaner corneal transplant.
If the therapy is given the green light, it will relieve many people struggling with corneal illnesses.
Cancer Cell: Peptide medicines under development for targeted therapy of prostate cancer.
Cancer Cell, an international academic publication, recently published a paper in which University of Michigan researchers presented a novel therapeutic technique for prostate cancer that explicitly targets genetic abnormalities in around half of the cases. Prostate cancer development is triggered by the relocation and chromosomal fusion of the TMPRSS2 and ERG genes. However, creating small chemical inhibitors targeting ERG has always been challenging.
Journal of Nature: Miraculous peptides that eliminate medication-resistant microorganisms.
Antibiotic overuse and misuse have been important topics of discussion as of late. The overuse of antibiotics has led to the rise of medication-resistant “superbugs” since more germs have become resistant to treatment. However, new antibiotics have been unable to keep up with bacterial advancements. By 2050, the World Health Organization estimates that 10 million people worldwide will lose their lives due to drug-resistant microorganisms. Some scientists have made various steps to modernize the arsenal of weaponry to fight germs. Scientists at MIT, Brazil’s University of Brasilia, and the Canada’s University of British Columbia have developed a new antibacterial peptide that is effective against a wide range of bacteria, even those that have developed resistance to antibiotics.
Fungal peptides targeted against TB are a promising new therapeutic option.
Scientists from Lund University discovered that in recent research published in the international journal Tuberculosis. Saprophytic ascomycetes (Pseudoplectania nigrella) have been studied for their potential application as a source of a novel antibiotic that can combat Mycobacterium TB.
Spirulina peptides may have a pronounced hypotensive impact on those with Hypertension.
Researchers at the University of Rome and others have shown that a peptide isolated from spirulina might lower blood pressure by relaxing blood vessel walls. Their findings appeared in the international journal Hypertension. Researchers want to use the findings to inform the creation of future hypertension medicines.
Natural peptides may increase insulin and glucose tolerance and decrease fat storage in those with diabetes.
Catechol somatostatin peptides are present naturally in the body and were recently used as a treatment for obese mice in a study published in the international journal Diabetes (CST). Mice’s glucose and insulin tolerance may be significantly enhanced by or, and the animals’ body weight can be decreased. The researchers note that CST is essential for controlling inflammation and insulin resistance in the liver due to obesity and recruiting macrophages.
Immunity is the body’s natural resistance against disease. In vitro studies have shown that a peptide found in frog mucus effectively against many types of influenza viruses.
Scientists are looking at frog mucus as a possible source of a new antimicrobial medicine since it includes chemicals that fight bacteria and viruses. Researchers have found that a host defense peptide can effectively eliminate multiple influenza virus strains in the brightly colored frog species Hydrophylax bahuvistara, native to southern India. Researchers have given the peptide the name “urumin,” and the findings have been published in the journal Immunity.
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